ライフサイエンスコーパス: ligand for

1 " platform to identify and validate covalent ligands for 11 different human proteins.

2 s establish macropa to be a highly promising ligand for (225) Ac chelation that will facilitate the c

3 The ligand for 4-1BB is expressed on antigen-presenting cell

4 e that consists of a nanobody and a peptidic ligand for a G protein-coupled receptor (GPCR), fused vi

5 anic molecule to function as a physiological ligand for a nuclear receptor and direct environmental s

6 lated protein (HPR), which can function as a ligand for a parasite receptor.

7 monolayer that presents a candidate peptide ligand for a receptor and a peptide substrate for an enz

8 de pQDRSKAMQAERTGQLRRLNPRF-NH(2) is a potent ligand for a sNPF/PrRP-type receptor in the starfish Ast

9 Interestingly, hybrubin A was found to be a ligand for a variety of GPCRs with a propensity for pote

10 d magnetic nanoparticles pull down selective ligands for a particular quadruplex topology from a seri

11 heterocycles are important high-affinity P2 ligands for a variety of highly potent HIV-1 protease in

12 n NB, neither drug reduced the expression of ligands for activating NK receptors or upregulated that

13 onsensus phosphopeptide sensor, and that the ligand for activation is surprisingly derived from the N

14 Y-ADGRE2 and attached to dermatan sulfate, a ligand for ADGRE2.

15 Extracellular adenosine, the ligand for AdoR, is a small metabolite that can be relea

16 This study sheds light onto the native ligands for AeOBP22 and provides insight into its potent

17 2 (SPSB2) that binds to iNOS, and selective ligands for AGRP-binding melanocortin (MC) receptors.

18 that might regulate activin B, the principal ligand for ALK7, identifying thereby a third family of m

19 mega-carboxyethyl)pyrrole (CEP), serves as a ligand for alpha(D)beta(2) CEP adduct with ECM is genera

20 as the first highly selective small-molecule ligand for alphavbeta8.

21 d to (+)-ryanodine, which is a high-affinity ligand for and modulator of ryanodine receptors-ligand-g

22 r inner sphere was the most probable type of ligand for arsenate on both phases and for selenate on s

23 ), an environmental contaminant, is a potent ligand for aryl hydrocarbon receptor (AhR).

24 Chiral diamines are particularly useful as ligands for asymmetric catalysis.

25 or 'Privileged chiral N-heterocyclic carbene ligands for asymmetric transition-metal catalysis' by Da

26 g ligand" (APRIL) is a natural high-affinity ligand for BCMA and transmembrane activator and calcium-

27 e to the challenge of identifying a suitable ligand for binding Al(3+) ion.

28 terobifunctional molecules consisting of one ligand for binding to a protein of interest (POI) and an

29 r template-driven selection of high-affinity ligands for biological targets from equilibrating combin

30 y activity, also binds to N. gonorrhoeae The ligand for both FH and FHL-1 was identified as neisseria

31 um benzoate as a base and a common phosphine ligand for both the Cu- and Pd-catalyzed processes were

32 complex class I (pMHC-I) molecules are major ligands for both forms of CD8.

33 rent literature on low-molecular-weight PSMA ligands for both PET imaging and therapeutic approaches,

34 d phosphines have been shown to be excellent ligands for C-N coupling reactions under mild reaction c

35 It is a high affinity ligand for cancer cell targeting.

36 reduce possible off-target toxicity of TNFSF ligands for cancer immunotherapy.

37 es can be considered as useful P-, N-, and O-ligands for catalysis and precursors to valuable beta-am

38 is(pyrazolyl)alkanes are a prolific class of ligands for catalysis, accessible by the condensation be

39 lic compounds, stereodefined 1,3-dienes, and ligands for catalytic asymmetric synthesis.

40 the site of PNI, but not CCL7, an alternate ligand for CCR2.

41 CD4+ T-cell frequency, and CCL20 expression (ligand for CCR6) were highest in rectal tissue, where HI

42 Mechanistically, tumor-derived CD155, the ligand for CD226, initiated phosphorylation of Y319 by S

43 activation/differentiation; however, natural ligands for CD33 remain elusive.

44 region locus 10 (H2-Q10) is a high-affinity ligand for CD8alphaalpha which also binds the MHC-Ib mol

45 rovide evidence that Qa-1(b) is a functional ligand for CD8alphaalpha, distinguishing it from its hum

46 ly, ANP and BNP were found to be the natural ligands for cell membrane-bound guanylyl cyclase recepto

47 Employing ligands for cereblon/cullin 4A E3 ligase and SI-109, we

48 Ligands for chemokine receptors CCR6 and CXCR2 are incre

49 e possibilities and challenges to find novel ligands for chemokine receptors.

50 nd cognitive systems; and 4) discovering new ligands for chemosensory receptors (e.g., those produced

51 are readily tuned by exchange of the OAc(-) ligand for Cl(-) (1-Cl), NO3(-) (1-NO3), and pyridine ([

52 The isomerized compounds are excellent ligands for Co(II) centers.

53 ns yielded vibrational modes of the diatomic ligands for conceivable H-cluster structures.

54 have the potential to act as a new class of ligands for coordination cages, metal-organic frameworks

55 n of the clusters as dianionic C sigma-bound ligands for coordination chemistry, ligand substituents

56 , we adapted a validated 8-N-benzyladenosine ligand for covalent bond formation and confirmed targete

57 dacnicolor, and validated as a high-affinity ligand for CRF receptor studies.

58 We identified l-fucose as a ligand for CTRP6 and that it bound to certain enteroaggr

59 The tert-butoxide is first demonstrated as a ligand for Cu-catalyzed coupling reaction, leading to al

60 The ligand for CXCR4; namely CXCL12, binds to the chimeric r

61 CXCL13, the ligand for CXCR5, was detected at 6-fold higher levels f

62 t of administration of LTE(4), the preferred ligand for CysLT(3)R, was additive with LTC(4).

63 blocked D8 binding to CS-A, the low affinity ligand for D8.

64 at each display multiple copies of mannoside ligand for DC-SIGN, yet differ in length and size.

65 Furthermore, non-pathogen-derived ligands for dectin 1 have not been characterized.

66 NEURL1 ubiquitin ligase, which targets Notch ligands for degradation, was upregulated in SCCIS.

67 Enkephalins, endogenous ligands for delta opioid receptors (DORs), are highly en

68 y is widely applied to achieve high affinity ligands for diagnostic and therapeutic purposes.

69 evaluation of a series of (18)F-labeled PSMA ligands for diagnostic application based on the theragno

70 w how the preferred binding orientation of a ligand for different proteins can be estimated via free

71 s Hh precursor protein to cholesterylated Hh ligand for downstream signaling.

72 To determine whether oxysterol ligands for EBI2 are increased in asthma exacerbation, a

73 We report a new chiral pyridinyloxazoline ligand for enantioselective, intramolecular silylation o

74 hesis of azotides and evaluation of these as ligands for enantioselective Lewis acid catalysis is rep

75 ient mice implicated IgG as the pathogenetic ligand for endothelial FcgammaRIIB in obesity-induced in

76 Stimulation with ephrinA1, a ligand for EphA2, induced further oligomerization and ac

77 , but there remains much to learn about this ligand, for example its reduction chemistry is scarce as

78 tune the response of biosensors to a set of ligands, for example, cross-reactivity to a given target

79 lide-lysine, used as the "recognition unit" (ligand) for F-actin in living cells.

80 ne fibrinogen-like 2 (Fgl2) was a functional ligand for FcgammaRIIB on CD8(+) T cells.

81 Ligands for FFAR3 induced Th2 cytokine production from h

82 FGF18, a high affinity ligand for FGFR3, is the only FGF-based drug currently i

83 Altogether, these results identify CRP as a ligand for FHR-1 and suggest that FHR-1 enhances, rather

84 erent ligands, VqmA does not require a bound ligand for folding or basal transcriptional activity.

85 l Review, we describe the development of new ligands for functionalizing and stabilizing metallic gol

86 body approach can generate multiple affinity ligands for future use in norovirus detection and possib

87 Pamoic acid is a potent ligand for G protein Coupled Receptor 35 (GPR35) and exh

88 The development of covalent ligands for G protein-coupled receptors (GPCRs) is not a

89 Here we demonstrate that physiological ligands for G protein-coupled receptors (GPCRs) promote

90 has been devoted towards the development of ligands for G4 that allow photoregulation of G4 folding.

91 Dexamethasone (DEX), a synthetic ligand for glucocorticoid receptor (GR), is routinely us

92 ever, the absence of endogenous or surrogate ligands for GPR27 complicates the examination of its bio

93 ves may provide a new type of organometallic ligand for high-performance single-molecule magnets.

94 cordingly, we simultaneously report MR1 as a ligand for human gammadelta T cells and redefine the par

95 nd alpha5 are coinhibitory and costimulatory ligands for human and mouse CD4 T cells, respectively.

96 5,10,15,20-tetra( p-benzoato)porphyrin (TBP) ligands, for hypoxia-tolerant type I PDT.

97 F-06684511 was identified as a candidate PET ligand for imaging BACE1 in the brain and showed high sp

98 of (18)F-JNJ-64413739, an (18)F-labeled PET ligand for imaging the P2X7 receptor in the brain.

99 s from cell extracts, and as affinity column ligands for inexpensive large-scale protein purification

100 gests an asymmetric mode of action of the Hh ligands for inhibiting the potential cholesterol transpo

101 T cells, HLA class I molecules are important ligands for inhibitory and activating killer immunoglobu

102 sponse to pathogen molecular mimicry of host ligands for inhibitory receptors.

103 So far no lipid ligand for integrin has been reported.

104 Fibroblast adhesion response to selective ligands for integrins alpha5beta1 and alphavbeta3, which

105 acterial-derived RNA and DNA can function as ligands for intracellular receptor activation and induce

106 Understanding how to design cell permeable ligands for intracellular targets that have difficult bi

107 Wnts thus act as ligands for ion channel activation in mammalian cells an

108 be predicting the mean binding affinity of a ligand for its protein targets.

109 na acetivorans NifB (MaNifB) as the nitrogen ligand for K1.

110 indicating a beta2-microglobulin-independent ligand for KIR2DS2.

111 ) KIR2DL1, KIR2DL2, and KIR2DL3, whereas the ligand for KIR3DL1 is HLA-Bw4.

112 repeat 2 (R2) that function as two distinct ligands for KLA.

113 s that contain a LAIR1 ectodomain(2-4) or as ligands for LILRB1(5).

114 by requiring overexpression of two separate ligands for localization.

115 yl)thiazol-2-amine (ARM1) was published as a ligand for LTA(4)H with potential anti-inflammatory prop

116 The ability of hepatocyte growth factor, the ligand for MET, to promote AKT activation and cell migra

117 libraries (DCLs) of receptor molecules, here ligands for metal cations.

118 ogenic SPOs, which are potentially useful as ligands for metal complexes in asymmetric catalysis.

119 hesizing pharmaceuticals, agrochemicals, and ligands for metal complexes, but strategies to selective

120 lthough initially developed as a theranostic ligand for metastasized cancer, FAPI (FAP inhibitor) tra

121 refore, [(11)C]13 is a potential PET imaging ligand for mGluR2 in different central nervous system-re

122 l positron emission tomography (PET) imaging ligands for mGluR2 in the brain.

123 that endomorphin-2 (EM2), an arrestin-biased ligand for microR, lengthens surface lifetimes of recept

124 Equipped with a triphenylphosphine ligand for mitochondria targeting, (mito) aPS showed exc

125 sicochemical properties for a diverse set of ligands for mostly "nontraditional" CNS targets and clas

126 ongoing clinical trials with sigma receptor ligands for multiple conditions, relatively little is kn

127 inform the design of subtype-selective DRD2 ligands for multiple human central nervous system disord

128 ar protons act as orthosteric and allosteric ligands for multiple receptors and channels.

129 ptide, linTT1 (AKRGARSTA), as a PC targeting ligand for nanoparticles.

130 myelin-associated inhibitors functioning as ligands for neuronal Nogo receptor 1 (NgR1).

131 tic ligand exchange of native oleate capping ligands for NHCs results in a bathochromic shift of the

132 mmetric catalysis using a chiral bioxazoline ligand for Ni.

133 ic ethers, a reaction that failed with known ligands for Ni and designer phosphines for Pd.

134 noimidazole was identified as an inexpensive ligand for nickel-catalyzed cross-electrophile couplings

135 ses partly depends on expression of CD112, a ligand for NK-cell receptor CD226 (DNAM-1).

136 Thus, incorporating affinity-matured ligands for NK cell-activating receptors might represent

137 receptor, and in the expression of Rae-1, a ligand for NKG2D.

138 Jacquemin et al., the authors reported that ligands for NKG2D are upregulated in vitiligo perilesion

139 osphatidylethanolamine (MTP-PE), a synthetic ligand for NOD2.

140 (68)Ga-HZ220 is a promising bimodal ligand for noninvasive PET imaging and intraoperative op

141 lysis, we show that Delta (Dl) serves as the ligand for Notch in the first and second divisions.

142 ive effects of C-type natriuretic peptide, a ligand for Npr2, against death of M-1 kidney epithelial

143 We also found that Sema3a, a chemorepellent ligand for Nrp1, is expressed by type I and IIa myofiber

144 olite of retinol (vitamin A), functions as a ligand for nuclear RA receptors (RARs) that regulate dev

145 e metabolite of dietary vitamin A, acts as a ligand for nuclear receptor transcription factors with m

146 ycerol into arachidonic acid, thus providing ligands for nuclear receptors as key regulators of hepat

147 itate nutrient absorption and are endogenous ligands for nuclear receptors that regulate lipid and en

148 isplay experiments to identify all-d peptide ligands for oncogenic KRas, providing a useful tool in t

149 erocyclic carbenes (NHCs) have been known as ligands for organometallic complexes since the 1960s, th

150 Boron-free AI-2 is the preferred ligand for PctA and TlpQ.

151 A simple ligand for Pd(II) orchestrates the C-H activation step i

152 Tumour cells frequently overexpress the ligand for PD-1, programmed cell death ligand 1 (PD-L1),

153 programmed cell death ligand 1 (PD-L1), the ligand for PD-1, which is further upregulated upon subse

154 lective reaction where DPEphos serves as the ligand for Pd.

155 grammed death ligand 1 (PD-L1) and PD-L2 are ligands for PD-1; the former is ubiquitously expressed i

156 modifying the endogenous peptide sequence of ligands for peptide-binding GPCRs.

157 establish 7(S)-HDHA as a possible endogenous ligand for peroxisome proliferator-activated receptor al

158 specific membrane antigen [PSMA]) is a novel ligand for PET imaging.

159 We also found that bilirubin is a selective ligand for PPARalpha and does not affect the activities

160 hibitor C4b-binding protein, which is also a ligand for PRELP.

161 ptors and now provide evidence that C4a is a ligand for protease-activated receptor (PAR)1 and PAR4.

162 peptoids have been useful in discovering new ligands for protein binding.

163 rk validates the ability of IDUP to discover ligands for proteins of biomedical relevance.

164 The binding affinity of the ligand for PSMA and its internalization properties were

165 ined (18)F-FESCH to be the most suitable PET ligand for quantifying A2A receptor expression in the ra

166 ed research has sought to identify selective ligands for receptor subtypes.

167 ntravascular activator of fibrinolysis and a ligand for receptors involved in cell signaling.

168 Besides ligands for receptors of known specificity, agents commo

169 MHC proteins that present peptide ligands for recognition by TCR form nanoscale clusters o

170 possible positions; 4) selection of the best ligands for RGD-recognizing integrin subtypes; 5) fine-t

171 ar dominated the discovery of small-molecule ligands for RNA.

172 ess the heterogeneity in the second exchange ligand for Sec14-like PITPs, we used structural, computa

173 o encounter and require different activating ligands for selection in the cortex and activation in th

174 the first one, the affinities of two similar ligands for seven bromodomains were calculated and retur

175 peptides(2) have previously been proposed as ligands for several members of the CrRLK1L family(1).

176 Nonclassical class I MHC-like molecules are ligands for several unconventional T cell populations.

177 soform, DMBT1(S8), is the major high-avidity ligand for Siglec-8 on human airways.

178 generates alpha-2,8-disialic acids that are ligands for Siglec-E in vivo.

179 that IFN-lambda cytokines are the exclusive ligands for signaling through IFNLR, it is not known whe

180 Furthermore, target cells that express the ligand for SIRPalpha, CD47, are more susceptible to CD8(

181 yload that we designed to act as an affinity ligand for specific conserved amino acid residues in the

182 Taking advantage of the RNA ligand for specific targeting and extracellular vesicles

183 ng in cancer and to gauge the selectivity of ligands for specific tumor-associated chaperome pools.

184 Membrane-bound ligands for stimulation and co-stimulation of T-cell rec

185 ced cytosolic delivery of the endogenous CDN ligand for STING, 2'3' cyclic guanosine monophosphate-ad

186 monophosphate (2'3'-cGAMP) is the endogenous ligand for STING, but is rapidly metabolized and poorly

187 Glucose is a natural ligand for sweet taste receptors (STRs) that are express

188 acellular fragment of Robo can function as a ligand for SYG-1/Neph to guide glial migration.

189 p32, LinTT1 (AKRGARSTA), as a GBM targeting ligand for systemically-administered nanoparticles.

190 tide-major histocompatibility complex (pMHC) ligand for T cell receptors (TCRs) is inactive from solu

191 jugated to an N-acetylgalactosamine (GalNAc) ligand for targeted delivery to hepatocytes.

192 o a trivalent N-acetylgalactosamine (GalNAc) ligand for targeted delivery to hepatocytes.

193 onstrated the successful selection of potent ligands for TEV protease and HDAC8.

194 of 68 mum), but LCA is also a highly potent ligand for TGR5 (EC(50) 0.52 mum).

195 lic acid and deoxycholic acid, the principal ligands for TGR5, are decreased in particular.

196 ing pocket conformation using a single known ligand for that GPCR.

197 HLA-F is the ligand for the activating NK cell receptor (NKR) KIR3DS1

198 stence of a novel, presently uncharacterized ligand for the activating NK cell receptor KIR2DS2.

199 expressed within epithelia, and is the major ligand for the activatory receptor, NKG2D, both attribut

200 otency to apelin-13, the endogenous peptidic ligand for the APJ receptor.

201 le bicyclic bridged ketal was developed as a ligand for the asialoglycoprotein receptor (ASGPR).

202 trated to function as a beta-arrestin-biased ligand for the beta(2)AR, stimulating beta-arrestin-depe

203 ne morphogenetic protein) type 9, which is a ligand for the BMP2 receptor.Objectives: Here we determi

204 capsules were functionalized with CXCL13-the ligand for the chemokine receptor CXCR5, which is freque

205 factor (EGF)-like growth factor (HBEGF) is a ligand for the EGF receptor (EGFR), one of the most comm

206 -subunit protein and a tolerogenic molecule (ligand for the endogenous aryl-hydrocarbon receptor; ITE

207 is a large (> 60-amino-acid) natural peptide ligand for the ErbB protein family members HER3 and HER4

208 ers of phosphatidylcholine lipids, a natural ligand for the IgM BCR expressed in the CH27 cells used.

209 blood coagulation cascade and an activating ligand for the immunosuppressive TAM family of receptor

210 Here, we identify a viral ligand for the inhibitory and activating NKR-P1 (NK1.1)

211 like growth factor 2 (IGF2) gene, encoding a ligand for the insulin-like growth factor 1 receptor (IG

212 ollectively, these results identify PTN as a ligand for the integrin Mac-1 on the surface of leukocyt

213 One gene-rh5-which encodes an essential ligand for the invasion of host erythrocytes, is suspect

214 Here we show that alpha2delta-1 is a ligand for the Low Density Lipoprotein (LDL) Receptor-re

215 support for selenocysteine as the ancestral ligand for the Mo/W atom.

216 Here, we show that elimination of CD47, a ligand for the myeloid cell inhibitory receptor SIRPalph

217 We show that an endogenous ligand for the natural killer (NK) cell receptor NKG2D,

218 Substance P, the principal ligand for the neurokinin-1 receptor, is a potent proinf

219 idation of D2:(244)Y, which is a bicarbonate ligand for the nonheme iron, induces the propagation of

220 Given that Delta-like 1 (DLL1) is a ligand for the Notch receptor and that a few individuals

221 Mechanistically, JAGGED-1, a transmembrane ligand for the NOTCH receptor, is downregulated in the P

222 Apelin-36 was discovered as the endogenous ligand for the previously orphan receptor APJ.

223 demonstrated that palmitoyl coenzyme A is a ligand for the PvrA, enhancing the binding affinity of P

224 lusion: (18)F-JNJ-64413739 is a suitable PET ligand for the quantification of P2X7R expression in the

225 2 glycan ligands and outcompetes the natural ligand for the receptor, resulting in single molecule bi

226 f a cinchona alkaloid-derived aminophosphine ligand for the silver(I) salt and the 2-bis(aryl)methylp

227 ach is the identification of a high affinity ligand for the target Siglec.

228 Xanthine is a ligand for the transcription factor MftR that leads to a

229 rse molecules composed of two instances of a ligand for the von Hippel-Lindau (VHL) E3 ligase.

230 an unsaturated N-heterocyclic carbene (NHC) ligand, for the first time, products derived from the mo

231 his dataset contains 70,219 and 9,511 unique ligands for the allosteric and competitive sets, respect

232 as employed to construct two metallo-organic ligands for the assembly of G2 and G3 Sierpinski triangl

233 nyl analogues were found to be high affinity ligands for the CB1 and CB2 cannabinoid receptors.

234 s (MHC-Ibs) have recently been identified as ligands for the CD8alphaalpha homodimer.

235 In this study we identified two novel biased ligands for the chemokine receptors CCR2 and CCR5 and ch

236 predicted that the library contained 453,000 ligands for the D(4) dopamine receptor.

237 rm high-throughput screening of G-quadruplex ligands for the development of drug molecules effective

238 acids are demonstrated as effective anionic ligands for the enantioselective coupling of methylene C

239 g affinity or the activation by the selected ligands for the examined members of the 5-HT2 receptor c

240 Interest in the combinations of ligands for the extraction processes is growing, since t

241 hus-generated molecules constitute agonistic ligands for the first and second binding pocket of TLR8.

242 ble, bioinspired, pseudopeptidic fluorescent ligands for the FK1 domain of this protein are described

243 apy; a class of steroids that are activating ligands for the glucocorticoid receptor (GR) transcripti

244 s farnesyl pyrophosphate (FPP) and cortisol, ligands for the glucocorticoid receptor (GR).

245 anding the structural diversity of available ligands for the high-affinity GHB binding sites, this st

246 Epibatidine and related compounds are potent ligands for the high-affinity nicotine receptors of the

247 HLA-C allotypes are ligands for the inhibitory KIRs (iKIRs) KIR2DL1, KIR2DL2

248 c N-methylated hexapeptides as high affinity ligands for the integrin alphavbeta3 is based on two con

249 However, in the presence of additional ligands for the integrin LFA-1, this biphasic response i

250 can guide the discovery of highly selective ligands for the IRE1alpha kinase site that allostericall

251 the peripheral nervous system by serving as ligands for the LRP1/NMDA-R system.

252 tures of negative allosteric modulator (NAM) ligands for the mGlu(5) receptor, M-MPEP (3) and fenobam

253 The ligands for the natural killer group 2 (NKG2D) protein r

254 the receptors, suggesting that they are true ligands for the NmU/PRXamide receptor in the slug.

255 99 that BAs were discovered to be endogenous ligands for the nuclear receptor FXR.

256 These lipids are endogenous ligands for the nuclear receptor PPARalpha, and we demon

257 PET ligands for the P2X7 receptor will not only be valuable

258 f oxidized phospholipids (oxPCCD36) that are ligands for the platelet pattern recognition receptor CD

259 s, and neurexophilin1 and neurexophilin3 are ligands for the presynaptic cell adhesion molecule alpha

260 opose a rationale for the development of new ligands for the protein.

261 erous NKR-ligand interactions, physiological ligands for the prototypical NK1.1 orphan receptor remai

262 In general, we envisage the use of these ligands for the relativistic enhancement of radiative de

263 f simple P-stereogenic N-phosphine-phosphite ligands for the Rh-catalyzed asymmetric hydrogenation of

264 piro[5.5]undecane derivatives as potent dual ligands for the sigma(1) receptor (sigma(1)R) and the mu

265 piro[5.5]undecane derivatives as potent dual ligands for the sigma-1 receptor (sigma(1)R) and the mu-

266 show the general feasibility of using linear ligands for the synthesis of zeolite types by reporting

267 ubated with ERBB inhibitors began to secrete ligands for the TGFbeta receptor and underwent EMT.

268 the rational design of selective and potent ligands for the treatment of various ERR-mediated diseas

269 tins are a family of growth factors that are ligands for the tyrosine kinase receptor, Tie2.

270 t the in situ affinity of both pMHC and CD80 ligands for their respective receptors is modulated by t

271 To identify cyclic-peptide ligands for therapeutic targets, phage-displayed peptide

272 ciently identifying selective small molecule ligands for therapeutically relevant RNAs.

273 ), which has previously been identified as a ligand for these molecules on Neisseria meningitidis As

274 clude the receptors CCR1 and CCR3; CCL7 is a ligand for these receptors.

275 KIR) family are not fully understood, as the ligands for these receptors are largely unidentified.

276 analgesics exist, the search for endogenous ligands for these receptors, and early attempts to eluci

277 nocytes, and B cells in HCC tumors expressed ligands for these receptors.

278 Thus, we identify the long-sought foreign ligand for this key immunoregulatory NKR family and reve

279 ed complex N-glycans, which serve as a major ligand for this lectin.

280 -DLBCL) and Burkitt lymphoma(1,3-6), and the ligand for this receptor has not yet been identified.

281 tilized diphosphine, as a uniquely effective ligand for this transformation.

282 odorants previously identified as potential ligands for this receptor.

283 es or microbe-derived lipopolysaccharides (a ligand for TLR4), macrophages with GIV mount a more tole

284 ment of B cells with lipopolysaccharide, the ligand for TLR4, results in SYK activation and that this

285 resistin is a clinically relevant endogenous ligand for TLR4, which promotes tumor progression via TL

286 wis acids, they are electron-rich and act as ligands for transition metals.

287 ional theory (DFT) based screening of chiral ligands for transition-metal-catalyzed reactions with we

288 ha action and identify a promising tRXRalpha ligand for treating CAC.

289 ess nicotinic acetylcholine receptor (nAChR) ligands for treating chronic pain.

290 Thus, NGF and NT-3 are "biased" ligands for Trk-A.

291 nked to pain and elevated levels of NGF (the ligand for TrkA) are associated with chronic pain.

292 We used the radiotracer [(11)C]DAA1106 (a ligand for TSPO) and positron emission tomography (PET)

293 onsiderably the development of high-affinity ligands for TSPO-based therapies or diagnostics.

294 ed to generate novel melanocortin probes and ligands for understanding and treating obesity.

295 of chiral NHCs as stereodirecting ancillary ligands for various enantioselective transformations.

296 4)Cu]-LLP2A), a high affinity peptidomimetic ligand for very late Ag-4 (VLA-4; also called integrin a

297 tified NSC622608 as the first small-molecule ligand for VISTA.

298 on of adhesion molecules (such as VCAM-1 the ligand for VLA-4), and leukocyte adhesion to vascular en

299 biological characterisation of a fluorescent ligand for VMAT2 suitable for live cell imaging.

300 is, apoptosis, and necroptosis; the specific ligand for ZBP1 activation remains ambiguous.