ライフサイエンスコーパス: lipoarabinomannan

1 gands, including zymosan, peptidoglycan, and lipoarabinomannan.

2 oglycan, arabinan, linker unit galactan, and lipoarabinomannan.

3 ipidated polysaccharides-arabinogalactan and lipoarabinomannan.

4 acterial lipopolysaccharide or mycobacterial lipoarabinomannan.

5 sphatidylinositol mannoside, lipomannan, and lipoarabinomannan.

6 by binding to the mannose-capped lipoglycan lipoarabinomannan.

7 in the early stage of arabinan synthesis in lipoarabinomannan.

8 its normal state and subsequent synthesis of lipoarabinomannan.

9 tic precursor of PIM4, PIM6, lipomannan, and lipoarabinomannan.

10 to phosphatidylinositol mannosides (PIMs) or lipoarabinomannan.

11 ntegrin, or with phosphatidylinositol-capped lipoarabinomannan.

12 yl-arabinogalactan-peptidoglycan complex and lipoarabinomannan.

13 cell wall antigens, such as mycolic acid and lipoarabinomannans.

14 Lipoarabinomannan, a component of the BCG cell wall that

15 sing site-specific lymphocytes; detection of lipoarabinomannan, a glycolipid of MTB, in urine; the st

16 HO-endorsed immunodiagnostic Alere Determine Lipoarabinomannan Ag-test (LAM-test) detects Mycobacteri

17 ed feature of the biosynthesis of lipomannan/lipoarabinomannan allows a significant revision of struc

18 berculosis virulence factors (the glycolipid lipoarabinomannan and its carrier protein) on the surfac

19 erculosis cell envelope lipoglycans, such as lipoarabinomannan and lipomannan, but a mechanism for li

20 binds to Mycobacterium tuberculosis surface lipoarabinomannan and results in bacterial agglutination

21 compared with other rapid diagnostics (urine lipoarabinomannan and sputum Xpert).

22 ted mice contain the mycobacteria components lipoarabinomannan and the 19-kDa lipoprotein and can sti

23 ced IL-8 response mediated by mannose-capped lipoarabinomannan and the mannose receptor is independen

24 , phosphatidylinositol mannoside, arabinosyl-lipoarabinomannan, and dimycolated trehalose (cord facto

25 ates that TLR1 and TLR2 are required for ara-lipoarabinomannan- and tripalmitoyl cysteinyl lipopeptid

26 The Alere Determine TB lipoarabinomannan antigen (LAM-test) is a World Health O

27 s the Xpert MTB/RIF assay), and detection of lipoarabinomannan antigen in urine.

28 alities, and a lower frequency of detectable lipoarabinomannan antigenuria and mycobacteriuria.

29 nd linear and mature branched lipomannan and lipoarabinomannan are prominent phospholipids/lipoglycan

30 A novel urine lipoarabinomannan assay (FujiLAM) has higher sensitivity

31 utum Xpert MTB/Rif Ultra, urine lateral-flow lipoarabinomannan assay (LF-LAM), chest x-ray, and sputu

32 f-care haemoglobin concentrations, and urine lipoarabinomannan assay results.

33 probability of tuberculosis (positive urine lipoarabinomannan assay, body-mass index <18.5 kg/m(2),

34 The lateral flow urine lipoarabinomannan assay, Determine TB LAM (Determine LAM

35 Next-generation, higher sensitivity urine-lipoarabinomannan assays are potentially promising tests

36 Utilizing a lipoarabinomannan-based enzyme-linked immunosorbent assa

37 Within minutes, M. avium, or its cell wall lipoarabinomannan, binds to the adherent macrophages and

38 vative (PPD), antigen 85, and mannose-capped lipoarabinomannan but not to nonmycobacterial antigens.

39 bacterium tuberculosis cell wall glycolipid, lipoarabinomannan, can inhibit CD4(+) T cell activation

40 lted in the absence of lipomannan (Cg-LM-A), lipoarabinomannan (Cg-LAM) and a multi-mannosylated poly

41 d phagocytosis of Mycobacterium tuberculosis lipoarabinomannan-coated microspheres.

42 g incubation with Mycobacterium tuberculosis lipoarabinomannan, colocalization of endocytosed lipoara

43 repeat Ultra, and for people with HIV, urine lipoarabinomannan) evaluation, and compared those findin

44 The best ligand was mannosyl-lipoarabinomannan, followed by lipomannan, phosphatidyli

45 Lipoarabinomannan-free culture filtrate proteins of M. t

46 virulent Erdman strain of M.tb, but not the lipoarabinomannan from M. smegmatis.

47 We hypothesized that lipoarabinomannan from M. tuberculosis (Mtb LAM) would p

48 Lipoarabinomannan from M. tuberculosis Erdman and M. lep

49 SP-D binds predominantly to lipoarabinomannan from the virulent Erdman strain of M.t

50 nomannan test, Fujifilm SILVAMP Tuberculosis Lipoarabinomannan (FujiLAM), in adults living with human

51 Selected mycobacterial antigens (Mtb41 > lipoarabinomannan > 38kd > Ag85B > Mtb39) expanded inhib

52 Although lipoarabinomannan has been found to exert effects on mac

53 loss), a rapid test detecting mycobacterial lipoarabinomannan in urine (Determine TB LAM), and a mol

54 with a lateral flow assay for M tuberculosis lipoarabinomannan in urine (Determine TB-LAM Ag test, Ab

55 uberculosis and its cell wall mannose-capped lipoarabinomannan induce PPARgamma expression through a

56 Mycobacterium tuberculosis mannose-capped lipoarabinomannan inhibits the release of proinflammator

57 The binding of SP-D to Erdman lipoarabinomannan is mediated by the terminal mannosyl o

58 l envelope glycosylated phosphatidylinositol lipoarabinomannan isolated from the virulent Mycobacteri

59 n of the major arabinosylated glycopolymers, lipoarabinomannan (LAM) and arabinogalactan (AG).

60 erial cell walls in two settings, as part of lipoarabinomannan (LAM) and arabinogalactan, each with m

61 Arguably, the most important are lipoarabinomannan (LAM) and its precursor, lipomannan (L

62 dies to the mycobacterial surface lipoglycan lipoarabinomannan (LAM) and its related capsular polysac

63 esis of phosphatidylinositol (PI)-containing lipoarabinomannan (LAM) and lipomannan (LM) of Mycobacte

64 ifferent M. tuberculosis antigens, including lipoarabinomannan (LAM) and purified protein derivative

65 e mycobacterial components, arabinose-capped lipoarabinomannan (LAM) and soluble tuberculosis factor

66 int-of-care assay that detects mycobacterial lipoarabinomannan (LAM) antigen in the urine to identify

67 The urine lipoarabinomannan (LAM) antigen test is a tuberculosis (

68 gned to: enhanced TB diagnostics using urine lipoarabinomannan (LAM) antigen tests (SILVAMP-LAM, Fuji

69 tol-anchored lipoglycans lipomannan (LM) and lipoarabinomannan (LAM) are cell envelope components cri

70 sitol mannosides (PIM), lipomannan (LM), and lipoarabinomannan (LAM) are essential components of the

71 Lipomannan (LM) and lipoarabinomannan (LAM) are key Corynebacterineae glycoc

72 curacy of urinary and pericardial fluid (PF) lipoarabinomannan (LAM) assays in tuberculous pericardit

73 terial genes involved in lipomannan (LM) and lipoarabinomannan (LAM) biosynthesis.

74 at mycobacterial phosphatidylinositol analog lipoarabinomannan (LAM) blocks a trans-Golgi network-to-

75 zyme-linked immunosorbent assay, and urinary lipoarabinomannan (LAM) by Alere Determine TB LAM assay.

76 Here we describe how M. tuberculosis toxin lipoarabinomannan (LAM) causes phagosome maturation arre

77 to sputum diagnostics, urine Xpert and urine-lipoarabinomannan (LAM) combined identified 88% of TB bl

78 Our study sought to determine whether urine lipoarabinomannan (LAM) could be validated in a sample c

79 he mycobacterial cell wall glycophospholipid lipoarabinomannan (LAM) could specifically induce human

80 Urinary lipoarabinomannan (LAM) detection is a promising approac

81 crosis factor alpha [TNF-alpha] cytokines by lipoarabinomannan (LAM) from pathogenic Mycobacterium tu

82 The mycobacterial cell wall component lipoarabinomannan (LAM) has been described as a virulenc

83 Current knowledge on the structure of lipoarabinomannan (LAM) has resulted primarily from deta

84 ion pathway for the mycobacterial lipoglycan lipoarabinomannan (LAM) in monocyte-derived antigen-pres

85 p results were: alpha, mycobacterial RNA and lipoarabinomannan (LAM) in sputum, and host metabolites

86 ll wall, with phosphatidylinositol anchoring lipoarabinomannan (LAM) in the cell envelope.

87 Testing for mycobacterial lipoarabinomannan (LAM) in urine is a practical but inse

88 AM (SILVAMP-LAM), detects the presence of TB lipoarabinomannan (LAM) in urine, and is substantially m

89 Lipoarabinomannan (LAM) is a component of the mycobacter

90 Lipoarabinomannan (LAM) is a high molecular weight, hete

91 acterium tuberculosis (Mtb), surface-exposed Lipoarabinomannan (LAM) is a key determinant of immunoge

92 Lipoarabinomannan (LAM) is a major antigen of Mycobacter

93 Lipoarabinomannan (LAM) is a structurally heterogeneous

94 Lipoarabinomannan (LAM) is composed of a phosphatidylino

95 We studied the diagnostic accuracy of the lipoarabinomannan (LAM) lateral flow assay (LFA), LAM en

96 both the cell wall arabinogalactan (AG) and lipoarabinomannan (LAM) of Mycobacterium tuberculosis an

97 The glycolipid lipoarabinomannan (LAM) plays an important role in media

98 s in the context of arabinogalactan (AG) and lipoarabinomannan (LAM) respectively.

99 Both a urinary lipoarabinomannan (LAM) test (Alere TB LAM) and GeneXper

100 ion with W4SS, chest radiograph (CXR), urine lipoarabinomannan (LAM) test, and sputum Xpert MTB/RIF (

101 Lateral flow urine lipoarabinomannan (LAM) tests could offer important new

102 l lipopolysaccharide (LPS) and mycobacterial lipoarabinomannan (LAM) that lacks terminal mannosyl uni

103 We sought to determine if urine lipoarabinomannan (LAM) would improve diagnosis of pulmo

104 The biosynthesis of lipoarabinomannan (LAM), a key mycobacterial lipoglycan

105 rating the tuberculosis-specific glycolipid, lipoarabinomannan (LAM), a promising urinary biomarker f

106 Lipoarabinomannan (LAM), a surface glycolipid, has been

107 cterial proteins, native antigen 85 complex, lipoarabinomannan (LAM), and Mycobacterium tuberculosis

108 cobacterial lipoglycans, lipomannan (LM) and lipoarabinomannan (LAM), are potent immunomodulators in

109 s of the M. tuberculosis surface lipoglycan, lipoarabinomannan (LAM), from the Erdman strain serve as

110 determined that a major capsular lipoglycan, lipoarabinomannan (LAM), from the Erdman strain serves a

111 results demonstrated that cell wall-derived lipoarabinomannan (LAM), mycolyl arabinogalactan-peptido

112 Lipoarabinomannan (LAM), one of the few known bacterial

113 rine assays to detect the lipopolysaccharide lipoarabinomannan (LAM), present in mycobacterial cell w

114 forming the unique arabinogalactan (AG) and lipoarabinomannan (LAM), respectively.

115 f presenting mycobacterial lipids, including lipoarabinomannan (LAM), to double-negative (DN; CD4(-)

116 o this envelope are arabinogalactan (AG) and lipoarabinomannan (LAM), two complex polysaccharides con

117 cerebrospinal fluid (CSF) Xpert MTB/RIF, CSF lipoarabinomannan (LAM), urine LAM, CSF total protein, a

118 We tested whether mannose-capped lipoarabinomannan (LAM)-induced inhibition of CD4(+) T c

119 h in sputum smear-negative (76.0%) and urine lipoarabinomannan (LAM)-negative (76.5%) patients.

120 Significant increases in lipoarabinomannan (LAM)-specific immunoglobulin G (IgG)

121 sis a new 5-methylthiopentose substituent on lipoarabinomannan (LAM).

122 gainst the mycobacterial cell wall component lipoarabinomannan (LAM).

123 not to a distinct CD14 ligand, mycobacterial lipoarabinomannan (LAM).

124 e bacterial LPS and mycobacterial glycolipid lipoarabinomannan (LAM).

125 ram-negative bacterial LPS and mycobacterial lipoarabinomannan (LAM).

126 iosynthesis of the cell envelope lipoglycan, lipoarabinomannan (LAM).

127 phatidylinositol mannosides, lipomannan, and lipoarabinomannan (LAM).

128 nan domains of both arabinogalactan (AG) and lipoarabinomannan (LAM).

129 e core of the key immunogenic polysaccharide lipoarabinomannan (LAM).

130 sitol-based lipoglycans, lipomannan (LM) and lipoarabinomannan (LAM).

131 synthesize a family of lipomannans (LM) and lipoarabinomannans (LAM) that are abundant components of

132 ctors at hospital admission (including urine lipoarabinomannan [LAM] detection) thought to be associa

133 ed disseminated tuberculosis (positive urine lipoarabinomannan [LAM], urine Xpert MTB/RIF, or tubercu

134 The TB lipoarabinomannan lateral flow assay (AlereLAM) offers e

135 osphatidylinositol mannoside, lipomannan and lipoarabinomannan levels were not altered.

136 Urine lateral flow lipoarabinomannan (LF-LAM) is a point-of-care tuberculos

137 nd urine Determine TB LAM Ag (a lateral flow lipoarabinomannan [LF-LAM] test), without symptom select

138 hospho-mannopyranose and thus indirectly for lipoarabinomannan, lipomannan, and the higher-order phos

139 ever, yielded less binding to mannose-capped lipoarabinomannan (ManLAM) and even lower levels of bind

140 M.tb mannose-capped lipoarabinomannan (ManLAM) blocks phagosome maturation.

141 s cell-wall glycolipids such as mannosylated lipoarabinomannan (ManLAM) can inhibit murine CD4+ T cel

142 l cell wall glycophospholipid mannose-capped lipoarabinomannan (ManLAM) could induce human peripheral

143 The cell wall component lipoarabinomannan (ManLAM) from Mycobacterium tuberculos

144 cell wall lipoglycan known as mannose-capped lipoarabinomannan (ManLAM) in mouse macrophages costimul

145 Recent work has indicated that mannosylated lipoarabinomannan (ManLAM) isolated from Mycobacterium t

146 ed protein derivative (PPD) and mannosilated lipoarabinomannan (ManLAM) stimulation.

147 art, by binding of the mannose caps of M. tb lipoarabinomannan (ManLAM) to the macrophage mannose rec

148 at the known virulence factor mannose-capped lipoarabinomannan (ManLAM) was sufficient to induce sTNF

149 ed and more branched forms of mannose-capped lipoarabinomannan (ManLAM) with a marked reduction of th

150 MTX is appended to mannose-capped lipoarabinomannan (ManLAM), an antigenic glycolipid in t

151 and Mycobacterium tuberculosis mannosylated lipoarabinomannan (ManLAM), modulate essential interacti

152 and H37Rv cell wall, but not mannose-capped lipoarabinomannan (ManLAM), than did cells stimulated wi

153 cell wall lipoglycan known as mannose-capped lipoarabinomannan (ManLAM).

154 man serum samples spiked with mannose-capped lipoarabinomannan (ManLAM).

155 sides (PIMs), lipomannan, and mannose-capped lipoarabinomannan (ManLAM).

156 culosis phosphatidylinositol [mannose-capped lipoarabinomannan (ManLAM)] interfered with the phagosom

157 lipoglycans [lipomannan (LM); mannose-capped lipoarabinomannan (ManLAM)] of 22 M.tb strains that rang

158 lipoteichoic acid (Gram-positive cocci), and lipoarabinomannan (Mycobacteria) become highly susceptib

159 e of cell wall-associated peptidoglycans and lipoarabinomannan on the Msm OM organization.

160 iomarkers including blood culture, and urine lipoarabinomannan, or urine Xpert (all p<0.05).

161 e acyl side chains of known T cell antigens, lipoarabinomannan, phosphatidylinositol mannoside, and g

162 osphatidylinositol-containing lipomannan and lipoarabinomannan, replaced instead by a novel truncated

163 A subset of IFN-gamma-producing lipoarabinomannan-responsive T cells coexpressed the cyt

164 losis restriction, we optimized a protective lipoarabinomannan-specific mAb, generating Fc variants.

165 ing cell wall components arabinogalactan and lipoarabinomannan, suggesting they are important for cel

166 ne tuberculosis biomarker-based lateral-flow lipoarabinomannan [TB-LAM], sputum Ultra, and sputum cul

167 han the current Alere Determine Tuberculosis Lipoarabinomannan test (AlereLAM).

168 dergo screening (Xpert MTB/RIF test, urinary lipoarabinomannan test, and chest radiography) to determ

169 evaluation of a novel point-of-care urinary lipoarabinomannan test, Fujifilm SILVAMP Tuberculosis Li

170 count or haemoglobin, and outperformed urine lipoarabinomannan testing in participants with elevated

171 Using the example of urine lipoarabinomannan testing, we illustrate how even tests

172 iagnostic yield of point-of-care urine-based lipoarabinomannan tests with that of sputum-based nuclei

173 the tuberculosis diagnostic yields of urine lipoarabinomannan tests, sputum NAATs, and SSM.

174 lysaccharides, capsular polysaccharides, and lipoarabinomannans that contain the Manalpha1-2Man disac

175 One immunoglobulin M (IgM) MAb bound to lipoarabinomannan, the second IgM MAb bound to mycolyl-a

176 yl-arabinogalactan-peptidoglycan complex and lipoarabinomannan; thus, its synthesis has attracted con

177 ds and lipoglycans such as mycolic acids and lipoarabinomannan to T cells.

178 -infected mice, confirming the occurrence of lipoarabinomannan trafficking to T cells in vivo.

179 osis diagnostics (ie, sputum Xpert and urine lipoarabinomannan), tuberculosis preventive therapy, ser

180 Furthermore, lipoarabinomannan was associated with T cells after thei

181 Lipoarabinomannan was the most potent mycobacterial lipi

182 e supramolecular structure of mannose-capped lipoarabinomannan, we designed and synthesized a set of

183 hatidylinositol mannoside and mannose-capped lipoarabinomannan, were potent inhibitors.

184 of two polysaccharides, arabinogalactan and lipoarabinomannan, which are found in the cell wall comp

185 idyl-myo-inositol mannoside, lipomannan, and lipoarabinomannan, which are key glycolipids/lipoglycans

186 dyl-myo-inositol mannosides, lipomannan, and lipoarabinomannan, which are key glycolipids/lipoglycans

187 ch attention has been paid to mannose-capped lipoarabinomannan, which mediates phagocytosis and intra

188 arabinomannan, colocalization of endocytosed lipoarabinomannan with the gpCD1b1 isoform was observed