ライフサイエンスコーパス: ligand-gated ion channel

1 the gating mechanism in the same pentameric ligand-gated ion channel.

2 receptor, three of the key features of this ligand-gated ion channel.

3 consequences of allosteric ion binding to a ligand-gated ion channel.

4 nal changes that take place in a functioning ligand-gated ion channel.

5 desensitization gate in this novel class of ligand gated ion channels.

6 the expression and behaviour of voltage and ligand gated ion channels.

7 nsporters can operate as anion-selective and ligand-gated ion channels.

8 t efficacy in heteromeric nAChRs and related ligand-gated ion channels.

9 lent cation binding site in other pentameric ligand-gated ion channels.

10 ing selective G-protein-coupled receptors or ligand-gated ion channels.

11 regulation between excitatory and inhibitory ligand-gated ion channels.

12 tylcholine receptors (nAChRs) are pentameric ligand-gated ion channels.

13 xt of current models of anesthetic action on ligand-gated ion channels.

14 similar to synaptic activation of classical ligand-gated ion channels.

15 ng the agonism, coagonism, and modulation of ligand-gated ion channels.

16 ditis elegans glutamate-activated pentameric ligand-gated ion channels.

17 and with their potency in inhibiting certain ligand-gated ion channels.

18 neral pathway to photosensitizing pentameric ligand-gated ion channels.

19 ating candidate agonists and antagonists for ligand-gated ion channels.

20 her represent one of the largest families of ligand-gated ion channels.

21 a complete understanding of drug actions on ligand-gated ion channels.

22 rally and functionally from simple bacterial ligand-gated ion channels.

23 LIC and possibly other homologous pentameric ligand-gated ion channels.

24 ing of the ion-conducting pore in pentameric ligand-gated ion channels.

25 losteric mechanisms of eukaryotic pentameric ligand-gated ion channels.

26 cal for the normal function of cysteine-loop ligand-gated ion channels.

27 inic AChRs (nAChRs) represent a paradigm for ligand-gated ion channels.

28 lcholine receptor (AChR) is the prototype of ligand-gated ion channels.

29 on relationships in GlyRs and possibly other ligand-gated ion channels.

30 r assembles from individual subunits to form ligand-gated ion channels.

31 tion, and has little to no efficacy at other ligand-gated ion channels.

32 s are members of the Cys-loop superfamily of ligand-gated ion channels.

33 properties of native and recombinant single ligand-gated ion channels.

34 NMDA receptors, when tested against various ligand-gated ion channels.

35 ssion and activity of dendritic voltage- and ligand-gated ion channels.

36 h nicotinic receptors and related pentameric ligand-gated ion channels.

37 tors, serine proteases, protein kinases, and ligand-gated ion channels.

38 ne a new molecular paradigm for gating among ligand-gated ion channels.

39 ) are members of the Cys-loop superfamily of ligand-gated ion channels.

40 fast synaptic transmission by functioning as ligand-gated ion channels.

41 GABAA) receptors, which are Cl(-)-permeable, ligand-gated ion channels.

42 ritical for channel gating in all pentameric ligand-gated ion channels.

43 ing on ion channels, most notably pentameric ligand-gated ion channels.

44 NMDA receptors are tetrameric ligand-gated ion channels.

45 RPV1 represents an excellent model system of ligand-gated ion channels.

46 members of the Cys-loop family of pentameric ligand-gated ion channels, 5-hydroxytryptamine type 3 re

47 y stimulation of the purinergic receptor P2X ligand-gated ion channel 7 (P2X7) by millimolar concentr

48 ious association of purinergic receptor P2X, ligand-gated ion channel, 7 (P2RX7), with asthma exacerb

49 in macrophages via purinergic receptor P2X, ligand-gated ion channel, 7 (P2X(7)), may play a role in

50 d signaling through purinergic receptor P2X, ligand-gated ion channel, 7 (P2X7 receptor; encoded by P

51 The P2X7 receptor is a trimeric ligand-gated ion channel activated by ATP.

52 P2X receptors (P2XRs) are ligand-gated ion channels activated by extracellular ATP

53 NMDA receptors (NMDARs) are Ca(2+)-permeant, ligand-gated ion channels activated by the excitatory ne

54 in the mammalian brain contain two types of ligand-gated ion channels: AMPA receptors (AMPARs) and N

55 acting ionotropic Glu receptors (iGluRs) are ligand gated ion channels and are believed to be involve

56 The 5-HT(3) receptor is an important ligand-gated ion channel and drug target in the central

57 iew, we discuss our current understanding of ligand-gated ion channel and G protein-coupled receptor

58 ic GABA(A)Rs and in the Erwinia chrysanthemi ligand-gated ion channel and may be essential for the ab

59 x-ray structure of a prokaryotic pentameric ligand-gated ion channel and offer insight into the stru

60 The activity of many ligand-gated ion channels and cell surface receptors is

61 Glycine receptors are chloride-permeable, ligand-gated ion channels and contribute to the inhibiti

62 into the signalling mechanisms of pentameric ligand-gated ion channels and enhance current understand

63 understanding the mechanisms of operation of ligand-gated ion channels and fast chemical synapses.

64 Targeting receptor proteins, such as ligand-gated ion channels and G protein-coupled receptor

65 nactive (R) and active (R*) conformations of ligand-gated ion channels and G protein-coupled receptor

66 (nAChR) belongs to the family of pentameric ligand-gated ion channels and is involved in fast synapt

67 (nAChRs) belong to the family of pentameric ligand-gated ion channels and mediate fast excitatory tr

68 are over-represented in membrane receptors, ligand-gated ion channels and nuclear receptor targets,

69 ave a fold similar to that of other Cys-loop ligand-gated ion channels and that amino acid 256 was un

70 yric acid (GABA(A)) receptors are pentameric ligand-gated ion channels and the main drivers of fast i

71 ) is a member of the Cys-loop superfamily of ligand-gated ion channels and the major mediator of inhi

72 , which is vestigial in bacterial pentameric ligand-gated ion channels and was largely removed for cr

73 s: G protein-coupled receptors, voltage- and ligand-gated ion channels and, in a recent update, 49 nu

74 elical receptors are proposed to function as ligand-gated ion channels and/or to act metabotropically

75 ors, nuclear hormone receptors, voltage- and ligand-gated ion channels) and approximately 3180 bioact

76 role of increasing synaptic strength via its ligand-gated ion channel, and a novel role through the s

77 (nAChRs) are in the superfamily of Cys-loop ligand-gated ion channels, and are pentameric assemblies

78 lobular proteins, the opening and closing of ligand-gated ion channels, and ligand binding to hydroph

79 Bacteria have many voltage- and ligand-gated ion channels, and population-level measurem

80 PhTX-433 inhibits several excitatory ligand-gated ion channels, and to improve selectivity tw

81 3 nonselectively inhibits several excitatory ligand-gated ion channels, and we recently showed that i

82 ghts on ethanol allosteric interactions with ligand-gated ion channels; and (iii) a first step for de

83 allosteric modulators (PAMs) for the GABA(A) ligand-gated ion channel are described.

84 Ligand-gated ion channels are activated by agonist bindi

85 Ligand-gated ion channels are allosteric membrane protei

86 Pentameric ligand-gated ion channels are an important family of mem

87 proaches, we show that eukaryotic pentameric ligand-gated ion channels are characterized by loose pac

88 sms by which agonists and other ligands bind ligand-gated ion channels are important determinants of

89 Allosteric modulators of ligand-gated ion channels are of particular interest as

90 Ligand-gated ion channels are prototypic oligomeric memb

91 Pentameric ligand-gated ion channels are targets of general anesthe

92 Allosteric modulators of pentameric ligand-gated ion channels are thought to act on elements

93 Cys-loop ligand-gated ion channels assemble as pentameric protein

94 N-methyl-d-aspartate (NMDA) receptors are ligand-gated ion channels assembled from GluN1 and GluN2

95 the expression of gephyrin, an organizer of ligand-gated ion channels at inhibitory synapses in hipp

96 and modulate a large number of voltage- and ligand-gated ion channels at the plasma membrane.

97 nesthetics modulate the function of cys-loop ligand-gated ion channels, binding to a putative site be

98 l shares gating principles with conventional ligand-gated ion channels, but the allosteric network th

99 Desensitization is a canonical property of ligand-gated ion channels, causing progressive current d

100 onnection including ligand-receptor binding, ligand-gated ion channels, chemotaxis, chromatin structu

101 alpha7 receptors are ligand-gated ion channels composed of five identical sub

102 The OR class insect odorant receptors are ligand-gated ion channels comprised of at least one comm

103 NMDA receptors are tetrameric ligand-gated ion channels comprised of GluN1, GluN2, and

104 Pentameric ligand-gated ion channels control synaptic neurotransmis

105 cotinic acetylcholine receptor, a pentameric ligand-gated ion channel, converts the free energy of bi

106 s), including the NMDA receptor subtype, are ligand-gated ion channels critical to fast signaling in

107 Members of the cys-loop ligand-gated ion channel (cysLGIC) superfamily mediate c

108 of the effect of agonist and anesthetics on ligand-gated ion channels, developed in earlier work, is

109 rystal structure of the Erwinia chrysanthemi ligand-gated ion channel (ELIC) in complex with a deriva

110 y binds to and stabilizes the pLGIC, Erwinia ligand-gated ion channel (ELIC), and decreases ELIC dese

111 rom prokaryote homologs-Erwinia chrysanthemi ligand-gated ion channel (ELIC), Gloeobacter violaceus l

112 e reduction in the membrane protein, Erwinia ligand-gated ion channel (ELIC).

113 rokaryotic homolog, the Erwinia chrysanthemi ligand-gated ion channel (ELIC).

114 nts of chlorpromazine binding in the Erwinia ligand-gated ion channel (ELIC).

115 Of the ligand-gated ion channels examined, 20% showed patterned

116 P2X7 is an important ligand-gated ion channel expressed in multiple immune ce

117 Glycine receptors (GlyRs) are inhibitory ligand-gated ion channels expressed in nerves of the spi

118 Functional studies of the ligand gated ion channel family (nicotinic acetylcholine

119 al closely related members of the pentameric ligand gated ion channel family.

120 As members of the Cys loop ligand-gated ion channel family, neuronal nAChRs are pen

121 eptor (5-HT(3)R) is a member of the Cys-loop ligand-gated ion channel family.

122 cell-surface receptors, and specifically for ligand-gated ion channels, for well over a century.

123 Voltage- and ligand-gated ion channels form the molecular basis of ce

124 The ligand-gated ion channel from Erwinia chrysanthemi (ELIC

125 ELIC, the pentameric ligand-gated ion channel from Erwinia chrysanthemi, is a

126 ing ideas about how activation proceeds in a ligand-gated ion channel from the binding of the agonist

127 l excitability, indicating that exclusion of ligand-gated ion channels from the axon is not absolute.

128 Likewise, mutations in the inhibitory ligand-gated ion channels, GABAA receptors (GABAARs), ca

129 rain's major inhibitory neuroreceptor is the ligand-gated ion channel gamma-aminobutyric acid (GABA)

130 Purinergic P2X receptors are a family of ligand-gated ion channels gated by extracellular adenosi

131 l, vanilloid) channels belong to a family of ligand-gated ion channels gated not only by the binding

132 ein motions underlying Gloeobacter violaceus ligand-gated ion channel gating in a membrane environmen

133 inhibits the currents of the homopentameric ligand-gated ion channel GLIC, yet the crystal structure

134 prokaryotic homologs, Gloebacter and Erwinia ligand-gated ion channel (GLIC and ELIC, respectively),

135 membrane domain of the Gloeobacter violaceus ligand-gated ion channel (GLIC) channel, characterize th

136 Gloeobacter violaceus ligand-gated ion channel (GLIC) has served as a valuable

137 etic propofol bound to Gloeobacter violaceus ligand-gated ion channel (GLIC), a bacterial homolog of

138 Crystal structures of Gloeobacter violaceus ligand-gated ion channel (GLIC), a proton-gated prokaryo

139 e bacterial Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC), a structural homolog of

140 /C) receptors, and the Gloeobacter violaceus ligand-gated ion channel (GLIC), are receptors that cont

141 tameric ligand-gated ion channel, Gloebacter ligand-gated ion channel (GLIC), represents an excellent

142 e bacterial Gloeobacter violaceus pentameric ligand-gated ion channel (GLIC), which is sensitive to a

143 ed ion channel (ELIC), Gloeobacter violaceus ligand-gated ion channel (GLIC)-and crystallized eukaryo

144 yotic proton-activated Gloeobacter violaceus ligand-gated ion channel (GLIC).

145 n and function of the prokaryotic pentameric ligand-gated ion channels, GLIC and ELIC, was examined b

146 The homologous prokaryotic pentameric ligand-gated ion channel, Gloebacter ligand-gated ion ch

147 bacterial homolog ELIC (Erwinia chrysanthemi ligand-gated ion channel) has a similar lipid sensitivit

148 e bacterial Gloeobacter violaceus pentameric ligand-gated ion channel homologue (GLIC).

149 ntameric ion channel analogous to pentameric ligand-gated ion channels, however, future patch clamp e

150 Many clinically important drugs target ligand-gated ion channels; however, the mechanisms by wh

151 icroscopy Torpedo model; the only pentameric ligand-gated ion channel imaged in a native lipid membra

152 eptors (adrenoceptors) and P2X1-purinoceptor ligand gated ion channels in male mice, thereby blocking

153 ntext of the alpha4beta2 nAChR, a widespread ligand-gated ion channel in the brain and a target for n

154 To examine the function of ligand-gated ion channels in a defined membrane environm

155 modulator that activates GPCRs in mammals or ligand-gated ion channels in invertebrates.

156 or TRPV1 is an outstanding representative of ligand-gated ion channels in ligand selectivity and sens

157 Glutamate receptors are essential ligand-gated ion channels in the central nervous system

158 The ligand-gated ion channels in the Cys-loop receptor super

159 hetics are known to modulate the activity of ligand-gated ion channels in the Cys-loop superfamily, t

160 the mRNA expression patterns of voltage- and ligand-gated ion channels in the DR using the Allen Mous

161 cysteine (Cys)-loop receptor super family of ligand-gated ion channels in the nervous system and is a

162 nAChRs are cholinergic receptors forming ligand-gated ion channels in the plasma membranes of cer

163 ently and allosterically modulate pentameric ligand-gated ion channels, including GABA(A) receptors (

164 e receptors, G-protein coupled receptors and ligand-gated ion channels, including the NMDA glutamate

165 ng at the extracellular domain of pentameric ligand-gated ion channels initiates a relay of conformat

166 GABA(A) receptors are pentameric ligand-gated ion channels involved in fast inhibitory ne

167 AChR) belongs to a superfamily of pentameric ligand-gated ion channels involved in many physiologic a

168 ed from presynaptic terminals activates both ligand-gated ion channels (ionotropic receptors) and a v

169 this review article, an auxiliary subunit of ligand-gated ion channels is defined using four criteria

170 the serotonin type 3A receptor, a pentameric ligand-gated ion channel, is crucial for regulating cond

171 on-gated prokaryotic homologue of pentameric ligand-gated ion channel (LGIC) from G. violaceus, have

172 Regulation of ligand-gated ion channel (LGIC) function and trafficking

173 For Cys-loop ligand-gated ion channels (LGIC), the protein movements

174 brain involves rapid opening and closing of ligand gated ion channels (LGICs).

175 indicate that switches in ion selectivity of ligand-gated ion channels (LGICs) do not affect network

176 Presynaptic ligand-gated ion channels (LGICs) have long been propose

177 Ligand-gated ion channels (LGICs) mediate fast synaptic

178 Pentameric ligand-gated ion channels (LGICs) play an important role

179 e only member of the Cys-loop superfamily of ligand-gated ion channels (LGICs) that is available in h

180 able the systematic creation of a toolbox of ligand-gated ion channels (LGICs) with orthogonal pharma

181 ellular excitation or inhibition by Cys-loop ligand-gated ion channels (LGICs), and is essential for

182 dulation is a general phenomenon of Cys-loop ligand-gated ion channels (LGICs), and whether this modu

183 The presence of two additional ligand-gated ion channels (LGICs), gamma-aminobutyric ac

184 can directly interact with certain types of ligand-gated ion channels (LGICs).

185 ray cocrystal structure within this class of ligand-gated ion channels (LGICs).

186 Pentameric ligand-gated ion channels mediate fast chemical transmis

187 e receptor (alpha7nAChR) is a homopentameric ligand-gated ion channel mediating fast synaptic transmi

188 cotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels mediating fast cholinergic syn

189 nker but also the M1-M2 linker of pentameric ligand-gated ion channels modulates function in vivo.

190 rocesses and is considered the prototype for ligand-gated ion channels, motivating a structural deter

191 line receptors (nAChR) are cation-selective, ligand-gated ion channels of the cysteine (Cys)-loop gen

192 imilarity, it is not clear whether these two ligand-gated ion channels operate in a similar manner.

193 Pentameric ligand-gated ion channels or Cys-loop receptors are resp

194 P2X receptors are a family of seven ligand-gated ion channels (P2X1-P2X7) that open in the p

195 The ligand-gated ion channel P2X7 receptor attracts special

196 NMDA receptors (NMDARs), ligand-gated ion channels, play important roles in vario

197 Desensitization in pentameric ligand-gated ion channels plays an important role in reg

198 tor (GABA(A)R) is a member of the pentameric ligand gated ion channel (pLGIC) family that mediates io

199 GLIC, a prokaryotic member of the pentameric ligand-gated ion channel (pLGIC) family, provides a uniq

200 The glycine receptor (GlyR) is a pentameric ligand-gated ion channel (pLGIC) mediating inhibitory tr

201 ic cation-selective member of the pentameric ligand-gated ion channel (pLGIC) superfamily.

202 ion-selective ion channels of the pentameric ligand-gated ion channel (pLGIC) superfamily.

203 The 5-HT(3) receptor, a pentameric ligand-gated ion channel (pLGIC), is an important therap

204 Pentameric ligand gated ion channels (pLGICs) mediate signal transd

205 Pentameric ligand-gated ion channels (pLGICs) are allosteric recept

206 Pentameric ligand-gated ion channels (pLGICs) are essential determi

207 Pentameric ligand-gated ion channels (pLGICs) are neurotransmitter-

208 Pentameric ligand-gated ion channels (pLGICs) are targets of genera

209 ructure of full-length eukaryotic pentameric ligand-gated ion channels (pLGICs) is still lacking.

210 ion channels, the superfamily of pentameric ligand-gated ion channels (pLGICs) is unique in that its

211 Pentameric ligand-gated ion channels (pLGICs) mediate fast chemical

212 Pentameric ligand-gated ion channels (pLGICs) mediate fast chemoele

213 Pentameric ligand-gated ion channels (pLGICs) mediate numerous phys

214 Pentameric ligand-gated ion channels (pLGICs) mediate signal transm

215 Pentameric ligand-gated ion channels (pLGICs) or Cys-loop receptors

216 Pentameric ligand-gated ion channels (pLGICs) play a central role i

217 Rapid opening and closing of pentameric ligand-gated ion channels (pLGICs) regulate information

218 Ketamine inhibits pentameric ligand-gated ion channels (pLGICs), including the bacter

219 Pentameric ligand-gated ion channels (pLGICs), such as nicotinic ac

220 y modulating agonist responses of pentameric ligand-gated ion channels (pLGICs).

221 ucture-based ligand discovery for pentameric ligand-gated ion channels (pLGICs).

222 and modulating membrane-embedded pentameric ligand-gated ion channels (pLGICs).

223 tructure-function relationship of pentameric ligand-gated ion channels (pLGICs).

224 ptors (GlyRs) are anion-permeable pentameric ligand-gated ion channels (pLGICs).

225 activity of anionic and cationic pentameric ligand-gated ion channels (pLGICs).

226 ic glutamate receptors (iGluRs), tetrameric, ligand-gated ion channel proteins comprised of three sub

227 f function of the ATP-gated P2X(2) receptor (ligand-gated ion channel, purinergic receptor 2) that is

228 t be incorporated into functional pentameric ligand-gated ion channel receptors.

229 A) receptors (GABARs) are chloride-permeable ligand-gated ion channels responsible for fast inhibitor

230 P2X7 receptors (P2X7Rs) are ligand-gated ion channels sensitive to extracellular ATP

231 They belong to the family of pentameric ligand-gated ion channels, sharing a highly conserved mo

232 have led to the identification of MPTL-1, a ligand-gated ion-channel subunit of the parasitic nemato

233 sory G protein-coupled receptors (GPCRs), 71 ligand-gated ion channel subunits and 141 voltage-gated-

234 ed calcium channels (VGCCs) and postsynaptic ligand-gated ion channels such as AMPA receptors (AMPARs

235 Its targets include ligand-gated ion channels such as the GABA(A) receptor,

236 GlyRs are members of the pentameric ligand-gated ion channel superfamily (pLGIC) that mediat

237 anniversary of the discovery of the Cys loop ligand-gated ion channel superfamily of neurotransmitter

238 e 5-HT3 receptor is a member of the Cys-loop ligand-gated ion channel superfamily participating in sy

239 nAChR) is a member of the important Cys loop ligand-gated ion channel superfamily that modulates neur

240 Prokaryotic members of the Cys-loop receptor ligand-gated ion channel superfamily were recently ident

241 tion to our knowledge of the entire Cys loop ligand-gated ion channel superfamily.

242 tors (GABAARs) are members of the pentameric ligand-gated ion channel superfamily.

243 ransient Receptor Potential A 1 (TRPA1) is a ligand-gated ion channel that contributes to inflammator

244 The serotonin type 3 receptor (5-HT(3)) is a ligand-gated ion channel that converts the binding of th

245 ane conductance regulator (CFTR) is the only ligand-gated ion channel that hydrolyzes its agonist, AT

246 The P2X4 receptor is a ligand-gated ion channel that is expressed on a variety

247 The NMDA-sensitive glutamate receptor is a ligand-gated ion channel that mediates excitatory synapt

248 and for and modulator of ryanodine receptors-ligand-gated ion channels that are critical for intracel

249 tivation, as illustrated here for pentameric ligand-gated ion channels that are principal to nervous

250 cotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that consist of pentameric com

251 NMDA-type glutamate receptors are ligand-gated ion channels that contribute to excitatory

252 AMPA receptors (AMPARs) are tetrameric ligand-gated ion channels that couple the energy of glut

253 Insect olfactory receptors operate as ligand-gated ion channels that directly transduce odor s

254 NMDA receptors are ligand-gated ion channels that mediate excitatory neurot

255 NMDA receptors are ligand-gated ion channels that mediate excitatory neurot

256 Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that mediate excitatory signal

257 Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synapt

258 Ionotropic glutamate receptors are ligand-gated ion channels that mediate excitatory synapt

259 Nicotinic acetylcholine receptors are ligand-gated ion channels that mediate fast chemical neu

260 Glutamate receptors are ligand-gated ion channels that mediate fast excitatory s

261 id type A (GABA(A)) receptors are pentameric ligand-gated ion channels that mediate fast inhibition i

262 receptor and related Cys-loop receptors are ligand-gated ion channels that mediate fast synaptic tra

263 Ionotropic glutamate receptors are ligand-gated ion channels that mediate much of the fast

264 GABA(A) receptors (GABA(A)Rs) are pentameric ligand-gated ion channels that mediate synaptic inhibiti

265 oxazolepropionic acid receptors (AMPARs) are ligand-gated ion channels that mediate the majority of f

266 cotinic acetylcholine receptors (nAChRs) are ligand-gated ion channels that modulate key physiologica

267 Ionotropic glutamate receptors (iGluRs) are ligand-gated ion channels that open their ion-conducting

268 MDA) receptors are obligate heterotetrameric ligand-gated ion channels that play critical roles in le

269 oxytryptamine type 3 (5-HT(3)) receptors are ligand-gated ion channels that play important roles in d

270 Mutations of several voltage-gated and ligand-gated ion channels that regulate neuronal excitab

271 5-HT(3) receptors are pentameric ligand-gated ion channels that regulate synaptic activit

272 AMPA receptors are ligand-gated ion channels that show multiple conductance

273 NMDA receptors are ligand-gated ion channels that underlie transmission at

274 the structure of the prototypical pentameric ligand-gated ion channel the Torpedo nicotinic acetylcho

275 s the first report showing the key role of a ligand gated ion channel, the purinergic P2X7 receptor i

276 One such ligand-gated ion channel, the NMDAR, impacts nearly all

277 numerous studies have focused on pentameric ligand-gated ion channels, the details of anesthetic bin

278 er in the human brain, activates a family of ligand-gated ion channels, the major subtypes of which a

279 excitability via the activation of specific ligand-gated ion channels, the P2X3 and P2X2/3 receptors

280 ilies such as G-protein-coupled receptors or ligand-gated ion channels, the sigma1 receptor is an evo

281 Similar to other ligand-gated ion channels, their gating cycle begins wit

282 M3 to reduce the sensitivities of pentameric ligand-gated ion channels to their surrounding membrane

283 (P2XRs) are ATP-activated calcium-permeable ligand-gated ion channels traditionally viewed as sensor

284 potential (TRP) ion channel superfamily, the ligand-gated ion channel TRPA1 has been implicated in no

285 ents show that G2A activation sensitizes the ligand-gated ion channel TRPV1 in sensory neurons via ac

286 Ligand-gated ion channels undergo conformational changes

287 or interactions of this structural family on ligand-gated ion channels, we employed HEK cells transfe

288 nt changes in the ionic permeability of some ligand-gated ion channels, we now show for the first tim

289 Using the Cys-loop superfamily of ligand-gated ion channels, we show that functional studi

290 (nAChRs) are in the superfamily of Cys-loop ligand-gated ion channels, which are widely expressed in

291 Members of the Cys-loop superfamily of ligand-gated ion channels, which mediate fast synaptic t

292 This study provides an example of a ligand-gated ion channel whose deactivation is sensitive

293 the N-methyl-D-aspartate receptor (NMDAR), a ligand-gated ion channel with essential roles in brain d

294 etylcholine receptor is a large, allosteric, ligand-gated ion channel with the subunit composition al

295 Inhibitory glycine receptors are pentameric ligand-gated ion channels with a definitive and clinical

296 Ionotropic glutamate receptors (GluRs) are ligand-gated ion channels with a modular structure.

297 NMDA receptors are ligand-gated ion channels with a regulatory intracellula

298 aves the way for engineering light-sensitive ligand-gated ion channels with subtype specificity throu

299 (PTX) is a noncompetitive antagonist of many ligand-gated ion channels, with a site of action believe

300 type glutamate receptors act as voltage- and ligand-gated ion channels, with functional properties de