ライフサイエンスコーパス: ligand-binding activity

1 xposed to elevated temperature, with loss of ligand binding activity.

2 without affecting integrin affinity state or ligand binding activity.

3 a series of Ala-substituted NgR1 mutants for ligand binding activity.

4 mutated receptors were then tested for their ligand binding activity.

5 occupied receptor, and has high constitutive ligand binding activity.

6 also induced a PK-C-dependent loss of VLDL-R ligand binding activity.

7 ation of lysine residues resulted in loss of ligand binding activity.

8 r was critically important for high affinity ligand binding activity.

9 sociated protein (RAP), an antagonist of LRP-ligand binding activity.

10 bunits into a heterodimer with high affinity ligand binding activity.

11 ge of DG elicits a conspicuous change in its ligand-binding activity.

12 gether were necessary and sufficient for the ligand-binding activity.

13 has been proposed to allosterically regulate ligand-binding activity.

14 an orphan receptor that functions without a ligand-binding activity.

15 of USP action that do not include for USP a ligand-binding activity.

16 evolution to generate folded molecules with ligand-binding activity.

17 id cloning of modular domains based on their ligand-binding activity.

18 -CFC homologs have distinct, highly specific ligand binding activities.

19 ility in the presence of arginine and retain ligand-binding activity after heat treatment at 60 degre

20 Although wild type sLDLR showed strong ligand binding activity, an sLDLR variant in which LA re

21 that lacks a DNA binding domain but retains ligand binding activity and is a potent dominant-negativ

22 otch fucosylation in the expression of Notch ligand binding activity and Notch signaling efficiency i

23 The resulting chip surface retained ligand binding activity and was used for monoclonal anti

24 other espin isoforms in their complement of ligand-binding activities and their effects on actin pol

25 L69 in the hydrophobic patch contributes to ligand-binding activity and specificity.

26 urified recombinant I domains have intrinsic ligand binding activity, and in several systems this int

27 GRP94/gp96 retained its native conformation, ligand binding activity, and in vitro chaperone function

28 ural derivatives of TZDs that lack PPARgamma ligand-binding activity as well as a PPARgamma antagonis

29 e a mechanism for the modulation of integrin ligand-binding activity as well as novel function for R-

30 the D2 domain, which displayed differential ligand binding activity: both had high affinity uPA bind

31 ream signaling require MET, specifically its ligand-binding activity, but not its DNA-binding domain.

32 AD strains had increased ClfB ligand binding activity compared to normal nasal carriag

33 In vitro, p.G116S showed 60% reduced ligand-binding activity compared with wild-type receptor

34 Both the sTF and annexin V domains had ligand-binding activities consistent with their native c

35 reduced with a chemical reducing agent, the ligand binding activity decreased by ~40%, but reduction

36 d protein that binds to LRP and inhibits its ligand binding activity displayed dramatically prolonged

37 eptors results in an agonist-induced loss of ligand binding activity (down-regulation) in an identica

38 xane A(2) receptor experienced a decrease in ligand binding activity due to the rearrangement of the

39 ha to CRBN, are characterized by the lack of ligand binding activity in at least one protein partner

40 Evolution of diverse catalytic and ligand-binding activities in a given protein fold is a w

41 ffect the protein's structure, dynamics, and ligand-binding activity in both its soluble and membrane

42 Our data show that LFA-1 has a low ligand-binding activity in resting human NK cells, but i

43 Because human sL-selectin retains ligand-binding activity in vitro, mouse sL-selectin and

44 e we have shown that IsdA has broad-spectrum ligand-binding activity, including fibrinogen and fibron

45 but not an antibody to CD40 that blocked the ligand-binding activity, inhibited these platelet-stimul

46 An AHR protein with normal ligand binding activity is expressed in the mutant but l

47 Ligand binding activity is regulated through conformatio

48 The ligand-binding activity is located in the approximately

49 ced changes in SCP-2 secondary structure and ligand binding activity may be important to the mechanis

50 e I domain can override regulation of ANTXR1 ligand-binding activity mediated by intracellular signal

51 orescence-based assay method for determining ligand binding activities of C-reactive protein (CRP) in

52 We compared the chaperone and ligand binding activities of this recombinant product wi

53 Here we describe the conformations and ligand binding activities of water-soluble and membrane-

54 Reduced ligand binding activity of alpha-dystroglycan is associa

55 becomes hyposialylated, which stimulates the ligand binding activity of alpha5beta1 fibronectin recep

56 of zinc and copper ions on the endocytic and ligand binding activity of asialoglycoprotein receptors

57 data suggest that the alpha2, 6 sialic acid ligand binding activity of CD22 is critical for its nega

58 Here, the ligand binding activity of CqsS is probed with structura

59 orphisms related to a functional decrease in ligand binding activity of CX3CR1 are associated with di

60 The properties and ligand binding activity of FhbA suggest that it plays mu

61 Ligand binding activity of indoor dust and its bioactiva

62 ransformed cell lines, the rapid increase in ligand binding activity of L-selectin that occurs follow

63 We have characterized the ligand binding activity of SdrG, a fibrinogen-binding mi

64 range conformational changes that alter the ligand binding activity of the head region; (iii) the st

65 Here, we report that the ligand binding activity of the VLDL-R in THP-1 monocytic

66 together, these studies demonstrate that the ligand binding activity of the VLDL-R is regulated by PK

67 c(2)155, we investigated the DNA-binding and ligand-binding activities of the putative TetR-like tran

68 -mannosylation are associated with a loss of ligand-binding activity of alpha-DG and are causal for v

69 n and mutation analyses demonstrate that the ligand-binding activity of alpha-dystroglycan is conferr

70 X2-generated ROS enhanced the activation and ligand-binding activity of alphaMbeta2 integrin followin

71 d IKKB inhibition significantly diminish the ligand-binding activity of B2 integrins in TNF-a-stimula

72 KKbeta inhibition significantly diminish the ligand-binding activity of beta2 integrins in TNF-alpha-

73 tributes of these micelles with the in vitro ligand-binding activity of hA(2)aR in these systems.

74 The ligand-binding activity of human FcmuR was further exami

75 motility, and invasion are regulated by the ligand-binding activity of integrin receptors, transmemb

76 Increased ligand-binding activity of integrins is critical for pla

77 While the ligand-binding activity of integrins is known to be modu

78 t the shorter p87 PIP5KIgamma, regulates the ligand-binding activity of integrins via talin.

79 cating that endogenous R-ras can control the ligand-binding activity of integrins.

80 pathogenic mutations on the conformation and ligand-binding activity of recombinant human PrP (rPrP).

81 the divalent cation is required for initial ligand-binding activity of the I domain and (2) ligand b

82 However, it remains unknown how ligand-binding activity of the integrin is regulated.

83 e, we provide evidence in vitro that S1R has ligand binding activity only in an oligomeric state.

84 cell model system, there was no serotonergic ligand binding activity or phosphoinositide hydrolysis.

85 stroglycan, our results demonstrate that the ligand-binding activity resides at the extreme N terminu

86 copy of repeat 5 resulted in a receptor with ligand binding activity similar to wild type LDLR.

87 RUNX1(+) cells expressing EPOR mRNA have EPO ligand binding activity that correlates with an increase

88 merization may explain the rapid increase in ligand binding activity that occurs after leukocyte acti

89 the focus of attention from studies of their ligand-binding activity to studies of animal models that

90 photometry revealed that neither oxidase has ligand-binding activity typical of the heme-copper oxida

91 nt changes in alphaIIbbeta3 conformation and ligand binding activity, underlying the dynamics of fibr

92 Efficient restoration of ligand binding activity upon reconstitution required the

93 (CRABPI) have been characterized as to their ligand binding activities using 1,8-ANS.

94 ers ( approximately 70%) by inhibiting LDL-R ligand-binding activity using human proprotein convertas

95 receptors on hepatocytes lose endocytic and ligand binding activity when hepatocytes are exposed to

96 M GdnHCl could be renatured as determined by ligand-binding activity, with a similar equilibrium diss

97 of their surface asialoglycoprotein receptor ligand binding activity; zinc-treated cells accumulated