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1 d spatially localizes it in proximity to the lipid droplet.
2 mitochondria, the endoplasmic reticulum and lipid droplets.
3 cerols (TGs), which enable energy storage in lipid droplets.
4 the structure and composition of human milk lipid droplets.
5 rapamycin (TOR) and a marked accumulation of lipid droplets.
6 translate into the removal of Plin2 coating lipid droplets.
7 infected cells to generate large numbers of lipid droplets.
8 artitioning of cellular triacylglycerol into lipid droplets.
9 terol to the lysosomal membrane and later to lipid droplets.
10 gh a mechanism involving formation of axonal lipid droplets.
11 lesteryl esters that coalesce into cytosolic lipid droplets.
12 in important for the assembly of cytoplasmic lipid droplets.
13 ed with a decreased accumulation of TAGs and lipid droplets.
14 Atg2 expression, permitting deregulation of lipid droplets.
15 in degradation and the dynamic regulation of lipid droplets.
16 Cos7 cells, brown adipocytes, and artificial lipid droplets.
17 ipophagy, a selective autophagy that targets lipid droplets.
18 myofibroblasts through the quantification of lipid droplets.
19 receptor transcriptional activities but more lipid droplets.
20 iculum, where it is esterified and stored in lipid droplets.
21 romoted rapid lipid synthesis, hiding within lipid droplets.
22 n, decreased ATP production, and accumulated lipid droplets.
23 iosynthesis and the formation of cytoplasmic lipid droplets.
24 were able to harvest lipids from macrophage lipid droplets.
25 face, but not to mitochondria, endosomes, or lipid droplets.
26 phosphorylation and translocation of HSL to lipid droplets.
27 TART domain functions to localize Them1 near lipid droplets.
28 ue to induction of autophagic degradation of lipid droplets.
29 of peroxisomes also impact the formation of lipid droplets.
30 species but accumulate free fatty acids and lipid droplets.
31 by lipophagy as the autophagic breakdown of lipid droplets.
32 stress, and enabling normal lipid storage in lipid droplets.
36 cific class of effectors is unable to induce lipid droplet accumulation, we demonstrate that the para
40 f dynein regulation, force adaptation, where lipid droplets adapt to opposition to motion by increasi
41 se results provide a direct link between the lipid droplet and proteasomal protein degradation and su
43 d increased lipid synthesis, accumulation of lipid droplets and alter synthesis of lipid mediators.
45 evealed an association of nsP3 with cellular lipid droplets and examined the spatial relationships be
46 ent intriguing evidence of the importance of lipid droplets and hormone-sensitive lipase (HSL) in reg
49 SDP1 increased TAG accumulation in cytosolic lipid droplets and markedly enhanced plant tolerance to
50 spho-S313 is sufficient for interaction with lipid droplets and may be the virus factor that induces
51 was associated with reduced contact between lipid droplets and mitochondria, and reduced triglycerid
53 tion, thereby leading to the accumulation of lipid droplets and promoting tumor-associated macrophage
55 s the ability of influenza virus to generate lipid droplets and severely suppresses the replication o
56 erm aleurone cells, where the ER accumulates lipid droplets and synthesizes storage protein accretion
57 also inhibited invasion, due to depletion of lipid droplets and the stored lipids, which are essentia
59 massively accumulated cholesterol ester-rich lipid-droplets and surfactant had an increased proportio
60 olgi, lysosome, peroxisome, mitochondria and lipid droplet) and show how these relationships change o
61 he dynamic interface between peroxisomes and lipid droplets, and also between these organelles and th
62 of adipocytes of the fat body, feeds on host lipid droplets, and has a specific requirement for dieta
63 f the inner core (composed of the cytoplasm, lipid droplets, and nucleus) decreased by 21.7% and 22.5
65 rculosis in humans, fatty acids derived from lipid droplets are considered the major carbon source.
67 f brain tissues from GBM patients shows that lipid droplets are highly enriched in tumor tissues whil
70 blocking the KRAS-HSL axis results in fewer lipid droplets, as well as metabolic reprogramming of th
72 novo lipogenesis; mitochondrial energy use; lipid droplet assembly, lipolytic catabolism, and fatty
73 inducible protein 2 (HIG2)/hypoxia-inducible lipid droplet-associated (HILPDA) as lipid droplet (LD)
74 Loss of OGT decreases O-GlcNAcylation of lipid droplet-associated perilipin 1 (PLIN1), which lead
76 NAFLD histology and identify the enzyme as a lipid droplet-associated RDH; our data suggest that HSD1
78 ets and may be the virus factor that induces lipid droplet biogenesis in rotavirus-infected cells.
79 gnificantly reduced the formation of hepatic lipid droplets, body weight gain, blood glucose, and imp
80 daquiline accumulated primarily in host cell lipid droplets, but heterogeneously in mycobacteria with
83 e that metformin reduces the accumulation of lipid droplets by increasing autophagic flux in vascular
84 was quantified by digital image analysis of lipid droplets, by measurement of basolateral triglyceri
85 ability of oil-in-water emulsions containing lipid droplets coated by CNCs/LAE complexes was determin
86 ept IMF with large, milk phospholipid-coated lipid droplets comprised of 48% dairy lipids (n = 115).
87 formula with large, milk phospholipid-coated lipid droplets containing dairy lipids is safe, well tol
88 , induces accumulation of perilipin 2-coated lipid droplets containing triglycerides enriched in C18:
89 ntil 17 wk of age: 1) Control IMF with small lipid droplets containing vegetable oils (n = 108); or 2
90 knockdown (KD) of LSD2 impaired formation of lipid droplet-containing adipocytes and down-regulated b
91 phK2-deficient macrophages have increases in lipid droplet-containing autophagosomes and autolysosome
95 , inhibition of PLA2 significantly decreased lipid droplets, decreased oxidative phosphorylation, and
96 enzymes correlated with reduced capacity for lipid droplet degradation and several alterations in the
98 , mitochondria, and lipid droplets; however, lipid droplets display weaker mutual activation between
99 istological stain for cellular membranes and lipid droplets due to its unrivaled fluorescent properti
102 nanomolar concentration to selectively stain lipid droplets emitting an intense and bright fluorescen
103 mark contact sites with ER and mitochondria, lipid droplets, endosomes, or plasma membrane, whereas d
106 depletion of the Ampkbeta1 subunit restores lipid droplet formation in E4bp4-LKO primary mouse hepat
108 induced by palmitate treatment, and promoted lipid droplet formation in sensory neurons, suggesting t
109 ivotal genes responsible for lipogenesis and lipid droplet formation in the liver and chronic inflamm
110 c pool of phosphatidic acid, associated with lipid droplet formation in the perinuclear ER, is respon
113 doplasmic reticulum membrane morphology, and lipid droplet formation, but not on growth at elevated t
114 esulted in Opi1p being localized to sites of lipid droplet formation, coincident with increased synth
115 e.g. triacylglycerol/phospholipid synthesis, lipid droplet formation, nuclear/endoplasmic reticulum m
116 -Cas9 screen identified genetic modifiers of lipid droplet formation; surprisingly, variants of sever
117 ads to changes in genes leading to increased lipid droplets formation in hepatocytes resulting in a d
118 uring Toxoplasma infection, the induction of lipid droplet generation is conserved not only during in
120 y of the following can suppress formation of lipid droplets (>-50%) but does not interfere with the p
121 umulation of neutral lipids in intracellular lipid droplets has been associated with the formation an
122 s a mechanism by which cytokines can control lipid droplet homeostasis and consequently resistance to
123 ions including microsomes, mitochondria, and lipid droplets; however, lipid droplets display weaker m
125 ion of oleic acid increased the frequency of lipid droplets in both C. neoformans and macrophages.
131 sport through the formation of intracellular lipid droplets in sensory neurons.SIGNIFICANCE STATEMENT
135 g adipocytes exhibited lower accumulation of lipid droplets, in line with the lower concentrations of
136 cognized role for bmm function, and possibly lipid droplets, in these cell types in the regulation of
137 ing the mechanism of NSP2-mediated viroplasm/lipid droplet initiation and interaction will lead to ne
138 ation and suggest that dynamic regulation of lipid droplets is a key aspect of some proteotoxic stres
142 s known for its critical role in controlling lipid droplet (LD) assembly at the LD-forming subdomain
143 h triacsin C, a fatty acid analogue, impairs lipid droplet (LD) biogenesis and ERAD, suggesting a rol
144 onserved protein, plays pivotal roles during lipid droplet (LD) biogenesis and is associated with var
147 rther investigate the function of DRP1 on ER-lipid droplet (LD) dynamics and the metabolic subsequenc
150 This study was designed to characterize lipid droplet (LD) formation in EC by manipulating pathw
153 are localized to endoplasmic reticulum (ER)-lipid droplet (LD) junctions where they mediate the dire
156 protein Snx14, an endoplasmic reticulum (ER)-lipid droplet (LD) tethering protein, as a factor requir
158 a phase-separated cellular constituent, the lipid droplet (LD), contributes to its antibacterial act
160 ductase domain containing flavoprotein, as a lipid droplet (LD)-associated protein highly enriched in
161 ed by the metalloprotease ADAM17/TACE, and a lipid droplet (LD)-mediated mechanism of protecting reti
163 tion of autophagy induces an accumulation of lipid droplets (LD) due to a decrease in fatty acid beta
165 t excess lipids, stored in organelles called lipid droplets (LD), are a key resource to fuel the ener
166 d significant increase in size and number of lipid droplets (LD), distance between the cisterns of ro
167 dden glucose depletion, yeast cells activate lipid-droplet (LD) consumption through micro-lipophagy (
168 Bovine luteal tissue contained abundant lipid droplets, LD-associated perilipins 2/3/5, hormone-
169 increased ACAT activity reduced the size of lipid droplets (LDs) and inhibited lipolysis and insulin
170 pose tissue on the ultrastructure of cardiac lipid droplets (LDs) and the expression and organization
174 Storage and consumption of neutral lipids in lipid droplets (LDs) are essential for energy homeostasi
190 ramuscular triglyceride (IMTG) stored within lipid droplets (LDs) does not directly contribute to ske
196 mics of single fatty acid analogs (FAas) and lipid droplets (LDs) in living yeast and mammalian cells
197 ctive was to identify the characteristics of lipid droplets (LDs) in ovarian steroidogenic cells.
198 in motors are recruited to triglyceride-rich lipid droplets (LDs) in the liver by the GTPase ARF1, wh
199 patocytes metabolize energy-rich cytoplasmic lipid droplets (LDs) in the lysosome-directed process of
200 tested whether the fraction of PLIN5-coated lipid droplets (LDs) is a determinant of skeletal muscle
203 ophic seedling growth, for which cytoplasmic lipid droplets (LDs) play a critical role as depots for
209 ing lipid species and a drastic reduction of lipid droplets (LDs) that play a critical role in virus
210 that CDCP1 depletes lipids from cytoplasmic lipid droplets (LDs) through reduced acyl-CoA production
215 y whereby cytoplasmic constituents including lipid droplets (LDs), storage compartments for neutral l
216 l infection by promoting the accumulation of lipid droplets (LDs), which robustly enhanced the format
230 tinct biosynthetic steps onto the surface of lipid droplets leads to efficient production of terpenoi
231 triglyceride metabolism, suggesting a novel lipid droplet-mediated pathway which may be targeted for
233 physicochemical environment has on both the lipid droplet microstructure and the lipid release patte
234 ept IMF with large, milk phospholipid-coated lipid droplets (mode diameter 3-5 mum) containing vegeta
235 nt infant milk formulas (IMFs) contain small lipid droplets (mode diameter ~0.5 mum) primarily coated
236 indices of generalized adipogenesis, such as lipid droplet morphology and fatty acid binding protein
239 ion to the nuclear envelope (NE) and nuclear lipid droplets (nLDs) and rapid dephosphorylation of pS3
240 2 or perilipin 3 in LiSa-2 cells influenced lipid droplet number and size as well as cell vitality.
242 with triglyceride accumulation and increased lipid droplet numbers in vitro, and decreased ketogenesi
244 yte TAGs are stored transiently as cytosolic lipid droplets or incorporated into lipoproteins (chylom
245 c cargo (e.g., proteins, protein aggregates, lipid droplets or organelles) to the vacuole (lysosome i
247 t these host organelles, which suggests that lipid droplets play a critical role at the coccidian hos
248 -chain fatty acyl-CoAs that are derived from lipid droplets, preventing their use as fuel for thermog
249 ated NSP2 colocalizes with rotavirus-induced lipid droplets prior to the accumulation of other rotavi
250 ormation in sensory neurons, suggesting that lipid droplets protect sensory neurons from lipotoxicity
258 in mediating CTL evasion, and show that the lipid-droplet-related gene Fitm2 is required for maintai
261 Plin2), a ubiquitously expressed cytoplasmic lipid droplet scaffolding protein, is hypothesized to co
263 ipocytes to blue light resulted in decreased lipid droplet size, increased basal lipolytic rate and a
267 anges in the perilipin (PLIN) content of the lipid droplets storing intramuscular triglyceride (IMTG)
268 ct that TGs and SEs are the typical cargo of lipid droplets suggests that these organelles could be c
270 In this study, we identified Ces3 as a major lipid droplet surface-targeting protein in adipose tissu
271 a lesser extent WD10784, increases lipid and lipid droplet synthesis and storage without restricting
273 orting a glycolytic phenotype and storage of lipid droplets that enable their adaptation and survival
275 tion results in increased biogenesis of host lipid droplets through rewiring of multiple components o
276 e hyperspectral-SRS imaging of intracellular lipid droplets to identify a previously unknown suscepti
277 ysosome-mediated catabolism of intracellular lipid droplets to impede the development of atherosclero
278 leus-vacuole junctions (NVJs) cooperate with lipid droplets to maintain viability and enhance NPC for
279 when overexpressed, relocalizes VPS13A from lipid droplets to subdomains of the endoplasmic reticulu
280 al. (2019) reveal that enteroviruses recruit lipid droplets to support lipid synthesis required for t
281 ncreased trafficking of cholesterol from the lipid droplets to the mitochondria, which was dependent
282 targets (solid polystyrene beads and liquid lipid droplets) to investigate the influence of size on
283 including components of glucose metabolism, lipid droplet trafficking, and cytoskeletal organization
284 y disrupted lipolysis without affecting ATGL lipid droplet translocation or ABHD5 interactions with p
286 t 405 nm, DAF immediately and brightly stain lipid droplets using a blue channel (410-500 nm) and cyt
288 somes and defective lysosomal degradation of lipid droplets via autophagy with an impaired luminal ac
295 f FSP27beta resulted in the fractionation of lipid droplets, whereas its overexpression decreased the
296 ted checkpoint forces these cells to utilize lipid droplets, which could potentially lead to therapeu
298 from PMP22-deficient mice contained abnormal lipid droplets, with both mRNA and protein levels of apo
299 th this, we observed significantly increased lipid droplets, with subsequent mobilization to mitochon
300 d metabolism, peroxisomes share a niche with lipid droplets within the endomembrane-secretory system.