ライフサイエンスコーパス: lipoic acid

1 two diabetic groups (with and without alpha-lipoic acid).

2 amins biotin and pantothenic acid, and alpha-lipoic acid.

3 E) cells and the reduction of this damage by lipoic acid.

4 ed to achieve tight, specific binding of the lipoic acid.

5 tive mitochondrial dysfunction is reduced by lipoic acid.

6 d be preserved by the insulin-like effect of lipoic acid.

7 compounds demonstrated cross-reactivity with lipoic acid.

8 plus lipoic acid, (3) HFD, and (4) HFD plus lipoic acid.

9 e capacity through daily administration of R-lipoic acid.

10 y volunteers (n = 43) for reactivity against lipoic acid.

11 poic acid, and synthetic molecular mimics of lipoic acid.

12 end reactive groups) appended onto a single lipoic acid.

13 lar to the normal physiological oxidation of lipoic acid.

14 at SIRT1, SIRT2, SIRT3, and SIRT4 can remove lipoic acid.

15 uced by the oxidative stress scavenger alpha-lipoic acid.

16 lipoamide, the reduced protein-bound form of lipoic acid.

17 ation, a high-fat diet with or without alpha-lipoic acid (1.65 g/kg) was given to the mice and to non

18 enzoic acid) porphyrin (10 mg/kg), and alpha-lipoic acid (100 mg/kg).

19 sed by preincubation with NAC (1 h) or alpha-lipoic acid (24 h) but not vitamin E.

20 weeks: (1) normal diet, (2) normal diet plus lipoic acid, (3) HFD, and (4) HFD plus lipoic acid.

21 R-lipoic acid (30 mg/kg) prevented hyperglycemia, reduced

22 linded manner to irbesartan 150 mg/d (n=14), lipoic acid 300 mg/d (n=15), both irbesartan and lipoic

23 ing diets supplemented with or without alpha-lipoic acid (400 mg/kg) for 11 months of diabetes.

24 obtained by Ugi-reaction between ferulic (or lipoic acid), a melatonin-like isocyanide, formaldehyde,

25 nin, a naturally occurring indole, and alpha-lipoic acid, a naturally occurring dithiol, were also in

26 t is involved in the endogenous synthesis of lipoic acid, a potent mitochondrial antioxidant.

27 To examine the effect of alpha-lipoic acid, a potent natural antioxidant, on atheroscle

28 Further analysis revealed that lipoic acid, a required cofactor covalently attached to

29 milarity between SAc and the reduced form of lipoic acid, a step which is similar to the normal physi

30 alpha-Lipoic acid, a thiol antioxidant, has been shown to have

31 ieve this goal, we combined the structure of lipoic acid, a universal antioxidant, with an appropriat

32 Administration of lipoic acid abrogates diabetic nephropathy in animal mod

33 s deficit in cINs could be reversed by Alpha Lipoic Acid/Acetyl-L-Carnitine (ALA/ALC) but not by othe

34 alpha-Lipoic acid administration for the entire duration of di

35 nd 70%, respectively, in diabetes, and alpha-lipoic acid administration inhibited these increases.

36 The effect of alpha-lipoic acid administration on retinal 8-hydroxy-2'deoxyg

37 generation, since it is reversed by systemic lipoic acid administration.

38 Male SD rats were pretreated with alpha-lipoic acid (ALA) and dihydrolipoic acid (DHLA) or appro

39 Alpha lipoic acid (ALA) and vitamin C (Vit-C) are very importa

40 nthesize a new UV active derivative of alpha-lipoic acid (ALA) by its esterification with 4-methoxybe

41 Alpha lipoic acid (ALA) is a nutraceutical and potent antioxid

42 alpha-lipoic acid (ALA) is a potent antioxidant that is used i

43 eating A-T cells with the antioxidant, alpha lipoic acid (ALA), restored mitochondrial respiration ra

44 ons at a much lower concentration than alpha-lipoic acid (ALA).

45 n of mixed tocopherols (666 IU/d) plus alpha-lipoic acid (ALA; 600 mg/d) or matching placebos for 6 m

46 gest that the lipoyl protein domain (but not lipoic acid alone) plays a regulatory role in the enzyma

47 ral antioxidant agents (ascorbic acid, alpha-lipoic acid, alpha-tocopherol, Mn(III)-tetrakis(4-benzoi

48 Lipoic acid also plays a critical role in stabilizing an

49 hondria, lipoic acid synthase produces alpha-lipoic acid, an antioxidant and an essential cofactor in

50 sartan, an angiotensin receptor blocker, and lipoic acid, an antioxidant, to affect endothelial funct

51 , the enzyme that catalyzes the synthesis of lipoic acid, an essential cofactor for several mitochond

52 trast to other eukaryotes, which manufacture lipoic acid, an essential cofactor for several vital deh

53 formation in human liver microsomes by alpha-lipoic acid, an inhibitor of NADPH: p450 reductase, supp

54 h proteins artificially substituted with the lipoic acid analogue xenobiotic 6-bromohexanoic acid (6B

55 s found that these enzymes could incorporate lipoic acid analogues including octanoic and hexanoic ac

56 phiphilic polyethylene glycol segment, and a lipoic acid anchoring group.

57 ies in AMA-positive sera that recognize free lipoic acid and a carrier-conjugated form of lipoic acid

58 d disulfide from asparagusic or, preferably, lipoic acid and a guanidinium cation polymerize into pol

59 tion and arborization were reversed by alpha lipoic acid and acetyl-L-carnitine treatments, which boo

60 on with the mitochondrial antioxidants alpha-lipoic acid and coenzyme Q(10) also suppresses Bak expre

61 malized by treatment with antioxidants alpha-lipoic acid and D-alpha-tocopherol and, surprisingly, PK

62 d as interacting with the dithiolane ring of lipoic acid and discriminating against the entry of biot

63 Both lipoic acid and glutaredoxins act in the reverse manner

64 the introduction of controllable numbers of lipoic acid and histamine anchors, along with hydrophili

65 combine two distinct metal-chelating groups, lipoic acid and imidazole, for the surface functionaliza

66 Lipoic acid and its reduced form, dihydrolipoic acid, ar

67 formin, the combination treatment of R-alpha-lipoic acid and metformin, and niacin.

68 ected a very slow LplA-catalyzed transfer of lipoic acid and octanoic acid from their acyl carrier pr

69 Lipoic acid and resveratrol were identified as being ben

70 Water soluble AuNCs were synthesized using lipoic acid and then thoroughly characterized.

71 ssible) thiol groups like disulfides such as lipoic acid and thiol stabilizing ligands coordinatively

72 s lipoylation system; the relative levels of lipoic acid and xenobiotic incorporation may be determin

73 anges and the Nrf2 inducers DL-sulforaphane, lipoic acid, and curcumin all replicate them without oxi

74 ased by 67%, 44%, and 75% in the irbesartan, lipoic acid, and irbesartan plus lipoic acid groups, res

75 vatives of potent antioxidant vitamin, alpha-lipoic acid, and related analogues were designed, synthe

76 Dihydrolipoic acid, lipoic acid, and resveratrol reduced microphthalmia-asso

77 yethylene glycol (PEG), lipoylated PEG, free lipoic acid, and synthetic molecular mimics of lipoic ac

78 rference (RNAi) reduced endogenous levels of lipoic acid, and the activities of critical components o

79 Alpha-lipoic acid appears to be effective as well.

80 Interestingly, SQ2 (mono lipoic acid appended), SQ5 and SQ6 (conjugated with hexy

81 ptable, and self-healing, those derived from lipoic acid are rigid, resilient, and brittle.

82 y complex I and enzymatic complexes carrying lipoic acid as a cofactor (pyruvate dehydrogenase, 2-oxo

83 e data have implications for patients taking lipoic acid as a dietary supplement.

84 S II pathway defects resulted in the loss of lipoic acid attachment to subunits of three key mitochon

85 ip surface was prepared using functionalized lipoic acid AuNPs deposited on SAM Au chips followed by

86 nd the subsequent reductive acylation of the lipoic acid-bearing domain (LBD) from the 24-meric trans

87 Here we show that the lipoylated lipoic acid-bearing domain (lip-LBD) (residues 1-84) of

88 pose a mechanism in which the closure of the lipoic acid binding site is triggered by the formation o

89 tein lipoyl synthase (LipA) is essential for lipoic acid biosynthesis via sulfur insertions into a pr

90 nt in generating the fatty acid precursor of lipoic acid biosynthesis.

91 CS1, molybdenum cofactor biosynthesis; LIAS, lipoic acid biosynthesis; CDK5RAP1, 2-methylthio-N(6)-is

92 lfur (FeS) clusters, molybdopterin, thiamin, lipoic acid, biotin, and the thiolation of tRNAs.

93 cid scavenging requires not only ligation of lipoic acid but also a lipoyl relay pathway in which an

94 tic can be incorporated into PDC in place of lipoic acid by the exogenous lipoylation system; the rel

95 ed that production of the metabolic cofactor lipoic acid by the lipoic acid synthetase, LipA, blunts

96 such that unnatural probes much larger than lipoic acid can be recognized.

97 We also show that lipoic acid can be reduced through a Sec-independent mec

98 The relative level of glutathionylated lipoic acid closely paralleled the degree of enzyme inhi

99 o the lysine residue that normally binds the lipoic acid cofactor of PDC-E2, reacts as well or better

100 ulting from enhanced oxidative damage to the lipoic acid cofactor of pyruvate dehydrogenase and alpha

101 As in yeast, lipoic acid cofactor was damaged in human D444V-homozygo

102 Treatment with exogenous lipoic acid compensated for some of these defects.

103 Remarkably, alpha-lipoic acid completely prevented the increase in plasma

104 difications of the disulfide bond within the lipoic-acid-conjugated PDC-E2 moiety, i.e., by an electr

105 ternative oxidase and decreased abundance of lipoic acid-containing components during several of the

106 t the relative incorporation of both 6BH and lipoic acid could be regulated by the balance between AT

107 mic treatment with either HC-030031 or alpha-lipoic acid could completely prevent hypersensitivity if

108 of a DLDH that carries its own substrate (a lipoic acid covalently attached to a lipoyl protein doma

109 treatment with irbesartan or irbesartan plus lipoic acid decreased 8-isoprostane levels.

110 n of either insulin or the antioxidant alpha-lipoic acid decreased proteinuria and oxidative stress,

111 xS15 is shown to be especially important for lipoic acid-dependent enzymes in mitochondria, highlight

112 Pretreatment with R-alpha-lipoic acid effectively protected ARPE-19 cells from acr

113 oligated with this zwitterion-terminated bis(lipoic) acid exhibit great colloidal stability over a wi

114 hia coli, two pathways for the attachment of lipoic acid exist, a de novo biosynthetic pathway depend

115 hway for de novo synthesis and attachment of lipoic acid exists in yeast.

116 l azides and photo-cross-linkers in place of lipoic acid, facilitating imaging and proteomic studies.

117 LplA1(Ct) is capable of utilizing exogenous lipoic acid for the lipoylation Therefore, host-derived

118 erichia coli and mitochondria that transfers lipoic acid from lipoyl-acyl carrier protein to the lipo

119 respiration due to the inability to generate lipoic acid from mitochondrially synthesized fatty acids

120 alpha-ketoglutarate dehydrogenase protected lipoic acid from modification by the electrophilic lipid

121 years ago as an enzyme activity that cleaved lipoic acid from small lipoylated molecules and from pyr

122 Lipoate-protein ligases are used to scavenge lipoic acid from the environment and attach the coenzyme

123 lated and biotinylated substrates as well as lipoic acid from two 2-oxoacid dehydrogenases and an iso

124 l coordinating ligands where we combined two lipoic acid groups, bis(LA)-ZW, (as a multicoordinating

125 irbesartan, lipoic acid, and irbesartan plus lipoic acid groups, respectively, compared with the plac

126 The lipoic acid hapten specificity of the reactive antibodie

127 The metabolic thiol antioxidant alpha-lipoic acid has been suggested to be of therapeutic valu

128 e that the long-term administration of alpha-lipoic acid has beneficial effects on the development of

129 syl acceptors with a longer spacer (C8-O-C8)-lipoic acid have a higher tendency to mimic a solution-p

130 ligands: (i) bis(LA)-PEG, which presents two lipoic acids (higher coordination) appended onto a singl

131 3xTg-AD mice fed 0.23% w/v lipoic acid in drinking water for 4 weeks showed an insu

132 Lipoic acid in LplA was bound in the same position as bi

133 ays for synthesis and covalent attachment of lipoic acid in prokaryotes.

134 our genes in the synthesis and attachment of lipoic acid in Saccharomyces cerevisiae.

135 in proving the crucial role of protein-bound lipoic acid in the reaction mechanism of the 2-oxoacid d

136 ochondrial RNase P, Rpm2, is not modified by lipoic acid in the wild-type strain, and it is imported

137 report that the nutritional supplement alpha-lipoic acid inhibits cystine stone formation in the Slc3

138 Lipoic acid is a covalently attached cofactor essential

139 Lipoic acid is a covalently bound cofactor found through

140 Our results suggest that dietary alpha-lipoic acid is a promising protective agent for reducing

141 Lipoic acid is a sulfur-containing cofactor required for

142 Lipoic acid is an essential cofactor for mitochondrial m

143 Lipoic acid is an essential cofactor of alpha-keto acid

144 Lipoic acid is an essential protein bound cofactor that

145 Lipoic acid is known to modulate the redox status of the

146 These results indicate that lipoic acid is not only assembled on the dehydrogenase l

147 Collectively, its functions explain why lipoic acid is required for cell growth, mitochondrial a

148 responses in primary biliary cirrhosis, with lipoic acid itself forming a component of the dominant a

149 (wt/vol) in drinking water], and/or R-alpha-lipoic acid (LA) [0.2% or 0.1% (wt/wt) in diet].

150 coordinating ligands that present one or two lipoic acid (LA) anchors, a hydrophilic polyethylene gly

151 ior insult was investigated by supplementing lipoic acid (LA) during their 6 months of GC (R+LA).

152 n previously that the dithiol compound alpha-lipoic acid (LA) exerts antiinflammatory effects by inhi

153 imple peptide coupling chemistry, one or two lipoic acid (LA) groups and poly(ethylene glycol) (PEG)

154 tion of ligands comprising either one or two lipoic acid (LA) groups chemically linked to a zwitterio

155 alpha-Lipoic acid (LA) has been found to attenuate diabetic pe

156 alpha-Lipoic acid (LA) has been shown to improve memory functi

157 the antioxidants vitamin E (VE) and R-alpha-lipoic acid (LA) in streptozotocin-induced diabetic rats

158 alpha-Lipoic acid (LA) is a cofactor for mitochondrial alpha-k

159 Lipoic acid (LA) is a sulfur-containing cofactor that co

160 cephalic neurons and co-treatment with alpha-lipoic acid (LA) or one of several other antioxidants pr

161 t 2 mo of dietary supplementation with alpha-lipoic acid (LA) prevented early glomerular injury in no

162 LipA requires Fe-S clusters for lipoic acid (LA) synthesis and a DeltasufT strain had ph

163 We investigated the role of (R)-alpha-lipoic acid (LA) vs. glutathione and ascorbic acid in tu

164 ether dietary supplementation with (R)-alpha-lipoic acid (LA) was effective at reducing oxidative str

165 hSMVT) has been suggested to transport alpha-lipoic acid (LA), a potent antioxidant and anti-inflamma

166 ligand exchange on hydrophobic CdSe QDs with lipoic acid (LA)-based ligands and their facile QD trans

167 o polar and aqueous media using multidentate lipoic acid (LA)-modified ligands.

168 mitochondrial antioxidant precursor R-alpha-lipoic acid (LA).

169 molecule that contains the prosthetic group lipoic acid (LA).

170 cation, old rats were treated with (R)-alpha-lipoic acid (LA; 40 mg/kg i.p. up to 48 h), a disulfide

171 vol) in the drinking water] and/or (R)-alpha-lipoic acid [LA, 0.5% (wt/wt) in the chow] improved thes

172 letion by RNAi or gene knockout also reduces lipoic acid levels and drastically decreases protein lip

173 Since free lipoamide and lipoic acid levels were shown to be undetectable in M. s

174 beta-ketoacyl synthase and exhibits lowered lipoic acid levels.

175 Escherichia coli lipoic acid ligase (LplA) catalyzes ATP-dependent covale

176 In the PRIME step, Escherichia coli lipoic acid ligase (LplA) site-specifically attaches a p

177 h rational design, we redirected a microbial lipoic acid ligase (LplA) to specifically attach an alky

178 atekeeper residue, tryptophan 37, in E. coli lipoic acid ligase (LplA), expands substrate specificity

179 ved from the natural Escherichia coli enzyme lipoic acid ligase (LplA).

180 d by a mutant of the Escherichia coli enzyme lipoic acid ligase (LplA).

181 C. trachomatis serovar L2 and show that the lipoic acid ligase LplA1(Ct) is capable of utilizing exo

182 Escherichia coli lipoic acid ligase site-specifically ligates a trans-cyc

183 -PRIME utilizes a mutant of Escherichia coli lipoic acid ligase, LplA(W37V), which can catalyze the c

184 ye resorufin, starting from Escherichia coli lipoic acid ligase.

185 anel of fluorophores that can be targeted by lipoic acid ligase.

186 diae show the presence of two genes encoding lipoic acid ligases and one gene encoding a lipoate synt

187 The two distinct lipoic acid ligases in Chlamydia trachomatis serovar L2,

188 ninhydrin, alloxan, dehydroascorbate, DTNB, lipoic acid/lipoamide, S-nitrosoglutathione, selenodiglu

189 r (iii) that are activated by strain such as lipoic acid/lipoamide.

190 egulated Ang II receptors differently: alpha-Lipoic acid lowered Ang II binding after 24 h, and vitam

191 na is impaired and may be corrected by alpha-lipoic acid (LPA), a drug that inhibits vascular histopa

192 Thus, the use of host-derived lipoic acid may be a critical process for in vivo replic

193 t mitochondria-targeted antioxidants such as lipoic acid may be an effective strategy for reducing or

194 for the lipoylation Therefore, host-derived lipoic acid may be important for intracellular growth an

195 Therefore, thiamine or lipoic acid may constitute potential therapeutic agents

196 c chloride-injected animals, suggesting that lipoic acids may be of use in preventing or attenuating

197 Mechanistic details of lipoic acid metabolism are unclear in eukaryotes, despit

198 Although a complete pathway of lipoic acid metabolism has been established in Escherich

199 sm has been established in Escherichia coli, lipoic acid metabolism in other bacteria is more complex

200 acillus subtilis requires three proteins for lipoic acid metabolism, all of which are members of the

201 Both to further our understanding of lipoic acid metabolism, and to improve LplA's utility as

202 immediate testing in progressive MS: R-alpha-lipoic acid, metformin, the combination treatment of R-a

203 les discussed in this review include biotin, lipoic acid, methylthioether modifications found in some

204 t conjugated form(s) of native or xenobiotic lipoic acid mimics contribute to the initiation and perp

205 In the absence of lipoic acid modification, the dehydrogenases are inactiv

206 egy to prepare AuNPs monofunctionalized with lipoic acid modified DNA oligos.

207 can function in utilization of host-derived lipoic acid-modified peptides.

208 E2 is glutathionylation, in which the lysine-lipoic acid moiety is further modified with glutathione

209 Recently, we replaced the lipoic acid moiety of PDC-E2 with a battery of synthetic

210 ic acid 300 mg/d (n=15), both irbesartan and lipoic acid (n=15), or matching placebo (n=14) for 4 wee

211 Neither the antioxidant dexlipotam (R-lipoic acid) nor the p38 MAP kinase inhibitor SB239063 c

212 c rats, treatment with the antioxidant alpha-lipoic acid normalized the amount of leukostasis but not

213 Supplementation of the culture medium with lipoic acid offered some protection against oxidative da

214 ing the effects of dietary administration of lipoic acid on a HFD-induced obesity model in terms of (

215 his study was to examine the effect of alpha-lipoic acid on retinal capillary cell apoptosis and the

216 catalyzes ATP-dependent covalent ligation of lipoic acid onto specific lysine side chains of three ac

217 of yeast cells, labeled by LplA with either lipoic acid or bromoalkanoic acid, and the most efficien

218 not improved by treatment with either alpha-lipoic acid or HES-DFO.

219 and shown to catalyze the transfer of either lipoic acid or octanoic acid from their acyl carrier pro

220 mutations in lipB are auxotrophic for either lipoic acid or octanoic acid.

221 Antioxidants, including N-acetylcysteine, lipoic acid, or quercetin, only minimally induced the in

222 Fe(II), lipoic acid, pectin, epigallocatechin and thiamine are a

223 dual reduction in autoantibodies against the lipoic acid-peptide, i.e., the primary tolerance-breakin

224 dant defence system and it is suggested that lipoic acid plays a pivotal part in defending the organe

225 ugs, choline (CHO), idebenone (IDB), R-alpha-lipoic acid plus acetyl-L-carnitine (LCLA), was found on

226 strates in addition to its normal substrates lipoic acid plus ATP.

227 Application of the antioxidant alpha-lipoic acid potently prevents glucose-induced oxidative

228 e II synthase for production of octanoate (a lipoic acid precursor) as well as longer fatty acids suc

229 ration of octanoyl-acyl carrier protein, the lipoic acid precursor, as well as longer chain fatty aci

230 In addition, a product is required for lipoic acid production, which is needed for the activity

231 tive to damage in diabetic mice with reduced lipoic acid production.

232 , but whether lower production of endogenous lipoic acid promotes diabetic nephropathy is unknown.

233 ells in sensitivity to acrolein toxicity and lipoic acid protection.

234 lipoyl-ACP:protein N-lipoyl transferase and lipoic acid protein ligase are expressed maximally in th

235 rminal sequences of lipoic acid synthase and lipoic acid protein ligase in intraerythrocytic stages o

236 st, whereas the second pathway consisting of lipoic acid protein ligase is located in the parasite's

237 propanethiol, glutathione, homocysteine, and lipoic acid provided no activity.

238 ared with enzyme expressed in the absence of lipoic acid (rDLDH(-LA)) or with enzyme lacking the firs

239 ioxidants epigallocatechin gallate and alpha-lipoic acid reduces polyglutamine aggregation.

240 chanism must exist for modification of other lipoic acid requiring enzymes (e.g. pyruvate dehydrogena

241 ific to the dehydrogenases in that the third lipoic acid-requiring enzyme of Escherichia coli, the gl

242 model to examine the therapeutic efficacy of lipoic acids (ROS-scavenging antioxidants).

243 tivities of the LipB and LipA proteins and a lipoic acid scavenging pathway catalyzed by the LplA pro

244 We report that lipoic acid scavenging requires not only ligation of lip

245 del of an expanded, three-enzyme pathway for lipoic acid scavenging that seems widespread in the Firm

246 n to utilize two lipoate-protein ligases for lipoic acid scavenging, whereas only one of the ligases

247 Anti-lipoic acid specific antibodies were detected in 81% (79

248 tants N,N-diethylethylenediamine (DEDA) onto lipoic acid stabilized Au (Au-LA) clusters with matching

249 ion with the AMPK activators AICAR and alpha-lipoic acid substantially prevented all of those changes

250 ir nondiabetic apoE(-/-) controls with alpha-lipoic acid supplement than in those without it.

251 Lipoic acid supplementation also restored myocardial asc

252 Lipoic acid supplementation led to important changes in

253 alpha-Lipoic acid supplementation represents an achievable adj

254 ptidase, inhibition of aldose reductase plus lipoic acid supplementation, and insulin therapy with an

255 stress, which is significantly attenuated by lipoic acid supplementation.

256 Lipoic acid synthase (LASY) is the enzyme that is involv

257 absence, we have generated mice deficient in lipoic acid synthase (Lias).

258 otein fusions of the N-terminal sequences of lipoic acid synthase and lipoic acid protein ligase in i

259 Lipoic acid synthesis comprising lipoic acid synthase and lipoyl-ACP:protein N-lipoyl tra

260 are lysine 2,3-aminomutase, biotin synthase, lipoic acid synthase and the activating enzymes for pyru

261 Here, we crossed mice heterozygous for lipoic acid synthase deficiency (Lias(+/-)) with Ins2(Ak

262 These results suggest that lipoic acid synthase deficiency increases oxidative stre

263 The putative lipoic acid synthase LipA(Ct), encoded by ctl0815, is ca

264 In mitochondria, lipoic acid synthase produces alpha-lipoic acid, an anti

265 es revealed that the genes/proteins encoding lipoic acid synthase, lipoyl-ACP:protein N-lipoyl transf

266 luding aconitase, respiratory complex I, and lipoic acid synthase, were diminished following depletio

267 ir Fe-S clusters directly from NFU1, such as lipoic acid synthase, which supports the Fe-S-dependent

268 ced by the pathway is the sole precursor for lipoic acid synthesis and attachment.

269 Lipoic acid synthesis comprising lipoic acid synthase an

270 anoyltransferase catalyzes the first step of lipoic acid synthesis in Escherichia coli, transfer of t

271 Our data suggest that lipoic acid synthesis in S. aureus promotes bacterial pe

272 We hypothesized that bacterial lipoic acid synthesis perturbs macrophage antimicrobial

273 The third protein, LipL, is essential for lipoic acid synthesis, but had no detectable octanoyltra

274 Thus, octanoate (C8), the precursor for lipoic acid synthesis, must also be a product of mitocho

275 nehe is a hypomorphic allele of Lipoic acid Synthetase (Lias), the enzyme that catalyzes

276 ccus aureus, we determine that the bacterial lipoic acid synthetase LipA suppresses macrophage activa

277 of the metabolic cofactor lipoic acid by the lipoic acid synthetase, LipA, blunts macrophage activati

278 se abnormalities were prevented by long-term lipoic acid therapy.

279 lowed a molecular comparison of the need for lipoic acid to be covalently attached to the lipoyl doma

280 1 mutant is rescued by addition of exogenous lipoic acid to host cells, suggesting that L. monocytoge

281 This study examines the ability of lipoic acid to increase brain glucose uptake and lead to

282 Administration of irbesartan and/or lipoic acid to patients with the metabolic syndrome impr

283 ponent, in contrast with the ability of free lipoic acid to serve as substrate for the dihydrolipoyl

284 l means instead of chemical reduction of the lipoic acid, to promote the transfer of CdSe-ZnS QDs to

285 Lipoic acid treatment in mice on HFD prevented several H

286 However, the roles of these proteins in lipoic acid utilization or biosynthesis have not yet bee

287 Treatment with irbesartan and/or lipoic acid was associated with statistically significan

288 The protein expressed without lipoic acid was indistinguishable from the wild-type pro

289 Lipoic acid was more effective in stimulating an insulin

290 These protective effects of alpha-lipoic acid were accompanied by a reduction of plasma gl

291 lipoic acid and a carrier-conjugated form of lipoic acid were also identified.

292 Essentially, a total of 23 xenobiotics and lipoic acid were coupled to the 12-mer peptide backbones

293 rolein and the protective effects of R-alpha-lipoic acid were examined with a variety of previously d

294 uctures in the absence and presence of bound lipoic acid were solved at 2.1 A resolution.

295 ihydrolipoic acid (the reduced form of alpha-lipoic acid), which contains free sulfhydryl groups as N

296 tor binding in cell membranes, whereas alpha-lipoic acid, which does not contain free sulfhydryl grou

297 1 by reducing the binding ability of PDP1 to lipoic acid, which is covalently attached to the L2 doma

298 molecular image formed by the association of lipoic acid with the immunodominant PDC-E2 peptide.

299 rs the nature of the disulfide groups in the lipoic acid, yielding a different product mixture than w

300 enase (E2-PDH) with a fatty acid derivative, lipoic acid, yielding the metabolic protein lipoyl-E2-PD