ライフサイエンスコーパス: lipidomics

1 rometry after direct infusion (i.e., shotgun lipidomics).

2 ro-Raman assay designed for single-organelle lipidomics.

3 an increasingly prominent discipline called lipidomics.

4 on the brain lipidome, we performed Shotgun Lipidomics.

5 with serum total and LDL cholesterol, and AT lipidomics.

6 t often used for untargeted metabolomics and lipidomics.

7 tleneck in high-throughput bottom-up shotgun lipidomics.

8 quencing, targeted metabolomics, and shotgun lipidomics.

9 on; this presents an analytical challenge in lipidomics.

10 on mass spectrometry (DIMS) metabolomics and lipidomics.

11 e ionization detection and mass spectrometry lipidomics.

12 ification remains a significant challenge in lipidomics.

13 idimensional mass spectrometry-based shotgun lipidomics.

14 uantification of lipids is a primary goal in lipidomics.

15 hogenesis of diseases but are challenging in lipidomics.

16 seful for a diverse range of applications in lipidomics.

17 y protein arrays and mass spectrometry-based lipidomics.

18 alysis, including proteomics, glycomics, and lipidomics.

19 were quantified using high-coverage targeted lipidomics.

20 issue as revealed by untargeted and targeted lipidomics.

21 reat interest for basic science and clinical lipidomics.

22 hromatography-mass spectrometry, and shotgun lipidomics.

23 ids has become a high impact goal in shotgun lipidomics.

24 rent to conventional mass spectrometry-based lipidomics.

25 d identification for LC-MS and MALDI imaging lipidomics.

26 Plasma metabolomics and lipidomics (1871 biochemicals) revealed 18 markedly elev

27 Lipidomics, a major part of metabolomics, constitutes th

28 In direct infusion/injection (or shotgun) lipidomics, accurate downstream identification and quant

29 nterventions for CM through metabolomics and lipidomics advances.

30 Metabolomics and lipidomics aim to profile the wide range of metabolites

31 Current mass spectrometry-based lipidomics aims to comprehensively cover wide ranges of

32 Mass-spectrometry-based lipidomics aims to identify as many lipid species as pos

33 Lipidomics aims to quantitatively define lipid classes,

34 Although shotgun lipidomics allows for high-throughput analysis, low-abun

35 Finally, gene expression and lipidomics analyses cells revealed that LXRbeta regulate

36 Transcriptomes and lipidomics analyses indicate that Notch activation suppr

37 Quantitative proteomics/lipidomics analyses revealed that the combined treatment

38 Accordingly, lipidomics analyses show increased PE levels in yeast su

39 Hormone and lipidomics analyses showed higher levels of JA, JA-isole

40 Mechanistically, lipidomics analyses showed that increased ceramides in P

41 In-depth lipidomics analyses showed that loss of MEK5/ERK5 pertur

42 Fatty acid incorporation and lipidomics analyses showed that LPIN1 knockdown blocks p

43 S-based FAHFA hydrolysis assays, LC-MS-based lipidomics analyses, and activity-based protein profilin

44 allow for a combined proteomics-metabolomics-lipidomics analysis (Multi-ABLE).

45 Here we highlight a variety of methods for lipidomics analysis at the tissue, cellular and subcellu

46 lasses prior to analysis, the "comprehensive lipidomics analysis by separation simplification" (CLASS

47 onstrating the potential for high-throughput lipidomics analysis by this approach.

48 Lipidomics analysis during zebrafish development demonst

49 Comparative lipidomics analysis identified more than 1,000 molecular

50 main existing lipid name dialects enabling a lipidomics analysis in a high-throughput fashion, and (3

51 Using global lipidomics analysis in experimental traumatic brain inju

52 s been demonstrated to be a powerful tool in lipidomics analysis in which the differentiation of the

53 ss spectrometry (MS) have made comprehensive lipidomics analysis of complex tissues relatively common

54 A systematic lipidomics analysis of LPO in the interaction of Arabido

55 Lipidomics analysis of lungs from post-natal day 7, day

56 Lipidomics analysis of the kdsr(I105R) mutant revealed c

57 tography tandem mass spectrometry (LC-MS/MS) lipidomics analysis of tissue extracts prepared using tw

58 Shotgun lipidomics analysis performed on mutant alleles of the p

59 s a primary hallmark of NPC1 deficiency, our lipidomics analysis revealed the buildup of several spec

60 otein level, mass spectrometry-based shotgun lipidomics analysis showed significant differences in th

61 Lipidomics analysis showed that ScBOR1p co-isolates with

62 (CLIP) in blocking MHC class II, comparative lipidomics analysis shows that human cluster of differen

63 In the present study, an advanced lipidomics analysis using high spectral resolution matri

64 of the lipid concentration levels in shotgun lipidomics analysis was tracked over a period of 3.5 yea

65 n with the Folch extraction-based whole lung lipidomics analysis.

66 extraction is usually the first step toward lipidomics analysis.

67 umentation, which could be widely applied in lipidomics analysis.

68 strategy provides a new tool for unsaturated lipidomics analysis.

69 d structure and concentrations prove to make lipidomics analytically challenging.

70 Using both lipidomics and a sterol response element reporter assay,

71 PUFA-PIs were identified using spatial lipidomics and determined to be determinant markers of m

72 HDLs were isolated, and lipidomics and differential proteomics tests were perfor

73 Mass spectrometry-based lipidomics and enzymatic assays demonstrate the targetin

74 We applied mass spectrometry-based lipidomics and gene and protein expression measurements

75 Here lipidomics and genetic models demonstrate a central role

76 We then performed lipidomics and identified an increase in the lipokine 12

77 ights the hypothesis generating potential of lipidomics and identifies novel region-specific lipid an

78 Using siRNA combined with lipidomics and membrane fluidity assays (FRAP and Laurda

79 nalytical approach will be extended to other lipidomics and metabolomics applications.

80 ratio in direct-MS analyses (e.g., "shotgun" lipidomics and MS imaging).

81 noprecipitation, and ChIP assays, along with lipidomics and MS-based approaches, we show that increas

82 pression networks, proteomics, metabolomics, lipidomics and phenomics with informatics techniques to

83 PGE(2) formation was analyzed by lipidomics and polymorphonuclear leukocyte (PMN) infiltr

84 ere assessed through integrated and targeted lipidomics and semitargeted proteomics approaches.

85 Using mass spectroscopic lipidomics and subcellular fractionation, we demonstrate

86 otein particles were isolated for untargeted lipidomics and to quantify TG.

87 A combined lipidomics and transcriptomics analysis was performed on

88 of subcellular Raman spectro-microscopy with lipidomics and transcriptomics suggests possible lipid r

89 trospray ionization-tandem MS-based mediator lipidomics and unbiased image analysis in mouse dissocia

90 proresolving lipid mediator lipidomics and/or protein expression, and identifying as

91 rotein science, systems biology, proteomics, lipidomics, and cell biology in general.

92 ication using a combination of metabolomics, lipidomics, and metabolic tracers to measure fatty acid

93 Longitudinal proteomic, lipidomics, and metabolomic analyses revealed that hepat

94 Here, using quantitative proteomics, lipidomics, and mouse genetics, we characterize epiderma

95 The combination of metabolomics, lipidomics, and phosphoproteomics that incorporates trip

96 RNA sequencing, and undirected metabolomics, lipidomics, and proteomics, along with bioinformatics te

97 etry has earned a central analytical role in lipidomics, and this role will continue to grow with tec

98 Integrating metabolomics, lipidomics, and transcriptomics, we link changes in the

99 S) has been used to support metabolomics and lipidomics applications to facilitate the separation and

100 In addition to such lipidomics applications, the exchange method should have

101 m (Waters) specifically for metabolomics and lipidomics applications; extracting polar metabolites an

102 The assessed shotgun lipidomics approach showed to be remarkably robust and r

103 Herein, we describe a shotgun lipidomics approach that exploits charge-switch derivati

104 Herein, we describe a shotgun lipidomics approach that utilizes a single-phase methyl

105 Using a nontargeted lipidomics approach, we demonstrate that plants lacking

106 Using a lipidomics approach, we demonstrated that eicosanoid pro

107 Using a targeted mass spectrometry-based lipidomics approach, we found that in db/db mice, PGE2/D

108 Using a targeted lipidomics approach, we observed that Toll-like receptor

109 Two recent studies in Cell apply lipidomics approaches to identify bioactive lipid mediat

110 mistry) and high throughput metabolomics and lipidomics approaches using mass spectrometry.

111 tly, there exist two mass spectrometry-based lipidomics approaches, one based on a division of lipids

112 Metabolomics and lipidomics are valuable tools for screening the metaboli

113 mers, particularly in an approach of shotgun lipidomics, are still missing.

114 tivity will further increase the power of MS lipidomics as a vital tool for impactful biochemical ana

115 dies, including proteomics, metabolomics and lipidomics, as well as investigations of multimodal biom

116 tor, a software that fully supports targeted lipidomics assay development.

117 first time we introduced an electrochemical lipidomics based on electrical impedance spectroscopy (E

118 Here, we used targeted lipidomics-based approaches to profile the time course o

119 All samples were differentiated using a lipidomics-based data workup employing multivariate data

120 We extended a new lipidomics-based liquid chromatographic-mass spectrometr

121 s and developed a sensitive, facile, shotgun lipidomics-based method for quantification of these comp

122 available yet in some other "omics" fields, lipidomics being one of them.

123 ncil Human Nutrition Research, and Cambridge Lipidomics Biomarker Research Initiative.

124 Causal pathways involving lipidomics, body mass index (BMI), and PWD were assessed

125 presents a tremendous improvement for tissue lipidomics by integrating genetics, fluorescence microsc

126 While shotgun lipidomics can be a sensitive approach to FA detection,

127 To exploit the specificity of LCM for lipidomics, catapulted tissue patches were directly coll

128 We used lipidomics combined with genetic and biochemical assays

129 The lipidomics community is in need of benchmark reference v

130 gest that patch clamp-assisted single neuron lipidomics could be broadly applied to investigate neuro

131 Further advancement of the discipline of lipidomics critically depends on the capability of high-

132 This nontargeted lipidomics CTS approach was applied in both positive- an

133 Lipidomics data also show an overall reduction in lipid

134 MS-DIAL 4 helps standardize lipidomics data and discover lipid pathways.

135 We demonstrate that lipidomics data generated in samples from three differen

136 ommonly used normalization methods using six lipidomics data sets from three large cohort studies (83

137 ucible and efficient analysis of HILIC-IM-MS lipidomics data, we developed an open-source Python pack

138 id enrichment analyses and visualizations of lipidomics data.

139 ocessing and visualization of LC-MS/MS-based lipidomics data.

140 of nine different multivariate metabolic and lipidomics datasets with classical toxicological paramet

141 GC-MS lipidomics demonstrate that this reduction correlated wi

142 Comparative metabolomics and lipidomics demonstrated that acetate is used as a nutrit

143 Thin layer chromatography and lipidomics demonstrated that the extracted lipids were f

144 We explored metabolomics and lipidomics differences between 352 cases of islet autoim

145 We found lipidomics (Direct Infusion-Mass Spectrometry) data the

146 Lipidomics enables the assessment of hundreds of lipid s

147 Mass spectrometry (MS)-based targeted lipidomics enables the robust quantification of selected

148 In lipidomics epidemiological studies should avoid mixed-ge

149 g transcriptomics, metabolomics, proteomics, lipidomics, epigenetic modifications, and the microbiome

150 Currently, a typical lipidomics experiment may track hundreds to thousands of

151 Large-scale untargeted lipidomics experiments involve the measurement of hundre

152 hromatography (LC)-MS-based metabolomics and lipidomics experiments.

153 assignment of identifications in untargeted lipidomics experiments.

154 Shotgun lipidomics exploits the unique chemical and physical pro

155 e in 2003 and the ensuing development of the lipidomics field have revealed that lipid metabolites ar

156 ing platforms continue to spur growth in the lipidomics field, more structurally unique lipid species

157 rometry (TWIM-MS) is of high interest to the lipidomics field.

158 address the following pressing issues in the lipidomics field: (1) to simplify the implementation of

159 his review, we will discuss the potential of lipidomics for cardiovascular research.

160 idimensional mass-spectrometry-based shotgun lipidomics for global analysis of fatty acids including

161 (31)P NMR-based lipidomics has become an important topic in a wide range

162 The field of lipidomics has been significantly advanced by mass spect

163 Lipidomics has emerged as a powerful technique for large

164 Lipidomics has experienced rapid progress, mainly becaus

165 ophospholipid (LPL) species based on shotgun lipidomics has not been established.

166 Shotgun lipidomics has recently gained popularity for lipid anal

167 mass spectrometry analysis of lipids (termed lipidomics) has begun to alter our understanding of how

168 nization spectrometry, also known as shotgun lipidomics, has emerged as a rapid and powerful toolbox

169 Recent advances in lipidomics have led to identification of plentiful lipid

170 andem mass spectrometry-based lipid mediator lipidomics identified that the n-3 PUFA-derived speciali

171 Lipidomics identified two lipids previously speculated t

172 We conclude that comprehensive lipidomics images generated by MALDI-MSI report accurate

173 , transcriptomics, proteomics, metabolomics, lipidomics, immunological assays, and flux balance analy

174 supports both targeted and untargeted LC-MS lipidomics, implementing data acquisition, user-friendly

175 e of the JCI, Poss et al. conducted targeted lipidomics in a case-control study involving over 600 in

176 ples of the power of mass spectrometry-based lipidomics in addressing cell biological questions.

177 eral recent applications of metabolomics and lipidomics in CM.

178 her, by exploiting the principles of shotgun lipidomics in combination with a novel strategy of sampl

179 -MS/MS offers new possibilities for targeted lipidomics in lipoproteins as well as for oxidative stre

180 hiatry, neurology, and neuro-oncology and of lipidomics in neurology will be reviewed.

181 nges in DNA methylation, gene expression and lipidomics in response to DR and aging in female mouse l

182 Using LC-UV-MS-MS-based lipidomics in tandem with functional screening at the si

183 The results demonstrated that untargeted lipidomics, in conjunction with chemometric tools has a

184 us mean concentrations derived from the NIST Lipidomics Interlaboratory Comparison Exercise.

185 zation (MALDI) matrix for spatially resolved lipidomics investigations that reacts with lipids in Pat

186 Lipidomics is a novel and emerging research field that m

187 Thus, lipidomics is an efficient discovery tool that informs g

188 Lipidomics is an emerging field in biomedical research t

189 Modern lipidomics is largely dependent upon structural ontologi

190 A combination of nano-DESI MSI and LC-MS/MS lipidomics is particularly useful for exploring changes

191 Lipidomics is the comprehensive analysis of molecular li

192 Mass spectrometry-based lipidomics is the primary tool for the structural analys

193 of lipid species in a biological sample, or lipidomics, is a valuable approach to elucidating diseas

194 friendly online workflow which leverages the lipidomics knowledge base and resources of the LIPID MAP

195 most significant challenges in contemporary lipidomics lies in the separation and identification of

196 a seasoned community of wet lab scientists, lipidomics lies significantly behind proteomics in the a

197 oris-supplemented mice were characterized by lipidomics mass spectrometry analysis.

198 mpact on whole-body physiology, we performed lipidomics, metabolomics, and RNA-seq analyses on a mous

199 files including proteomics, transcriptomics, lipidomics, metabolomics, autoantibodies and immune cell

200 the isotopic distribution in the context of lipidomics, metabolomics, glycoscience, or even space ex

201 The lipidomics method was applied to serum samples from 192

202 peripheral organs as determined via targeted lipidomics methods.

203 published genome-wide association studies of lipidomics (n=4034) and BMI (n=734 481), and genetic ass

204 e aimed to link single lipid metabolites and lipidomics networks to the risk of developing HF.

205 Furthermore, lipidomics networks were linked to HF risk in a multiste

206 Shotgun lipidomics of adipose tissue from wild-type mice demonst

207 icle presents a novel method for small-scale lipidomics of bacterial cells by integrating extraction

208 Lipidomics of human blood plasma is an emerging biomarke

209 Lipidomics of Pxmp2(-/-)mammary fat pad showed a decreas

210 Shotgun lipidomics of skeletal muscle revealed a decreased conte

211 ts can be used for comprehensive, untargeted lipidomics of the most abundant lipid species in whole b

212 Electrical lipidomics of the secretome shed new lights in cell free

213 Because lipidomics offers a biologically and analytically attrac

214 Lipidomics on platelet membrane extracts showed that pso

215 ids that accumulate in obesity, we performed lipidomics on quadriceps muscles from obese mice with im

216 r disease (CVD).METHODSWe performed targeted lipidomics on serum samples from individuals with famili

217 trometry, either by direct infusion (shotgun lipidomics) or coupled with liquid chromatography.

218 nd validated 2 lipid metabolites and several lipidomics patterns as potential novel biomarkers of HF

219 gested that MELDI will contribute to current lipidomics pipelines with a deeper level of structural i

220 Our expanded targeted lipidomics platform (569 species across 32 classes) allo

221 lipids were performed using the established lipidomics platform based on ultra-performance liquid ch

222 s rationale, this study presents a validated lipidomics platform to map the fecal lipidome, which int

223 ays of recovery, analysed using metabolomics/lipidomics platforms and compared to exercise controls.

224 ation and the application of high-throughput lipidomics platforms.

225 website, long recognized as a leading global lipidomics portal.

226 Lipidomics profiling covering >1000 lipids was performed

227 This study applied mass spectrometry-based lipidomics profiling to population-based cohorts and ide

228 Using combined lipidomics, proteomics and bioinformatics, we isolated a

229 own method, 'nativeomics', unifying 'omics' (lipidomics, proteomics, metabolomics) analysis with nati

230 Contemporary lipidomics protocols are dependent on conventional tande

231 Quantitative bottom-up shotgun lipidomics relies on molecular species-specific "signatu

232 Shotgun lipidomics relies on the direct infusion of total lipid

233 crochip-based lipid extraction into cellular lipidomics research.

234 o facilitate prediction of CCS in broadscale lipidomics research.

235 main limitations for LC-MS-based untargeted lipidomics reside in the lack of adequate computational

236 The lipidomics results showed that there was a significant a

237 Within a gender-restricted cohort lipidomics revealed a compositional signature that indic

238 Metabolomics and lipidomics revealed dysregulated metabolites in AMD RPE

239 Lipidomics revealed large numbers of eoxPL formed within

240 Targeted lipidomics revealed that LEI105 concentration-dependentl

241 Genome-wide genetic screens and lipidomics revealed the dynamics of DoxSL accumulation a

242 ion with a dedicated high-resolution shotgun lipidomics routine enables both quantification and in-de

243 t ideal for high-throughput metabolomics and lipidomics screening-e.g., for clinical phenotyping, dru

244 Shotgun lipidomics showed that MUFAs were significantly reduced

245 Interrogation of the lipidomics signature revealed abnormal cardiolipin remod

246 luding contributions by the recently founded Lipidomics Standards Initiative.

247 Using untargeted and targeted lipidomics strategies, we identify two long-chain satura

248 A "shotgun" lipidomics strategy consisting of sequential functional

249 A novel mass spectrometry (MS)-based lipidomics strategy that exposes glycerophospholipids to

250 C-MS based fatty acid profiling with shotgun lipidomics strategy.

251 Plasma lipidomics studies also identified changes in etherlipid

252 Metabolomics and lipidomics studies are becoming increasingly popular but

253 ent with the oxygenation pattern observed in lipidomics studies.

254 techniques, which limits the application in lipidomics study.

255 We show by using lipidomics that thrombin-activated human platelets gener

256 (2020) show by cell-specific lipidomics that Trem2 deficiency leads to cholesterol es

257 metry-based workflow for enhanced structural lipidomics that, in a single experiment, can yield almos

258 Lipidomics, the comprehensive measurement of lipids with

259 SI-MS) is the most widely used technology in lipidomics, the potential for multiple charging presents

260 In this study we utilized lipidomics to analyze serum samples from mice exposed to

261 Here we used electron microscopy and lipidomics to characterize defects in Fatp4(-/-) mice.

262 Here, we perform comprehensive lipidomics to create a lipid network map during ZIKV inf

263 d underscore the utility of metabolomics and lipidomics to determine the underlying physiological mec

264 The new application of lipidomics to developing assays for lipolytic enzymes re

265 in combination with mass spectrometry-based lipidomics to discover that DDHD2 regulates brain trigly

266 Here, we used targeted serum lipidomics to identify a new panel of GPCs, and tested w

267 Here, we used mass spectrometry-based lipidomics to map the mediator lipidome during the trans

268 Although the application of lipidomics to platelet biology is still in its infancy,

269 We used (13)C tracers and lipidomics to probe fatty acid metabolism, including des

270 onal activation could be maintained, we used lipidomics to quantify AAMvarphi-derived eicosanoids, po

271 s spectrometry based vacuolar proteomics and lipidomics to show that recycling of two specific groups

272 in combination with chemical proteomics and lipidomics, to determine the impact of acute DAGL blocka

273 ng for developers of mass spectrometry-based lipidomics tools, (2) to offer a tool that unifies and n

274 However, the conventional lipidomics tools, such as mass spectrometry, cannot inve

275 thod expands the capabilities of Raman-based lipidomics toward the analysis of single organelles with

276 High resolution LC-MS untargeted lipidomics using data independent acquisition (DIA) has

277 A combined approach of genomics and lipidomics was applied to identify and characterize a hu

278 Eventually, the potential of fecal lipidomics was exemplified within a clinical context of

279 Lipidomics was performed on first trimester maternal pla

280 assessed at fasting state, while untargeted lipidomics was undertaken using all blood samples.

281 Here, UHPLC-MS/MS lipidomics was used to measure dynamic changes in lipid

282 roducing the disciplines of metabolomics and lipidomics, we describe a mass spectrometry-based metabo

283 on remains a bottleneck of modern untargeted lipidomics, we developed LipidHunter, a new open source

284 gms and cell sorting with RNA sequencing and lipidomics, we find that wild-type microglia acquire a d

285 volunteers and using mass spectrometry-based lipidomics, we found that n-3PUFA mainly affected the ep

286 of CRISPR-based genetic screens and unbiased lipidomics, we identified calcineurin B homologous prote

287 Here, by employing comprehensive lipidomics, we identify omega-3 (omega-3) fatty acid epo

288 ric data were collected, and biochemical and lipidomics were measured in plasma samples from particip

289 romatography-mass spectrometry (LC-MS)-based lipidomics were used to examine serum and hepatic lipids

290 erent lipid classes were profiled by shotgun lipidomics with the use of a triple-quadrupole mass spec

291 un and targeted analysis in metabolomics and lipidomics without requiring extensive in-house acquisit

292 Here, we describe a lipidomics workflow and open-source software package for

293 of the DMS separation in this unique shotgun lipidomics workflow is its ability to separate many isob

294 When integrated into a larger lipidomics workflow, LipidMatch may increase the probabi

295 uid-chromatography mass spectrometry (LC-MS) lipidomics workflow, we elucidated more than 100 isomers

296 ctable separation technique within a shotgun lipidomics workflow, with a special focus on phospholipi

297 and isomeric lipids that by standard shotgun lipidomics workflows are difficult to assess precisely,

298 to conventional LC-MS-based metabolomics and lipidomics workflows has been shown to enhance peak capa

299 nce values to assess the validity of various lipidomics workflows in providing accurate quantitative

300 ts indicate that adding CCS to databases and lipidomics workflows increases the specificity and selec