ライフサイエンスコーパス: lineage

1 istent across different genetic backgrounds (lineages).

2 of the SEC14L-PITP superfamily in the green lineage.

3 ena species, but conserved in the Armillaria lineage.

4 ither MyD88 or the IL-12Rbeta2 in the T cell lineage.

5 ral crest-derived sox9a(+)/sox10(+) skeletal lineage.

6 araphid species and arose within the centric lineage.

7 sistent with purifying selection within this lineage.

8 ng cyst morphotypes for other species in the lineage.

9 T cells and cells of the monocyte/macrophage lineage.

10 when compared to those of a tobacco-adapted lineage.

11 ent stem cells was skewed toward the myeloid lineage.

12 archaeal relatives of the eukaryotic nuclear lineage.

13 ymphopoiesis and skewing towards the myeloid lineage.

14 TPO and CXCL12 regulate beta4GalT1 in the MK lineage.

15 ence of paternal provisioning in the hominin lineage.

16 hat originate from cells of the Schwann cell lineage.

17 mobilized among diverse plasmids within this lineage.

18 rent levels of vector marking in the various lineages.

19 sed predominantly in the hematolymphoid cell lineages.

20 geny among several dominant marine bacterial lineages.

21 ing osteogenic, chondrogenic, and adipogenic lineages.

22 t has a shared evolutionary origin in all 10 lineages.

23 ca and North American Dumosae and Prinoideae lineages.

24 trasting feedback responses among some plant lineages.

25 his picture is complicated by several hybrid lineages.

26 prise the most ubiquitous and diverse enzyme lineages.

27 closely associated osteoblast or chondrocyte lineages.

28 occur within three independent phylogenetic lineages.

29 nts harbored up to seventeen unique parasite lineages.

30 ricting their differentiation into secretory lineages.

31 oeolog expression divergence among polyploid lineages.

32 veals a requirement for GATA6 in various SAN lineages.

33 and assess the invasion capacity of emerging lineages.

34 ructure and sequence elements shared by both lineages.

35 tibiotic resistance was largely found in Ecc lineage 1, which had a higher rate of multidrug resistan

36 We found that Unc-4 functions in lineage 11A to promote cholinergic neurotransmitter iden

37 s data on repetitive trait evolution between lineages [4, 8].

38 isolates from 22/23 of the prevalent global lineages (96%).

39 rties more in line with betacoronaviruses in lineages A and C, and be a key component in the evolutio

40 The evolved lineages acquired numerous parallel mutations, many medi

41 cells, competent enhancers are primed during lineage acquisition, and formation of de novo enhancers

42 Analysis of 13 T-lineage acute lymphoblastic leukemias identified a recur

43 ants from two distinct lineages, one monocot lineage (Alismatales) and one eudicot lineage (Lentibula

44 Washington state, with lack of a predominant lineage and limited transmission among communities.

45 chromatin remodeling complex, that are SARS lineage and pan-coronavirus specific, respectively.

46 between an ancestor of the Eurasian Roburoid lineage and Quercus pontica and North American Dumosae a

47 cessibility for BATF is observed in other Th lineages and allows acquisition of the IL-9-secreting ph

48 h phylogenetic relationships among the major lineages and divergence time estimates within Orthoptera

49 offspring were generated from each of these lineages and examined for outcomes previously found to b

50 capabilities, we track intestinal stem cell lineages and gut microbial colonization in single animal

51 fferential patterns of HEV-specific antibody lineages and highlights the necessity of the long vaccin

52 th a variety of preparation types, microbial lineages and isotope labels to determine its consistency

53 ation biased cells toward various endodermal lineages and that conditions favoring a polymerized cyto

54 however, originate from diverse saprotrophic lineages and the impacts of genetic variation across spe

55 enesis in both dorsal and ventral progenitor lineages and, if so, whether it regulates common or uniq

56 l trials, growth rates differed among family lineages, and the highest mortality under OA occurred in

57 matin at AgR loci are regulated in a locus-, lineage-, and stage-specific manner during B lymphopoies

58 O lineages is strongly supported, but the A lineage appears paraphyletic.

59 d simple vicariance of Caribbean and Pacific lineages, are needed to better understand the evolutiona

60 arcode editing for elucidating developmental lineages at the whole organism level.

61 We also demonstrate how different lineage B viruses can recombine to gain entry into human

62 d that the majority of HCWs had the dominant lineage B.1.

63 Differential abundance of lineages between locations and size-fractions associated

64 Using a MIXL1 reporter, we explore mesoderm lineage-bias within the human pluripotent stem cell comp

65 pluripotency while simultaneously exhibiting lineage-bias.

66 It is one of the most prevalent carrier lineages but also frequently causes severe invasive dise

67 Why some AIV lineages but not others evolve in this way is unknown.

68 synthetic pathways in different Brassicaceae lineages by shuffling the genes encoding a core palette

69 iR-223 restricts the EHT of lymphoid-myeloid lineages by suppressing the mannosyltransferase alg2 and

70 CRE-ERT2 (Lkb1(Lgr5-KO) mice) and the traced lineages by using a CRE-dependent TdTomato reporter.

71 AI) viruses of the H5 A/goose/Guangdong/1/96 lineage can cause severe disease in poultry and wild bir

72 tic gene-of-interest expression with the CRE lineage can compromise viability and impede auditory ana

73 lusively) members of the pandemic generating lineage capable of causing the diarrhoeal disease choler

74 regulates the allocation of oligodendrocyte lineage cell fates.This article has an associated 'The p

75 canonical NF-kappaB kinase, IKKbeta, in Scx-lineage cells in mice increased apoptosis and the deposi

76 ctive was to ablate proliferating osteoblast lineage cells in order to investigate the importance of

77 at Day 1, but astrocytes and oligodendrocyte lineage cells subsequently became more responsive.

78 , but it has remained unclear to what extent lineage choice is influenced by clonotypically expressed

79 rom Sierra Leone and Nigeria, where distinct lineages circulate.

80 gene of H5 isolates belonged to the Eurasian lineage, classified into three subgroups (HA-II, HA-III,

81 provided evidence that TGF-beta disrupts the lineage commitment and promotes the accumulation of tumo

82 nderstanding of NONO in stem cell functions, lineage commitment and specification.

83 ockout of either PKS or GCM revealed spatial lineage commitment in the transition from bilaterality o

84 H3K27me3 and telomere integrity in stem cell lineage commitment that may have implications in aging a

85 g against a direct role for CSF1R in myeloid lineage commitment.

86 atory networks that influence cell fates and lineage commitment.

87 ole in mammary gland development and luminal lineage commitment.

88 selection model of CD4(+) and CD8(+) T cell lineage commitment.

89 uted to genomic position and the kinetics of lineage commitment.

90 D117(+/-)CD94(+)NKp80(+)) NKDIs were NK cell lineage committed despite Notch activation.

91 ging to study and to delineate, owing to its lineage complexity and lack of a concise genetic definit

92 ntiation of each myoblast along the myogenic lineage complicates teasing apart at what stages of diff

93 tes an embryo's response to perturbations in lineage composition.

94 with T cell receptor (TCR) sequencing reveal lineage connections in T cell populations.

95 We show that the 26 co-occurring V. cholerae lineages continuously compete for limited space on nutri

96 th immune-suppressing drugs restores myeloid lineage-controlled cellular mechanisms.

97 eceptor antagonization inhibited mesenchymal lineage conversion in TGFbeta1-exposed human and murine

98 a differentiation is both dependent on early lineage decision and on a yet unidentified regulatory me

99 ly, the two isoforms differentially affected lineage decision toward a cardiac cell fate.

100 NA methylation turnover might facilitate key lineage decisions.

101 equency of intermediate-penicillin-resistant lineages decreased post-PCV.

102 ls (NDWI), whereas the diversity of parasite lineages decreased with increasing NDVI.

103 en mechanism, both hyperplasia and stem cell lineage defects.

104 tal stage and context-dependent functions of lineage-defining transcription factors in regulating spe

105 N2) and an IBV (B/Brisbane/60/2008, Victoria lineage), demonstrating their broad-spectrum prophylacti

106 tegies based on the dynamics of the pathogen lineages derived from networks and centrality metrics.

107 this was caused by expansion of specific sub-lineages, designated CC17-A1, CC17-A2 and CC23-A1.

108 WGS also allowed for strain lineage determination, which may be important for future

109 lizes with GATA4 (GATA binding protein 4), a lineage-determining cardiac transcription factor not pre

110 The lineage-determining transcription factor BCL6 inhibited

111 nd STAT5 at sites that can subsequently bind lineage-determining transcription factors, depending upo

112 enesis, and deleting Pdgfra in adult adipose lineage did not affect WAT homeostasis.

113 tem and progenitor cell (HSPC) formation and lineage differentiation involve gene expression programs

114 dental pulp cells, periodontal neural crest lineage differentiation is characterized by repressive H

115 RA locus activation and enforced alphabeta T lineage differentiation.

116 igate the impact of environmental factors on lineage dispersal velocities.

117 Advance in determining cardiac lineage diversification has often been limited by the un

118 eles were present prior to pea aphid biotype lineage diversification, we estimated that the insertion

119 evolutionary turnover of the mammalian stem lineage during the Early-Middle Permian transition (273

120 Lineage effects may occur through maternal responses to

121 n liver parenchymal and non-parenchymal cell lineages emerge.

122 One dominant lineage emerges that initiates and drives systemic metas

123 daughter cells towards absorptive enterocyte lineage ensuring epithelial growth.

124 to chytrid fungi, an early diverging fungal lineage exhibiting characteristics found in both animals

125 exual selection as an important force behind lineages facing extinction threats, identifying the rele

126 ineages, including tier 2 virus neutralizing lineages, following boosting.

127 but is required to enrich mRNAs in the germ lineage for robust germline development.

128 role for BMP10 in the specification of this lineage from cardiovascular mesoderm.

129 the emergence of cattle specialist C. jejuni lineages from a background of host generalist strains th

130 sulfide spring P. mexicana but not ancestral lineages from nonsulfidic habitats due to convergent ada

131 ogenously generating similar lung epithelial lineages from pluripotent stem cells.

132 redictive value of surface markers to define lineages, functions, or subpopulations.

133 Seven genetically distinct LASV lineages have been identified.

134 Neural lineages have been implicated as cells of origin, as hav

135 Oak lineages have diversified among geographic regions, foll

136 nt recombination events between these allele lineages have increased the frequency of KLRA*02 extrace

137 Our analysis suggests that multiple lineages have independently colonised cycads from angios

138 Although studies have proposed lineage heterogeneity within GMPs, it is unclear if comm

139 om an individual cell, placing them within a lineage hierarchy.

140 Tracing the lineage history of cells is key to answering diverse and

141 The cellular lineages identified by pigment presence or absence (wild

142 Cancer cells progressively adopt alternate lineage identities, computationally predicted to be medi

143 e strains from the three most prevalent LASV lineages (II, III and IV).

144 f other CD34(+) cell populations into the NK lineage in a non-contact dependent manner.

145 Deletion of Csk and PTPRJ in the MK lineage in mice results in increased SFK activity, but p

146 ghlighting an instructive role of tumor cell lineage in reprogramming the stromal microenvironment.

147 rns of the adult-born neural progenitor (NP) lineages in detail.

148 we identified all phosphate-binding protein lineages in the Evolutionary Classification of Protein D

149 the potential to differentiate into various lineages in vitro, including osteogenic, chondrogenic, a

150 BASL (BREAKING OF ASYMMETRY IN THE STOMATAL LINEAGE) in the simplifying context of cultured cell fil

151 dditional HGT events from diverse angiosperm lineages, including large and recent transfers from the

152 families correlate with specific eukaryotic lineages, including many photosynthetic groups.

153 evels of somatic hypermutation (SHM) of most lineages, including tier 2 virus neutralizing lineages,

154 Distinct lineages infect plants, invertebrates, and vertebrates,

155 In recent years, H5 HPAI viruses of this lineage infecting poultry in Asia have spilled over into

156 of functional differentiation of the NK cell lineage influences the magnitude and specificity of inte

157 lTagging, permitting the parallel capture of lineage information and cell identity via a combinatoria

158 vement of genes from a distantly related AFC lineage into An. funestus, an event that predated and pl

159 ction of at least seven different SARS-CoV-2 lineages into California, including epidemic WA1 strains

160 The human lineage is marked by a transition in hand use, from loco

161 Monophyly of the M, C, and O lineages is strongly supported, but the A lineage appear

162 difference between the two jawed vertebrate lineages is the presence of a single large gill cover in

163 Mixed lineage kinase 3 (MLK3), also known as MAP3K11, was init

164 K3)-mediated pathways of apoptosis and mixed lineage kinase domain-like pseudokinase (MLKL)-dependent

165 -interacting protein kinase-3 (RIPK3), mixed lineage kinase-like (MLKL) and NADPH oxidase.

166 he Rhodobacterales, an alpha-proteobacterial lineage known frequently to associate with algae.

167 hat multiple immune cell populations contain lineage-labeled particles, suggesting a phagocytic role

168 raining the number and depth of hierarchical lineage labels and by flagging and delabelling virus lin

169 for a whole-genome duplication event in the lineage leading to L. japonica, which occurred after its

170 ndamentally, the autoantigen-specific B cell lineage leads to production of the pathogenic autoantibo

171 onocot lineage (Alismatales) and one eudicot lineage (Lentibulariaceae).

172 Acute myeloid leukemia (AML) with mixed lineage leukemia 1 (MLL1) gene rearrangement is characte

173 Oligodendrocyte lineage markers and birthdating experiments indicated a

174 t predates the divergence of different avian lineages, most genes belong to an avian-specific gamma-c

175 coupled detection of CRTH2 and IL7Ralpha on lineage negative (Lin(-)) cells.

176 In bone marrow, CSF1R-FRed was absent in lineage-negative hematopoietic stem cells, arguing again

177 us (DR) contains the greatest number of Pet1-lineage neurons, a predominantly serotonergic group dist

178 In particular, a major V. cholerae lineage occasionally grows to large numbers on particles

179 a (AML) is a cancer derived from the myeloid lineage of blood cells, characterized by overproduction

180 ne-ligated P450 variant, P411-C10, yielded a lineage of engineered P411 enzymes that together accommo

181 demic planning.IMPORTANCE A recently emerged lineage of human-like H3N2 (H3.2010.1) influenza A virus

182 he stages, ImageAEOT generates an artificial lineage of this cell based on the population characteris

183 Sauropods were among the most diverse lineages of dinosaurs, with an ample geographic distribu

184 We detected four different paternal lineages of domestic sheep and resolved, at the global l

185 enetic reporter mice, we identified discrete lineages of intestinal antigen-specific CD8(+) T cells,

186 nce of prophages in cultures of the dominant lineages of marine bacteria has contributed to an ongoin

187 Currently, viruses of two distinct lineages of parvoviruses (PVs, family Parvoviridae; subf

188 vidence for significantly more transmissible lineages of SARS-CoV-2 due to recurrent mutations.

189 radiation of Chlorophyceae and the principal lineages of the Ulvophyceae late in the Neoproterozoic E

190 al challenge with both the African and Asian lineages of ZIKV, impairing virus dissemination to brain

191 pulation to position single cells of diverse lineages on the surface of defined multicellular aggrega

192 lly focused on four plants from two distinct lineages, one monocot lineage (Alismatales) and one eudi

193 mpact on liver progenitors, other endodermal lineages, or vasculature.

194 o cell-cycle-dynamic rather than tissue/cell-lineage origin.

195 We sought to quantify the lineage output and dynamics of gene-modified clones; thi

196 h representatives of earlier diverging algal lineages, P. margaritaceum has expanded repertoires of g

197 lens through which to study this variation (lineage, phenotype, and plasticity) and its relevance to

198 The development and consequences of lineage plasticity during tumorigenesis have remained my

199 Herein we review current understanding of NE lineage plasticity dynamics, exemplified by prostate can

200 A well-known pathway of lineage plasticity in cancer - the histological transfor

201 iew, we provide an overview of the impact of lineage plasticity on cancer progression and therapy res

202 served in around 10-20% of these patients is lineage plasticity, which manifests in a partial or comp

203 le for mSWI/SNF complexes in therapy-related lineage plasticity, which may also be relevant for other

204 n impact of cellular status on initiation of lineage plasticity.

205 Cells of the monocyte/macrophage lineage play a key role in providing chemokines and cyto

206 cifically cells of the nonclassical monocyte lineage, play a direct role in the pathogenesis of PH.

207 We identified a distinct AT2-lineage population, damage-associated transient progenit

208 ermline and soma formation, and then undergo lineage priming.

209 ption factor regulatory networks control the lineage programming and maturation of thymic precursor c

210 patterns of shape variation across all major lineages, reconstructed the evolutionary history of cran

211 achine learning to perform cell tracking and lineage reconstruction.

212 and Fn1 (fibronectin) expressed in the Isl1 lineages regulate PAA formation.

213 analyses suggest that the Ly6C(lo) monocyte lineage regulates PH through complement, phagocytosis, A

214 evelopment and provide new insights into the lineage relationships of the prostate epithelium.

215 tiating states with computationally inferred lineage relationships.

216 subsets fit into the bone marrow neutrophil lineage remains unclear.

217 presence or absence (wild-type or knock-out lineages, respectively) followed a strict oral/aboral pr

218 governed by molecular subtype mutations and lineage-restricted differentiation.

219 yoepithelial cells, that are maintained in a lineage-restricted manner during homeostasis or after mi

220 y evaluate blastema heterogeneity or address lineage restriction of closely related cell types.

221 developmentally important, but contentious, lineages-Shh and Cux2.

222 identified by their position in the myogenic lineage, simultaneously with the quantification of autop

223 l lineages, we find that single cells of all lineages sort to the interior of ectodermal aggregates,

224 estimates within Orthoptera, as well as the lineage-specific and dynamic patterns of evolution for h

225 Thus, our data characterize lineage-specific chromatin reconfiguration and a unique

226 Our findings provide insights into how lineage-specific crosstalk between epithelium and neighb

227 This situation illuminates multiple lineage-specific diversifications of NOSs and NO/nitrite

228 Lineage-specific epigenomic changes during human cortico

229 to test an alternative null hypothesis: that lineage-specific genes do have homologs outside of the l

230 tor" is necessary and sufficient to activate lineage-specific genes while restricting the gene expres

231 super-interactive promoters-are enriched for lineage-specific genes, suggesting that interactions at

232 which reveals 5hmC enrichment in absorptive lineage-specific genes.

233 ere, we generated a mouse model with primate-lineage-specific isoforms of C4, human C4A and/or C4B.

234 trophectoderm, and identify deeply conserved lineage-specific markers that pre-date the eutherian-mar

235 approaches for testing associations between lineage-specific rates of speciation and phenotypic evol

236 We map this increase to lineage-specific symmetrization events of normally asymm

237 However, contributions of lineage-specific TE insertions to recent regulatory adap

238 ings highlight the importance of considering lineage-specific TEs in studying evolution of gene regul

239 binding partner PAX8 (P = 2x10-10), a known lineage-specific transcription factor in OC.

240 Lineage specification is governed by gene regulatory net

241 ched in pluripotent cells whilst surrounding lineage-specified trophectoderm expresses EFNA ligands.

242 table association with one successful clonal lineage (ST258/512) yet have been mobilized among divers

243 fore differentiating into nonmyocyte cardiac lineages, such as vascular smooth muscle cells, pericyte

244 are present in a diverse array of eukaryotic lineages, suggesting an ancestral EPR-1 was a component

245 rget in prostate cancer due to its role as a lineage survival factor in prostate luminal epithelium.

246 Here, using the melanoma lineage survival oncogene MITF as a model, we show that

247 alphabeta lineage T cells, most of which are CD4(+) or CD8(+) and

248 nsic castration-resistant and self-sustained lineage that emerges early during prostate development a

249 ecific genes do have homologs outside of the lineage that, even while evolving at a constant rate in

250 labels and by flagging and delabelling virus lineages that become unobserved and hence are probably i

251 ce of the presence of two independent diderm lineages, the Halanaerobiales and the Negativicutes, wit

252 n transcriptome atlas in the entire male GSC lineage: the most dramatic switch occurs from early to l

253 s, and therefore, represents a key reference lineage to understand early origins and evolution of the

254 s that distinguish ectodermal and endodermal lineages to drive sorting have not been fully elucidated

255 differentiated into prefrontal cortex (PFC) lineages to efficiently test early-developmental hypothe

256 ogical, and disturbance-related) of dominant lineages to improve LSM representations.

257 ed oxidative stress through NADPH oxidase in lineage-traced microglia.

258 manifested as larger lesion size, increased lineage-traced SMC participation in the lesion, decrease

259 d SMC participation in the lesion, decreased lineage-traced SMCs in the lesion cap, and increased alk

260 firm the fidelity and sensitivity of the EMT lineage tracing (Tri-PyMT) model and highlight the diffe

261 Lineage tracing aims to identify all progeny arising fro

262 eterogeneity of these cells as determined by lineage tracing and single-cell sequencing in developmen

263 Lineage tracing confirmed that germ cells die as clones

264 y, we generate the most complex experimental lineage tracing dataset to date, 34,557 human cells cont

265 We performed lineage tracing experiments to determine the fates of pe

266 ncoding and optimal transport principles for lineage tracing in settings where existing experimental

267 bulk RNA sequencing, and an innovative dual lineage tracing mouse to understand the mechanism by whi

268 Tamoxifen-inducible genetic lineage tracing of mature adipocytes and single-cell RNA

269 Trajectory modeling together with lineage tracing revealed that airway and alveolar stem c

270 ostembryonic day 5 (P5) gonads and performed lineage tracing to analyze primordial follicles and wave

271 Here, we used random lineage tracing to localize and quantify clonal expansio

272 By combining Cxcr4-CreER-mediated lineage tracing with Cxcr4 inhibition or conditional Cxc

273 Using genetic lineage tracing, clonal analysis, multiplexed in situ hy

274 Using scRNA-seq profiling and genetic lineage tracing, we show that RUNX1(+) PLCs are unaffect

275 Using cell lineage tracing, we show that skate trunk vertebrae aris

276 Lineage-tracing and activity-tracing studies in the mous

277 irculating memory (TCIRCM), and TRM pools by lineage-tracing and single-cell transcriptome analysis.

278 Here, by combining lineage-tracing experiments with a model of severe gland

279 Herein we use multicolor lineage-tracing models to confirm that the mature SMC ca

280 Recent studies have applied transgenics, lineage-tracing, and transcriptomics to help decipher th

281 commonly involves both myeloid and erythroid lineage transformation.

282 show how fluctuations of cell cycles across lineage trees help in understanding the coordination of

283 and their differentiation along the myeloid lineage triggers cellular cues that drive reactivation.

284 fossil record of these otherwise terrestrial lineages until the Silurian and Devonian, respectively.

285 as targeted in the Scleraxis-expressing cell lineage using the ScxCre deletor.

286 ompare representative viruses to G1 and Y280 lineage viruses that have infected humans.

287 fferentiation of the monolayers, the EC cell lineage was significantly altered by both the culture me

288 intrinsic differences between the epithelial lineages, we find that single cells of all lineages sort

289 cible factor-1alpha in the Ly6C(lo) monocyte lineage were exposed to hypoxia.

290 phids from a non-tobacco-adapted (NTA) aphid lineage, when compared to those of a tobacco-adapted lin

291 individuals are linked to earlier Neolithic lineages, whereas on the paternal side a Steppe ancestry

292 ibody of interest and its inferred ancestral lineage, which branches in the tree are likely to harbor

293 hylogenetically diverse antibiotic-resistant lineages, widespread geographical mixing, and frequent r

294 ylococcus aureus ST45 is a major global MRSA lineage with huge strain diversity and a high clinical i

295 ans increased diversification rates in those lineages with known acoustic communication.

296 duces variability in the wild-type seam cell lineage, with a proportion of animals showing an increas

297 revealed an overall increase in innate cell lineages, with a concomitant reduction in T cell number.

298 ibrio cholerae consist of dozens of distinct lineages, with primarily (but not exclusively) members o

299 ethodology for live imaging of the germ cell lineage within floral organs of Arabidopsis using light

300 However, the presence of cryptic lineages within the upwelling zone cannot be easily acco