ライフサイエンスコーパス: ligand-specific

1 ephrine on the transport of (131)I-P-GUS was ligand specific.

2 The dose response of chimeric receptors was ligand specific.

3 ions of expressed genes, which are partially ligand-specific.

4 es) or the desensitization rate constant was ligand-specific.

5 of the MAP kinase pathway is cell type- and ligand-specific.

6 combinations of TLR ligands is cytokine- and ligand-specific.

7 teins, but not the 46-kDa protein, exhibited ligand-specific 125I-syringolide binding activity.

8 Ligand-specific activation and cell-cell contact were re

9 Functional selectivity is the ligand-specific activation of certain signal transductio

10 eads to reproductive anomalies; differential ligand-specific activation of HOX genes may be a molecul

11 olymorphic residues in eSRK are required for ligand-specific activation of self-incompatibility in vi

12 Ligand-specific activation of TLR2 and TLR9 are dependen

13 Furthermore, we found ligand-specific active displacement of PR from the MMTV

14 eosinophils and CD4+ T cells are capable of ligand-specific adhesion that is mediated predominantly

15 f concept for the modulation of isoform- and ligand-specific aGPCR functions using unique tools, and

16 The results indicate significant, ligand-specific allosteric coupling between thrombin exo

17 or that is composed of two chains: a unique, ligand-specific alpha chain and a beta common chain (bet

18 kin-9 receptor (IL-9R) complex consists of a ligand-specific alpha chain and IL-2R gamma chain.

19 Their receptors are composed of a ligand-specific alpha subunit and a shared common signal

20 ence of tumor phenotype may be attributed to ligand-specific alterations in Notch receptor responses

21 e to the active receptor conformation and 2) ligand-specific alterations in signaling, which probably

22 5d-PGJ2 regulated IL-8 gene expression via a ligand-specific and PPARgamma-dependent pathway.

23 ere, we have analyzed a complementary set of ligand-specific and tissue-specific mouse mutants to sho

24 Ucn 1, opening new avenues for the design of ligand-specific antagonists based on CRF-BP.

25 eno-associated viral vectors (AAVs) encoding ligand-specific antagonists into the tibialis anterior (

26 mologous synthetic oligopeptides function as ligand-specific antagonists of macromolecular traffickin

27 receptor alpha in cells, they functioned as ligand-specific antagonists, indicating that estradiol-a

28 In addition, by using a ligand-specific antibody, we have shown that the peptide

29 om a filamentous virus, M13, combined with a ligand-specific antibody.

30 We proposed a new ligand-specific approach devoted to the binding site pre

31 likely to permit both receptor-specific and ligand-specific assembly of a coactivator complex, and t

32 s and biochemical experiments to unravel the ligand-specific association of membrane proteins GPR124

33 odimers consisting of an alpha-subunit and a ligand-specific beta-subunit that confers their unique b

34 rmational change which allosterically alters ligand specific binding sites and changes ligand selecti

35 However, other ligand-specific binding determinants optimize CrmD for t

36 gand binding sites suggest that species- and ligand-specific binding may be determined by as few as t

37 ional patterns indicate strong selection for ligand-specific binding pockets.

38 nds for the same VEGF receptors can generate ligand-specific biological responses.

39 e for biotechnology and synthetic biology as ligand-specific biosensors enabling real-time monitoring

40 amers have been engineered into a variety of ligand-specific biosensors, termed aptasensors.

41 Interference with the Dll4 signal by ligand-specific blocking antibodies is sufficient to inh

42 trol complex transcriptional programmes in a ligand-specific, cell-type-specific and context-specific

43 Nevertheless, we observed ligand-specific changes in FRET.

44 We observed ligand-specific changes in the NMR spectra of (13)CH(3)-

45 ies of the enzyme-ligand complexes is due to ligand-specific changes in the spatial relationship betw

46 Ligand-specific co-receptor recruitment provides a mecha

47 These experiments identify Gpr124 as a ligand-specific coactivator of canonical Wnt signaling.

48 tern of gene expression via cooperation with ligand-specific cofactors such as MEK1-ERK1/2 or JNK1/2.

49 eveals that surface expression of WSX-1, the ligand-specific component of the IL-27R, is low on these

50 he first to show a possible mechanism of the ligand-specific conformation-dependent agonist activatio

51 Here we use NMR spectroscopy to investigate ligand-specific conformational changes around a central

52 n the transmembrane (TM) domain is occupied, ligand-specific conformational changes occur in the ECL2

53 fluorescence resonance energy transfer, how ligand-specific conformational changes of uOR translate

54 Here, we describe ligand-specific conformational changes that occur upon b

55 ing modes for different ligands resulting in ligand-specific conformational dynamics of the binding s

56 binding and provides functional evidence for ligand-specific conformational states.

57 eing used to characterize state-specific and ligand-specific conformational states.

58 In summary, our study correlates ACKR3 ligand-specific conformational transitions with chemokin

59 DynamicBind accurately recovers ligand-specific conformations from unbound protein struc

60 pled receptors is believed to originate from ligand-specific conformations that activate only subsets

61 her, these data indicate that DORs may adopt ligand-specific conformations whose distinct recycling p

62 , G(i)-, and G(q)-proteins, 2) that there is ligand-specific coupling of the beta(2)AR to G-proteins,

63 s, the spirocycle acrylamides preferentially liganded specific cysteines on diverse protein classes.

64 f agonists for binding domain accounts for a ligand-specific desensitization pattern.

65 t not by low-efficacy agonists, suggesting a ligand-specific desensitization pattern.

66 omalies" that may simply arise from receptor/ligand-specific differences between half-lives in soluti

67 No evidence for ligand-specific differences in receptor phosphorylation

68 ific transmembrane conformational changes or ligand-specific differences in the kinetics of transmemb

69 NA ORN versus imidazoquinoline translates to ligand-specific differential phosphorylation and transcr

70 Since V(T) is the sum of the ligand-specific distribution volume (V(S)) and the nondi

71 Since V(T) is the sum of the ligand-specific distribution volume (V(S)) and the nondi

72 ressed in a variegated manner, which creates ligand-specific diversity within the NK cell pool.

73 of two major TLRs, TLR2 and TLR4, and their ligand-specific dynamic regulation in the model human in

74 IL-5 had no ligand-specific effect on mIL-5Ralpha or sIL-5Ralpha mRN

75 This inference is supported by observed ligand-specific effects of mutations in this region and

76 MADs are sufficient for inducing most of the ligand-specific effects, and are the primary targets of

77 two residues where mutations had significant ligand-specific effects.

78 e cannabinoid receptor 1 (CB1R), we identify ligand-specific endocytic dwell times, that is, the time

79 rs, cell-type-specific endocytic regulation, ligand-specific endocytic regulation, and endosomal regu

80 m diffusion-limited binding indicates that a ligand-specific energy barrier between the unbound and b

81 n to exist in a GTP-bound state and act as a ligand specific ERalpha co-activator of E2-induced trans

82 elucidate the molecular mechanism underlying ligand-specific estrogen regulation of HOXA10 expression

83 human HOXA10 gene that mediated differential ligand-specific estrogen-responsive transcriptional acti

84 interaction with a target promoter revealed ligand-specific exchange rates.

85 ption of alpha-synuclein and risk of PD in a ligand-specific fashion and constitutes a potential targ

86 T(reg) and T(H)17 cell differentiation in a ligand-specific fashion, constituting a unique target fo

87 ere deficient in adhesion and migration in a ligand-specific fashion, with impaired responses to lami

88 mobilization of a DNA duplex modified with a ligand specific for a cell receptor.

89 nist U-75302, but not by chemerin peptide, a ligand specific for another RvE1 receptor ChemR23.

90 epitope previously described for Lewis X, a ligand specific for DC-SIGN among the C-type lectin fami

91 Combinations of troglitazone and a ligand specific for either retinoid X receptor or retino

92 ytes was desensitized by MMK-1, an agonistic ligand specific for formyl peptide receptor-like-1 (FPRL

93 A high-affinity ligand specific for mHTT aggregates could serve as a pos

94 scarinic receptor (M3), we used carbachol, a ligand specific for muscarinic receptor, as the secretag

95 Here we show that a ligand specific for NOD1, a peptide derived from peptido

96 n, we generated transgenic mice expressing a ligand specific for the CD28 receptor, which normally sh

97 l)-3-isoquinoline-carboxamide (PK11195) is a ligand specific for the peripheral benzodiazepine recept

98 e in rate was produced only with serine (the ligand specific for the substrate receptor trTsr); no si

99 hange in rate was produced by aspartate (the ligand specific for the tethering receptor Tar).

100 A ligand specific for the WW domain of Pin1 was covalently

101 ligand for both VEGFR-1 and -2) or VEGF-B (a ligand specific for VEGFR-1) led to activation of Erk-1/

102 ty is insensitive to the presence of various ligands specific for 5-HT receptor subtypes.

103 Simultaneous treatment with ligands specific for both PPARgamma and RXR has a synerg

104 The selectivity of ligands specific for certain cells can be used to prefer

105 Radiolabeled ligands specific for cholinesterases have potential for

106 ein-conducting channels of the ER, formed by ligands specific for co- and posttranslational transport

107 (RXR), and PPARgamma-RXR can be activated by ligands specific for either receptor; the presence of bo

108 s) can activate transcription in response to ligands specific for either subunit of the dimer.

109 of RXR-PPARgamma heterodimers to respond to ligands specific for either subunit.

110 ntegrin signaling, we examined the effect of ligands specific for integrin alpha IIb beta 3 on the fu

111 Small-molecule ligands specific for prostate-specific membrane antigen

112 or-posterior axis, whereas in zebrafish only ligands specific for RAR caused embryonic malformations.

113 dine binding to rat brain membranes, whereas ligands specific for serotonin type 3 receptors (5-HT(3)

114 lygalacturonic acid were functionalized with ligands specific for targeting expressed EphA2 receptors

115 and deep active site gorge and indicate that ligands specific for the acylation site at the base of t

116 led mono- (scFv) and bivalent (mAb) affinity ligands specific for the endothelial cell adhesion molec

117 muli including costimulation of T cells with ligands specific for the T-cell receptor (TCR)-CD3 compl

118 hey display receptors that are responsive to ligands specific for their environment.

119 consequences of activating these receptors, ligands specific for TLR2 or dectin-1 were microinjected

120 e received a single intravenous injection of ligands specific for TLR2, TLR3, TLR4, TLR5, TLR7, and T

121 fibroblasts (HIF) were exposed to bacterial ligands specific for Toll-like receptor (TLR)2/6 and 4,

122 work has shown that antigens adjuvanted with ligands specific for Toll-like receptor 4 (TLR4) and TLR

123 This ligand-specific force history effect resembled the effec

124 nthesis and provide preliminary evidence for ligand-specific gene activation by a nuclear receptor.

125 importance, these differences are linked to ligand-specific GHS-R1a conformations, as assessed by in

126 ucidate the dynamic features associated with ligand-specific GPCR conformations.

127 al consequences and a predicted mechanism of ligand-specific GPCR oligomerization.

128 transmembrane protein tyrosine kinase and a ligand-specific GPI-linked protein.

129 timulation is receptor-specific (ErbB-2) and ligand-specific (heregulin).

130 studies have permitted the determination of ligand-specific high-spin states which reveal similariti

131 The aspartate receptor is one of the ligand-specific, homodimeric chemoreceptors that detects

132 irus infection triggers NK receptor-induced, ligand-specific IL-12-dependent NK cell expansion, yet s

133 egies to provide IL-12 signaling in vivo for ligand-specific IL-2-primed NK cell-based therapies.

134 sed IL-27 receptor (IL-27R), composed of the ligand-specific IL-27Ralpha chain and gp130.

135 r cells, indicating the formation of KIR2DS2 ligand-specific immunological synapses.

136 oad mechanistic foundation for understanding ligand-specific induction of gene expression profiles.

137 Yet how it relays ligand-specific information across the cell membrane for

138 raphy based on diffusion MRI can incorporate ligand-specific information provided by (11)C-DTBZ PET i

139 construct into rat embryo cells demonstrated ligand specific inhibition of AP-1 transactivation.

140 One peptide, C3dp1 (APQHLSSQYSRT) exhibited ligand-specific inhibition at midmicromolar IC(50).

141 To develop ligand-specific inhibitors that would also assist in ide

142 t Ser2.60, plays a crucial role in mediating ligand specific interactions for CP55,940, HU210, and AM

143 ward Gq/11, underline the key role of TM3 in ligand-specific interactions and of calcium ion as a lig

144 or-ligand "anchor points" interspersed among ligand-specific interactions that "tune" the relative IF

145 tant component of receptor mobility and that ligand-specific interactions with remodeling complexes c

146 This suggests that ligand-specific intracellular receptor transport is requ

147 teract with diffusing ligands and to adopt a ligand-specific lid conformation, thus, slowing down dis

148 steines, and the pattern was consistent with ligand-specific "lid" conformations of ECL2.

149 The transmission of ligand-specific local and long range conformational even

150 A) knockdown of STING and MAVS resulted in a ligand-specific loss of IRF3 responsiveness.

151 ometry using either NKG2D tetramers or NKG2D ligand-specific mAb, H60 was identified as the NKG2D lig

152 pecially when these agents are conjugated to ligand-specific mAbs or peptides, which make the dynamic

153 ors (aTFs) that control gene expression in a ligand-specific manner and tested their ability to repre

154 receptor activation of the JNK cascade in a ligand-specific manner explaining several behavioral phe

155 extracellular nucleotides in a receptor- and ligand-specific manner, but the structural bases of thei

156 icate that a prokaryote, P. aeruginosa, in a ligand-specific manner, mobilizes eukaryotic NEU1 to enh

157 a cells and inhibit tumor cell adhesion in a ligand-specific manner.

158 on and intracellular signaling pathways in a ligand-specific manner.

159 mmodation of a non-native metal complex in a ligand-specific manner.

160 nment of the high-spin ferriheme in a highly ligand-specific manner.

161 nment of the high-spin ferriheme in a highly ligand-specific manner.

162 nment of the high-spin ferriheme in a highly ligand-specific manner.

163 s from the plasma membrane to endosomes in a ligand-specific manner.

164 ed state that permits faster activation in a ligand-specific manner.

165 xpression was regulated by LRP1 ligands in a ligand-specific manner.

166 ct ligands varies in a voltage-dependent and ligand-specific manner.

167 nd differentiate into memory-like cells in a ligand-specific manner.

168 mbrane affects their binding affinities in a ligand-specific manner.

169 epithelium and olfactory bulb in an odorant ligand-specific manner.

170 nucleic acid-sensing TLRs in a receptor- and ligand-specific manner.

171 itin-dependent control of pAKT dynamics in a ligand-specific manner.

172 ulate diverse signaling pathways, often in a ligand-specific manner.

173 ic G protein interactions in a receptor- and ligand-specific manner.

174 gh both G protein and arrestin pathways in a ligand-specific manner.

175 cells by the PRRs TLR3, MDA5, or RIG-I in a ligand-specific manner.

176 and BB affect expression of several miRs in ligand-specific manner; the most robust changes consisti

177 uman milk and helminth parasites may share a ligand-specific mechanism involved in the generation of

178 This ligand-specific mechanosensing is effected through an ac

179 The ligand-specific models built in this study can be used i

180 w chamber, and microkinetic studies reveal a ligand-specific modulation of L-selectin affinity by DRE

181 Ligand-specific molecular switches composed of RNA were

182 mbination of nonspecific surface effects and ligand-specific near-surface effects.

183 peptide ligands and is useful for analyzing ligand-specific negative selection of CD4 single positiv

184 IL-2 culture did not impair IL-12-dependent ligand-specific NK cell expansion.

185 ich NK cells use to create a diverse pool of ligand-specific NK cells.

186 erative signaling, is here shown to regulate ligand-specific Notch signaling.

187 Inhibition of DLL1/4 with ligand-specific Notch1 decoys increased sprouting of sin

188 1.5 to 6 h after Notch signal activation via ligand-specific or EGTA induction in cultured primary hu

189 A new ligand specific parameter alpha that allows for quantify

190 EFG, denoted W, were expressed by assigning ligand-specific parameters: W(X) to ligands X and W(N) t

191 stem could have been refined toward distinct ligand-specific pathways channeled through MAX2, the mos

192 By elucidating these ligand-specific pathways, this study advances our unders

193 s were developed through modular grafting of ligand-specific peptides into a highly compliant and fle

194 resentative selection of current and popular ligand-specific predictors, meta-predictors that combine

195 I) precursors and the lack of a general, non-ligand-specific protocol for their synthesis have hamper

196 activate beta-catenin signaling through the ligand-specific receptor complex GPR124-RECK and classic

197 Our findings support the concept of multiple ligand-specific receptor conformations and demonstrate t

198 This offers a model to specifically study ligand-specific receptor conformations leading to G prot

199 individual binding poses are associated with ligand-specific receptor conformations that were further

200 This phenomenon may result from ligand-specific receptor phosphorylation by GPCR kinases

201 Promoter deletion analysis suggests that ligand-specific receptor transactivation and utilization

202 : (i) an aptamer sequence, which serves as a ligand-specific receptor, and (ii) an aptamer-complement

203 en by an age-related shift in transport from ligand-specific receptor-mediated to non-specific caveol

204 Smad2 and Smad3 by heteromeric complexes of ligand-specific receptors.

205 Ligand-specific recruitment of arrestins facilitates fun

206 Thus, ligand-specific regulation is defined by interchangeable

207 The mechanism of ligand-specific regulation of HOX gene expression by est

208 ceptor, and they support the hypothesis that ligand-specific regulation of opioid receptors occurs in

209 earlier described with 5-HT and DA, there is ligand-specific requirement for protein kinase C (PKC) i

210 dulated by different ligands, thus eliciting ligand-specific responses ("biased agonism").

211 Ligand-specific responses were temporally regulated: we

212 nal studies, our structures suggest a unique ligand-specific role of residue H142 on the alpha4 subun

213 pressing human CXCR5 (CD8(hCXCR5)) exhibited ligand-specific signaling and chemotaxis in vitro Six in

214 GPCRs), however, the molecular mechanisms of ligand-specific signaling at KOR have remained unclear.

215 of microRNA-dependent targets in response to ligand-specific signaling in ECs.

216 -evolution has given rise to highly adapted, ligand-specific signaling pathways that control gene exp

217 ion and trigger the immune responses through ligand-specific signaling pathways.

218 les into a non-immune cell and reconstituted ligand-specific signalling when these cells are conjugat

219 Thus, regulation of miRNA biogenesis by ligand-specific SMAD proteins is critical for control of

220 h forms heteromeric complexes with different ligand-specific SMADs after activation.

221 lationships within this novel class of VMAT2 ligands, specific stereochemical forms of MTD, lobelane,

222 utions between 1.65 and 1.80 A reveal unique ligand-specific structural changes in the binding site t

223 only modulates the proportions of responding ligand-specific T cells or also alters responses at the

224 architecture of the evolving inflammation is ligand-specific; TLR4 ligands cause transmural panarteri

225 electing drugs with affinity for a molecular ligand specific to the disease state.

226 exchange activity was inhibited by a peptide ligand specific to the SH3 domain of the Src family tyro

227 We examined the effects of ligands specific to alpha-helix F (alphaHF) of plasminog

228 PAI-1 mechanism, and could be stabilized by ligands specific to alphaHF, controls bifurcation betwee

229 p 2 (ECL2) connecting TM4 and TM5 in binding ligands specific to different subfamilies; or even the d

230 values generated in the multiplex assay for ligands specific to each receptor were comparable to tho

231 e enhanced by administration of high-avidity ligands specific to receptors expressed on T cells.

232 tional and proteomic analyses identified six ligands specific to senEVs, highlighting their role in p

233 top of the channel and coated with adhesive ligands specific to target cell receptors.

234 The method is suitable for finding ligands specific toward proteins of unknown function and

235 The CD28 ligand-specific transgenic mice will facilitate evaluati

236 We propose that either ligand-specific transmembrane conformational changes or

237 overall trends in naming conventions, though ligand-specific trends were prominent.

238 of Smad proteins by heteromeric complexes of ligand-specific type I and II receptors.

239 of SMAD proteins by heteromeric complexes of ligand-specific type I and type II receptors with serine

240 regulated Smads, by heteromeric complexes of ligand-specific type I and type II serine/threonine kina

241 inating interaction patterns responsible for ligand-specific voltage sensitivity and present new insi

242 These conformational changes imparted a ligand-specific volume to the binding pocket, from 490 A

243 s altered by GR coexpression in a locus- and ligand-specific way.

244 ediated transcriptional responses are highly ligand-specific, with different ligands eliciting marked

245 on of canonical signaling in NIH3T3 cells is ligand-specific; Wnt11 could effectively repress canonic