ライフサイエンスコーパス: ligand-binding domain

1 nel and kinetics of glycine binding with its ligand binding domain.

2 R (hPXR) by interacting with its promiscuous ligand binding domain.

3 ed folding of full-length transcripts of the ligand binding domain.

4 with binding hot spots within the PPARgamma ligand binding domain.

5 nts and cocrystallization with the RORgammat ligand binding domain.

6 ine-rich nuclear export signals (NES) in its ligand binding domain.

7 nt missense mutations in the Dalpha7 nAChR's ligand binding domain.

8 ed recruitment of cofactor motifs to the FXR-ligand binding domain.

9 ation of truncated AR protein that lacks the ligand binding domain.

10 nd UT-155) also binding the carboxy-terminal ligand binding domain.

11 by insertion of the estrogen receptor-alpha ligand-binding domain.

12 fferences in the quaternary structure of the ligand-binding domain.

13 nd the beta8-beta9 loop in the extracellular ligand-binding domain.

14 dues facing the heterodimer interface of the ligand-binding domain.

15 (GR) GRalpha, as the GRbeta isoform lacks a ligand-binding domain.

16 ardants and dust extracts to human PPARgamma ligand-binding domain.

17 mprove key interactions with the human GluA2 ligand-binding domain.

18 ovo amino acid substitutions, all within the ligand-binding domain.

19 ller structure resembling the alpha-integrin ligand-binding domain.

20 en receptor (AR) splice variants lacking the ligand-binding domain.

21 activated by targeting a site outside of its ligand-binding domain.

22 binding of glutamate to a solvent-accessible ligand-binding domain.

23 EID1 mimics helix H1 of the nuclear receptor ligand-binding domain.

24 receptor assembly, driven by closure of the ligand-binding domain.

25 AFs), AF-1 in the N-terminal and AF-2 in the ligand-binding domain.

26 hrough a pathway that bypasses its canonical ligand-binding domain.

27 truncated AR variant proteins lacking the AR ligand-binding domain.

28 on based on the crystal structures of the MR ligand-binding domain.

29 ng by selectively interacting with the GluA2 ligand-binding domain.

30 ee clinically relevant GR modulators from GR ligand binding domains.

31 n, suggesting uncoupling of the pore and the ligand binding domains.

32 ion channel and linkers connecting it to the ligand-binding domains.

33 , where these domains frequently function as ligand-binding domains.

34 RNA splicing to produce isoforms with 1 or 2 ligand-binding domains.

35 interactions between the amino-terminal and ligand-binding domains.

36 nal rearrangements of the amino-terminal and ligand-binding domains.

37 sion system was used to express SdrF and its ligand-binding domains.

38 M) and greater than AHR containing the mouse ligand-binding domain (0.08 nM).

39 h a newly identified region of the PPARgamma-ligand binding domain (1).

40 lical proteins that consist of a periplasmic ligand-binding domain; a transmembrane region; a cytopla

41 rom the combination of three residues in the ligand-binding domain: A354 and A370, and N325.

42 promotes conformational changes in the EphA4 ligand-binding domain allowing the formation of signalin

43 onocytes also express Siglec-14, which has a ligand-binding domain almost identical to Siglec-5 but s

44 Rbeta antibodies, we showed that an in-frame ligand binding domain and C terminus were present in the

45 t formed by the interface of two neighboring ligand binding domains and act by stabilizing the agonis

46 beta isoform, however, lacks helix 12 of the ligand-binding domain and cannot bind GCs.

47 that some MODY1 mutations, positioned on the ligand-binding domain and hinge regions of the receptor,

48 of an electrostatic interaction between the ligand-binding domain and linker region to the pore that

49 explanation for this discrepancy is that the ligand-binding domain and NCoR1 peptides used for in vit

50 on of diverse AR variant species lacking the ligand-binding domain and possessing ligand-independent

51 On the AMPAR extracellular domains, the ligand-binding domain and possibly a stretch of linker,

52 nisms: firstly, by direct binding to Nurr1's ligand-binding domain and promoting its transcriptional

53 r composed of the alpha7 nAChR extracellular ligand-binding domain and the transmembrane domain of al

54 olling the tension of the linker between the ligand-binding domain and the transmembrane ion channel

55 alternatively spliced isoform that lacks the ligand-binding domain and thus no longer localizes at th

56 he formation of an active catalytic, but not ligand-binding domain, and that mutations that inhibit t

57 nzalutamide-resistant prostate cancers where ligand-binding domain antagonists are ineffective.

58 They typically consist of a ligand-binding domain (aptamer) whose folding changes dr

59 es of these compounds in the zebra fish zVDR ligand binding domain as complexes with NCoA-2 coactivat

60 fied, full-length LRH-1, as well as isolated ligand binding domain, bound to PGC1alpha with higher af

61 ative splicing and retains the extracellular ligand binding domain but lacks the intracellular signal

62 n monocytes and neutrophils, share identical ligand-binding domains but have opposing signaling funct

63 l transactivation domain, and the C-terminal ligand binding domain, but not the DNA-binding domain of

64 ess-type MMTV integration site family member-ligand-binding domain, but lacks the transmembrane domai

65 racterized AF2 interaction surface in the GR ligand-binding domain, but Lin11, Isl-1, Mec-3 (LIM) dom

66 tudies revealed an essential role for the GR ligand-binding domain, but no clear requirement for liga

67 We solve crystal structures of LasR ligand-binding domains complexed with noncognate autoind

68 lly for F-actin binding proteins, the DNGR-1 ligand binding domain contacts three actin subunits heli

69 ctivator peptide binds to the human RXRalpha ligand binding domain containing two clinically relevant

70 easurements reveal that interactions between ligand-binding domains control the conformational rearra

71 ged as a triangle, with an interface between ligand-binding domains D1 and D5.

72 c-finger DNA-binding domain and the putative ligand-binding domain decrease NR2F1 transcriptional act

73 ects 9cRA-induced coactivator binding to the ligand binding domain demonstrated that UVI3003 signific

74 its high constitutive activity, both direct (ligand-binding domain-dependent) and indirect activation

75 mational change in a loop on the side of the ligand-binding-domain dimer, which leads to the formatio

76 ents in the AMPAR extracellular domain, with ligand-binding domain dimers losing their local 2-fold r

77 and antiestrogen resistance and suggest that ligand-binding domain dysfunction leads to endocrine the

78 conformational changes of the extracellular ligand-binding domains (ECDs) associated with receptor a

79 ansfected partial receptor consisting of the ligand binding domain (ER-bla; ERalpha beta-lactamase ce

80 activated fusion protein, which contains the ligand binding domain from a target NHR (human thyroid r

81 stitutive activity reveals uncoupling of the ligand-binding domain from conserved connector residues,

82 interactions of RID1 and RID2 with 20 other ligand-binding domains from different NR subtypes were o

83 drives these conformations, we decoupled the ligand-binding domains from specific transmembrane segme

84 ring in the portion of the gene encoding the ligand-binding domain, functionally suppressed RARA-medi

85 We show how TARPs sculpt the ligand-binding domain gating ring, enhancing kainate pot

86 n fluorescent protein (GFP) insertion into a ligand-binding domain, generating the requisite alloster

87 ring (SAXS) experiments using isolated GluA2 ligand-binding domain (GluA2-LBD) are consistent with bi

88 data for 7-CKA binding to the isolated GluD2 ligand binding domain (GluD2-LBD), we find that binding

89 antagonism, the crystal structure of the GR ligand-binding domain (GR LBD) complex with a nonsteroid

90 Thus, the CD22 ligand-binding domain has a crucial function in regulati

91 Structures of a soluble ligand-binding domain have provided atomic-scale insight

92 vivo whereas adding another mutation in the ligand-binding domain (I634A) severely compromises homod

93 seudo-four-fold symmetric arrangement of the ligand-binding domains, illustrating subtle changes in s

94 The crystal structure of the zebrafish VDR ligand binding domain in complex with LCA and the SRC-2

95 odulators were cocrystallized with the GluA2 ligand binding domain in order to decipher the impact of

96 bimagrumab binds to both ActRIIA and ActRIIB ligand binding domains in a competitive manner at the cr

97 ystal structures of the human and insect TLX ligand-binding domain in complex with Atro box peptides.

98 t the crystal structure of the zebrafish VDR ligand-binding domain in complex with the ZK168281 antag

99 ve solved the crystal structure of the GluN1 ligand-binding domain in complex with TK40 and show that

100 reduces coactivator interaction with the CAR ligand-binding domain in mammalian two-hybrid assays; an

101 conserved in all x-ray structures of the RXR ligand-binding domain in the presence of agonist and coa

102 hydrogen bonds in the GluA2 (AMPA receptor) ligand-binding domain in the presence of several full an

103 Inserted (I) domains function as ligand-binding domains in adhesins that support cell adh

104 fold to four-fold symmetry transition in the ligand-binding domains in both subtypes.

105 Closure of the ligand-binding domain, induced by cGAMP, leads to a 180

106 The ligand-binding domain influences assembly through a proc

107 on Model", which demonstrates how two tandem ligand-binding domains interact to regulate protein func

108 apping at two sites in the lower lobe of the ligand binding domain is consistent with deformation of

109 assays revealed that His323 of the PPARgamma ligand binding domain is important for binding to S1P.

110 tanding of how ADPR interacts with the TRPM2 ligand binding domain is lacking, hampering the rational

111 f the beta11-12 linker in the extracellular, ligand-binding domain is an integral component of the de

112 eterotetramer complex than they do when each ligand-binding domain is examined alone.

113 stablishment of a ring-like structure in the ligand-binding domain layer of the receptor.

114 st binding modulates the conformation of the ligand-binding domain "layer" of the intact receptors an

115 pressed in prostate cancer (PCa) lack the AR ligand binding domain (LBD) and function as constitutive

116 f human NR5A1 (steroidogenic factor-1, SF-1) ligand binding domain (LBD) bound to PIP2 and PIP3 show

117 stic fashion, i.e., helix 12 not sealing the ligand binding domain (LBD) effectively, and therefore r

118 show how competitive antagonists rupture the ligand binding domain (LBD) gating "ring," how agonists

119 xible protein residues (pREST region) in the ligand binding domain (LBD) has considerably improved th

120 pe III domain ((10)Fn3), that target the PXR ligand binding domain (LBD) interactions with the steroi

121 We also show that the GR ligand binding domain (LBD) is not required for SMRT-med

122 teractions of various ligands within the AhR ligand binding domain (LBD) may contribute to differenti

123 both wild-type AR and the two most common AR ligand binding domain (LBD) mutants.

124 currences harbor activating mutations in the ligand binding domain (LBD) of ER, which have been shown

125 model examining the interaction between the ligand binding domain (LBD) of RORalpha or RORgamma with

126 Co-crystallization of the ligand binding domain (LBD) of RORgammat with a series o

127 to monitor structural rearrangements in the ligand binding domain (LBD) of the mGluR7/7 homodimer re

128 ructure, starting with the first view of the ligand binding domain (LBD) published in 1998, and in ma

129 ystal structure of compound 10 within the GR ligand binding domain (LBD) unveils a novel binding conf

130 igands bind directly to recombinant RORgamma ligand binding domain (LBD), promote recruitment of a co

131 tified on AR, both located in its C-terminal ligand binding domain (LBD).

132 o acid residues, Tyr-454 and Arg-461, in its ligand binding domain (LBD).

133 ased on identities of key amino acids in the ligand binding domain (LBD).

134 controlled by conformational changes in the ligand binding domain (LBD); however, glutamate receptor

135 the toxin acts like a straightjacket on the ligand-binding domain (LBD) "gating ring," restraining t

136 r, we biochemically reconstituted the GLR3.3 ligand-binding domain (LBD) and analyzed its selectivity

137 The RARbeta ligand-binding domain (LBD) and DNA-binding domain (DBD)

138 ators bind within the dimer interface of the ligand-binding domain (LBD) and stabilize the agonist-bo

139 es binding of neurotransmitter agonists to a ligand-binding domain (LBD) and structural rearrangement

140 ARs, we manipulated the coupling between the ligand-binding domain (LBD) and the ion channel by inser

141 eptor splicing variants (ARVs) that lack the ligand-binding domain (LBD) are associated with the deve

142 hus, endocrine therapies that inhibit the AR ligand-binding domain (LBD) are effective in treating PC

143 A crystal structure of the ERalpha ligand-binding domain (LBD) as a complex with resveratro

144 Here, we produce biosensors based on a ligand-binding domain (LBD) by using a method that, in p

145 of the GluA2 AMPA subtype glutamate receptor ligand-binding domain (LBD) dimers to characterize a nat

146 The presence of intact ligand-binding domain (LBD) ensures the strict androgen-

147 of YSA and SWL with the extracellular EphA2 ligand-binding domain (LBD) has for many years precluded

148 tal structures of GluN1/GluN2A NMDA receptor ligand-binding domain (LBD) heterodimers in complex with

149 mined the crystal structure of the PPARgamma ligand-binding domain (LBD) in complex with VSP-51, whic

150 t stability of the D1 dimer interface in the ligand-binding domain (LBD) is an important determinant

151 static interactions at the apex of the AMPAR ligand-binding domain (LBD) is essential for gating by p

152 Using ligand-binding domain (LBD) mutants for electrophysiolog

153 tal structures of the key analogue 2i in the ligand-binding domain (LBD) of GluA2 and GluK3 were dete

154 tallography reveals that SJB7 resides in the ligand-binding domain (LBD) of hPXR, interacting with th

155 Given that the ligand-binding domain (LBD) of PPARG is the same in kill

156 nding pocket in the C-terminal region of the ligand-binding domain (LBD) of RORgammat was discovered

157 , we report the structure of the periplasmic ligand-binding domain (LBD) of the transmembrane chemore

158 ined the effects of mutations within the AhR ligand-binding domain (LBD) on the activity of diverse A

159 forms the ion channel, the membrane-proximal ligand-binding domain (LBD) that binds agonists such as

160 prototypical iGluR, reveals a clamshell-like ligand-binding domain (LBD) that closes in the presence

161 ng a FQNLF motif, that interacts with the AR ligand-binding domain (LBD) upon activation.

162 nnects the DNA-binding domain (DBD) with the ligand-binding domain (LBD) via a mix of positively char

163 Agonists bind to the ligand-binding domain (LBD) which is arranged as a dimer

164 l domains: an amino-terminal domain (ATD), a ligand-binding domain (LBD), a channel-forming transmemb

165 ses harbored mutations of ESR1 affecting its ligand-binding domain (LBD), all of whom had been treate

166 omposed of an amino terminal domain (ATD), a ligand-binding domain (LBD), and a transmembrane domain

167 R is activated by androgens that bind to its ligand-binding domain (LBD), causing the transcription f

168 amolecular interaction between CAR's DBD and ligand-binding domain (LBD), enabling the homodimer-hete

169 hrough their modulation of the extracellular ligand-binding domain (LBD), less is known about their r

170 It is activated by androgens through its ligand-binding domain (LBD), which consists predominantl

171 A 'clamshell' ligand-binding domain (LBD), which contains the ligand-b

172 membrane-distal N-terminal domain (NTD) and ligand-binding domain (LBD), which is fused to the ion c

173 rs by stabilizing the apo state of the GluN1 ligand-binding domain (LBD), which is incapable of trigg

174 osed clamshell-like structure of the bilobed ligand-binding domain (LBD).

175 a periplasmic NTD fused to the conventional ligand-binding domain (LBD).

176 formational dynamics of the nuclear receptor ligand-binding domain (LBD).

177 h subtype-specific residues in the PPARdelta ligand-binding domain (LBD).

178 al effects and the ability to bind the Nurr1 ligand-binding domain (LBD).

179 ated that many bacterial chemoreceptors have ligand-binding domains (LBD) of the dCACHE family, a str

180 ors (GPCRs) that contain large extracellular ligand binding domains (LBDs) and form constitutive dime

181 lar dynamics simulations of GluN1 and GluN2B ligand binding domains (LBDs) of NMDARs to investigate t

182 Glutamate binding to clamshell-shaped ligand binding domains (LBDs) triggers opening of the in

183 n function and involves rearrangement of the ligand binding domains (LBDs).

184 aised by the presence of large extracellular ligand-binding domains (LBDs) and constitutive homo/hete

185 However, steroid receptor ligand-binding domains (LBDs) are inherently unstable, a

186 those produced by NMDAR mutants in which the ligand-binding domains (LBDs) are locked in the closed c

187 The ligand-binding domains (LBDs) of the four subunits are e

188 tal structures of the ML032222a and PbiGluR3 ligand-binding domains (LBDs) reveal endogenous glycine

189 reaches the recessed binding pocket in iGluR ligand-binding domains (LBDs).

190 -GluN2A dimer interface of the extracellular ligand-binding domains (LBDs).

191 tor (MR) on Ser-843, a residue placed on the ligand binding domain, lowers affinity for agonists, pro

192 s missense variants within amino terminal or ligand-binding domains (misATD+LBD) and null variants le

193 galactomannoprotein antigen with two tandem ligand-binding domains (Mp1p-LBD1 and Mp1p-LBD2), was fo

194 ed or enriched post treatment, including two ligand-binding domain mutations in ESR1.

195 nd-dependent transactivation function in the ligand binding domain of ERalpha C terminus (AF-2) and a

196 endometrial cancer mutation that alters the ligand binding domain of ESR1, while epitope tagging the

197 o probe the conformation of the desensitized ligand binding domain of functioning AMPAR complexes.

198 ructure was obtained of 1b when bound in the ligand binding domain of GluK1.

199 cine ligand by anisotropy measurement at the ligand binding domain of GluN1 subunit.

200 y assay showed that PB directly binds to the ligand binding domain of hPXR (K(D) = 1.42 x 10(-05)).

201 al structures of each homologue bound to the ligand binding domain of hRXRalpha.

202 Cys(79) in the ligand binding domain of LasR appears to be important fo

203 The amino-terminal ligand binding domain of SIRPalpha is highly polymorphic

204 fusion of the Zif268 DNA binding domain, the ligand binding domain of the human estrogen receptor and

205 crystal structure of an agonist bound to the ligand binding domain of the PPARalpha receptor have bee

206 analyses reveal that 7j occupies the typical ligand binding domain of the PPARgamma agonists with, ho

207 X-ray studies of four rexinoids bound to the ligand binding domain of the retinoid X receptor reveal

208 depended on the source of the extracellular ligand binding domain of the subunit.

209 Crystal structures of the ligand binding domains of most of the phylogenetically w

210 iquitin ligase, interacts with the hinge and ligand binding domains of PPARgamma and is a bona fide E

211 lecule positive allosteric modulators of the ligand-binding domain of (S)-2-amino-3-(3-hydroxy-5-meth

212 teract with a binding site distinct from the ligand-binding domain of apoER2 for selenium delivery.

213 Mice with a mutated CD22 ligand-binding domain of CD22 showed strongly reduced Ca

214 ds to the cleft between the two lobes of the ligand-binding domain of each subunit.

215 allosteric binding site in the extracellular ligand-binding domain of ELIC.

216 te the potential of Nanobodies to target the ligand-binding domain of EphA4.

217 romoted the direct binding of LXRbeta to the ligand-binding domain of ERalpha and initiated an extran

218 ncluding those with hotspot mutations in the ligand-binding domain of ERalpha, remain dependent on ER

219 loop connecting Helix 11 and Helix 12 in the ligand-binding domain of ERalpha, which leads to a stabi

220 we utilize chimeric constructs, in which the ligand-binding domain of GluD1 is replaced by that of Gl

221 design using X-ray crystal structures of the ligand-binding domain of human GluA2 led to the discover

222 rimetry (ITC) analyses demonstrated that the ligand-binding domain of MCP2901 (MCP2901LBD) bound to c

223 their extracellular binding domains with the ligand-binding domain of metabotropic glutamate receptor

224 ith the acetylcholine-binding protein or the ligand-binding domain of nicotinic receptors.

225 ded mostly by the three-layer, alpha-helical ligand-binding domain of nuclear receptors.

226 We found that AA binds to and stabilizes the ligand-binding domain of peroxisome proliferator-activat

227 hown that heme decreases the affinity of the ligand-binding domain of Rev-erb NRs for NCoR1 peptides.

228 re, we report the crystal structures for the ligand-binding domain of RORgammat in both apo and ligan

229 ificity mapped primarily to the cytoplasmic, ligand-binding domain of STING.

230 resent the crystal structure of the isolated ligand-binding domain of the GluN1-GluN2A NMDA receptor

231 % sequence similarity with the extracellular ligand-binding domain of the human alpha7 nAChR, to inve

232 potent and selective Nanobodies against the ligand-binding domain of the human EphA4 receptor.

233 of non-steroidal ligands able to bind to the ligand-binding domain of the MR and recruit different co

234 uch as the acetylcholine-binding protein and ligand-binding domain of the nAChR alpha9 subunit, we sy

235 X-ray diffraction studies of the ligand-binding domain of the receptor are elucidating th

236 ng products lacking the entire extracellular ligand-binding domain of the receptor while retaining th

237 g of GK-15 into the N-terminal extracellular ligand-binding domain of the umami (T1R) receptor was pe

238 of a leucine by threonine in helix 8 of the ligand-binding domain of the zebrafish MR confers the an

239 iA through fusion of the Spinach2 aptamer to ligand-binding domains of cdiA riboswitches.

240 tructures for the soluble amino-terminal and ligand-binding domains of glutamate receptor ion channel

241 the heterodimeric complex formed between the ligand-binding domains of human PXR and RXRalpha.

242 designed corresponding to the extracellular ligand-binding domains of LRP1.

243 (AChBPs) are unique spatial homologs of the ligand-binding domains of nicotinic acetylcholine recept

244 Here we show that fusing ligand-binding domains of nuclear receptors to split Cas

245 udies reveal that only subtle changes in the ligand binding domain, often identified only in retrospe

246 rosine (Y) 537 amino acid residue within the ligand binding domain on (18)F-fluoroestradiol ((18)F-FE

247 H08), a radioligand for PET that engages the ligand binding domain on GR.

248 and novel CAR designs that have alternative ligand binding domains or confer regulated function and/

249 In addition to its carboxy terminus ligand-binding domain, PBK directly interacts with the a

250 viral DGR system targets putative tail fibre ligand-binding domains, potentially generating >10(18) p

251 s further modulated by ligand binding in the ligand-binding domain, providing evidence for Pin1-depen

252 etion of a conserved, unique sequence in the ligand binding domain (PXR174-210) did not interact with

253 GAMP, leads to a 180 degrees rotation of the ligand-binding domain relative to the transmembrane doma

254 In fact, the ERRbeta ligand-binding domain remains the last unsolved ERR stru

255 domains are primed for activation while the ligand-binding domain remains unchanged.

256 sites at lysine 122 and 275 in the AF-1 and ligand binding domains, respectively, of FXR were subjec

257 A point mutation (E102Q) in the ligand-binding domain results in the juvenile form of am

258 ar docking analysis of PioOH-bound PPARgamma ligand-binding domain revealed an altered hydrogen bondi

259 Crystallization of the DGluR1A ligand-binding domain reveals amino acid exchanges that

260 ntagonist AP5; crystallization of the KaiR1D ligand-binding domain reveals that these ligands stabili

261 isoform of ERbeta (mERbeta2) with a modified ligand-binding domain sequence.

262 The alphaI domain (AID), a ligand binding domain shared by seven integrin alpha-sub

263 Recombinant soluble molecules displaying ligand-binding domains show marked quantitative and qual

264 h brace the heterodimer interface within the ligand binding domain, stabilize actively gating recepto

265 ulated ectodomain cleavage that releases the ligand-binding domain (sTie2) into the circulation.

266 The GR ligand-binding domain suffices for these biological resp

267 have additional intersubunit contacts in the ligand binding domain that occur at both conserved and n

268 C-terminal angiopoietin domains to the Tie2 ligand-binding domain, the mechanisms for Tie2 activatio

269 olubility and stability of an active ERRbeta ligand-binding domain, thereby providing a protein tool

270 ZNF764 physically interacted with GR at ligand-binding domain through its KRAB domain, and both

271 nd JH, which has been mapped to a particular ligand-binding domain, thus establishing this bHLH-PAS p

272 together with in silico modeling of the AHR ligand binding domain to identify indole, a microbial tr

273 ACVR1-R206H and -G328R do not require their ligand binding domain to over-activate BMP signaling in

274 w approaches that use genotyping of the AHR1 ligand binding domain to screen for DLC sensitivity amon

275 ciable pre-complex, enabling its neighboring ligand binding domain to tightly clamp the two polypepti

276 dicate that CITCO binds directly to the hPXR ligand-binding domain to activate hPXR.

277 number of riboswitches that utilize the same ligand-binding domain to regulate transcription or trans

278 ors can bind within a pocket adjacent to the ligand-binding domain to stabilize specific conformation

279 possibly a stretch of linker, connecting the ligand-binding domain to the fourth membrane-spanning se

280 g the linker that connects the extracellular ligand-binding domain to the transmembrane region.

281 e opportunities through the use of different ligand-binding domains to enable multiplexed genome regu

282 PAR region that links the four extracellular ligand-binding domains to the central ion channel in the

283 A of the C-terminal part of the periplasmic ligand-binding domain upon ligand occupancy in the citra

284 erved tertiary architectural elements of the ligand binding domain using an in vitro single-turnover

285 the structure of the glutamine-II riboswitch ligand binding domain using X-ray crystallography.

286 n rat brain membranes and the purified GluN1 ligand-binding domain using glycine site GluN1 radioliga

287 h a crystallographic analysis of the GluRIIB ligand binding domain, we use this system to characteriz

288 s of both eutomers in complex with the GluA2 ligand binding domain were solved.

289 Two X-ray structures of ligand binding domains were obtained: 2e in GluA2-LBD an

290 uctures of the three modulators in the GluK1 ligand-binding domain were determined, locating two modu

291 y BMP7 and were sensitive to deletion of the ligand binding domain, whereas the engineered ACVR1(Q207

292 ve splicing of the flip/flop cassette of the ligand-binding domain, which controls motions in the dis

293 ous conformations of the estrogen receptor's ligand-binding domain, which in turn produces differenti

294 soform encoded by splice variant 7 lacks the ligand-binding domain, which is the target of enzalutami

295 tion leads to a conformational change in the ligand-binding domain, which mimics the conformation of

296 es, the ion channels are closed, whereas the ligand-binding domains, which are physically coupled to

297 rthermore, two NES were characterized in the ligand binding domain, whose deletion caused Nurr1 to ac

298 ized state, when ligands remain bound at the ligand binding domain with the conformation similar to t

299 The nearly 150 crystal structures of VDR's ligand-binding domain with various vitamin D compounds a

300 domain arrangement consisting of individual ligand binding domains, with a defined higher order arch