ライフサイエンスコーパス: ligand-gated channel

1 recognition by insect ORs, a novel class of ligand-gated channel.

2 channels, but not sodium (Na(+)) channels or ligand-gated channels.

3 , a common theme for activating mutations in ligand-gated channels.

4 data of ethanol action on a wide variety of ligand-gated channels.

5 of the OFF bipolar that arises directly from ligand-gated channels.

6 tivity modulators or downstream effectors of ligand-gated channels.

7 ity filter found universally in voltage- and ligand-gated channels.

8 mechanisms for the superfamily of pentameric ligand-gated channels.

9 vealing a new role for the ICD in pentameric ligand-gated channels.

10 mediates rapid excitatory responses through ligand-gated channels (5-HT3 receptors).

11 ction of a variety of ion channels including ligand-gated channels activated by ATP, acetylcholine, G

12 The P2X receptors (P2XRs) are a family of ligand-gated channels activated by extracellular ATP thr

13 re are three forms of IP3R, all of which are ligand-gated channels activated by the second messenger

14 ormational changes predicted to occur during ligand-gated channel activation and desensitization.

15 This cross-regulation of ligand-gated channel activity by protein kinases may pla

16 allostery that are shared with conventional ligand-gated channels and (ii) the R domain modulates CF

17 ides a framework for understanding gating in ligand-gated channels and how mutations in the acetylcho

18 fects that have been observed for pentameric ligand-gated channels and may represent a previously unk

19 erpretation of protein allostery for general ligand-gated channels and receptors.

20 Although both voltage- and ligand-gated channels are being extensively studied, the

21 Our demonstration that ligand-gated channels are subject to MCI, as are voltage

22 Different classes of ligand-gated channels associate with distinct sets of in

23 The role of desensitization of ligand-gated channels at fast chemical synapses has been

24 TR gating is distinct from that of a typical ligand-gated channel because its ligand (ATP) is usually

25 gand-binding domain akin to those of classic ligand-gated channels; binding of pisiferic acid induces

26 Unlike conventional ligand-gated channels, CFTR is an ATPase for which ligan

27 urther emphasizes the importance of pursuing ligand-gated channel characterization in their native en

28 c Ca(2+)-gated K(+) channel that, like other ligand-gated channels, converts the chemical energy of l

29 c properties that are common to conventional ligand-gated channels (e.g. unliganded openings and cons

30 For ligand-gated channels each state can represent a differe

31 hosphorylated CFTR behaves as a conventional ligand-gated channel employing cytoplasmic ATP as a read

32 forms are a family of ubiquitously expressed ligand-gated channels encoded by three individual genes.

33 +]i increases result from Ca2+ entry through ligand-gated channels, entry through voltage-gated chann

34 to menthol or cold, TRPM8 behaves like many ligand-gated channels, exhibiting rapid activation follo

35 ated ion channels (5-HT3) are members of the ligand-gated channel family, which includes channels tha

36 zation remain unavailable for the pentameric ligand-gated channel family.

37 show that the binding domains of tetrameric ligand-gated channels form either a 4-fold symmetric gat

38 GABAARs are heteropentameric ligand-gated channels formed by the combination of 19 po

39 butyric acid) exerts its effects through two ligand-gated channels, GABA(A) and GABA(C) receptors, an

40 Like other pentameric ligand-gated channels, glycine receptors (GlyRs) contain

41 De novo mutations in voltage- and ligand-gated channels have been associated with an incre

42 Despite their widespread nature, no ligand-gated channels have yet been found within the out

43 RPV1 or vanilloid receptor is a nonselective ligand-gated channel highly expressed in primary sensory

44 may prove useful for investigating models of ligand-gated channels in biological membranes.

45 Q) due to each of the different voltage- and ligand-gated channels in the cells in the presence of fa

46 Ligand-gated channels, in which a substrate transport pa

47 s are thought to occur through impact on the ligand-gated channels including the GABA(A) receptor.

48 cognized that this small molecule influences ligand-gated channels, including the GABAA receptor and

49 an affect neuronal excitability by acting on ligand-gated channels, including those gated by glutamat

50 Activation of ligand-gated channels is initiated by the binding of sma

51 For ligand-gated channels, it is challenging to separate lig

52 This increases Ca2+ binding to ligand-gated channels known as ryanodine receptors (RyR2

53 ty of crystallographic information for these ligand-gated channels, little is known about the structu

54 AMPA receptors (AMPARs) are tetrameric ligand-gated channels made up of combinations of GluA1-4

55 Ligand-gated channels mediate synaptic transmission thro

56 GABAA receptors are pentameric ligand-gated channels mediating inhibitory neurotransmis

57 te Ca(2+) entry through voltage-dependent or ligand-gated channels of the plasma membrane.

58 c [Ca2+]i can result from Ca2+ entry through ligand-gated channels or voltage-gated Ca2+ channels, or

59 c activation opening voltage gated channels, ligand gated channels, or mobilizing Ca(2+) release from

60 P receptors can modulate voltage- as well as ligand-gated channels permeable to calcium and may play

61 In ligand-gated channels, pore opening is conferred through

62 ctance expands the complex repertoire of the ligand-gated channel properties associated with EAAT4.

63 partate receptor (NMDAR) is unique among all ligand-gated channels, requiring two ligands-glutamate a

64 binding of neurotransmitters in voltage- and ligand-gated channels, respectively.

65 In certain ligand-gated channels, such as BK channels and MthK, a C

66 y inference, other members of the homologous ligand-gated channel superfamily, which include the iono

67 type A receptors (GABA(A)Rs), which are the ligand-gated channels target of the major inhibitory neu

68 Vanilloid receptor subtype 1 (VR1) is a ligand-gated channel that can be activated by capsaicin

69 TRPML1 is a ligand-gated channel that can be activated by phosphatid

70 oned vanilloid receptor subtype 1 (VR1) is a ligand-gated channel that is activated by capsaicin, pro

71 2+ release channel (ryanodine receptor) is a ligand-gated channel that is activated by micromolar cyt

72 f ADPR or AMPCPR, identify TRPM2 as a simple ligand-gated channel that obeys an equilibrium gating me

73 IP3 receptors--ligand-gated channels that release Ca2+ from intracellul

74 loop receptors (CLRs) are commonly known as ligand-gated channels that transiently open upon binding

75 Akin to ligand-gated channels, the dilated state of the midplane

76 ngly and contrary to what is expected from a ligand-gated channel, these activations occur in a seemi

77 esumably occupy overlapping binding sites on ligand-gated channels, these interactions cannot be iden

78 dulate T currents but not other voltage- and ligand-gated channels thought to mediate pain sensitivit

79 ge-gated Ca(2+) channels, various Ca(2+)- or ligand-gated channels, Trp family channels, and even the

80 As a ligand-gated channel, TRPA1 can be activated by electrop

81 tamate receptors are postsynaptic tetrameric ligand-gated channels whose activity mediates fast excit

82 alized by considering CFTR as a hydrolyzable-ligand-gated channel with cytoplasmic ATP as ligand.

83 TR gating that combines the allosterism of a ligand-gated channel with its unique enzymatic activity.

84 2+) permeable isoform, is by far the fastest ligand-gated channel with the channel-opening and -closi