ライフサイエンスコーパス: ligase

1 the cancer-specific MAGE-A11-HUWE1 ubiquitin ligase.

2 phospho-inactivates Nedd4-2, an ubiquitin E3 ligase.

3 us end-joining mechanism that utilizes a DNA ligase.

4 nding switches its activity toward SidE-type ligase.

5 F8 is a direct target of the APC/C ubiquitin ligase.

6 tion and validation of targets of the GID E3 ligase.

7 Parkin (PRKN), which encodes an E3 ubiquitin ligase.

8 DAb) fused to the UBOX domain of the CHIP E3 ligase.

9 determining the substrate specificity of the ligase.

10 itination and degradation of an E3 ubiquitin ligase.

11 the efficient assembly of an active ribozyme ligase.

12 components of an intracellular E3 ubiquitin ligase.

13 in and multicomponent RING-type E3 ubiquitin ligases.

14 tases, transferases, hydrolases, lyases, and ligases.

15 inding positions, scaffold-class) and the E3 ligases.

16 dification with ubiquitin, including ~600 E3 ligases.

17 termediate is a common first step of all DNA ligases.

18 ts of the SKP1-CUL1-F-box (SCF) E3 ubiquitin ligases.

19 ubstrate adaptors of CUL3-based E3 ubiquitin ligases.

20 of ubiquitination is conferred by ubiquitin ligases.

21 ied relative to the ~ 600 predicted human E3 ligases.

22 e of target-HECT domain E3 ubiquitin protein ligase 1 (HECTD1) expression, an increase of HSP90 ubiqu

23 e, we identify mindbomb E3 ubiquitin protein ligase 1 (MIB1) as a novel E3 ubiquitin ligase for WRN p

24 olymerase delta, flap endonuclease 1 and DNA ligase 1.

25 factor 2 (FGF2) and Ariadne RBR E3 ubiquitin ligase 2 (ARIH2).

26 Codepletion of POLD2 with either ligase 3 (LIG3) or ligase 4 (LIG4) does not further redu

27 tion of POLD2 with either ligase 3 (LIG3) or ligase 4 (LIG4) does not further reduce translocation fr

28 wo aldehyde dehydrogenases, a fatty-acid-CoA ligase, a fatty acid desaturase and associated oxidoredu

29 Recent work has shown that FBOX E3 ligases, a substrate recognition component of the ubiqui

30 tudies indicated that the ZSWIM8 Cullin-RING ligase accelerates degradation of numerous miRNAs in cel

31 ts illuminate a surprising plasticity of the ligase active site in its interactions with ATP and meta

32 a distinctive off-pathway distortion of the ligase active site.

33 ar mechanisms behind their dual protease and ligase activities are still poorly understood, limiting

34 dent of Parkin mitochondrial recruitment and ligase activity but requires an intact ubiquitin-like (U

35 ade of CD79A or CD79B ubiquitination or Cbls ligase activity is sufficient to impede BCR-mediated ant

36 -encoded LANA protein enhances the ubiquitin ligase activity of RLIM, leading to enhanced RLIM autoub

37 he SUMO-SIM interaction on ICP0 E3 ubiquitin ligase activity regarding PML II degradation.

38 ced kinase 1 (PINK1) activity, and Parkin E3 ligase activity toward CDGSH iron sulfur domain 1 (CISD1

39 RC1 from extracts and enhance PRC1 ubiquitin ligase activity towards histone H2A.

40 TRAF6 E3 ubiquitin ligase activity was required for the former but was disp

41 thus, regulate their substrate specificity, ligase activity, and subcellular localization.

42 Because of their dual protease and ligase activity, plant legumains have become of particul

43 its DNA-dependent ATP hydrolysis and SUMO E3 ligase activity.

44 show that AtLEGbeta exhibits a true peptide ligase activity.

45 ose that the PM-anchored Rsp5/Rcr1 ubiquitin ligase-adaptor complex can provide an acute response to

46 on source-dependent regulation of the GID E3 ligase, an important regulator of cellular metabolism du

47 ance between the actions of the E3 ubiquitin ligase anaphase-promoting complex or cyclosome (activate

48 MUL1 is a multifunctional E3 ubiquitin ligase anchored in the outer mitochondrial membrane with

49 In summary, UBR5 is a novel MYC ubiquitin ligase and an endogenous rheostat for MYC activity.

50 MMS21 encodes a SUMO E3 ligase and an essential component of the Smc5/6 complex,

51 complex/cyclosome (APC/C) is an E3 ubiquitin ligase and critical regulator of cell cycle progression.

52 by ubiquitination and deubiquitination by E3 ligase and DUB machinery positioned at the gate.

53 ar E2 enzyme that interacts with the RFA4 E3 ligase and forms UBC26-RFA4-receptor complexes in nuclea

54 egions of a "bait" protein with BioID biotin ligase and identify proximal proteins that are biotin ta

55 nas effector AvrPtoB acts as an E3 ubiquitin ligase and promotes bacterial virulence.

56 rsal pathway licensed by ZATTZNF451 SUMO2 E3 ligase and SUMOylation of TOP2.

57 ghts into the large family of MAGE ubiquitin ligases and identify approaches for developing cancer-sp

58 eened an RNAi library targeting ubiquitin E3 ligases and observed that knockdown of the E3 ligase Kel

59 , where they recruit CUL4 and MDM2 ubiquitin ligases and the proteasome.

60 E2 variants, including more than a dozen E3 ligases and their putative targets.

61 level, many MAGEs bind to E3 RING ubiquitin ligases and, thus, regulate their substrate specificity,

62 a alters the phosphorylation of TRIM2 (an E3 ligase) and optineurin (an autophagy receptor), which me

63 inding protein, deubiquitinase and ubiquitin ligase, and its versatile role in various signaling path

64 adaptor for cullin3-containing E3 ubiquitin ligases, and KLHL15 gene mutations were recently describ

65 fPP1 for egress: a HECT E3 protein-ubiquitin ligase; and GCalpha, a fusion protein composed of a guan

66 RING-finger E3 ligases are instrumental in the regulation of inflammato

67 ic roles of two closely related E3 ubiquitin ligases are required for netrin-1-dependent filopodial r

68 PARK2 gene encoding parkin, an E3 ubiquitin ligase, are associated with autosomal recessive early-on

69 , a putative adaptor of cullin3 E3 ubiquitin ligase, as a novel TRPM4-interacting protein.

70 ots and in immunoprecipitation and ubiquitin ligase assays.

71 Using PIKES, we show that ligase assemblies of Cullin4 with individual substrate r

72 ng the coordination between pol beta and DNA ligase at the final ligation step to maintain the BER ef

73 By fusing eCRs to the biotin ligase BASU, we established ChromID, a method for identi

74 binds to the WD40 domain of the E3 ubiquitin ligase beta-TrCP and blocks its interaction with phospho

75 We target the biotin-ligase BirA* to the AIS by generating fusion proteins of

76 ol the subcellular location of the H2Bub1 E3 ligase, Bre1.

77 Herein, we use a peptide ligase, butelase 1, to label the human transferrin recep

78 cific recruitment of the Rnf40-containing E3 ligase by Egr2, the central transcriptional regulator of

79 at E6AP/UBE3A is distinguished from other E3 ligases by having a 12 nM binding site at the proteasome

80 omal degradation of mTOR by the E3 ubiquitin ligase c-Cbl.

81 nism by which the mitochondria, through MUL1 ligase, can inhibit the CRL2(VHL) complex leading to hig

82 RING-type E3 ligases catalyze both reactions in collaboration with sp

83 , MS39 (compound 6), and a first-in-class E3 ligase cereblon-recruiting EGFR degrader, MS154 (compoun

84 The ubiquitin ligase CHIP (C terminus of HSC70-interacting protein) pr

85 mpetitive binding to A3G or the E3 ubiquitin ligase complex as the sole mechanism.

86 ch-like 3-Cullin 3 (KLHL3-CUL3) E3 ubiquitin ligase complex have shed light on the importance of WNK'

87 CRL2(VHL) ligase complex regulates HIF-1alpha protein levels under

88 In yeast, the Asi1/Asi2/Asi3 ubiquitin ligase complex safeguards the INM proteome through the c

89 gering its association with the E3 ubiquitin ligase complex SCF(MAX2) and downstream targets SUPPRESS

90 ents and two F-box adaptors of a cullin-RING ligase complex that promotes thermotolerance as part of

91 6, that together co-opt a cellular ubiquitin ligase complex to overcome host defences and promote vir

92 quired for formation of the NPR1-Cullin 3 E3 ligase complex to ubiquitinate SINC-localized substrates

93 er element of the E3 cullin 4-RING ubiquitin ligase complex, and a binding target of immunomodulatory

94 ncodes Cullin 3 (CUL3), a component of an E3 ligase complex, are thought of as risk factors for ASD a

95 cofactor binding and stabilization of the E3 ligase complex, such as the zinc-binding motif and N- an

96 feedback loop via the COP1/SPA E3 ubiquitin ligase complex, suggesting a mechanism that maintains lo

97 ndria and operates upstream of the CRL2(VHL) ligase complex.

98 1), an adaptor for CUL3 (CULLIN3) ubiquitin ligase complex.

99 at FBXL16 might not form a functional SCF-E3 ligase complex.

100 ylase (PHD, alias EGLN), and an E3 ubiquitin ligase component for HIF destruction called von Hippel-L

101 h genetic analysis to define the cullin-RING ligase components that act together with CUL-6 to promot

102 or together with other cullin-ring ubiquitin ligase components, which comprise a greatly expanded gen

103 r cyclosome (APC/C), is a large E3 ubiquitin ligase composed of 14 subunits.

104 st (POI) and another to an E3 ubiquitin (E3) ligase, connected via a linker.

105 ulated post-translationally by the ubiquitin ligase COP1 (also called RFWD2).

106 We identified a cullin-RING ubiquitin ligase (CRL), containing the substrate adaptor ZSWIM8, t

107 Co-opting Cullin4 RING ubiquitin ligases (CRL4s) to inducibly degrade pathogenic proteins

108 rome c is targeted for degradation by the E3 ligase CUL9 in neurons.

109 fied interaction partner is the E3 ubiquitin ligase cullin 3, which was revealed to regulate CD22 sur

110 Here, we report that the E3 ubiquitin ligase Cullin 5/RBX2 (CRL5) controls the stability of AR

111 terest in developing strategies to target E3 ligases, de-ubiquitinases, and/or ubiquitin receptors wi

112 We then determined crystal structures of ligase-defective NgrRnl-Ala mutants in complexes with AT

113 , associates with dystrophin and inhibits E3-ligase-dependent polyubiquitination at Lys 3584 (referre

114 ified a P3-inducible U-box type E3 ubiquitin ligase, designated as P3-inducible protein 1 (P3IP1), wh

115 usly identified substrates of the redirected ligase do not explain these phenotypes.

116 ted missense mutations in the RING ubiquitin ligase domain and a subset of mutations in the extracell

117 However, unlike SidE ubiquitin ligases, DupA displays increased affinity to PR-ubiquiti

118 This unveiled regulatory targets of the GID ligase during a metabolic switch.

119 eleterious variants in the Ubiquitin protein ligase E3 component N-recognin 5 (UBR5) gene.

120 Ubiquitin ligases (E3s) embedded in the endoplasmic reticulum (ER)

121 trate ubiquitination together with ubiquitin ligases (E3s), many E2s can also autoubiquitinate, there

122 of the tool and compare it to other peptide ligase enzymes.

123 ognition and degradation by the E3 ubiquitin ligase FBW7 in a manner independent of a canonical degro

124 In this study, we show that the E3 ubiquitin ligase Fbw7 is required for the maintenance of mature B

125 Ubiquitin ligase FBXO32 specifically inhibits epidermal renewal wi

126 nd that loss of the Elf5-regulated ubiquitin ligase FBXW7 ensures stabilization of its putative prote

127 n this study, we assessed the role of the E3 ligase FBXW7 in mature B-cell neoplasms.

128 its reduced degradation by the E3 ubiquitin ligase FBXW7.

129 nce of the well-described and functional MYC ligase, FBXW7, UBR5 depletion leads to accumulation of M

130 ich targets Bcl-xl to the cereblon (CRBN) E3 ligase for degradation.

131 20 (APC/C(CDC20)) form the main ubiquitin E3 ligase for these two proteins.

132 be the identification of SCF-Fbxl8 as the E3 ligase for Thr-283 phosphorylated cyclin D3.

133 nd transfers it to the SCF-TrCP E3-ubiquitin ligase for ubiquitination and destruction.

134 tein ligase 1 (MIB1) as a novel E3 ubiquitin ligase for WRN protein.

135 mploy protein ubiquitylation by ubiquitin E3 ligases for functional regulation or protein quality con

136 n (Ub) proteasome system, specifically E3 Ub ligases, for perception and initiation of signaling tran

137 within a disordered region contributes to E3 ligase function.

138 revised allosteric mechanism for how CUL-E3 ligases function.

139 Parkin is an E3 ubiquitin ligase, functioning in mitophagy.

140 We determine that the Siah2 E3 ubiquitin ligase functions in a coincidence detection circuit link

141 ated the promoters of 4-coumarate:coenzyme A ligase genes (Os4CL3 and Os4CL5) resulting in accumulati

142 tination and three antagonistic E3 ubiquitin ligases: Grr1 and Ptr1 maintained basal Sir2 levels in t

143 alyses revealed that DupA and SidE ubiquitin ligases harbor a highly homologous catalytic phosphodies

144 for in vitro applications, these polypeptide ligases have not been utilized for the semisynthesis of

145 tracts and identify this as the E3 ubiquitin ligase, HECTD1.

146 ed for resistance to tunicamycin, whereas E3 ligase Hel2-mediated ubiquitination of uS10 was not.

147 ), which is composed of the two E3 ubiquitin ligases HOIP and HOIL-1L and the adaptor protein SHARPIN

148 host BTB-BACK domain-containing ubiquitin E3 ligase homologue, leading to its rapid turnover.

149 ) controls the stability of the E3 ubiquitin ligase Hrd1 (hydroxymethylglutaryl reductase degradation

150 mes, the ER-associated degradation ubiquitin ligase Hrd1 and zinc metalloprotease Ste24, promote degr

151 revious studies have shown a role for the E3 ligase HUWE1 in modulating c-MYC, an oncogene frequently

152 y, we report that depletion of the ubiquitin ligase HUWE1, or the histone acetyltransferase KAT5, top

153 mplate base and the N-terminal domain of DNA ligase I mediates its interaction with pol beta.

154 Previously, we identified E3 ubiquitin ligase IDOL as a negative regulator of brain lipoprotein

155 SV proteostasis and that Parkin is a key E3 ligase in the autophagy-mediated clearance of SV protein

156 AUXIN RESISTANT1 (AXR1) functions as the E1-ligase in the rubylation pathway.

157 the efficiency of various promiscuous biotin ligases in comparison with one-step affinity purificatio

158 Among the several RING-domain E3 ligases in humans, many utilize two distinct E2s for pol

159 etion of the N-end rule pathway ubiquitin E3 ligases in NatB mutants did not restore NAD(+) levels.

160 , full-length LGR5 interacting with these E3 ligases in whole cells has not been reported, and only L

161 by the coordination of multiple E3 ubiquitin ligases, including Rsp5, the Dsc complex, and a newly ch

162 protein signaling protein 2 (RGS2) by its E3 ligase, increasing the potential for rational design of

163 The sterol-responsive E3 ubiquitin ligase inducible degrader of the LDLR (IDOL) specificall

164 Blocking ubiquitination of Smo by an E1 ligase inhibitor or by mutating two lysine residues in i

165 The E3 ligase inhibitor RTA405 enhanced SMAD3-regulated gene ex

166 At least in yeast, the UBR1/UFD4 ubiquitin ligase interacts with the 26S proteasome, suggesting an

167 We identified UBR4 and UBR5 as ubiquitin E3 ligases involved in HC ER-associated degradation.

168 factor SALL4 by the CRL4(CRBN) E3 ubiquitin ligase is a plausible major driver of thalidomide terato

169 A KRAS-specific DARPin fused to the VHL E3 ligase is compared to a pan-RAS intracellular single dom

170 has shown that the activity of many acid:CoA ligases is posttranslationally controlled by acylation o

171 of E3 Skp1/Cullin-1/F-box protein ubiquitin ligases, is modified by a prolyl hydroxylase that mediat

172 is study, we found that deficiency of the E3 ligase Itch, which leads to spontaneous colitis and rect

173 on, which is regulated by itchy E3 ubiquitin ligase (ITCH), a negative regulator of inflammation.

174 essential prerequisite for ligation by XRCC4:Ligase IV (X4L4).

175 s not enhance ligation by pre-adenylated DNA ligase IV, indicating that this co-factor is not utilize

176 ound HF-NHEJ to be strictly dependent on DNA Ligase IV, XRCC4 and XLF, members of the canonical branc

177 igases and observed that knockdown of the E3 ligase Kelch-like protein 42 (KLHL42) impairs TGF-beta-d

178 ractions that, in the context of a ubiquitin ligase, lead to protein degradation(1).

179 e double minute (MDM2), the p53 E3 ubiquitin ligase, leading to accelerated MDM2 degradation.

180 n Hippel-Lindau (VHL) and cereblon (CRBN) E3 ligase ligands and a variety of linkers, which resulted

181 enome contains an estimated 600 ubiquitin E3 ligases, many of which are single-subunit E3s (ssE3s) th

182 Upstream of USP30, the E3 ligase March5 ubiquitinates mitochondrial proteins whose

183 ular gene expression.IMPORTANCE E3 ubiquitin ligases mark their substrates for degradation and theref

184 nfected skin, kallikrein 6 and the ubiquitin ligase MDM2 are upregulated concomitant with keratin 10

185 l regulatory mechanism: another E3 ubiquitin ligase Mdm2 directly binds parkin and enhances its enzym

186 rane-associated ring CH (MARCH) E3 ubiquitin ligase-mediated ubiquitination and downregulation of cel

187 uggest a model in which the ZSWIM8 ubiquitin ligase mediates TDMD by directing proteasomal decay of m

188 Avadomide, a CRL4CRBN E3 ubiquitin ligase modulator, demonstrated clinical activity in rela

189 chromatin response, we tested the ubiquitin ligase mutant uls1Delta, which selectively impairs local

190 we further discovered that the E3 ubiquitin ligase Nedd4 is required for developmental myelination t

191 iates interaction with the E3 ubiquitin (Ub) ligase Nedd4-2.

192 Here, we show that the HECT-domain E3 ligases NEDD4 and NEDD4L are expressed in the crypt stem

193 , chaperoned by Cdc37/Hsp90, recruits the E3 ligase, NEDD4, to catalyze polyubiquitination of pro-IL-

194 USP7 deubiquitinates the E3 ubiquitin ligase NEDD4L, which mediates the degradation of SMAD2.

195 RNF43, an E3 ubiquitin ligase, negatively regulates Wnt signalling by inducing

196 Naegleria gruberi RNA ligase (NgrRnl) exemplifies the Rnl5 family of adenosine

197 ected cell protein 0 (ICP0), an E3 ubiquitin ligase of herpes simplex virus 1 (HSV-1), can derepress

198 a (c-Cbl) is a recently identified ubiquitin ligase of nuclear beta-catenin and a suppressor of color

199 Our screen identifies UBR5, an E3 ligase of the HECT-type family, as a novel regulator of

200 wo fluorescently labeled DNA with the T4 DNA ligase on the single-molecule level.

201 labeling techniques use a promiscuous biotin ligase or a peroxidase fused to a protein of interest, e

202 al activity and suggest that an E3 ubiquitin ligase other than FBXO25 regulates ELK-1 ubiquitination

203 e demonstrate that tumor-derived UBR5, an E3 ligase overexpressed in human OC associated with poor pr

204 The recently discovered peptide asparaginyl ligases (PALs) from cyclotide-producing plants are effic

205 maged mitochondria involves the E3 ubiquitin ligase Parkin and PTEN-induced kinase 1 (PINK1), which c

206 ss-of-function mutations in the E3 ubiquitin ligase parkin have been implicated in the death of dopam

207 The E3 ubiquitin ligase Parkin promotes the degradation of damaged mitoch

208 Parkinson's disease-associated E3 ubiquitin ligase Parkin.

209 In concert with these E3 ligases, PDIA3 was shown to cleave ubiquitinated HC mole

210 Here, we identified the E3 ubiquitin ligase Peli1 as an important regulator of T cell metabol

211 he Dsc complex, and a newly characterized E3 ligase, Pib1.

212 ay technology, we identified an E3 ubiquitin ligase PIRE (PBL13 interacting RING domain E3 ligase) th

213 or function, tripartite motif 21 (TRIM21) E3 ligase plays an essential role in the p62-Keap1-Nrf2 axi

214 ctural analysis it was proposed that RING E3 ligases prime the E2~ubiquitin conjugate (E2~Ub) for cat

215 Here, PJA1, an E3 ligase, promoted ubiquitination and degradation of phosp

216 E3 ligases provide a novel point of intervention for therap

217 E3 ligase recruiters remain central to this process yet rel

218 ex, composed of the PROTAC, the POIs, and E3-ligases related proteins (E3Ps).

219 er activity than previously described biotin ligase-related proximity labeling methods, such as BioID

220 out the organization and regulation of these ligases remains elusive.

221 Numbering more than 600 members, these ligases represent the most selective way to intervene wi

222 Cullin-RING complexes, the largest family of ligases, require multi-unit assembly around one of seven

223 that inhibits alanine racemase and d-alanine ligase required for d-alanine incorporation into cell wa

224 ARIH2 encodes TRIAD1, an E3 ubiquitin ligase required for termination of emergency granulopoie

225 ociated RING-CH 8 (MARCH8), the E3 ubiquitin ligase responsible for MHC II ubiquitination specificall

226 In yeast, the main ubiquitin ligase responsible for the sorting of proteins to the ly

227 only a very small fraction of the assembled ligases retain catalytic activity due to the presence of

228 ) mapped onto a full structural model of the ligase revealed long-range allostery extending from the

229 Here, we identify the E3 ligase RFWD3 as an essential modulator of stalled fork s

230 noncanonical TRIM that lacks an E3 ubiquitin ligase RING domain, is a critical negative regulator of

231 The Arabidopsis E3 ubiquitin ligases RING-H2 FINGER A3A (RHA3A) and RHA3B mediate the

232 that eas-1 inhibits a conserved E3 ubiquitin ligase rnf-145/RNF145, which, in turn, promotes nuclear

233 membrane complex consisting of the ubiquitin ligase RNF185, the ubiquitin-like domain containing prot

234 ing key melanoma oncoproteins, the ubiquitin ligase RNF4 promotes tumorigenesis and confers resistanc

235 ct combining the RING domain of ubiquitin E3 ligase RNF4 with a protein-specific camelid nanobody med

236 at this process is regulated by E3 ubiquitin ligase RNF41 and define a new ubiquitin-mediated mechani

237 : forming RSPO-bridged complexes with the E3 ligases RNF43 and ZNRF3 to inhibit ubiquitylation of Wnt

238 s homologs Lgr4/6 and stem-cell-expressed E3 ligases Rnf43/Znrf3, is expressed in nodose-petrosal and

239 lisome components that bind to the ubiquitin ligase SCF(Dia2).

240 ic peptidase 7) opposes the activities of E3 ligases, stabilizes DNA-bound NF-kB, and thereby promote

241 DNA damage sites by SUMO-targeted ubiquitin ligase (STUbL) activity.

242 ubiquitin-like protein SUMO and the SUMO E3 ligase Su(var)2-10 are required for piRNA-guided deposit

243 ination by a member of the largest ubiquitin ligase subtype and reveal how a defined architecture wit

244 arboxylic acid cycle (TCA) gene succinyl-CoA ligase subunit-beta (SUCLA2), causing global protein hyp

245 osteric, reversible PTP inhibitor with an E3 ligase targeting ligand through a well-designed linker,

246 mic network of redox-responsive E3 ubiquitin ligases targeting fungal sirtuin 2 (Sir2), an antioxidat

247 vation is driven through the LSD, a known E3 ligase-targeting domain, in MCC.

248 omplex is an essential cullin-RING ubiquitin ligase that connects metabolic and heavy metal stress to

249 AS) 1, a small ubiquitin-related modifier E3 ligase that facilitates C/EBPbeta degradation.

250 Here we identify COP1 as the ubiquitin E3 ligase that is essential for LT-induced c-Jun degradatio

251 RNF12/RLIM, a key developmental E3 ubiquitin ligase that is mutated in an intellectual disability syn

252 f TRAIP, a replisome-associated E3 ubiquitin ligase that is mutated in microcephalic primordial dwarf

253 RLIM is an E3 ubiquitin ligase that leads to the ubiquitination and degradation

254 In contrast, Iso2 was a potent ligase that reduced levels of the mutant form of p53 in

255 However, the E3 ligase that regulates phosphorylated cyclin D3 and wheth

256 RNF128 is an E3 ubiquitin ligase that targets p53 for degradation.

257 Von Hippel-Lindau (VHL) is an E3 ubiquitin ligase that targets proteins, including HIF-1alpha, for

258 llisions are detected by ZNF598, a ubiquitin ligase that ubiquitinates sites on the ribosomal 40S sub

259 CF-FBXL17, a dimerization-quality-control E3 ligase that ubiquitylates and helps to degrade inactive

260 TurboID is an engineered biotin ligase that uses ATP to convert biotin into biotin-AMP,

261 eveloped have utilized ligands to recruit E3 ligases that are ubiquitously expressed in both tumor an

262 RNA helicases and tripartite motif (TRIM) E3 ligases that lead to their functional coordination in ve

263 teraction partners, including a number of E3 ligases that modulate DHCR14 levels.

264 triphosphate (ATP)-dependent polynucleotide ligases that seal 3'-OH RNA strands in the context of 3'

265 igase PIRE (PBL13 interacting RING domain E3 ligase) that interacts with both PBL13 and RBOHD.

266 in (FANCD2) by the multisubunit ubiquitin E3 ligase, the FA core complex, is an obligate step in acti

267 nteract with their cognate TRIM/TRIM-like E3 ligases through similar epitopes in the helicase domains

268 PROTACs recruit the E3 ligase to the POI and cause proximity-induced ubiquitina

269 me scaffold most related to contemporary CoA ligases toward more specialized functions including beta

270 ng to the release of the essential ubiquitin ligase TRAF6 from the complex.

271 The E3 ubiquitin ligase TRIM21 plays a crucial role as a negative regulat

272 y the cytosolic Fc receptor and E3 ubiquitin ligase TRIM21.

273 ction, the strongest hits were the ubiquitin ligase TRIM32 and two retroelement-derived proteins, PEG

274 pends on levels of the centrosomal ubiquitin ligase TRIM37.

275 hich releases the PFK-targeting E3 ubiquitin ligase tripartite motif (TRIM)-containing protein 21 (TR

276 UMO (Small Ubiquitin-like Modifier) and SUMO ligase Ubc9 are required for efficient repression of int

277 The ubiquitin ligase, Ube3a, plays important roles in brain developmen

278 complex cooperates with cytosolic ubiquitin ligase UBE3C and p97 ATPase in degrading their membrane

279 Here, we show that the ubiquitin ligase ubiquitin-like PHD and RING finger domain-contain

280 inyltransferase, and the double-E3 ubiquitin ligase UBR1-RAD6/UFD4-UBC4/5 are shown to form an analog

281 ivity of the E7-associated host E3 ubiquitin ligase UBR4.

282 rgets it for degradation using the ubiquitin ligase UBR4.

283 Here, we show how ubiquitin ligase UBR5 functions as a molecular rheostat to prevent

284 The Cullin 5 (CUL5) Ring E3 ligase uses adaptors Elongins B and C (ELOB/C) to bind d

285 previously identified a novel cullin-RING E3 ligase utilizing F-box only protein 44 (FBXO44) as the s

286 Here we show that the E3 ligase VHL interacts with Daam2 and their mutual antagon

287 re, we described the discovery of a novel E3 ligase von Hippel-Lindau-recruiting EGFR degrader, MS39

288 Parkin is an E3 ubiquitin ligase well-known for facilitating clearance of damaged

289 7 directly interacts with TRAF6 E3 ubiquitin ligase, which catalyzes K63 polyubiquitination for NF-ka

290 induces phosphorylation of XIAP E3 ubiquitin ligase, which enhances ubiquitination and proteasomal de

291 Our study also identified an E3 ubiquitin ligase, which targets the RdDM compotent NRPD1 for UPS-m

292 ole is Rsp5, a member of the Nedd4 family of ligases whose distinguishing features are a catalytic ho

293 derstanding crosstalk and competition for E3 ligases will be key in ultimately developing a global pi

294 RNF4 is a ssE3 ligase with a C-terminal RING domain and disordered N-te

295 characterized RNA-binding RING E3-ubiquitin ligase with functions in embryonic development.

296 HACE1 is an E3 ubiquitin ligase with important roles in tumor biology and tissue

297 TRIM32 is an E3 ubiquitin ligase with innate antiviral activity.

298 whereas LGR5 did not interact with either E3 ligase with or without RSPO.

299 The UBE3A gene encodes an E3 ubiquitin ligase with three known protein isoforms in humans.

300 show that the NEDD4 family HECT E3 ubiquitin ligase WWP2 and a tumor-suppressing transmembrane protei

301 TPRK acts via the transmembrane E3 ubiquitin ligase ZNRF3, a negative regulator of Wnt signaling prom