ライフサイエンスコーパス: lifelong

1 that result from blasts are significant and lifelong.

2 The amplified ISG profile is then maintained lifelong.

3 lergic is common, often serious, and usually lifelong.

4 develops for auditory feedback, even in the lifelong absence of vision.

5 sponses, and treatment regimens that require lifelong adherence to suppress the virus.

6 HIV infection can be effectively treated by lifelong administration of combination antiretroviral th

7 evant levels of beta-globin it would require lifelong administration.

8 Lifelong aerobic exercise prevented age- and WD-related

9 ow that a male's presence by itself leads to lifelong alterations in life history in female mice.

10 Peanut allergy is usually lifelong and accidental exposure impose formidable risk.

11 establishment of latent infection, which is lifelong and can precede tumor development by years, req

12 Traumatic brain injury (TBI) can have lifelong and dynamic effects on health and wellbeing.

13 Infection is lifelong and has been associated with chronic weight los

14 icrobial succession, which may contribute to lifelong and intergenerational deficits in growth and de

15 enotypes in a scalable manner, incorporating lifelong and whole-phenome context.

16 the disease is complex, multifactorial, and lifelong, and affects nutrition and psychological wellbe

17 and how they modulate host immunity, persist lifelong, and contribute to tumorigenesis.

18 nt of gluten-related disorders is based on a lifelong, and strict, gluten-free diet.

19 History A 28-year-old man presented with lifelong anejaculation, which had become an issue becaus

20 value for a 1-time alternative treatment to lifelong anti-VEGF treatment for nAMD.

21 th mechanical valve replacement necessitates lifelong anticoagulation with a vitamin K antagonist.

22 Lifelong anticoagulation with warfarin or alternative vi

23 inability to grow in pediatric patients, and lifelong anticoagulation.

24 Lifelong antiplatelet treatment is recommended after isc

25 Lifelong antiretroviral (ARV) drug combination dosing al

26 re hoping to avoid the potential pitfalls of lifelong antiretroviral therapy and other HIV-related di

27 orts further study of the universal need for lifelong aspirin in secondary prevention for all adults

28 mold conidia daily and typically experience lifelong asymptomatic clearance.

29 lyomavirus (JCPyV) establishes a persistent, lifelong, asymptomatic infection within the kidney of th

30 ways proceed as smoothly and reliably as the lifelong beating of our heart or filtration of blood by

31 ve been identified which limit the potential lifelong benefits of CAR T cell therapy.

32 Furthermore, the degree of lifelong bilingualism (i.e., high, moderate, or low use)

33 ecent epidemiological evidence suggests that lifelong bilingualism may act as CR delaying the onset o

34 Hematopoietic stem cells (HSCs) that sustain lifelong blood production are created during embryogenes

35 lling of hematopoietic stem cells (HSCs) for lifelong blood production.

36 uture risk of brain disorders and to enhance lifelong brain functions.

37 n in these developmental tasks important for lifelong brain health and development.

38 We modulated somatic state through a lifelong brood size manipulation in wild jackdaws and me

39 luoridation are that it provides substantial lifelong caries prevention, is economic, and reduces hea

40 resembling HIV-1 seropositive individuals on lifelong cART, exhibits age-related, progressive neuroco

41 patitis C virus is capable of establishing a lifelong chronic infection in the liver, which could dev

42 is a highly successful parasite that causes lifelong chronic infections and is a major cause of abor

43 tion.IMPORTANCE Gammaherpesviruses establish lifelong chronic infections in cells of the immune syste

44 t organs, especially the brain, leading to a lifelong chronic phase.

45 (GHVs) are DNA tumor viruses that establish lifelong, chronic infections in lymphocytes of humans an

46 eaves people living with HIV-1 burdened by a lifelong commitment to expensive daily medication.

47 ns, we identified a healthy adult woman with lifelong complete knockout of HAO1 (expected ~1 in 30 mi

48 his effective chemotherapy agent and lead to lifelong complications, particularly in pediatric cancer

49 t of smouldering systemic mastocytosis, is a lifelong condition associated with reduced quality of li

50 , potentially life-threatening and typically lifelong condition with a significant burden of illness.

51 n the intrauterine environment can result in lifelong consequences for metabolic health during postna

52 Given the unknown etiology of ASD and the lifelong consequences of the disorder, identifying group

53 lopment is affected in NF1, possibly causing lifelong consequences that cannot be rescued by reducing

54 s a neurodevelopmental disorder with serious lifelong consequences, autism has received considerable

55 heart consumes circulating nutrients to fuel lifelong contraction, but a comprehensive mapping of hum

56 n immunodeficiency virus (HIV; PHIVs) face a lifelong cumulative exposure to HIV and antiretroviral t

57 nherited variation to create a challenge for lifelong cytopoiesis.

58 Antiretroviral therapy requires lifelong daily dosing to attain viral suppression, resto

59 interventions from infancy, can suffer from lifelong debilitation caused by underdeveloped maxillae.

60 es, just when DNA repair systems begin their lifelong decline.

61 ymphocyte repertoire development, to provide lifelong defense against pathogens while maintaining sel

62 t the need to closely monitor these patients lifelong despite liver transplantation and maintain mult

63 Autonomous lifelong development and learning are fundamental capabi

64 educe the likelihood of early development of lifelong diabetes-related morbidity.

65 Both can lead to lifelong disabilities, such as chronic obstructive pulmo

66 m newborns often results in major injury and lifelong disability.

67 The lifelong disease activity, implying a need for immunosup

68 th perinatal morbidity and increased risk of lifelong disease, including neurodevelopmental impairmen

69 e required to treat IBD throughout what is a lifelong disease.

70 ifest both acute infection and chronic, even lifelong, disease.

71 ocalized DC tissue surveillance and reveal a lifelong division of labor between DC subsets, with cDC2

72 effects lead to dismal patient adherence to lifelong drug regimens.

73 rldwide, as these individuals can experience lifelong drug-resistant epilepsy, cerebral palsy, feedin

74 only for weeks, rather than decades, making lifelong durability largely irrelevant.

75 mors or in memory B cells, the reservoir for lifelong EBV infection, remains incompletely understood.

76 Limitations of this study include the lifelong effect of a genetic perturbation not being the

77 revent osteoporosis and fractures due to the lifelong effect on BMD observed in the study.

78 rtant roles in shaping brain development and lifelong emotional behavior.SIGNIFICANCE STATEMENT Epige

79 ne whether women who have performed regular, lifelong endurance exercise acquire the same beneficial

80 Lifelong engagement in reserve-enhancing activities atte

81 egrates early life dietary cues that lead to lifelong epigenetic adaptations to a perceived nutrition

82 hat committed (>=4 weekly exercise sessions) lifelong exercise results in substantial benefits in exe

83 Athletes with a lifelong exercise volume >2000 MET-min/wk (n=75) had a s

84 Lifelong exposure of rats to low-dose BPA at 25 and 250

85 This study aimed to investigate whether lifelong exposure to different doses of BPA induced uter

86 We show that lifelong exposure to low Omega(sw) did not enable the co

87 These results suggest that lifelong exposure to low PCSK9 levels and cumulative exp

88 vaccinated 50 healthy, adult volunteers with lifelong exposure to Pf 3 times, at 4-week intervals, wi

89 imed to investigate the relationship between lifelong exposure to the constituents of smoky coal (and

90 ntate neurogenesis may therefore represent a lifelong extension of development that maintains heighte

91 agnosia (DP) is a condition characterised by lifelong face recognition difficulties.

92 This strongly supports the necessity of a lifelong follow-up and suggests that therapeutic strateg

93 Lifelong follow-up is mandatory in these patients.

94 and recurrent disease is common, leading to lifelong follow-up of patients.

95 These findings can explain lifelong food allergies observed in human subjects as th

96 rye and barley and is one of the most common lifelong food-related disorders worldwide.

97 and mass upon return to the hive, during the lifelong foraging career of individual bees.

98 tionally distinct SSC subset responsible for lifelong generation of periosteal osteoblasts.

99 Whether the risk of CAD associated with lifelong genetic exposure to increased serum calcium lev

100 Lifelong genetic exposure to lower levels of low-density

101 Neither lifelong genetic inhibition of ATP citrate lyase nor lif

102 genetic inhibition of ATP citrate lyase nor lifelong genetic inhibition of HMGCR was associated with

103 t AD risk would be lower in individuals with lifelong, genetically predicted increases in concentrati

104 only treatment for celiac disease (CeD) is a lifelong gluten-free diet (GFD).

105 The treatment of celiac disease (CD) is a lifelong gluten-free diet (GFD).

106 A strict, lifelong gluten-free diet is the only treatment.

107 The beneficial effects of sustained or lifelong (>25 years) endurance exercise on cardiovascula

108 In this woman, lifelong HAO1 knockout is safe and without clinical phen

109 rse outcomes co-occur, with implications for lifelong health and social outcomes.

110 Male development, fertility, and lifelong health are all androgen-dependent.

111 Early social stress has potent lifelong health effects.

112 utero and perinatal stressors may alter the lifelong health trajectory of a child, increasing the ri

113 r stillbirth and has significant impact upon lifelong health.

114 ) in the ventral dorsal aorta (VDA), support lifelong hematopoiesis.

115 Individuals with congenital amusia have a lifelong history of unreliable pitch processing.

116 stography, we evaluated 46 young adults with lifelong HIV and 20 matched HIV-negative controls.

117 Little is known about the effects of lifelong human immunodeficiency virus (HIV) or antiretro

118 urviving a single infection often results in lifelong immunity to the infecting pathogen.

119 period and could prime the immune system for lifelong immunity.

120 lls to expand upon demand, thereby providing lifelong immunity.

121 e first influenza virus variant encounter on lifelong immunity.

122 ly insured transplant recipients who receive lifelong immunosuppressant drug coverage compared with a

123 onor tissue scarcity and the requirement for lifelong immunosuppression.

124 er, offer to patients remains limited due to lifelong immunosuppression.

125 tentially life-threatening infections due to lifelong immunosuppression.

126 o long-term graft survival that necessitates lifelong immunosuppressive therapy after renal transplan

127 y of evidence that intrauterine growth has a lifelong impact on cardiovascular health.

128 dietary intake during pregnancy, may have a lifelong impact on the individual's susceptibility to di

129 antly to infant mortality and morbidity with lifelong impact.

130 th results in developmental disabilities and lifelong impairments.

131 There are potential lifelong implications of NSSH, such as an increased freq

132 placental functioning due to stress can have lifelong implications.

133 ons.IMPORTANCE Herpes simplex virus persists lifelong in neurons and can reactivate to cause recurren

134 The assumption that lifelong increased brood size reduced somatic state was

135 Lifelong increased free testosterone had beneficial effe

136 reservoir size in the body, which guarantees lifelong infection and resumption of virus replication a

137 Cytomegalovirus (CMV) establishes a lifelong infection facilitated, in part, by circumventin

138 uses are ubiquitous pathogens that establish lifelong infection in >95% of adults worldwide and are a

139 esis.IMPORTANCE Gammaherpesviruses establish lifelong infection in a majority of adults worldwide and

140 mplify the latent reservoir and to establish lifelong infection in memory B cells.

141 suppression following HSCT while maintaining lifelong infection in myeloid lineage cells.

142 Herpes simplex virus 1 (HSV-1) establishes a lifelong infection in neuronal cells.

143 ating nerve endings, eventually establishing lifelong infection in neurons of the sensory or autonomi

144 ions.IMPORTANCE Gammaherpesviruses establish lifelong infection in over 95% of all adults and are ass

145 sm of immune evasion.IMPORTANCE HSV-1 causes lifelong infection in the human population and can be fa

146 onse and B cell differentiation to establish lifelong infection is thought to also precipitate malign

147 nipulate B cell differentiation to achieve a lifelong infection of memory B cells.

148 Herpes simplex virus 1 (HSV-1) causes a lifelong infection of neurons that innervate barrier sit

149 Lifelong infection of the gastric mucosa by Helicobacter

150 biquitous in the human population and causes lifelong infection that can be fatal in neonatal and imm

151 neurotropic virus that causes a persistent, lifelong infection that increases risk for other sexuall

152 Human cytomegalovirus (HCMV) causes a lifelong infection through establishment of latency.

153 ed and co-opted by a latent virus to balance lifelong infection with transmission.

154 To accomplish the remarkable task of lifelong infection, the Epstein-Barr virus (EBV) switche

155 ically infects most people and establishes a lifelong infection.

156 unodeficiency virus (SIV) avoid AIDS despite lifelong infection.

157 or nonindependence between pathogens causing lifelong infection.

158 their ability to induce a chronic, and often lifelong, infection known as brucellosis.

159 uses are ubiquitous pathogens that establish lifelong infections and are associated with a variety of

160 randed DNA, enveloped viruses that establish lifelong infections and cause a range of diseases.

161 cts mucosal epithelial cells and establishes lifelong infections in sensory neurons.

162 uses are ubiquitous pathogens that establish lifelong infections in the majority of adults worldwide.

163 These viruses establish lifelong infections that place their respective human an

164 known to establish persistent and sometimes lifelong infections.

165 iruses are ubiquitous viruses that establish lifelong infections.

166 ndelian randomization estimates representing lifelong inhibition of targets were generated using inve

167 ceptibility in a transgenic mouse model with lifelong innate immune system hyperactivation.

168 selection favored the evolution of increased lifelong investment in VAT in individuals likely to suff

169 wean early, mature slowly, and exhibit high lifelong investments in maintenance.(3-6) These adaptati

170 fusion-dependent haemoglobinopathies require lifelong iron chelation therapy with one of the three ir

171 f care, affected patients are subjected to a lifelong journey of corrective surgeries and multidiscip

172 es infect virtually all humans and establish lifelong latency and reactivate to infect other humans.

173 Like EBV and KSHV, MHV68 establishes lifelong latency in B cells.

174 f alphaherpesviruses is the establishment of lifelong latency in host sensory ganglia with occasional

175 (CMV) is a beta-herpesvirus that establishes lifelong latency in infected hosts.

176 , herpes simplex virus 1 (HSV-1) establishes lifelong latency in neurons.

177 , are neuroinvasive pathogens that establish lifelong latency in peripheral ganglia following the ini

178 ollowing acute infection, BoHV-1 establishes lifelong latency in sensory neurons.

179 ), an important bovine pathogen, establishes lifelong latency in sensory neurons.

180 vercome innate immune responses to establish lifelong latency throughout a susceptible individual's l

181 amily members may promote the maintenance of lifelong latency.

182 Herpes simplex virus (HSV) establishes lifelong latent infection and can cause serious human di

183 Herpes simplex virus 1 (HSV-1) establishes a lifelong latent infection in peripheral nerve ganglia.

184 E Herpes simplex virus 1 (HSV-1) establishes lifelong latent infections in neurons within trigeminal

185 mplex virus 1 (HSV-1) establish and maintain lifelong latent infections in neurons.

186 Herpes simplex virus 1 (HSV-1) establishes lifelong latent infections in neurons.

187 be attributed to their ability to establish lifelong latent infections in the dorsal root ganglia (D

188 s are neuroinvasive pathogens that establish lifelong latent infections in the host peripheral nervou

189 stress is characteristic of reactivation of lifelong latent infections.

190 ainable management of natural resources is a lifelong learning environment where the poor communities

191 Consequently, the derived LV and lifelong low blood pressure (BP) appear to be partly sus

192 ith a view to obtain comparative metrics for lifelong LTL attrition and learn about the temporal asso

193 Despite advances in cancer treatment, lifelong lymphoedema (limb swelling and the accompanying

194 Lifelong maintenance of a functional NSPC pool necessita

195 is a previously unrecognised determinant of lifelong male metabolic health.

196 tment in VAT in individuals likely to suffer lifelong malnutrition because of its importance in fight

197 rtainty as to the primacy of aspirin for the lifelong management of all patients with chronic coronar

198 a chronic condition and long-term, sometimes lifelong, management is required.

199 immunodeficiency virus (HIV)-1 but requires lifelong medication due to the existence of a latent vir

200 he complexities and expenses associated with lifelong medication, developing an effective curative in

201 y on daily ART, HIV-1-infected children face lifelong medications to control infection.

202 Diabetes mellitus is a lifelong metabolic disease that requires frequent subcut

203 The lifelong metabolic improvements in the offspring were ac

204 reindustrial human survival was dependent on lifelong moderate-intensity endurance physical activity

205 Pneumonectomy patients require lifelong monitoring and may benefit from expeditious ass

206 Our study highlights the importance of lifelong monitoring of cardiovascular risk factors in wo

207 Bipolar disorder is a lifelong mood disorder characterized by extreme mood swi

208 fection in neonates leading to mortality and lifelong morbidity.

209 atients with inflammatory bowel disease have lifelong needs to learn how to manage their symptoms and

210 born in the adult hippocampus, a region with lifelong neurogenesis and plasticity.

211 apacity of the olfactory epithelium (OE) for lifelong neurogenesis and regeneration depends on the pe

212 eural stem cell (NSC) number is critical for lifelong neurogenesis.

213 eases in newborn infants, often resulting in lifelong neurologic impairments or death.

214 Most children who survive nHSV develop lifelong neurological and behavioral deficits, despite a

215 r synaptic transmission, producing early and lifelong neurological deficits, including childhood abse

216 sis does not represent neuronal turnover but lifelong neuronal addition.

217 Varicella-zoster virus (VZV) establishes lifelong neuronal latency in most humans world-wide, rea

218 al congenital brain disorder contributing to lifelong neuropsychiatric morbidity in affected children

219 ift our view of hydrocephalus from that of a lifelong neurosurgical disorder to that of a preventable

220 on violates the adaptive fetal prediction of lifelong nutritional deficit, preferential VAT investmen

221 hat separated individuals according to their lifelong occupational activities.

222 Lifelong oral anticoagulation, either with warfarin or a

223 hin flocks of jackdaws, a species that forms lifelong pair-bonds.

224 aneous leishmaniasis in C57BL/6 mice and for lifelong parasite persistence in draining lymph nodes (d

225 We examined the effects of lifelong PCB exposure on the reproductive processes of m

226 for understanding how the virus establishes lifelong persistence in infected people, in whom it can

227 cal for the establishment of EBV latency and lifelong persistence within its host, whereas any retain

228 (+) HPCs by HCMV.IMPORTANCE HCMV establishes lifelong persistence within the majority of the human po

229 manipulating immune responses to promote its lifelong persistence, a result of millions of years of c

230 ruses (gammaHVs) have a dynamic strategy for lifelong persistence, involving productive infection, la

231 ved with the host immune system to establish lifelong persistence.

232 Lifelong persistent infection has also been linked with

233 GMZ2 is well tolerated and immunogenic in lifelong-Pf-exposed adults from Gabon, with similar anti

234 vector strategy has the capacity to mediate lifelong phenotype correction and reduce the tumorigenic

235 uals are at risk for kernicterus and require lifelong phototherapy.

236 Together, our results suggest that lifelong physical activity is associated with DNA methyl

237 We investigated the effect of lifelong physical activity on global DNA methylation pat

238 es involved in understanding time-dependent, lifelong physiological processes.

239 not merely a context that sets the stage for lifelong plasticity.

240 We suggest that humans display a lifelong preoccupation with the sociality of moral oblig

241 e, but also to include "cultural humility"-a lifelong process of learning, self-reflection, and self-

242 Human lymphopoiesis is a dynamic lifelong process that starts in utero 6 weeks postconcep

243 stem cells (LT-HSCs) are responsible for the lifelong production of mature blood cells and are the ra

244 protection, as LTBI subjects are most often lifelong protected against the disease.

245 influenza A virus should offer long-term or lifelong protection against that strain, preventing rein

246 at infection by Toxoplasma gondii triggers a lifelong protective immunity due to the persistence of p

247 r strategies of nuclear maintenance, linking lifelong protein persistence to gene regulation and nucl

248 Instead, lifelong reactivity is conferred by allergen-specific lo

249 virus, helping explain how the virus causes lifelong recurrent disease.

250 MDD patients often suffer from lifelong recurring episodes of increasing severity, redu

251 supporting cells (SCs) in their ears retain lifelong regenerative capacities that depend on prolifer

252 Lifelong regular physical activity is associated with re

253 n of effective treatments that could promise lifelong remission.

254 celerate therapeutic intervention to achieve lifelong remission.

255 ooth regeneration is hampered by the lack of lifelong replacing oral dentition in most conventional m

256 ion in rare human diseases; the capacity for lifelong rescue of a lethal condition related to Walleri

257 goal of multimodality therapy is to minimize lifelong residual treatment-associated toxicity while ma

258 nts, tobacco smoke, and other early-life and lifelong risk factors for the development and exacerbati

259 fatal; asymptomatic VL (AVL) may establish a lifelong risk of reactivation.

260 account for those at low short-term but high lifelong risk.

261 etal or neonatal death, neurodisability, and lifelong risks to the health of the affected child.

262 eactions (DHRs) can be serious and result in lifelong sequelae.

263 th reduced risk of dementia than widowed and lifelong single people, who are also underdiagnosed in r

264 d worse physical health the elevated risk in lifelong single people.

265 relative risks of being widowed, divorced or lifelong single, compared with being married.

266 peak bone mass, an important determinant of lifelong skeletal health.

267 disruptions in sleep and behavior, including lifelong spindle decreases and later life NREM sleep fra

268 When we adjusted the effect of CXL to a lifelong stabilizing effect, the ICER decreased to euro1

269 roughout life and at the same time guarantee lifelong storage and remote recall of established memori

270 effective treatment for coeliac disease is a lifelong strict gluten-free diet; however, the diet is r

271 ug seeking and drug taking that can remain a lifelong struggle.

272 Anxiety disorders are common, can result in lifelong suffering, and frequently begin before adolesce

273 d to compare the risks of HSCT with those of lifelong supportive therapy.

274 s (HIV)-integrated proviral DNA necessitates lifelong suppressive antiretroviral therapy (ART).

275 ction, virus-elicited antibodies can provide lifelong surveillance and protection from future insults

276 computed tomography-aortography (CTA) in the lifelong surveillance of patients after endovascular ane

277 fter sustained viral response (SVR) and need lifelong surveillance.

278 ctiveness of minimally invasive, potentially lifelong TES treatment of epilepsy either alone or as a

279 To my surprise, a lifelong theme emerged that I was unaware of, that is, t

280 HIV-1 infection requires lifelong therapy with antiretroviral drugs due to the ex

281 ed off-treatment response) without requiring lifelong therapy.

282 for chronic hepatitis B require long-term or lifelong therapy.

283 del for colorectal adenoma and cancer with a lifelong time horizon was developed, calibrated to the A

284 vention versus standard-of-care alone over a lifelong time horizon.

285 Lifelong tracking studies will allow researchers to iden

286 The progression of lifelong trajectories of socioeconomic inequalities in h

287 (HSV-1) and HSV-2 can efficiently establish lifelong, transcriptionally silent latency states in sen

288 tal hydrops and symptomatic anemia requiring lifelong transfusions to fully compensated hemolysis.

289 Patients with vitiligo require lifelong treatment to regain and maintain their pigment.

290 ch resupply active virus, thus necessitating lifelong treatment with associated compliance, cost, and

291 However, some of these patients need lifelong treatment with immunosuppressive medications to

292 icating that successful therapy will require lifelong treatment.

293 Currently, patients rely on lifelong treatments that alleviate the symptoms, but no

294 Lifelong venom immunotherapy (VIT) is recommended; howev

295 ind a highly penetrant detrimental impact of lifelong very low levels of LDL cholesterol due to del2.

296 an adjunct to other therapies might achieve lifelong viral control.

297 cular disorder and the most leading cause of lifelong visual loss.

298 fespan in sedentary mice They also show that lifelong voluntary aerobic exercise has remarkable prote

299 for congenital forms of hypogonadism must be lifelong, whereas testosterone treatment of late-onset h

300 llergies (eg, fish, shellfish, and nuts) are lifelong, without any disease-transforming therapies, an