ライフサイエンスコーパス: life course

1 ical lens to examine these topics across the life course.

2 lth, human capital, and wellbeing across the life course.

3 prehypertension, and hypertension across the life course.

4 of social psychological processes across the life course.

5 acts during specific critical periods of the life course.

6 men and Mexican Americans increased over the life course.

7 sity and cardiometabolic outcomes across the life course.

8 promote cardiovascular health throughout the life course.

9 tion predicts psychiatric illness across the life course.

10 neficial for fracture prevention through the life course.

11 nmental exposures experienced throughout the life course.

12 effect of an upward social mobility over the life course.

13 rs impact brain and cognition for the entire life course.

14 multiple adverse health outcomes across the life course.

15 and psychiatric disorders changed across the life course.

16 aging modalities and other stages across the life course.

17 blings has a lasting impact on that person's life course.

18 istic, and interventional research along the life course.

19 orbidities and their consequences across the life course.

20 ors influence health and well-being over the life course.

21 focus on prevention at earlier stages of the life course.

22 as a risk factor for IHD in women across the life course.

23 nts with diabetes, particularly early in the life course.

24 a risk factor for poor health throughout the life course.

25 reported higher cognitive activity over the life course.

26 itable and genetically stable throughout the life course.

27 tage of life, and as a setting point for the life course.

28 ant to minimizing caries risk throughout the life course.

29 -reaching implications for health across the life course.

30 regnancy events and chronic disease over the life course.

31 t of human development in the balance of the life course.

32 lack of sophisticated phenotyping across the life course.

33 dynamics, risks, and consequences across the life course.

34 ntellectual decline in the first half of the life course.

35 lties in relationships shaped the subsequent life course.

36 clerosis early in life and tracks across the life course.

37 ealth and wellbeing is needed throughout the life course.

38 tructural and functional plasticity over the life course.

39 =0.07 and 0.06, respectively) throughout the life course.

40 alth-related events, and patterns across the life course.

41 ded to understand sexual function across the life course.

42 .001 and 0.001, respectively) throughout the life course.

43 d infant growth and disease risk through the life course.

44 a long-term impact on health throughout the life course.

45 , well-being, learning, or behavior over the life course.

46 inable functional alterations throughout the life course.

47 tic loading appears to contribute across the life course.

48 tes of aortic root remodeling over the adult life course.

49 ssessment of economic effects over a woman's life course.

50 rsistent obesity and overweight early in the life course.

51 gely primary mental disorders throughout the life course.

52 s likely to improve children's wellbeing and life course.

53 mortality or other health outcomes over the life course.

54 erminants of LV mass tracking over the adult life course.

55 of oxidative stress and inflammation over a life course.

56 two measures taken at two time points in the life course.

57 ifferent factors at different periods in the life course.

58 lth of offspring throughout their subsequent life course.

59 r understanding of its determinants over the life course.

60 factor for psychiatric disorders across the life course.

61 mbrace the entire living world and the whole life course.

62 childhood and overweight/obesity across the life course.

63 aps in access to oral health care across the life course.

64 c and lifestyle factors operating across the life course.

65 nd, according to their needs, throughout the life course.

66 ong women during this critical period of the life course.

67 ed protective effect varies across a child's life course.

68 00 chance of being killed by police over the life course.

69 increase the risk of anxiety throughout the life course.

70 riences (ACEs) and ill health throughout the life course.

71 t lymphocyte function is retained across the life course.

72 (HAP) constituents estimated over the entire life course.

73 o Bacteroides ratios that persist across the life course.

74 nts shape inflammatory phenotypes across the life course.

75 farming exposures on atopy endure across the life course.

76 alth challenges with implications across the life course.

77 comitant biological responses throughout the life course.

78 s, can influence health and disease over the life course.

79 rain development and function throughout the life course.

80 pre-conception to maximise health across the life course.

81 ical coronary atherosclerosis throughout the life-course.

82 ldwide that SDH affect health throughout the life-course.

83 higher levels of sexual involvement over the life-course.

84 scular health and healthcare over the entire life-course.

85 determines disease susceptibility across the life-course.

86 ic and environmental factors acting over the life-course.

87 ic and environmental factors acting over the life-course.

88 re of opportunities and constraints in their life courses.

89 g individual's activity patterns through the life- course.

90 tanding the migration patterns of individual life-courses.

91 s in health and human development across the life course?

92 her social factors to impact health over the life course; (2) early gender-normative influences by pa

93 behaviour) at different times throughout the life course affects the risk of many diseases and, ultim

94 re scarce data on how body weight during the life course affects this relationship.

95 ned statistically significant throughout the life course, although the substantive size of associatio

96 All responses were robust across the life course, although we observed an age-associated shif

97 Thus, life-course analysis illustrates that BPA is associated

98 ve error and ocular structure we performed a life-course analysis including both maternal and child c

99 We simulated growth trajectories across the life course and adjusted for secular trends.

100 ychiatric disorders, consistently across the life course and coincident with the experience of the lo

101 posure related to SEP accumulates across the life course and contributes to raised levels of fibrinog

102 le et al, "Mental Disorders Across the Adult Life Course and Future Coronary Heart Disease: Evidence

103 o different forms of malnutrition during the life course and have the double burden of malnutrition (

104 ; (b) analyzing exposure in relation to both life course and historical generation; (c) developing me

105 redisposition is more prominent early in the life course and in the early years of AUD.

106 ween socioeconomic position (SEP) across the life course and inflammation (as measured by CRP levels)

107 ognitive performance achieved earlier in the life course and less from declines in later life.

108 is a robust predictor of obesity across the life course and may interact with genes affecting metabo

109 in resistant than white Europeans across the life course and potentially experience beta-cell exhaust

110 on methylation are highly stable across the life course and that developmental change in the genetic

111 of left ventricular (LV) mass over the adult life course and the determinants of such change.

112 Extensive exposure data over the life-course and baseline specimens provide important opp

113 he social determinants of health, across the life course, and in wider social and economic spheres--t

114 in QALE loss by dental conditions across the life course, and people with high school or less educati

115 and the normalisation of violence across the life course, and transform men's power over women and ch

116 arly life that could be followed through the life course; and the establishment of human epigenetic m

117 Adopting a life course approach, these associations remained statis

118 investigated in longitudinal studies using a life course approach.

119 This highlights the importance of a life-course approach for frailty prevention.

120 The life-course approach to age-related diseases, when syste

121 Specifically, by adopting a life-course approach, they use a multilevel regression w

122 There has been a shift towards a life-course approach, with large cohort longitudinal stu

123 es influence cognitive impairment across the life course are warranted.

124 Most important, the gradient begins the life course as a gradient in developmental health, sugge

125 ealth promotion activities across the entire life course, as well as in access to treatment for ACS a

126 We demonstrate that life-course associations between early growth phenotypes

127 henotypes and birth outcomes, as well as the life-course associations between these birth outcomes an

128 These life-course associations have often been attributed to t

129 revention, with a greater focus early in the life course before disease processes are established.

130 0.03, p = 0.007), and persistent across the life course (beta = 0.26, SE = 0.04, p < 0.0001).

131 Within each cohort, individual life course BMI trajectories were created between 10 and

132 olic and diastolic blood pressure across the life course, but lower measures of adiposity, compared t

133 risk factors for refractive error across the life course, but ophthalmic examination in such cases to

134 Life course cellular mechanisms involved in this develop

135 uggesting a multiplicative effect of adverse life course circumstances coupled with genetic risk on p

136 hat the detrimental effects of disadvantaged life course circumstances for health and aging may be fu

137 223 927 children were included in the Danish Life Course cohort.

138 therapeutic strategies; however, additional life-course cohort studies spanning childhood and young

139 ease and to place these studies in a broader life-course context.

140 84 with reduced alcohol consumption over the life-course, contributing new evidence of an effect befo

141 ning and restoring higher CVH throughout the life course could provide substantial benefits for the p

142 olescence could yield understanding into the life course development of cardiovascular risk.

143 of events, differences in events across the life course, differences in events for men and women, re

144 s associated with health outcomes across the life course, DNA methylation may be an underlying mechan

145 e a global platform to reduce ACEs and their life-course effect on health.

146 Without all such time points, life course effects will remain only partially understoo

147 Life-course epidemiologic studies frequently obtain data

148 ity for intervention, based on evidence from life-course epidemiology, developmental (embryo) program

149 likelihood of staying after controlling for life-course events.

150 opment of miRNA biomarkers for the impact of life-course exposure as well as diagnosis and prognostic

151 etween grandparents' (first generation (G1)) life-course exposure to chronic poverty and grandchildre

152 Life-course exposure to early undernutrition followed by

153 s in a cohort that has experienced different life-course exposures and has different confounding stru

154 e associations under 2 causal structures for life-course exposures and timing of methylation measurem

155 and they support the importance of equity in life-course exposures for reducing racial disparities in

156 oeconomic variation, and we determined which life-course exposures were associated with these inequal

157 ult because of time-dependent confounding by life-course exposures.

158 lity and may reduce risk for dementia due to life-course factors.

159 mother's birth on GBW, adjusted for maternal life-course factors: maltreatment as a child, education

160 orrelation of .711 (p = 2.26e-12) across the life course for general cognitive function.

161 as observed at nearly every point across the life course for major depressive episode, panic disorder

162 ng of risk and protective factors across the life course for many of these problem behaviours.

163 ars are known to be a critical period in the life course for shaping attitudes and behaviors.

164 early childhood is the optimum period in the life course for the primary prevention of adult adiposit

165 mental and physical health problems over the life course; for example, meta-analyses indicate that ex

166 These findings imply that the life-course framework is crucial for understanding the c

167 is substantially heritable across the human life course from adolescence to old age.

168 U.S. cohorts with observations spanning the life course from young adulthood to later life, and impu

169 e HR status fluctuates throughout the cancer life course, from tumor initiation to the development of

170 As part of the Healthy Ageing across the Life Course (HALCyon) collaborative research programme,

171 As part of the Healthy Ageing across the Life Course (HALCyon) programme, men and women from seve

172 rticipating in the Healthy Ageing across the Life Course (HALCyon) research programme, ranging in age

173 d whether these associations vary across the life course has important clinical implications.

174 The obesity-hypertension link over the life course has not been well characterized, although th

175 d the trajectory of body-mass index over the life course have been associated with brain atrophy, whi

176 se in cumulative SEP disadvantage across the life course (hazard ratio = 1.16, 95% confidence interva

177 We administered an HIV test and a life-course history interview to participants.

178 personality occur unevenly during the dogs' life course, however, their dynamics seems to be specifi

179 ls differentiate and mature during the human life course; human cytomegalovirus (HCMV) infection is a

180 ements of inflammatory biomarkers across the life course if we wish to understand pathogenic processe

181 rajectory of lipids and lipoproteins for the life course in adults and to determine whether CRF modif

182 ransitions between categories of BP over the life course in contemporary, multiracial/multiethnic pop

183 n measures were not different throughout the life course in exposed females or males (all P>0.44), al

184 ion that mtDNA deletions accumulate over the life course in post-mitotic cells of many species.

185 d by social and economic conditions over the life course in producing adverse birth outcome dispariti

186 related role of lead burden and SES over the life course in relation to psychological functioning in

187 line BMI, the rate of change in BMI over the life course increased the risk of incident hypertension

188 of the cohort trends raises questions about life-course inequalities in the social and health enviro

189 Data from the Life-course Influences on Fetal Environments (LIFE) Stud

190 ealth and multiple health domains across the life course, interventions that ameliorate these initial

191 iated with cardiometabolic outcomes over the life course into adulthood.

192 Psychological distress at any point in the life course is associated with higher cardiometabolic ri

193 Cardiac remodeling over the adult life course is characterized by a distinct pattern of in

194 rdiovascular risk factors develop across the life course is incompletely known.

195 SEP over the life course is related to the risk of incident heart fai

196 rdiovascular health promotion throughout the life course is required.

197 ulation of psychobiological risks across the life course is summarized and represents an important di

198 of overweight and/or obesity over the adult life course is unknown.

199 of their effect on several traits across the life course is warranted.

200 the development of refractive error over the life-course is required, particularly at the time of pub

201 t with individual vulnerabilities across the life-course is required.

202 , by maintaining brain health throughout the life course, is essential.

203 ations of individual- and neighborhood-level life-course (LC) socioeconomic status (SES) with inciden

204 e continue to have high non-HDL-C over their life course, leading to significantly increased risk of

205 formation of mild carotid stenosis along the life course leads to progressive damage that may create

206 wealth) and neighborhood factors across the life course may be necessary.

207 development of personality across the human life course may be observed from three different standpo

208 EP indicators at different points across the life course may be related to a combination of 28 inflam

209 elomere length and physical fitness over the life course may contribute to increased risk of several

210 tal timing, further investigation across the life course may help quantify the full effects and the c

211 mal levels of these risk factors through the life course may prevent atrial remodeling and AF.

212 r weight or body mass index (BMI) across the life course may provide insights into the aetiology of o

213 ychiatric disorders in the first half of the life course may reduce the population burden of age-rela

214 evels were generally stable over the 30-year life course; mean non-HDL-C measured in young adulthood

215 close relationships and its effect in their life-course migration.

216 hts into the developmental components of the life course model of ageing may lead to the design of bi

217 de a common mechanistic process underlying a life course model of ageing.

218 A life course model places ageing in the context of the at

219 Using a two-stage structured life course modeling approach, we tested the hypothesis

220 man cortex DNA methylation data spanning the life course (n = 1397, ages = 1 to 108 years).

221 Psychological distress profiles over the life course (no distress, childhood only, adulthood only

222 nt with which humans interact throughout the life course, nor does it allow for interrelationships be

223 elevated risk of developing obesity over the life-course (odds ratio=1.36; 95% confidence interval=1.

224 studies to evaluate the role of IL-6 in the life course of asthma are needed.

225 derstanding the epidemiologic profile of the life course of mental disorders is fundamental for resea

226 d microsimulation model, which simulated the life course of patients on the transplant waiting list a

227 eplacement therapy (RRT) initiation over the life course of pediatric kidney diseases.

228 findings have important implications for the life course of YLPHIV who may be at increased risk of pr

229 ic information were collected throughout the life-course of individuals.

230 impact of overweight and obesity during the life course on cancer risk remain scarce.

231 e has profound adverse consequences over the life course on human, social, and economic capital.

232 ld development, with implications for future life course outcomes.

233 eschool has demonstrated positive effects on life-course outcomes, limitations in knowledge on progra

234 lomere length (LTL) decreases over the adult life course owing to the cumulative burden of oxidative

235 ed biological aging in the first half of the life course, particularly in men.

236 This study sought to assess whether life course patterns of psychological distress assessed

237 nt temperament predict adult personality and life-course patterns?

238 urther, the relative importance of different life-course periods for rate of late-life memory decline

239 Life-course persistent asthma and tobacco smoking are ri

240 Our findings suggest that life-course persistent offending may represent a viable

241 Study members with life-course-persistent asthma had elevated blood eosinop

242 Study members with life-course-persistent asthma had shorter leukocyte telo

243 Life-course-persistent asthma is related to a proposed b

244 her genetic risk were more likely to develop life-course-persistent asthma than were those with a low

245 Blood eosinophil count mediated 29% of the life-course-persistent asthma-leukocyte telomere length

246 Asthma was classified as life-course-persistent, childhood-onset not meeting crit

247 od-onset asthma cases remit and which become life-course-persistent, who might develop impaired lung

248 e findings are reviewed and discussed with a life course perspective, examining the contribution of i

249 Adopting a life course perspective, we examined the effects of earl

250 d myocardial infarction were assessed from a life-course perspective and a current view separately.

251 disparities, it is critical to incorporate a life-course perspective and integrate social theory.

252 es, positive and negative, arise from both a life-course perspective and within a socioecological fra

253 al to quantify the effects of smoking from a life-course perspective in future research and to sugges

254 Applying a life-course perspective would entail modeling transition

255 ertension and myocardial infarction from the life-course perspective, and the risk increased with age

256 l infarction, with a particular focus from a life-course perspective.

257 Further studies are needed to determine the life course progression of these changes.

258 ons between religious practices early in the life course (regular service attendance and prayer/media

259 ons between religious practices early in the life-course (regular service attendance and prayer/media

260 he authors examined the impact of changes in life-course SEP on incidence of dementia and cognitive i

261 s study, the authors examined the effects of life-course SEP on inflammatory and hemostatic markers:

262 We examined associations between life-course SES and late-life memory function and declin

263 Individuals who experienced life-course SES improvement had intermediate AA compared

264 nvestigations of the link between changes in life-course socioeconomic position (SEP) and cognitive d

265 When more specific information about women's life-course socioeconomic status is taken into account,

266 Associations declined in magnitude with life course stage and number of previous lifetime disord

267 t promoting optimal nutrition throughout the life course, starting with continued breastfeeding, may

268 size has its roots earlier in life, yet few life-course studies have data on siblings with which to

269 ing five topics in more detail: the need for life-course studies of pediatric cardiac disease and epi

270 ng, biomarkers, cardioprotective strategies, life-course studies, long-term monitoring technologies,

271 ects of distal causes experienced across the life course, such as segregation, that operate through m

272 iated with increased suicide risk during the life course, supporting the developmental origin of heal

273 developmentally appropriate times during the life course, target multiple risks, and build on existin

274 Throughout the life course, telomere length decreases with age and is i

275 e impact of exposures experienced across the life course (termed 'exposome').

276 designs addressing energy balance across the life course, the development and application of highly r

277 anges in physical activity behavior over the life course, the domains of physical activity in which t

278 The higher the sugar consumption along the life course, the higher the dental caries increment.

279 finding that is consistent with labeling and life course theories.

280 energy allocation strategies throughout the life course, thereby affecting diverse health outcomes.

281 ence offspring adiposity and when across the life course these effects may manifest themselves.

282 Throughout the life course, these pathways can lead to insulin resistan

283 ding how multiple stressors combine over the life course to affect the risk of morbidity and mortalit

284 activity level and low bodyweight across the life course to prevent diabetes.

285 These life-course trajectories are shaped both by societal dri

286 The life course trajectory differs in high and low resource

287 for BMI can vary in their effects across the life course, underlying the importance of evaluating BMI

288 Covariates included sex and life course variables, such as family income, breast-fee

289 etween "stable Non-manual" profiles over the life course versus "Manual to Non-manual" profiles (beta

290 5-15 years of life lost, estimated along the life course via the generalized gamma model.

291 Measures collected across the life-course were analysed to explore the association of

292 omes experienced by individuals during their life course) were examined using multivariable regressio

293 overall physiological wear-and-tear over the life course, which could partially be the consequence of

294 these factors can be promoted throughout the life course, which, at the individual as well as the soc

295 Adolescence is a formative phase of the life course with multiple physical, emotional and social

296 lth and development, and mothers' health and life-course with home visits beginning during pregnancy

297 ct serotonin receptor populations across the life course, with an emphasis on the contribution of dif

298 terminants of behavior change throughout the life course would contribute greatly to understanding wh

299 s influenced by factors occurring across the life course, yet exposures to area conditions have only

300 The heart progressively remodels over the life course, yet longitudinal data characterizing such r