ライフサイエンスコーパス: lipidic

1 iso-nitrogenous (42% crude protein) and iso-lipidic (12% lipid) diets, such as high (35%) and low (1

2 ional change is primarily dependent upon the lipidic aldehyde studied, not the protein sequence.

3 A series of 25 chiral anti-cancer lipidic alkynylcarbinols (LACs) were devised by introduc

4 as a proof-of-concept, we show that generic lipidic alkynylcarbinols can be devised to be bioactivat

5 densation of lipidic isocyanides either with lipidic amines and oligosaccharidic acids or with fatty

6 DNA nanostructures with lipidic anchors are promising as membrane protein mimics

7 res of the alpha3beta4 nicotinic receptor in lipidic and detergent environments, using functional rec

8 roved efficient in the ligation to peptidic, lipidic and fluorescently labeled amines and in macrocyc

9 ing proved benefits of those on weight, BMI, lipidic and glucose profile, inflammatory markers.

10 this novel bioactive packaging enriched with lipidic and inorganic nanomaterials represents an innova

11 Cisternae appear to contain considerable lipidic and other material and to contain a substantial

12 tween chemical compounds present in dust and lipidic and phenotypic profiles in the cells.

13 dismutase, catalase, glutathione peroxidase, lipidic and protein peroxidation).

14 osol fluid (MAF) based on the water-soluble, lipidic, and cellular constituents of necrotic tuberculo

15 Thus, complexes formed in the presence of a lipidic antagonist to fusion are incompletely assembled,

16 ore with less stressed membrane, and becomes lipidic as it dilates, bending membrane into a highly cu

17 e the bending rigidity and tilt modulus, for lipidic assemblies of arbitrary lipid composition and sh

18 lowing to quantify the elastic properties of lipidic assemblies of arbitrary shape and composition (i

19 Our results suggest a model for the lipidic Bak pore, whereby the mitochondrial targeting C-

20 e amine oxide detergent micelles, whereas in lipidic bicelles a higher population of dimeric and high

21 gh rational design based on an extrahelical, lipidic binding site.

22 treatment was seen to cause the inclusion of lipidic bodies into the nucleus.

23 us, and in the number, size, and location of lipidic bodies.

24 mulatory compounds were neither peptidic nor lipidic but instead were composed of sulfur and aromatic

25 inuity between the two adherent membranes is lipidic, but not aqueous.

26 s, solid lipid nanoparticles, nanostructured lipidic carriers and supramolecular carriers, which alte

27 The lipidic chlorophyll a and beta-carotene (beta-car) in cy

28 was a significant (P<0.001) reduction in the lipidic component of plaques in the regression group, an

29 ution MRI accurately quantifies fibrotic and lipidic components of atherosclerosis in this model.

30 hanism for regulation of HCN channels by the lipidic components of the membrane.

31 trol fluidity homeostasis, we quantified the lipidic composition of insect SF9 and mammalian HEK 293T

32 usefulness of this technique to analyse the lipidic composition of margarine in a quick and easy way

33 he synaptic vesicle cycle require a specific lipidic composition of presynaptic and vesicle membranes

34 ve and their open probability depends on the lipidic composition of the membrane in which they reside

35 Hundreds of cytotoxic natural or synthetic lipidic compounds contain chiral alkynylcarbinol motifs,

36 rs to be significant sources of phenolic and lipidic compounds, with the latter cultivar also represe

37 ave studied the kinetics of establishing the lipidic connection between hemagglutinin-expressing cell

38 ral fusion proteins apparently involve local lipidic connections that evolve into a bilayer septum in

39 s to have great interactive surface with the lipidic content of the solution.

40 s to detect the cancerous samples due to the lipidic content of their secretions.

41 Knowledge of the lipidic contribution will hopefully inspire development

42 ration of the tryptophan side chain into the lipidic core stabilizes the membrane-bound conformation.

43 leogel mixtures and influenced the growth of lipidic crystal network.

44 pped oleogels were structured by layer(s) of lipidic crystals surrounding the air bubbles, which had

45 0% in the oleogel samples containing smaller lipidic crystals.

46 mbrane proteins uses a spontaneously forming lipidic cubic mesophase.

47 hough reconstitution of membrane proteins in lipidic cubic mesophases plays a prominent role in membr

48 omes, reconstitution of membrane proteins in lipidic cubic mesophases presents significant challenges

49 alyzing the beta2AR unfolding temperature in lipidic cubic phase (LCP) as a function of cholesterol c

50 The application of lipidic cubic phase (LCP) bilayer media for crystallizat

51 Lipidic cubic phase (LCP) crystallization has proven suc

52 We used GPCR engineering and lipidic cubic phase (LCP) crystallization to determine t

53 receptor (GPCR) family have established the lipidic cubic phase (LCP) environment as the medium of c

54 serial femtosecond crystallography (SFX) in lipidic cubic phase (LCP) for protein structure determin

55 acterize membrane protein (MP) properties in lipidic cubic phase (LCP) is important for studying comp

56 izing G protein-coupled receptors (GPCRs) in lipidic cubic phase (LCP) often yields crystals suited f

57 Lipidic cubic phase (LCP) provides a suitable stabilizin

58 ZM241385 has previously been crystallized in lipidic cubic phase (LCP), structural differences in the

59 es on the use of lipids capable of forming a lipidic cubic phase (LCP).

60 as a G protein, requires crystallization in lipidic cubic phase (LCP).

61 for membrane protein crystallization uses a lipidic cubic phase as the hosting medium.

62 however, an X-ray structure solved from the lipidic cubic phase for one peptide reveals an alternati

63 ing local rearrangement of the highly curved lipidic cubic phase into a lamellar structure, which is

64 Crystals obtained in the lipidic cubic phase reveal the binding site of an endoge

65 Here we present a lipidic cubic phase SFX structure of the light-driven pr

66 nism, we have examined the properties of the lipidic cubic phase system and the dynamics of the GPCR

67 and soluble additives into the bicontinuous lipidic cubic phase under excess hydration are summarize

68 ork is the first incorporation of NKA into a lipidic cubic phase with consequent enzyme functionality

69 rotein crystallogenesis and transport in the lipidic cubic phase, the nature of the interaction betwe

70 h quality membrane protein crystals from the lipidic cubic phase.

71 grown in a membrane mimetic matrix known as lipidic cubic phase.

72 ns, they would assemble to form bicontinuous lipidic cubic phases (LCPs) that exhibit the well-known

73 Transient lipidic cubic phases form in trans-chain phospholipid/bu

74 yoEM, we demonstrate the formation of stable lipidic cubic phases in hydrated lipid/solvent (cis-chai

75 ept of membrane protein crystallization from lipidic cubic phases, "in cubo", has yielded well-ordere

76 Because of the plasticity of lipidic cubic phases, it is envisaged that when mixed wi

77 croED structure of full-length human MP20 in lipidic-cubic phase to a resolution of 3.5 angstrom.

78 teins have established the usefulness of the lipidic-cubic phases (LCPs) in the field of crystallogra

79 rial surfaces of land plants are coated by a lipidic cuticle, which forms a barrier against transpira

80 d compromised starvation survival and formed lipidic cysts instead of tumors, suggesting defective ut

81 et of lipid bilayers to bury its hydrophobic lipidic domain, leaving the hydrophilic polysaccharide c

82 ative ETC that uses rhodoquinone (RQ) as the lipidic electron transporter and fumarate as the final e

83 However, exactly how fatty acids and lipidic elements are transported across the cell envelop

84 ll biosynthesis by exporting fatty acids and lipidic elements of the cell wall.

85 facilitate the transport of fatty acids and lipidic elements to the mycobacterial cell wall remains

86 erol), present in Apis mellifera honey, is a lipidic entomological marker secreted by the salivary gl

87 with a positively stained core enclosed in a lipidic envelope with a mean diameter of 74 +/- 14 nm.

88 These structures were solved in a lipidic environment and are complemented by electrophysi

89 ytochrome, MtrA, insulated from the membrane lipidic environment by embedding within a 26 strand beta

90 sm experiments to show that Cu(I) ions and a lipidic environment drive the insertion of the Nterm int

91 ous studies demonstrating a requirement of a lipidic environment for optimal activity with this enzym

92 ures of the human a7 nicotinic receptor in a lipidic environment in resting, activated, and desensiti

93 ed proteins can elucidate how changes in the lipidic environment modulate membrane protein stability.

94 In a lipidic environment, Rv3806c is trimeric, creating a Ubi

95 bility limitations of phenolic acids in many lipidic environments are now greatly improved by their e

96 constituting transmembrane proteins in their lipidic environments remains challenging and standard ap

97 ences for different PA species in particular lipidic environments were compared.

98 apoptotic BNIP3 protein dimerizes tightly in lipidic environments, and that this association has a st

99 rmediate (I1) on pathway to the formation of lipidic fibrils, which incorporate lipid molecules on pr

100 may have an important role to tune ionic and lipidic flows through the pulmonary surfactant membrane

101 fferent chemical compounds produced from the lipidic fraction of different foodstuffs.

102 onance ((1)H NMR) has been used to study the lipidic fraction of margarines of different compositions

103 Rather, these results support the model of a lipidic fusion pore developing within a hemifused contac

104 essary for successful fusion, during which a lipidic fusion pore develops in a local and transient he

105 the plasma membrane, forming a ~4-nanometer lipidic fusion pore flanked by putative soluble NSF-atta

106 his suggests that fusion is completed when a lipidic fusion pore with net positive curvature is forme

107 exes likely contribute part of a protein and lipidic fusion pore.

108 We have developed a lipidic gene transfer vector, LPDII, where DNA was first

109 led receptor (GPCR), with more similarity to lipidic GPCRs than to the homologous peptidic GPCRs.

110 ion of fusion proteins in the context of the lipidic hypothesis of fusion.

111 ing that the pores are narrow and not purely lipidic in structure.

112 ance varies widely, another model proposes a lipidic initial pore.

113 bilayers through two semistable, nonlamellar lipidic intermediate states to a fusion pore.

114 ined by means of Ugi reactions incorporating lipidic isocyanides as surrogates of sphingolipids.

115 of glycolipid frameworks by condensation of lipidic isocyanides either with lipidic amines and oligo

116 on of aliphatic, dipeptidic, glucosidic, and lipidic isocyanides with several amino acids, thus givin

117 : a rupture-insertion pathway leading to the lipidic junction and a hemifusion-stalk pathway leading

118 on diaphragm and a novel structure termed a 'lipidic junction'.

119 Liposomes with lipidic junctions were ruptured with membrane edges stab

120 essential for the transition of I1 to mature lipidic L2 fibrils.

121 , a hybrid bilayer nanodomain forms with one lipidic leaflet and one peptidic leaflet.

122 Highly lipidic lesions (851 [24%] of 3500 lesions, present in 5

123 The lipidic liquid-crystalline cubic phase (LCP) is a membra

124 n MRI and histopathology for the analysis of lipidic (low signal on T2W, r = 0.81) and fibrous (high

125 gin of the formation of the known classes of lipidic lyotropic liquid crystalline phases, their struc

126 Storage of lipidic material and altered lysosomes were detected in

127 show that its correct reconstitution in the lipidic matrix can be used to generate macroscopic proto

128 process to extend the use of anthocyanins in lipidic media.

129 In vitro, the lipidic mediator resolvin D1 (RvD1) down regulated the M

130 The lipidic mediator RvD1, which stimulates Abeta phagocytos

131 The effect of incorporating the lipidic medium-chain triglyceride (MCT) into polymeric f

132 rotein translocation across membranes with a lipidic membrane pore being a transient translocation in

133 e, which in turn triggers the formation of a lipidic membrane pore with a putative toroidal structure

134 in membrane insertion and the formation of a lipidic membrane pore, the key intermediate in unconvent

135 mbrane tension facilitating the formation of lipidic membrane pores.

136 membrane leaflet, inducing the formation of lipidic membrane pores.

137 ch rapidly and stably integrates cargos into lipidic membranes of nanocarriers after simple mixing th

138 All living cells are surrounded by lipidic membranes that separate metabolic and macromolec

139 ein in lipid bilayers through the use of the lipidic mesophase method, and determined its structure a

140 tions of membrane protein crystallization in lipidic mesophases and for studies of the suitability of

141 ions for the mechanism of crystallization in lipidic mesophases as discussed.

142 d selective membrane protein transporters in lipidic mesophases, exemplified by the bacterial ClC exc

143 for crystallogenesis of membrane proteins in lipidic mesophases.

144 he crystallization of membrane proteins from lipidic mesophases.

145 the crystallization of membrane proteins in lipidic mesophases.

146 salts and the addition of key enzymes of the lipidic metabolism in the INFOGEST digestion method on s

147 peptide synthetases (NRPSs) produce complex lipidic metabolites by using a thio-template mechanism o

148 hat an insect endosymbiont acquires specific lipidic metabolites from the transport lipoproteins in t

149 se results show that a family of chlorinated lipidic metabolites is produced from alpha-chloro fatty

150 ty to sense pathogens and commensals through lipidic metabolites.

151 ation and redirection of fatty acids towards lipidic metabolites.

152 n using LC-QTOF-MS and GC-Q-MS for polar and lipidic metabolites.

153 cells, LXR agonists reduced SR-B1-dependent lipidic-micelle-induced Erk phosphorylation.

154 by numerical modelling reveal that these non-lipidic microgels not only decrease boundary friction by

155 o) by mechanisms that may involve endogenous lipidic modulators.

156 Compound 3, which bore a lipidic moiety in a branched tetramer structure, showed

157 totype system, giant lipids resemble natural lipidic molecules by capturing their essential features.

158 A lipidic N,N'-dimethylethylenediamine derivative (4) cont

159 trate in vivo a postformulation strategy for lipidic nanocarrier functionalization with the use of a

160 ation to achieve multiplexing capability for lipidic nanocarriers.

161 substrate-bound human ABCB1 reconstituted in lipidic nanodiscs, revealing a single molecule of the ch

162 metal ionophores in Mtb's metal-fluctuating lipidic niche.

163 ins, most of which were related to different lipidic oxidation in the two classes of pasta.

164 in the long-range transport of extracellular lipidic particles, enabling embryonic growth.

165 on, the stalk or rhombohedral phase exhibits lipidic passages (stalks) between adjacent bilayers, rep

166 ide, designated mycoketide, which contains a lipidic pathogen-associated molecular pattern.

167 aluable insights into asthma mechanisms once lipidic peroxidation assessed by urinary metabolomics is

168 ish, membrane adhesion and fusion on a novel lipidic platform suitable for imaging by fluorescence mi

169 ay important role in the sealing function of lipidic polymers in planta.

170 n sum, we propose that activated Bax induces lipidic pore formation and that MOM proteins assist clea

171 t are at least partially composed of lipids (lipidic pore formation).

172 Corresponding to a physical theory for lipidic pore formation, Bax potently diminished the line

173 Using a theory for lipidic pore formation, we analyzed these data to quanti

174 ince the membrane monolayer must bend during lipidic pore formation, we here explore the effect of in

175 s developed that describes the dynamics of a lipidic pore in a liposome.

176 The edge tension of a lipidic pore is calculated by using the theory to quanti

177 osis, enabling the proposal of a BAK-induced lipidic pore with the topography of a "worm hole."

178 ent with a decrease in the line tension of a lipidic pore.

179 lity data are inconsistent with formation of lipidic pores capable of transporting megadalton-sized m

180 Evidence suggests that the formation of such lipidic pores is a major mechanism for alpha-pore-formin

181 s with diameters of 25-100 nm, suggestive of lipidic pores.

182 dimers form disordered clusters to generate lipidic pores.

183 oil rich in docosahexaenoic acid (DHA-OR) on lipidic postprandial oxidative stress in Wistar rats.

184 de level and antioxidant status related to a lipidic postprandial state.

185 This work compared the (1)HNMR lipidic profile of chicken eggs produced in conventional

186 ffspring survival, such as the production of lipidic-rich parental milk in mammals.

187 The deleterious effects of ammonium-based lipidic salts on cellular processes have been well-estab

188 Here, we show that the lipidic secretome from the opportunistic pathogen Pseudo

189 ted into membranes at SecYEG or from SecA at lipidic sites.

190 These results suggest that the shift in PUFA lipidic species caused by the absence of Elovl5, in the

191 ing to a reduction in the energy of a purely lipidic stalk by several tens of k(B)T.

192 To determine the lipidic structure of the pore, the pores in peptide-lipi

193 to the production of the various contrasting lipidic structures that are assembled together to give r

194 at the protein epsin 1 induces highly curved lipidic structures when added with clathrin to appropria

195 ts blocking of an access route for a natural lipidic substrate.

196 The structures show cavities for both lipidic substrates, which converge at the active site.

197 nnector indicates a defined interaction with lipidic surfaces, suggesting that, when bound to larger

198 routines to align MD trajectories of complex lipidic systems, to determine the water/lipid interface,

199 , wherein two of the components provided the lipidic tails while a third one incorporated either the

200 A panel of lipidic tetraalkylammonium chlorides has been prepared a

201 The lipidic vesicle envelope is apparently a functional anal

202 Previous studies reported numerous lipidic vesicles in the sorghum root hair and speculated

203 A domain and several chimeric variants with lipidic vesicles was examined here by isothermal titrati