ライフサイエンスコーパス: lipoteichoic acid

1 o sensitize to TLR2 ligands (peptidoglycan + lipoteichoic acid).

2 ollowing exposure to either peptidoglycan or lipoteichoic acid.

3 esponses that were stimulated by IL-1beta or lipoteichoic acid.

4 (a diacylated bacterial lipopeptide) and to lipoteichoic acid.

5 and this expression was inducible by LPS or lipoteichoic acid.

6 esidues from the cell wall teichoic acid and lipoteichoic acid.

7 ionic ligands such as lipopolysaccharide and lipoteichoic acid.

8 -alanylation of membrane-associated D-alanyl-lipoteichoic acid.

9 l-Dcp in the incorporation of D-alanine into lipoteichoic acid.

10 reactive mAbs BC019, BC020, and BC021 target lipoteichoic acid.

11 pha-toxin stimulation following priming with lipoteichoic acid.

12 the phosphocholine residues of pneumococcal lipoteichoic acid.

13 kbone structure in their membrane-associated lipoteichoic acid.

14 - to 3-fold) with gram-positive bacteria and lipoteichoic acid.

15 ive shock was induced by coadministration of lipoteichoic acid (3 mg/kg intravenously) and peptidogly

16 ty acid produced by intestinal bacteria, and lipoteichoic acid, a cell wall component of gram-positiv

17 fatty acid produced by intestinal bacteria, lipoteichoic acid, a cell wall component of gram-positiv

18 Lipoteichoic acid, a known NLRP6 ligand, also promotes N

19 be inhibited by laminin and by streptococcal lipoteichoic acid, a molecule previously implicated as t

20 In addition, lipoteichoic acid, a PAMP produced by Gram-positive bact

21 onferring responsiveness to endotoxin and to lipoteichoic acid, a product of Gram-positive bacteria,

22 to P. aeruginosa but not to the response to lipoteichoic acid, a specific ligand of TLR2.

23 imulation that differs from stimulation with lipoteichoic acid, a TLR2 agonist.

24 ylic acid (poly I:C), a TLR3 ligand; but not lipoteichoic acid, a TLR2 ligand, upregulate macrophage

25 ternalization of S. aureus and its component lipoteichoic acid, accompanied by a marked defect in tum

26 Bacterial lipoteichoic acid activates the platelet-activating fact

27 LPS, Gram-positive bacterial wall component lipoteichoic acid and bacterial heat shock protein Gro-E

28 forms of LPS was competed for efficiently by lipoteichoic acid and by rough mutant (Ra and Rc) forms

29 In contrast, microbial lipopolysaccharide, lipoteichoic acid and flagellin stimulated a limited num

30 gtP synthesises the glucolipid precursor for lipoteichoic acid and has been suggested to function as

31 iver, lung) caused by a) coadministration of lipoteichoic acid and peptidoglycan (Gram-positive shock

32 overed that two cell wall components, namely lipoteichoic acid and peptidoglycan of the Gram-positive

33 ative (lipopolysaccharide) or Gram-positive (lipoteichoic acid and peptidoglycan) shock 24 hrs later.

34 delta potentiates PAFR expression induced by lipoteichoic acid and pneumococci.

35 ated LL-37 to quench macrophage responses to lipoteichoic acid and poly(I:C) signaling via TLR2 and T

36 nd IFN-gamma-pretreated macrophages, whereas lipoteichoic acid and synthetic unmethylated deoxycytidi

37 with the TLR4 agonist LPS and TLR2 agonists lipoteichoic acid and zymosan.

38 obial ligands for TLR2 (peptidoglycan [PGN], lipoteichoic acid) and TLR4 (lipopolysaccharide), by pro

39 osis by microbial products through the TLR2 (lipoteichoic acid) and/or TLR4 (LPS) pathway.

40 Bacterial LPS, lipoteichoic acid, and hsp60 also competed against iodin

41 to bacterial LPS (endotoxin), lipoproteins, lipoteichoic acid, and other acylated microbial products

42 be inhibited by the bacterial products LPS, lipoteichoic acid, and peptidoglycan.

43 Bacterial lipopolysaccharides, lipoteichoic acid, and synthetic amphipathic helical pep

44 ll components, such as lipopolysaccharide or lipoteichoic acid, and viral nucleic acids, such as doub

45 ty to a broad range of LPS structures and to lipoteichoic acid, and, moreover, MD-2 enhances the resp

46 eptidoglycan cell wall, wall-teichoic acids, lipoteichoic acids, and capsular polysaccharide.

47 udies suggested a possible role for purified lipoteichoic acid as a vaccine target for eliciting prot

48 e activity of particles with adherent LPS or lipoteichoic acid as would be expected if alarmins are s

49 emistry and genetics of polyglycerophosphate lipoteichoic acid biosynthesis but it has remained uncle

50 r insights into the functional redundancy of lipoteichoic acid biosynthesis enzymes in Bacillus subti

51 sCD14, sPGN, smooth LPS, ReLPS, lipid A, and lipoteichoic acid but not by dextran, dextran sulfate, h

52 s, Gram-negative bacteria, and Gram-positive lipoteichoic acid, but not to Gram-positive bacteria, pe

53 crophages were stimulated in vitro with LPS, lipoteichoic acid, CD40 ligand, or low molecular mass hy

54 e bacteria and their LPS, peptidoglycan, and lipoteichoic acid components.

55 mmation in response to S. pneumoniae and its lipoteichoic acid, demonstrate that S. pneumoniae binds

56 the TLR2-specific agonist, peptidoglycan or lipoteichoic acid, did not cause an inflammatory respons

57 d heat-inactivated Staphylococcus aureus and lipoteichoic acid differentially alter expression of the

58 Here, using the D-alanylation of lipoteichoic acid (Dlt) pathway as a paradigm, we have i

59 macrophages, the epithelial-cell response to lipoteichoic acid does not require Toll-like receptor 2

60 dies, proinflammatory molecules such as LPS, lipoteichoic acid, dsRNA, TNF-alpha, and IFN-gamma can i

61 mination in HL-60 cells exposed to LPS, TNF, lipoteichoic acid, f-MLP, or hydrogen peroxide, which ar

62 ation of diacylglycerol and the cessation of lipoteichoic acid formation in B. subtilis.

63 erotype C and D capsule polysaccharides mask lipoteichoic acid from detection by agglutinating antibo

64 Similarly, E. faecalis capsule masks lipoteichoic acid from detection, which correlates with

65 ide (LPS) from Gram-negative bacteria and to lipoteichoic acid from Gram-positive bacteria.

66 s and bacterial cell wall components such as lipoteichoic acid from Gram-positive bacteria.

67 murium strains, as well as LPS, lipid A, and lipoteichoic acid from Pseudomonas aeruginosa and Lister

68 popolysaccharide (LPS) (Gram-negative rods), lipoteichoic acid (Gram-positive cocci), and lipoarabino

69 r products including Gram-positive bacteria (lipoteichoic acid), Gram-negative bacteria (lipopolysacc

70 e immunization against clumping factor A and lipoteichoic acid have all proven unsuccessful in clinic

71 A (PspA), choline binding protein A (CbpA), lipoteichoic acid, immunoglobulin A1 (IgA1) protease, pn

72 ds, including LPS in gram-negative bacteria, lipoteichoic acid in gram-positive bacteria, and phospho

73 D-alanine into membrane-associated D-alanyl-lipoteichoic acid in Lactobacillus casei requires the 56

74 oic acid in the S. pneumoniae cell wall, and lipoteichoic acid in the S. pneumoniae membrane were pre

75 acellular HlpA formed soluble complexes with lipoteichoic acid in vitro and bound readily to heparan

76 rane products of S. pneumoniae that included lipoteichoic acid induced disruption of the epithelial b

77 onserved (poly)glycerolphosphate backbone of lipoteichoic acid is a major antigenic target of the hum

78 ork constitutes the first demonstration that lipoteichoic acid is sufficient to induce expression of

79 ed alditol repeats of cell-wall teichoic and lipoteichoic acids is 3:2; and (iii) 50% of the mature c

80 The biosynthesis of lipoteichoic acids is a potential target for the develop

81 acL (previously known as RafX) as a putative lipoteichoic acid ligase required for LTA assembly.

82 Gram-positive bacteria, lipopolysaccharide, lipoteichoic acid, lipid A and muramyl dipeptide elicit

83 lly involved in the inflammatory response to lipoteichoic acid, lipopeptides, and glycans from a vari

84 oreover, after challenge with peptidoglycan, lipoteichoic acid, live or heat-killed Staphylococcus au

85 The D-alanylation of lipoteichoic acid (LTA) allows the Gram-positive organis

86 dltA exhibited a loss of D-alanyl esters in lipoteichoic acid (LTA) and a loss of intrageneric coagg

87 NO production by macrophages in response to lipoteichoic acid (LTA) and a synthetic lipopeptide (Pam

88 his inhibition is mediated by staphylococcal lipoteichoic acid (LTA) and acts selectively on keratino

89 Macrophage stimulation by lipoteichoic acid (LTA) and hemoglobin (Hb) requires Tol

90 overed that two cell wall components, namely lipoteichoic acid (LTA) and peptidoglycan (PepG) of the

91 ureus and the bacterial cell wall components lipoteichoic acid (LTA) and peptidoglycan (PGN) induced

92 us, its exoproducts, or cell wall components lipoteichoic acid (LTA) and peptidoglycan (PGN).

93 yldiacylglycerol, a cell membrane anchor for lipoteichoic acid (LTA) and predicted product of the Iag

94 Lipoteichoic acid (LTA) and wall teichoic acid (TA) isol

95 ns two distinct teichoic acid (TA) polymers, lipoteichoic acid (LTA) and wall teichoic acid (WTA), wh

96 molecules of Gram-positive bacteria such as lipoteichoic acid (LTA) and whether gelsolin's interacti

97 ls of bacterial lipopolysaccharide (LPS) and lipoteichoic acid (LTA) are associated with different ca

98 possible inhibitors of Staphylococcus aureus lipoteichoic acid (LTA) biosynthesis from a screen of ~2

99 rol transferase gene that is responsible for lipoteichoic acid (LTA) biosynthesis in Lactobacillus ac

100 ol transferase gene that plays a key role in lipoteichoic acid (LTA) biosynthesis in Lactobacillus ac

101 oteins responsible for the esterification of lipoteichoic acid (LTA) by D-alanine.

102 tion with either lipopolysaccharide (LPS) or lipoteichoic acid (LTA) by using a custom microarray, re

103 lipid, lysyl-phosphatidylglycerol (LPG), and lipoteichoic acid (LTA) contribute to LukAB deposition a

104 PS-mimetic molecules-taxol from yew bark and lipoteichoic acid (LTA) from gram-positive bacterial cel

105 It is known that lipoteichoic acid (LTA) from Gram-positive cariogenic ba

106 mally to other bacterial substrates, such as lipoteichoic acid (LTA) from Staphylococcus aureus, whic

107 ylococcus aureus-derived cell-wall component lipoteichoic acid (LTA) governs the second phase of immu

108 The D-alanylation of membrane-associated lipoteichoic acid (LTA) in gram-positive organisms requi

109 To define the role of lipoteichoic acid (LTA) in innate immunity to gram-posit

110 compound, HSGN-94, has been shown to reduce lipoteichoic acid (LTA) in S. aureus, but the mechanism

111 cell wall components peptidoglycan (PGN) and lipoteichoic acid (LTA) induced the secretion of proinfl

112 Here, we show that S. aureus lipoteichoic acid (LTA) inhibits platelet aggregation ca

113 Lipoteichoic acid (LTA) is a Gram-positive cell surface

114 Lipoteichoic acid (LTA) is a major component of the cell

115 Lipoteichoic acid (LTA) is an amphiphilic molecule from

116 Lipoteichoic acid (LTA) is an essential bacterial membra

117 Lipoteichoic acid (LTA) is an important cell wall compon

118 Lipoteichoic acid (LTA) is an important cell wall compon

119 Lipoteichoic acid (LTA) is an important cell wall polyme

120 Lipoteichoic acid (LTA) is an important cell wall polyme

121 Lipoteichoic acid (LTA) is an important cell wall polyme

122 In Staphylococcus aureus RN4220, lipoteichoic acid (LTA) is anchored in the membrane by a

123 Staphylococcus aureus lipoteichoic acid (LTA) is composed of a linear 1,3-link

124 Type 1 lipoteichoic acid (LTA) is present in many clinically im

125 exclusively in Gram-negative bacteria, while lipoteichoic acid (LTA) is specific to Gram-positive bac

126 a leading cause of gram-positive sepsis, and lipoteichoic acid (LTA) may be important in causing gram

127 hesized that the S. aureus cell wall product lipoteichoic acid (LTA) may contribute to the developmen

128 oactive adduct to the teichoic acid (TA) and lipoteichoic acid (LTA) of the surface of Streptococcus

129 ect of purified lipopolysaccharide (LPS) and lipoteichoic acid (LTA) on expression and function of TL

130 ipid anchor of a cell surface polymer called lipoteichoic acid (LTA) or with deletion of genes import

131 Lipoteichoic acid (LTA) purified from 2 strains of virid

132 osine triphosphate (ATP) and the TLR2 ligand lipoteichoic acid (LTA) selectively and synergistically

133 R are co-expressed by pulp fibroblasts under lipoteichoic acid (LTA) stimulation.

134 haride (LPS) and the Gram-positive bacterial lipoteichoic acid (LTA) substantially upregulated transc

135 esponse to the TLR2/6 agonist staphylococcal lipoteichoic acid (LTA) was abolished only in the index

136 uctose homopolymer levan, and a glucosylated lipoteichoic acid (LTA) was identified in a micellar fra

137 eveloped a method for obtaining pneumococcal lipoteichoic acid (LTA) with none, one, or two acyl chai

138 Lipoteichoic acid (LTA), a cell wall polymer of gram-pos

139 Lipoteichoic acid (LTA), a cell wall ribitol polymer fro

140 ient mice to demonstrate that staphylococcal lipoteichoic acid (LTA), a constituent of Gram-positive

141 Lipoteichoic acid (LTA), a glycerol phosphate polymer, i

142 Lipoteichoic acid (LTA), a glycerol phosphate surface po

143 In this study, we examined the effects of lipoteichoic acid (LTA), a major cell-wall factor of Gra

144 In contrast, lipoteichoic acid (LTA), a predominant surface glycolipi

145 ), a critical MC differentiation factor, and lipoteichoic acid (LTA), a Toll-like receptor 2 ligand.

146 ecies biofilm model to investigate bacteria, lipoteichoic acid (LTA), and lipopolysaccharide (LPS) si

147 (PAMP), including lipopolysaccharide (LPS), lipoteichoic acid (LTA), and Pam(3)Cys, a bacterial lipo

148 a, IL-8, their combination, endotoxin (LPS), lipoteichoic acid (LTA), and staphyloccocal enterotoxin

149 n was observed in S. pneumoniae, TLR2 ligand lipoteichoic acid (LTA), and TLR4 ligand pneumolysin (PL

150 nce of bacterial lipopolysaccharide (LPS) or lipoteichoic acid (LTA), histones are released from the

151 One form, lipoteichoic acid (LTA), is anchored in the cell membran

152 tivation by soluble peptidoglycan (sPGN) and lipoteichoic acid (LTA), main stimulatory components of

153 accharide (III-PS), group B antigen (GB-Ag), lipoteichoic acid (LTA), or Escherichia coli lipopolysac

154 de (III-PS), group B polysaccharide (GB-PS), lipoteichoic acid (LTA), or peptidoglycan (PG).

155 (TLR) 4 and TLR2 receptors recognize LPS or lipoteichoic acid (LTA), respectively.

156 roducts such as lipopolysaccharide (LPS) and lipoteichoic acid (LTA), suggesting a role for SR-AI/II

157 Upon incubation with lipoteichoic acid (LTA), the major cell wall component o

158 The TLR 2 ligand, lipoteichoic acid (LTA), the TLR 4 ligand, LPS, and the

159 wing relatively short exposure times to LPS, lipoteichoic acid (LTA), thymidine homopolymer phosphoro

160 an and Wood), as well as S. aureus cell wall lipoteichoic acid (LTA), were incubated in thrombin-inhi

161 eins (Slps), including SlpA, SlpB, SlpX, and lipoteichoic acid (LTA), which interact with pattern rec

162 l 10- and 18-amino acid sequences suppressed lipoteichoic acid (LTA)- and lipopolysaccharide (LPS)-in

163 eas csdEF plays a role in galactosylation of lipoteichoic acid (LTA).

164 in keratinocytes exposed to S. aureus and to lipoteichoic acid (LTA).

165 lve the binding of this protein to cell wall lipoteichoic acid (LTA).

166 surface markers lipopolysaccharide (LPS) and lipoteichoic acid (LTA).

167 their cell-wall components LPS, lipid A, and lipoteichoic acid (LTA).

168 ut not to TLR-2 alone or TLR-2 and S. aureus lipoteichoic acid (LTA).

169 Lipoteichoic acids (LTA) are polymers of alternating uni

170 arides (LPS) from Gram-negative bacteria and lipoteichoic acids (LTA) from Gram-positive bacteria wit

171 Lipoteichoic acids (LTA), cell wall components of gram-p

172 l teichoic acids (WTA) or to the membrane as lipoteichoic acids (LTA).

173 on of highly conserved cell wall components (lipoteichoic acid [LTA] and peptidoglycan [PGN]), which

174 choic acid, WTA) or to membrane glycolipids (lipoteichoic acid, LTA).

175 ined ligands for toll-like receptor (TLR) 2 (lipoteichoic acid; LTA), TLR3 (polyIC), TLR4 (lipopolysa

176 hoic acids; WTA) or to membrane glycolipids (lipoteichoic acids; LTA).

177 Lipoteichoic acids (LTAs) are Gram-positive bacterial ce

178 Lipoteichoic acids (LTAs) are membrane-anchored molecule

179 Wall teichoic acids (WTAs) and membrane lipoteichoic acids (LTAs) are the major polyanionic poly

180 Lipoteichoic acids (LTAs) belong to the immunostimulator

181 uman recombinant mannose-binding protein and lipoteichoic acids (LTAs) by enzyme-linked immunosorbent

182 Additionally, we show that lipoteichoic acids (LTAs) can interact with LLS and that

183 In contrast, the membrane-anchored lipoteichoic acids (LTAs) do not show significant variat

184 primarily produce lipid-anchored TAs called lipoteichoic acids (LTAs) that bind and sequester the ma

185 and 2D NMR revealed that both were atypical lipoteichoic acids (LTAs) with poly-(beta1->4)-ManNAc ba

186 h comprising part structures of the complete lipoteichoic acid molecule with two PCho residues.

187 ptor agonists, including lipopolysaccharide, lipoteichoic acid, muramyl dipeptide, and heat shock pro

188 In general, TLR-2s are presumed to recognize lipoteichoic acid of Gram-positive microbes-and TLR-4s,

189 ulin (Ig) G2 subtype, recognized ChoP on the lipoteichoic acid of Streptococcus pneumoniae and on the

190 gnificantly less hydrophobic, contained less lipoteichoic acid on its surface, and demonstrated reduc

191 fically, two inflammatory bacterial ligands, lipoteichoic acid or LPS (agonists of glial TLR2 and TLR

192 Activation of neutrophils with LPS, lipoteichoic acid, or N-palmitoyl-S-[2,3-bis(palmitoylox

193 strate interactions between SPLUNC1 and LPS, lipoteichoic acid, or polymyxin B.

194 We found that inflammatory stimuli (LPS, lipoteichoic acid, or TNF-alpha) caused an increase in c

195 that prolong neutrophil life span, including lipoteichoic acid, peptidoglycan, dexamethasone, and gra

196 l sulfoxide (as described previously) before lipoteichoic acid/peptidoglycan (n = 7).

197 ed with ODQ (as described previously) before lipoteichoic acid/peptidoglycan (n = 9).

198 In vivo, administration of lipoteichoic acid/peptidoglycan or lipopolysaccharide re

199 injury, and hepatocellular injury caused by lipoteichoic acid/peptidoglycan or lipopolysaccharide.

200 even TLR ligands were tested in this system: lipoteichoic acid/peptidoglycan, zymosan, poly (I:C), LP

201 Gram-positive human pathogen with a complex lipoteichoic acid (pnLTA) structure.

202 dies, proinflammatory molecules such as LPS, lipoteichoic acid, polyinosinic-polycytidylic acid (poly

203 to beta-1,3-glucan, lipopolysaccharide, and lipoteichoic acid, polysaccharides found on cell surface

204 tured human pulp fibroblasts stimulated with lipoteichoic acid produce all the proteins required for

205 activation of TLR2 from bacterial products (lipoteichoic acid) produced by commensal bacteria at the

206 nase in the diacylglycerol cycle that drives lipoteichoic acid production.

207 LtaA (lipoteichoic acid protein A), a predicted membrane perme

208 erred from studies that show added exogenous lipoteichoic acid reduces antimicrobial activity, rescue

209 ternalization of S. aureus and its component lipoteichoic acid requires the COOH-terminal cytoplasmic

210 sure of macrophages to a mixture of HlpA and lipoteichoic acid resulted in a synergistic response in

211 ontrast, plots from py-GC/DMS of lipid A and lipoteichoic acid showed poor matches to plots for a Gra

212 tion with TLR agonists Staphylococcus aureus lipoteichoic acid (SLTA; TLR2 ligand) and Escherichia co

213 vation guided the neuronal growth toward the lipoteichoic acid-stimulated fibroblasts.

214 results, which showed expression of C5aR in lipoteichoic acid-stimulated pulp fibroblasts.

215 ss efficient in killing vaccinia virus after lipoteichoic acid stimulation than wild-type cells.

216 prototypical Gram-positive bacterium with a lipoteichoic acid structure containing repeating units o

217 hat the presence of extracellular domains of lipoteichoic acid synthase (LtaS) and the beta-lactam re

218 r efficient function of the Mn(2+)-dependent lipoteichoic acid synthase (LtaS), a membrane-localized

219 ession of ltaSa, encoding a stress-activated lipoteichoic acid synthase, and sigma(X) functions prima

220 minal domains of two transmembrane proteins, lipoteichoic acid synthase, LtaS, and O-acyteltransferas

221 In gram-positive bacteria, lipoteichoic acid synthesis requires Mn, with TerC famil

222 ted by bacterial cell-wall motifs, including lipoteichoic acid-T (LTA-T).

223 vity of the potent bacterial lipids, LPS and lipoteichoic acid, that stimulate host innate immune res

224 In contrast to purified, natural lipoteichoic acid, the (poly)glycerolphosphate conjugate

225 ated HEK/TLR4 cells, while peptidoglycan and lipoteichoic acid (TLR2 ligands) activated HEK/TLR2 cell

226 e peptides in response to TLR2 activation by lipoteichoic acid (TLR2/6 activator) or palmitoyl (3)-Cy

227 atterns presented by lipopolysaccharides and lipoteichoic acid, TLR4 is a candidate gene for resistan

228 ion and tissue regeneration, is activated by lipoteichoic acid-treated pulp fibroblasts, and governs

229 Whereas Staphylococcus aureus (Sa) lipoteichoic acid treatment confirmed that many late-res

230 ngly, the composition of membrane-associated lipoteichoic acid was not affected.

231 The TLR2 activation by PGN, but not by lipoteichoic acid, was abolished by muramidase digestion

232 hus preserving its function as an anchor for lipoteichoic acid, which is a primary mediator of adhere

233 ther bacterial components, including LPS and lipoteichoic acid, with higher affinities than for PCP,

234 hat IL-4 and IL-13 and Staphylococcus aureus lipoteichoic acid work in combination through p63 to fur

235 proteins (srtA), or the glycolipid anchor of lipoteichoic acid (ypfP) bound GFP-CWT similar to wild-t