ライフサイエンスコーパス: light sensitivity

1 seven-TM protein structure for retinal-based light sensitivity.

2 in bipolar cells dynamically control retinal light sensitivity.

3 rements in TOC1 gene dosage clearly enhanced light sensitivity.

4 s to produce similar shifts in ganglion cell light sensitivity.

5 100-fold shift in the threshold for far-red light sensitivity.

6 ith performance on a clinical test measuring light sensitivity.

7 iral titers were more effective at restoring light sensitivity.

8 ular surface pain who reported no or minimal light sensitivity.

9 ics but did cause a significant reduction in light sensitivity.

10 f G-protein-coupled receptors with ambiguous light sensitivity.

11 orted symptoms and association with measured light sensitivity.

12 we designed high-photocurrent ChRs with high light sensitivity.

13 sulting in plants with dramatically enhanced light sensitivity.

14 nd demonstrate that its truncation causes UV light sensitivity.

15 photoreceptors with outer-segment discs and light sensitivity.

16 50-fold, resulting in a >10-fold decrease in light sensitivity.

17 ow on- and off-latencies, and relatively low light sensitivity.

18 sulting in plants with dramatically enhanced light sensitivity.

19 ponse to light, positive masking, has normal light sensitivity.

20 t the expense of a moderate reduction in rod light-sensitivity.

21 tions 10-fold higher than required to impart light-sensitivity.

22 er time than players without these symptoms: light sensitivity (16.0 vs 3.0 days, P = .001), emotiona

23 oral patterns explained the most variance in light sensitivity (48%) and the least variance in vomiti

24 es favorable for optogenetics including high light sensitivity, a broad, red-shifted activation spect

25 ent demonstrated in navigational ability and light sensitivity among 3 groups of subjects with RPE65

26 rminus plays an important role in modulating light sensitivity and activity of the protein.

27 phosphodiesterase (LAPD) with complementary light sensitivity and catalytic activity by recombining

28 Many of the humans demonstrated increases in light sensitivity and in visual acuity.

29 (a proxy for cell size) and IR, and between light sensitivity and IR, with larger and more sensitive

30 The light sensitivity and kinetics of component 1 suggested

31 nd higher input resistance, yet showed lower light sensitivity and lower maximal light responses than

32 this study is responsible for increasing the light sensitivity and operational range of rod bipolar c

33 Here we report a mechanism that controls the light sensitivity and operational range of rod-driven bi

34 congenital amaurosis (LCA) in which retinal light sensitivity and optomotor responses are partially

35 hodopsin actuator, CheRiff, which shows high light sensitivity and rapid kinetics and is spectrally o

36 ide-mediated photocurrents that maintain the light sensitivity and reversible, step-like kinetic stab

37 lar specialization and show an extremely low light sensitivity and sluggish kinetics.

38 mediated by viral gene therapy, can restore light sensitivity and some vision to mice blind from out

39 ogenetic inhibition tools with unprecedented light sensitivity and temporal precision.

40 Light sensitivity and the involvement of unstable protei

41 h the appropriate illumination, AAQ restores light sensitivity and visual behavior.

42 the electroretinogram was normal in terms of light sensitivity and waveform, but the light threshold

43 t ocular discomfort (focusing on burning and light sensitivity) and consider querying about depressio

44 se variants have altered spectral responses, light sensitivity, and channel selectivity.

45 n vision), in 99% for ocular symptoms (pain, light sensitivity, and discomfort), and in 95% for dryne

46 s also resulted in leaf chlorosis, increased light sensitivity, and dwarfism due to decreased levels

47 Abundance, light sensitivity, and genetic requirement indicate that

48 ates under high light intensities, increased light sensitivity, and lower PSII efficiency, without af

49 hereas patients with symptoms of irritation, light sensitivity, and pain revealed a specific increase

50 utant shows: (i) slower growth rates, higher light sensitivity, and reduced amounts of PS I; (ii) a r

51 s to use existing neuronal tissue to restore light sensitivity, and to augment existing strategies to

52 Improvements in ambulatory navigation, light sensitivity, and VF were consistent in both interv

53 Interestingly, light sensitivity appeared to correlate with the concent

54 n, with ChR2-EYFP and Arch-ER2 demonstrating light sensitivity approaching that of in utero or virall

55 These light sensitivities are virtually identical to those of

56 eneral increase in IC, pain, irritation, and light sensitivity are associated with increased IC in th

57 Animals with enhanced dim-light sensitivity are at higher risk of light-induced re

58 -year-old child had nearly the same level of light sensitivity as that in age-matched normal-sighted

59 Pld(null) flies exhibit decreased light sensitivity as well as a heightened susceptibility

60 Furthermore, the light sensitivity associated with levels of the TIM prot

61 The differential light sensitivities at the 10 most sensitive locations f

62 e than a 2 log(10)(cd.s/m(2)) improvement in light sensitivity at 1 year and subsequent available fol

63 ted chronic ocular surface pain symptoms and light sensitivity at least most of the time over 1 week.

64 on of retinal dopamine in goldfish increases light sensitivity at photopic backgrounds.

65 nstructed a hypothesis for the regulation of light sensitivity at the level of rod synapse.

66 t topical products induce severe irritation, light-sensitivity, burning, scaling, and inflammation.

67 slowing of visual processing would increase light sensitivity but should also reduce movement respon

68 The SVFA generally underestimated light sensitivity, but its results were more similar to

69 g DHA dietary restriction documented reduced light sensitivity by DHA-deprived retinas.

70 re is an adaptation increasing photoreceptor light sensitivity by facilitating the diffusion of the s

71 emotely administered survey, measurements of light sensitivity by light dosimetry and by text message

72 synaptic lateral inhibition to ganglion cell light sensitivity by measuring the effects of surround i

73 ow-luminance visual acuity (P = 0.0151), and light sensitivity (central 3 degrees and 9 degrees ; P =

74 led theoretical ChR2 variants with augmented light sensitivity (ChR2+), red-shifted spectral sensitiv

75 nical visual assessment, were used to assess light sensitivity, contrast sensitivity and spatial acui

76 hotosensitive activity of OVB-organoids, and light sensitivities could be reset after transient photo

77 atically, accounting for a major part of the light-sensitivity difference between rods and cones in d

78 roperties do not contribute to the intrinsic light sensitivity differences between rods and cones.

79 The unit of differential light sensitivity (DLS) in perimetry is the decibel.

80 Differential light sensitivity (DLS) in white-on-white perimetry is u

81 r evidence that the mutation mainly enhances light sensitivity downstream of phytochrome A (phyA) and

82 t RP patients demonstrated possible improved light sensitivity during the initial months of follow-up

83 rhodopsins (ChRs) whose current strength and light sensitivity enable minimally invasive neuronal cir

84 of these findings varied with the degree of light sensitivity except that lower overall light sensit

85 The acceptable light sensitivity, favorable spectral sensitivity, and s

86 account for the persistence of the increased light sensitivity following retinal dopamine depletion.

87 ready published by Medeiros et al. combining light sensitivities from SAP and retinal thickness from

88 lls when photoreceptors have degenerated and light sensitivity has been irreversibly lost.

89 ings suggest that evolution of stomatal blue-light sensitivity helped modern ferns exploit the shady

90 n improve azobenzene performance in terms of light sensitivity (higher molar extinction coefficient),

91 Due to its high operational light sensitivity, iChloC makes it possible to inhibit n

92 Enabling near-infrared light sensitivity in a blind human retina may supplement

93 The general hypothesis of increased light sensitivity in bipolar patients was not supported.

94 tructures are molecularly designed to induce light sensitivity in excitable cells without gene modifi

95 We also show that restoration of light sensitivity in rd10 rods is attributable to assemb

96 s of constitutive skin color and ultraviolet light sensitivity in relation to risk of cutaneous malig

97 prolonged dark adaptation leads to increased light sensitivity in rods by dissociating RGS9-1 from R9

98 ed expression of a ChR2 variant with greater light sensitivity in SGNs reduced the amount of light re

99 ll responses in these animals have a reduced light sensitivity in the dark-adapted state.

100 improvements in mean mobility and full-field light sensitivity in the injected eye by day 30 that per

101 low luminance deficit, contrast sensitivity, light sensitivity in the macula, and rod-mediated dark a

102 light entrainment and seasonal variations in light sensitivity in the mammalian circadian clock are i

103 Relative to HFA, the tablet overestimated light sensitivity in the nasal field while underestimati

104 hotoreceptors, is widely assumed to regulate light sensitivity in the rod outer segment through inter

105 s of opsins evolved a seven-TM structure and light sensitivity independently.

106 conceptual design strategies for installing light sensitivities into the immune signaling network an

107 Engineering light-sensitivity into proteins has wide ranging applica

108 We show that decreased light sensitivity is due to increased inhibitory input a

109 The origin of such light sensitivity is not understood and a key question i

110 Light sensitivity is restored to the resulting apo-opsin

111 Light sensitivity is restored when apo-opsin combines wi

112 RH1 and RH2 visual pigments with the optimum light sensitivities (lambdamax) at 478 nm and 485 nm, re

113 maintain physiological rhythmicity; (3) weak light sensitivity leads to the reduction of circadian fl

114 y, the data indicate that sex differences in light sensitivity might play a key role for ensuring the

115 rate that zTrpa1b/ligand pairing offers high light sensitivity, millisecond-scale response latency in

116 ted Arabidopsis plants with greatly enhanced light sensitivity, mutants variably altered in Pfr-to-Pr

117 Continued light sensitivity necessitates the regeneration of 11-ci

118 as having achromatopsia presented with mild light sensitivity, nonspecific otitis media, and mild de

119 We found that the light sensitivities of presynaptic, inhibitory pathways

120 protoporphyrin IX dramatically increased the light sensitivity of both TRPA1 and TRPV1 via generation

121 The light sensitivity of cone ERGs of BALB/c mice, which had

122 esent study also highlights the differential light sensitivity of cry1 and cry2 in controlling hypoco

123 n is explained by natural alleles that alter light sensitivity of GI, specifically in the evening, an

124 t pulses and for orders-of-magnitude-greater light sensitivity of inhibited cells.

125 nnels expressed by ipRGCs, which reduces the light sensitivity of M2-M6 ipRGCs in the neonatal retina

126 reased the rate of maintained firing and the light sensitivity of ON ganglion cells.

127 The physiological function and light sensitivity of OPN3 in melanocytes are yet to be d

128 investigate the extreme slow growth rate and light sensitivity of Paulinella, which are key to photos

129 Chromophore regeneration kinetics, light sensitivity of photoreceptors, and phototransducti

130 receptor co-action mechanism to sustain blue light sensitivity of plants under the broad spectra of s

131 t for future research aimed at enhancing the light sensitivity of residual cones to restore vision in

132 multiple molecular mechanisms regulating the light sensitivity of rods and cones.

133 G90D decreased the light sensitivity of rods but spared them from severe re

134 s effects, 67RuvC constructs suppress the UV light sensitivity of ruvA, ruvAB and ruvABC mutant strai

135 at the photopigment underlying the intrinsic light sensitivity of SCN-projecting RGCs has an absorpti

136 This response pattern paralleled the blue light sensitivity of stomatal opening in the two leaf su

137 of the SST-SSTR1 system in the regulation of light sensitivity of the central clock in the SCN at dus

138 leucine-rich repeats-that result in reduced light sensitivity of the circadian clock.

139 ght into the retina in order to increase the light sensitivity of the eye.

140 er surround illumination further reduced the light sensitivity of the ganglion cell.

141 Microperimetry allows mapping of light sensitivity of the macula and provides topographic

142 To measure and analyze retinal light sensitivity of the macula in STGD1 using fundus-co

143 e examined light signaling by exploiting the light sensitivity of the Neurospora biological clock, sp

144 Light sensitivity of the opsin pigment is restored throu

145 on and amacrine cells without destroying the light sensitivity of the retina by maximally activating

146 sitive detection of GFP while preserving the light sensitivity of the retina, and can be used to obta

147 Because of the selective blue light sensitivity of the retinal ganglion cells governin

148 Light sensitivity of this organ is epitomized in the flu

149 DENAQ confers light sensitivity on a hyperpolarization-activated inwar

150 Melanopsin is the photopigment that confers light sensitivity on intrinsically photosensitive retina

151 Brief application of AAQ bestows prolonged light sensitivity on multiple types of retinal neurons,

152 Photoswitch compounds such as DENAQ confer light-sensitivity on endogenous neuronal ion channels, e

153 Here we describe a method for bestowing light sensitivity onto endogenous ion channels that does

154 We showed that PAL treatment confers light sensitivity onto endogenous K+ channels in isolate

155 Azobenzene photoswitches confer light sensitivity onto retinal ganglion cells (RGCs) in

156 c approaches have been limited by either low light sensitivity or slow kinetics, and lack adaptation

157 llular Mg2+ has no significant effect on the light sensitivity or the kinetics of the photoresponse.

158 Dry eye patients reported more frequent light sensitivity (OR = 15.0, 95% CI = 6.3-35.7) and spo

159 , dry eye patients experienced more frequent light sensitivity (OR = 9.2, 95% CI = 2.0-41.7), but les

160 ing (OR: 3.16, 95% CI: 1.74-5.73, P < .001), light sensitivity (OR: 2.59, 95% CI: 1.48-4.55, P = .001

161 luminance VA, low-luminance deficit, mesopic light sensitivity), or rods (scotopic light sensitivity,

162 59.7% reduction in marked to severe daytime light sensitivity (P < 0.0001), a 41.5% reduction in mar

163 1.5% reduction in marked to severe nighttime light sensitivity (P < 0.0001), a 53.1% reduction in mar

164 minance visual acuity (P < .01) and scotopic light sensitivity (P = .05).

165 e mechanisms will maximize a photoreceptor's light sensitivity range and therefore may be common in o

166 We characterize light sensitivity recovery in continuously illuminated w

167 dividual traits, such as sex-differences, on light sensitivity remains to be established.

168 Restoration of light sensitivity requires chemical re-isomerization of

169 Restoration of light sensitivity requires chemical reisomerization of r

170 ion could overcome nearly all of the loss of light sensitivity resulting from the biochemical blockad

171 esopic light sensitivity), or rods (scotopic light sensitivity, rod-mediated dark adaptation [RMDA]).

172 Dryness and light sensitivity scales were then calculated, summed, a

173 ed a new step-function opsin with ultra-high light sensitivity (SOUL).

174 The arr mutants show altered red light sensitivity, suggesting a general involvement of t

175 ications, and newer issues such as Transient Light Sensitivity Syndrome are safety concerns of flap c

176 ons of femtosecond lasers included transient light-sensitivity syndrome, rainbow glare, opaque bubble

177 as diffuse lamellar keratitis and transient light-sensitivity syndrome.

178 coherence tomography, color vision testing, light sensitivity testing, and electroretinograms (retin

179 rd mice showed significantly lower pupillary light sensitivity than rd/rd mice alone.

180 t length on the basis of circadian rhythm of light sensitivity that is set from dusk, early flowering

181 ocurrents, red-shifted spectrum, and extreme light sensitivity) that have created new opportunities i

182 included two symptom questions (dryness and light sensitivity) that inquired about frequency and int

183 To restore light sensitivity, the all-trans-retinaldehyde must be c

184 To restore light sensitivity, the unliganded apo-opsin combines wit

185 ons and clinical measures such as full-field light sensitivity threshold for white, red, and blue col

186 Mean change in full-field light sensitivity threshold white light, averaged over b

187 n between maximum pupillary constriction and light sensitivity thresholds corroborates the introducti

188 We then imparted light sensitivity through covalent attachment of a synth

189 ular pattern of axonal connections, enhances light sensitivity through the principle of neural superp

190 e developed a new chemical gate that confers light sensitivity to an ion channel.

191 Restoring light sensitivity to apo-opsin requires thermal re-isome

192 retinal ganglion cells, primarily conferring light sensitivity to bipolar cells.

193 by genetic modification approaches to render light sensitivity to cells.

194 By conferring sustained light sensitivity to degenerate retinas after a single i

195 provide molecular-level control by endowing light sensitivity to endogenous biomolecules.

196 onstrate the utility of TULIPs by conferring light sensitivity to functionally distinct components of

197 er with earlier studies linking variation in light sensitivity to photoreceptor genes, our work sugge

198 r vision restoration aim to confer intrinsic light sensitivity to retinal ganglion cells when photore

199 e cells as a possible strategy for imparting light sensitivity to retinas lacking rods and cones.

200 by RetGC activating proteins (GCAPs) imparts light sensitivity to rods and cones by producing cyclic

201 Restoration of light sensitivity to the apo-opsin involves the conversi

202 Restoration of light sensitivity to the bleached opsin requires chemica

203 Restoration of light sensitivity to the bleached opsin requires chemica

204 orhodopsin, a rod photopigment, and restored light sensitivity to the electroretinogram.

205 ed by gene therapy, we related the degree of light sensitivity to the level of remaining photorecepto

206 etic small molecule photoswitch, can restore light sensitivity to the retina and behavioral responses

207 These approaches aim to restore light sensitivity to the retina as well as visual percep

208 and symptoms of hyperacusis (sensitivity to light, sensitivity to noise) tended to cluster together

209 e assays, we further show that JB253 bestows light sensitivity upon rodent and human pancreatic beta

210 We induced near-infrared light sensitivity using gold nanorods bound to temperatu

211 cuity, mesopic contrast sensitivity, mesopic light sensitivity, visual acuity, and contrast sensitivi

212 light sensitivity except that lower overall light sensitivity was associated with lower ranked sensi

213 This enhanced light sensitivity was more exaggerated in a relatively l

214 However, light sensitivity was reduced by approximately fourfold

215 In single cell recordings rod light sensitivity was shown to be a function of the amou

216 125A mutant, which exhibited slow growth and light sensitivity, was used to isolate suppressor strain

217 constitutive skin color and skin ultraviolet light sensitivity were assessed by colorimetry and minim

218 -retinaldehyde and the recovery rate for rod light sensitivity were faster in FATP4-deficient mice th

219 Somewhat surprisingly, dark current and light sensitivity were normal in individual rods (record

220 ated Ca(2+) release from internal stores and light sensitivity were strongly attenuated.

221 uity, retinal sensitivity, color vision, and light sensitivity, were assessed for 6 months.

222 ese two changes may be of importance for dim light sensitivity, which is consistent with our proposal

223 nged red illumination reduces Chrimson's red light sensitivity, which is reflected by a blue shift of