ライフサイエンスコーパス: limiting

1 on and highly effective in vivo if Ag is not limiting.

2 on different subsets of food as food becomes limiting.

3 step, rather than iminium formation, is rate-limiting.

4 at the PB thin film is shown not to be rate-limiting.

5 d nutrients are plentiful, but when space is limiting.

6 t are used in situations where molybdenum is limiting.

7 sis predicts that the most important factors limiting a species' distribution act at the coarsest spa

8 are critical for rational drug discovery, as limiting a virtual screen to a single conformation will

9 ral neuropathy is among the most common dose-limiting adverse effects of cancer treatment, leading to

10 resent study provides evidence in support of limiting alcohol intake in adherence to the USDGA recomm

11 tre against infection status in that season, limiting analysis to households with infection(s).

12 showed that cleavage of the C-H bond is rate-limiting and formation of the strained four-membered pal

13 affect any organ system and can be treatment-limiting and life-threatening, such as diabetic ketoacid

14 tic studies suggest a change in the turnover-limiting and selectivity-determining step induced by the

15 from non-inflammatory arthralgia (NIA), self-limiting arthritis (SLA), and undifferentiated arthritis

16 metabolizes cytosolic dopamine (DA), thereby limiting auto-oxidation, but is also thought to generate

17 At sites where P was not limiting, available P delta(18)O(P) increased by up to 3

18 rface, particularly in the riparian zone, is limiting base flow nitrate concentrations.

19 This modest limiting Bayes factor rises to 8.7 if we accept the more

20 ed autoimmune phenotypes can be rectified by limiting BCR repertoires or attenuating BCR signaling st

21 duction of immunosuppression in case of self-limiting BKPyV-DNAemia can be minimized.

22 to distinguish patients with transient, self-limiting BKPyV-DNAemia from those with persisting BKPyV-

23 ble to generate novel NP-inspired scaffolds, limiting both the number and types of compounds accessib

24 reflects the ability of Zn to promote a rate-limiting C-H reductive elimination step, and calculation

25 The efficacy of these agents in limiting calcification was confirmed experimentally by t

26 ps out a novel molecular pathway crucial for limiting cancer cell proliferation, in which ABHD5-media

27 nction, wound healing and hair growth, while limiting cancer development.

28 ng the results of present contemplation as a limiting case of available work, and it is found to be i

29 In limiting cases such as this, we herein introduce the use

30 These results suggest that limiting CD4 T-cell help mteaserrlie the diminished or a

31 A limiting characteristic of Tac is the high intra and int

32 pid substrate-catalyst binding precedes rate-limiting chlorenium attack, controlling the face selecti

33 evanescent white dot syndrome is a rare self-limiting condition of the outer retina.

34 dulation in legumes challenged with nitrogen-limiting conditions requires infection of the root hairs

35 ot produce siderophores but grows under iron-limiting conditions using enterobacterial siderophores.

36 Under nitrogen-rich, carbon-limiting conditions, unphosphorylated ManX stimulates th

37 of growth experiments under iron- and cobalt-limiting conditions.

38 nt water retention and EM fungi under carbon-limiting conditions.

39 ated bed nets reduce malaria transmission by limiting contact between mosquito vectors and human host

40 S) catheter after successful PCI of all flow-limiting coronary lesions in 898 patients presenting wit

41 To determine whether information-limiting correlations exist, we implanted eight Utah arr

42 first time, strong evidence for information-limiting correlations.

43 ron-containing fragment closely approaches a limiting description as a "free" boryl anion in the cond

44 ve so far been restricted to high pressures, limiting detailed studies and applications.

45 Rate-limiting diffusion across cytoplasm was demonstrated by

46 Immunosuppressive therapy may be helpful in limiting disease progression, with rituximab showing eff

47 signaling molecules by Mtb remains elusive, limiting drug discovery.

48 e kinase inhibitor delivery to the tumors by limiting drug-carrying blood flow and the drug concentra

49 SLUG to directly repress pro-apoptotic BMF, limiting drug-induced apoptosis.

50 r is constrained by observational scale [2], limiting ecological understanding and precise management

51 Drug resistance is a critical problem limiting effective antiviral therapy for HIV/AIDS.

52 beta-cells against virally mediated lysis by limiting EMCV replication.

53 1 particles, which restricts fusion with the limiting endosomal membrane and prevents cellular infect

54 Expression levels of the rate-limiting enzyme aromatase, but not estrogen receptors, m

55 FADS1 encodes a rate-limiting enzyme for omega-3 and omega-6 fatty acid metab

56 against tyrosine hydroxylase (TH), the rate-limiting enzyme in catecholamine synthesis.

57 Interestingly, HMG-CoA reductase, the rate-limiting enzyme in cholesterol synthesis, was reduced in

58 ACC Synthase 7 (ACS7), which encodes a rate-limiting enzyme in ethylene biosynthesis.

59 nolpyruvate carboxykinase 1 (PCK1), the rate-limiting enzyme in gluconeogenesis, at Ser90.

60 inate synthase 2 (ALAS2), the first and rate-limiting enzyme in the heme biosynthetic pathway.

61 tinaldehyde dehydrogenase 2 (RALDH2), a rate-limiting enzyme in the retinoic acid (RA)-producing path

62 posed of RRM1 and RRM2 subunits, is the rate-limiting enzyme in the synthesis of deoxyribonucleoside

63 High expression of the rate-limiting enzyme of de novo GTP synthesis is associated w

64 se-6-phosphate amidotransferase 1), the rate-limiting enzyme of HBP, promotes cardiomyocyte growth.

65 ne palmitoyltransferase 1A (CPT1A), the rate-limiting enzyme of mitochondrial fatty acid (FA) transpo

66 cerate dehydrogenase (PHGDH), the first rate-limiting enzyme of serine synthesis, is frequently overe

67 The rate-limiting enzyme of the pathway, glutamine-fructose amido

68 yl-CoA oxidase 1) encodes the first and rate-limiting enzyme of the very-long-chain fatty acid (VLCFA

69 th tryptophan hydroxylase 1 (Tph1), the rate limiting enzyme regulating peripheral serotonin synthesi

70 hosphoribosyltransferase (NAMPT) is the rate-limiting enzyme, converting nicotinamide into nicotinami

71 thioadenosine phosphorylase (MTAP), the rate-limiting enzyme, to relieve strain.

72 nt images presented upregulation of the rate-limiting enzymes for the production of dopamine and mela

73 a protective role in CMT1B Schwann cells by limiting ERK/c-Jun hyperactivation.

74 We observed D. armatus in light-limiting, excess-light, and sinusoidal-light environment

75 We found that limiting exogenous glutamine protects actively dividing

76 -lamp shields and gloves also contributed to limiting exposure to droplets from SARS-CoV-2 during sli

77 Root hydraulic conductivity is a limiting factor along the water pathways between the soi

78 d the capacity of intensive care units was a limiting factor during the peak of the pandemic and is g

79 e HPLC part of this analysis was the primary limiting factor for each analyte (rather than the ion-mo

80 sential macronutrient for plants and a major limiting factor for plant growth and crop production.

81 ht-time) temperature is considered a greater limiting factor for reduced rice yield than a similar in

82 ts reveal that stochasticity is an important limiting factor for self-assembly and that the specific

83 DNA needed for an assembly project can be a limiting factor for small organisms or precious samples.

84 ans or animals, which has been a significant limiting factor in disease control to date.

85 -bed volume) of very small columns is also a limiting factor to decrease the column length.

86 Although the low CTC-rate seems a limiting factor, results indicate high specificity.

87 h theory predicting limitation from a single limiting factor, the linear J(CO2) response on the sandy

88 Diagnostic testing remained one of the limiting factors for early identification and isolation

89 its transcriptional regulator HIF-1alpha as limiting factors for HSPC proliferation.

90 t target BP is acceptable and what should be limiting factors in uptitration to adequate levels of HF

91 mpare its impact to well-studied performance-limiting factors internal to the visual system.

92 esulted in a predictable sequence of primary limiting factors to GPP beginning with air temperature i

93 e images due to external and patient-related limiting factors.

94 nisms and thus may have an important role in limiting fibrosis.

95 e depletion rather than DSB movement is rate limiting for HDR.

96 anine + tyrosine, isoleucine, histidine, but limiting for lysine, leucine, and threonine.

97 ess, establishing metabolic reprogramming as limiting for tumor initiation.

98 y season (e.g., early vs. late) was lacking, limiting further analysis.

99 icities attributed to (177)Lu-PSMA were self-limiting G1-G2 dry mouth (66%), transient G1-G2 nausea (

100 s typically manifests as a short-lived, self-limiting gastrointestinal infection in humans, however p

101 n behavioral health integration, potentially limiting generalizability.

102 tores (phosphocreatine/ATP), but potentially limiting greater ATP delivery during increased workload.

103 with enhanced virus production under carbon-limiting growth conditions.

104 Acinetobacter baumannii (AB) is critical for limiting healthcare-associated infections and providing

105 -D-arginine vasopressin showed no benefit in limiting hematoma expansion or improving functional outc

106 ad, I suggest that sodium's critical role in limiting herbivore performance makes it a commodity used

107 One factor limiting HFA accumulation in these plants is the ineffic

108 hic approaches is often time consuming, thus limiting high-throughput screening tests.

109 iding end-of-life care to patients with life-limiting illnesses.

110 drugs including inducing innate sensing and limiting immunosuppressive factors in the TME.

111 21-2.57), and those with increased number of limiting impairments 1.54 (1.11-2.14).

112 This demonstrates that PI3P is rate limiting in some pathways.

113 ed by bacteria or bacterial polysaccharides, limiting inactivation and aiding transmission.

114 ny when hosts undergo allopatric speciation, limiting inter-host bacterial dispersal and genomic reco

115 These are: limiting interaction to a few repeated contacts akin to

116 gether with evidence for ECT2 autoinhibition limiting interaction with CYK4 in the cytoplasm, these r

117 ysteine impairs mitochondrial respiration by limiting intracellular iron availability through an oxid

118 es, inducing severe noise in the dataset and limiting its applications in biomedical studies.

119 however, chemoresistance is a major problem limiting its effectiveness.

120 tion prevents its interaction with caspases, limiting its processing, oligomerization, and capacity t

121 (1.7 h) and low aqueous solubility (27 muM), limiting its use in animal models of chronic disease.

122 ve cohorts that are predominately male, thus limiting knowledge of cerebral growth in females with AS

123 aradoxical effects, promoting the ability of limiting levels of Axin to turn off Wnt signaling.

124 and sebaceous differentiation program whilst limiting lipid production and cell proliferation.

125 or to improve visual function is critical in limiting long-term sequela.

126 e significantly better than control cells at limiting M. tuberculosis replication.

127 m whereas that for alpha-T(3) tends toward a limiting maximum as the mass of the rest of the system i

128 Internal limiting membrane (ILM) drape sign is an important OCT c

129 functional outcomes of the inverted internal limiting membrane (ILM) flap technique and the complete

130 After core vitrectomy, internal limiting membrane (ILM) was peeled between the optic ner

131 to their propitious location above the inner limiting membrane (ILM), allowing direct visualization o

132 In Group 2, the integrity of the external limiting membrane at 3 months postoperatively was the on

133 The penetration of outer limiting membrane by photoreceptor nuclei and Muller cel

134 tment (JPL; 146 patients), PPV plus internal limiting membrane peeling (ILMP; 50 patients), PPV plus

135 nated nerve fiber layer (1.3%), and internal limiting membrane wrinkling (1.3%).

136 olic signaling by the mTORC1 kinase on their limiting membranes.

137 GlcNAc is a rate-limiting metabolite for N-glycan branching.

138 Iron (Fe) is a growth-limiting micronutrient for phytoplankton in major areas

139 hat the value for alpha-(14)C tends toward a limiting minimum whereas that for alpha-T(3) tends towar

140 t normally induces an anti-viral response by limiting mRNA translation.

141 Ascl1, interfering with its DNA binding and limiting neurogenesis within LGE progenitors.

142 sed chemotherapy agent with significant dose-limiting neurotoxicity resulting in peripheral neuropath

143 rs like sulfide and by providing degradation-limiting nitrogen through biological nitrogen fixation.

144 ed replication, and S phase progression upon limiting nucleotide levels.

145 nergetic compromise blocked proliferation by limiting nucleotide triphosphate synthesis.

146 rocesses result in N acting as the proximate limiting nutrient in most surface environments.

147 t with iron being a well-established primary limiting nutrient in this region.

148 Because phosphorus (P) is one of the most limiting nutrients in agricultural systems, P fertilisat

149 ties have increased supplies of biologically limiting nutrients, such as nitrogen (N) and phosphorus

150 Another barrier close in value to the limiting one is found along the cascade assembly pathway

151 Identifying knowledge gaps limiting operation of such models is the logical step to

152 The dose-limiting organ is most likely the stomach.

153 Liver represented the dose-limiting organ.

154 petent CD-1 mice revealed kidney as the dose-limiting organ.

155 liver and spleen, which we identify as dose limiting organs.

156 fication tools tailored for TEs are lacking, limiting our ability to dissect TE expression dynamics a

157 le ecosystem functions is poorly understood, limiting our ability to predict how soil biodiversity lo

158 brief sessions in constrained environments, limiting our ability to probe naturalistic behaviors and

159 nteritis is largely restricted to outbreaks, limiting our knowledge of the contribution of sporadic i

160 ARS-CoV-2 has been performed inconsistently, limiting our understanding of alternative viral infectio

161 Limiting our understanding of Bti efficacy and the path

162 phosphatase 2A (PP2A) is poorly understood, limiting our understanding of PP2A-regulated signaling.

163 ational changes in EF-Tu coordinate the rate-limiting passage of aa-tRNA through the accommodation co

164 Moreover, by anchoring a self-limiting passivant (1-butanethiol) on the perovskite sur

165 mune responses in cancer remains incomplete, limiting patient benefit.

166 reduction in patient volume (n = 62 [100%]), limiting patient companions (n = 59 [95.2%]), use of a s

167 IK3IP1 promotes extrafollicular responses by limiting PI3K signaling during initial interactions betw

168 largely limited by their on-target and dose-limiting platelet toxicity.

169 an overdependence on a single analogy risks limiting policy discussions in potentially deleterious w

170 duction in the levels and activity of a rate-limiting polyamine biosynthetic enzyme, ornithine decarb

171 n their native areas, but much less on those limiting potential changes in distributions of species t

172 arge quantities represents a costly and rate-limiting prerequisite for high throughput screening.

173 nts with zero/near-zero last-24-hour OME and limiting prescriptions to a conservative multiplier of t

174 ound excitonic state is found to be the rate-limiting process.

175 Our findings indicate that limiting proliferation particularly in the RPE layer is

176 on are as important as atmospheric oxygen in limiting pyrite reactivity over Earth's history.

177 They catalyze the rate-limiting reaction in the conversion of cellobiose to glu

178 lysis shows that Fro-DO accelerates turnover limiting reductive elimination via LUMO lowering.

179 eaction using Ir(ppy)(3) supports a turnover-limiting reductive elimination.

180 Limiting research and policy interventions is the low te

181 l stoichiometry of life; and maximization of limiting resource use efficiency across scales.

182 lowing both injury and recovery, potentially limiting restoration of normal muscle performance.

183 ess tumor growth and metastases, in part, by limiting ROS activity.

184 responses in all participants, and no trial-limiting safety concerns were identified.

185 e to antiviral drug resistance and treatment-limiting side effects.

186 Environmental filtering and limiting similarity mechanisms can simultaneously struct

187 ry preferences do not change as food becomes limiting, so individuals expand their diets as they comp

188 ted via their far-field light emission, thus limiting spatial resolution.

189 By limiting spillover, glutamate transporters are believed

190 Masking had the greatest effect in limiting spread of respiratory droplets, whereas slit-la

191 ions and social distancing are beneficial in limiting spread, recommendations around face mask use ar

192 disequilibrium, and to maximize power while limiting spurious findings.

193 doubly reduced FeMo-co core of the E(4)(2H)* limiting-state by (1)H, (57)Fe, and (95)Mo ENDOR to illu

194 gamma-C(sp(3) )-H bond cleavage is the rate-limiting step during the reaction process.

195 The simulations reveal that the limiting step for binding of flexible molecules to ice i

196 temporal window, sample processing is a time-limiting step for research on the early life-history sta

197 Initiation is a rate-limiting step in cap-dependent translation and is the ma

198 We find that the rate-limiting step in mRNA cleavage frequently involves unmas

199 a rate nearly 10 times faster than the rate-limiting step in photosynthetic electron transport.

200 ion of the O-H bond in H(2) O is a critical, limiting step in plasmonic photosynthesis.

201 ation of proteostasis is a critical and rate-limiting step in the consolidation of new memories(5-10)

202 IMPDH1 catalyzes the rate-limiting step in the de novo synthesis of guanine nucleo

203 substrate, and its availability is the rate-limiting step in this pathway.

204 ghly isoergic with two triplet excitons, the limiting step is the triplet-triplet annihilation pathwa

205 to N-formylkynurenine in the first and rate-limiting step of kynurenine pathway.

206 ne 2, 3-dioxygenase 1 (IDO) catalyzes 1 rate-limiting step of L-tryptophan metabolism, and emerges as

207 ning, also termed deadenylation, is the rate-limiting step of mRNA degradation in eukaryotic cells.

208 - the correlation is linear because the rate-limiting step of the catalytic cycle, nucleotide release

209 ation has been widely recognized as the rate-limiting step of the experimental workflow.

210 ing events are productive and implies a rate-limiting step, probably associated with recruitment of g

211 Methane activation is the rate-limiting step, while the activation of CO(2) and the C-O

212 to the aromatic ring is involved in the rate-limiting step.

213 , these data show that HS17B3 acts as a rate-limiting-step for the maximum level of testosterone prod

214 ur results thus revealed that different rate-limiting steps (e.g., substrate channel diffusion) in th

215 to be of importance for hemostasis, the rate-limiting steps of CLEC-2-induced platelet activation are

216 refolding and provides key insight into rate-limiting steps of G-quadruplex conformational dynamics.

217 Given that rate-limiting steps of metastasis are known to occur while tu

218 imer that reduces the energy barrier of rate-limiting steps of the catalytic cycle of Ca(2+) transpor

219 ic filament and the donor template in yeast, limiting strand rejection by the Sgs1 and Mph1 helicases

220 provide evidence that malonyl-CoA, the rate-limiting substrate for fatty acid synthesis (FAS), is pr

221 optimal Vbeta recombination signal sequences limiting synchronous rearrangements and essential for al

222 While this strategy is appealing for limiting systemic exposure of nanocarrier delivered toxi

223 understanding of cage catalysis in general, limiting the ability to design new systems.

224 The BBB has been blamed for limiting the access of therapeutic drugs to the brain, w

225 ave used simplified models of crop canopies, limiting the accuracy of predictions.

226 keleton may negatively regulate GSIS by both limiting the amount of insulin proximal to the PM and pr

227 e niche ligand-receptor interaction; and (2) limiting the amount of stem cell receptors available for

228 and ultimately destroy the transducer itself limiting the amplitude of generated picosecond strain.

229 We performed a GWAS on the genotyped cohort, limiting the cases to either the reproductive or metabol

230 Plants may benefit from limiting the community of generalist floral visitors if

231 strain TCR reactivity for InsB(9-23) by both limiting the development of pathogenic T cells and suppo

232 inding modes of FPR2 remain elusive, thereby limiting the development of potential drugs.

233 eninsula, we aimed to unravel the mechanisms limiting the dispersal of matrilines and generating gene

234 There is a lot of information on the factors limiting the distributions of species in their native ar

235 infection decreased Mphi half-life, thereby limiting the duration of memory.

236 regulates endocrine cell differentiation by limiting the duration of RA signalling.

237 large density of nanocrystals were embedded, limiting the efficiency of solar cells.

238 ind that this process can play a key role in limiting the emergence of cancer.

239 deprivation of the germinal center reaction, limiting the generation of memory B cell and long-lived

240 sorb massive amounts of carbon dioxide, thus limiting the global warming otherwise expected from post

241 the reovirus outer capsid protein sigma3 in limiting the induction of a necrotic form of cell death

242 riers, indicating that scattering mechanisms limiting the mobility are mitigated by doping.

243 btaining the results can be protracted, thus limiting the number of compounds that can be advanced in

244 life-history stages, with energy constraints limiting the onset of male reproduction but playing a la

245 imental for the device performance by mainly limiting the open circuit voltage, interfacial layers ar

246 s or outpatient treatment of milder disease, limiting the options available to pregnant women with se

247 separation of blood and lymphatic vessels by limiting the plasticity of committed endothelial cells.

248 nces when aligned with the reference genome, limiting the potential of whole metagenomics.

249 diversity and distribution of species, thus limiting the potential to assess their local environment

250 g efficacy of radiotherapy while drastically limiting the received dose and reducing the possible dam

251 egregated the community into research silos, limiting the replication and clinical translation of fin

252 ulating viral large-T-antigen expression and limiting the replication of archetype BKPyV, suggesting

253 se findings provide insight into the factors limiting the response time of organic mixed-conductor-ba

254 Limiting the rise in global mean temperatures relies on

255 ns, preventing modification localization and limiting the sensitivity of the search.

256 ween maintaining essential supply chains and limiting the spread of the virus.

257 nd co-dependent nature of this relationship, limiting the success of translational efforts.

258 ct few lyases over the last several decades, limiting the types of C-C bond-forming transformations p

259 viruses have a short period of replication, limiting the utility of molecular tests.

260 finer-scale behavioural change, potentially limiting the validity of using GPS to infer at-sea behav

261 ter (64)Cu-DOTATATE PET/CT SRI was moderate, limiting the value on an individual-patient basis.

262 a relatively constant organic carbon burial, limiting the variations of surface Earth temperature and

263 tion's dietary niche expands as food becomes limiting, the Niche Variation Hypothesis (NVH) and Optim

264 gase activities are still poorly understood, limiting their applications.

265 ing algorithms to the specifics of the data, limiting their areas of application.

266 e number of patients treated with each drug, limiting their feasibility.

267 erials have unchanging mechanical properties limiting their mechanical performance and service life.

268 Fs typically form insoluble aggregates, thus limiting their processing via additive manufacturing tec

269 nterdisciplinary hypothesis-testing toolkit, limiting their scope and application.

270 ways beneficial in treating a disease, while limiting their side effects, is of broad significance.

271 less frequently described in literature thus limiting their use as routine tools in control laborator

272 ts of therapeutic applications significantly limiting therapeutic effectiveness.

273 ts in negative effects on growth and health, limiting therapeutic potential.

274 ultiple T cell responses share a common rate-limiting threshold and a conceptually simple model of CD

275 infectious and autoinflammatory diseases by limiting tissue damage/inflammation.

276 he cytoplasmic side of the membrane, is rate limiting to transport.

277 to the UPF2-mediated regulation of GLUR1 by limiting total GLUR1 levels.

278 Safety, dose-limiting toxicities (DLTs), maximum-tolerated dose (MTD)

279 Primary endpoints were determination of dose-limiting toxicities at the maximum administered dose, sa

280 etermine the maximum tolerated dose and dose limiting toxicities of brentuximab vedotin combined with

281 ed before CAR-NKT cell infusion, and no dose-limiting toxicities were observed.

282 No dose-limiting toxicities were reported.

283 ted dose was not reached; there were no dose-limiting toxicities.

284 patients treated at 1 mg/kg experienced dose-limiting toxicity (DLT) from immune-related adverse even

285 ates of peripheral neuropathy, the main dose-limiting toxicity of bortezomib.

286 Due to dose-limiting toxicity of the small molecule payload, antibod

287 Dose-limiting toxicity was not observed.

288 attachment of the tethered head is the rate-limiting transition in the KIF1A stepping cycle.

289 ting, and endoscopy revealed only minor self-limiting ulcers in 5 patients.

290 es to proliferate and which nutrients become limiting under lysosomal dysfunction are unclear.

291 n this heterogeneous pigment remain unknown, limiting understanding of the properties of its light-re

292 Stewardship will have a crucial role in limiting unnecessary antimicrobial use and AMR.

293 By limiting unrestricted activation of intracellular effect

294 Reduced food availability is the key factor limiting urban offspring growth and survival, at least i

295 ents and quantitatively explain slip pulses' limiting velocities.

296 geria, the majority developed fever and self-limiting vesiculopustular skin eruptions.

297 rupting the viral life cycle is critical for limiting viral spread and disease, it has proven challen

298 n might represent a natural immune mechanism limiting viral spread.IMPORTANCE HIV infection modulates

299 tiviral program that is broadly effective in limiting virus replication and in suppressing the pro-in

300 hanisms acting when other amino acids become limiting, we tested the efficacy of prokaryote-specific