ライフサイエンスコーパス: lipoxygenase

1 vels of NF-kappaB, AKT, ERK1/2, COX-2, and 5-lipoxygenase.

2 ar ratio of a key SPM biosynthetic enzyme, 5-lipoxygenase.

3 d to the values obtained at pH 9 for soybean lipoxygenase.

4 and its 13-hydroperoxide (LOOH) catalysed by lipoxygenase.

5 nd its conversion to bioactive lipoxins by 5-lipoxygenase.

6 biosynthetic enzymes 12-lipoxygenase and 15-lipoxygenase.

7 can catalyze lipid peroxidation similarly to lipoxygenases.

8 d regulators of axon degeneration, including lipoxygenases.

9 dels involving autoxidation and oxidation by lipoxygenases.

10 satetraenoic acid (15(S)-HETE), the major 15-lipoxygenase 1 (15-LO1) metabolite of arachidonic acid,

11 the peroxidation of linoleic acid by soybean lipoxygenase 1.

12 In this respect, 15-lipoxygenase-1 (15-LOX-1) is a key enzyme that catalyzes

13 15-Lipoxygenase-1 (15-LOX-1), which is crucial to productio

14 elial cells (HAECs) and determine whether 15-lipoxygenase-1 (15LO1) binding with phosphatidylethanola

15 n of 15-HpETE-PE depends on activation of 15-lipoxygenase-1 (15LO1) in complex with PE-binding protei

16 oleic acid peroxidation catalyzed by soybean lipoxygenase-1 (EC 1.13.11.12, Type 1).

17 Human 15-lipoxygenase-1 (h-15-LOX-1) is a mammalian lipoxygenase

18 nase-2 (COX-2), p65- nuclear factor kappa B, lipoxygenase-1 (LOX-1) and toll-like receptor 4 (p < 0.0

19 f IR treatment on urease, trypsin inhibitor, lipoxygenase-1 and lipoxygenase-3 activities were invest

20 was sufficient for complete inactivation of lipoxygenase-1 and lipoxygenase-3, regardless of the moi

21 We employed soybean lipoxygenase-1 as a model system to investigate the impa

22 our data propose that V-ATPase regulates 15-lipoxygenase-1 expression and consequent SPM biosynthesi

23 4-induced human M2 polarization abrogated 15-lipoxygenase-1 expression and prevented the related bios

24 ingly, the ERK-1/2 pathway contributes to 15-lipoxygenase-1 expression and SPM formation in M2-like M

25 teric (or cooperative) inhibition of soybean lipoxygenase-1 of longer alkyl protocatechuates is rever

26 rophages displayed higher RvD1 levels and 15-lipoxygenase-1 protein abundance, which were prevented b

27 iants of the prototypic plant enzyme soybean lipoxygenase-1 substituted at amino acid residues inferr

28 eptor, 5-lipoxygenase-activating protein, 15-lipoxygenase-1, prostaglandin D2, and proinflammatory cy

29 ndings on C-H and O(2) activation of soybean lipoxygenase-1, these results support the emergence of m

30 Induction of eicosanoid (12-lipoxygenase (12-LO) and cyclooxygenase 2 (COX2))- and r

31 12-Lipoxygenase (12-LO) is activated by high-fat diets and

32 few compounds selectively inhibiting the 12-lipoxygenase (12-LO) pathway are known.

33 in inflammatory fluids, and platelet-type 12-lipoxygenase (12-LO), expressed by platelet MPs.

34 cribed in part to increased expression of 12-lipoxygenase (12-LOX) and its arachidonate metabolite 12

35 irst demonstrate that human platelet-type 12-lipoxygenase (12-LOX) can directly catalyze the regiosel

36 12-Lipoxygenase (12-LOX) is a key enzyme in arachidonic aci

37 show for the first time that platelet 12(S)-lipoxygenase (12-LOX), a highly expressed oxylipin-produ

38 ALOX12 is a gene encoding arachidonate 12-lipoxygenase (12-LOX), a member of a nonheme lipoxygenas

39 We previously showed that 12-lipoxygenase (12-LOX), which is required to generate the

40 epithelium induces the production of the 12-lipoxygenase (12-LOX)-dependent lipid inflammatory media

41 The 12/15-lipoxygenase (12/15-LO) enzyme is upregulated in the bra

42 WT mice high fat diet feeding induced 12/15-lipoxygenase (12/15-LO) expression in the endothelium an

43 osis, here we investigated the role of 12/15-lipoxygenase (12/15-LOX) in TF expression.

44 12/15-Lipoxygenase (12/15-LOX) is induced in beta-cells and ma

45 g target between species, such as with 12/15-lipoxygenase (12/15-LOX), which contributes to ischemic

46 The 12/15-lipoxygenase (12/15LO) enzyme is widely distributed with

47 ith an inducible, endothelium-specific 12/15-lipoxygenase (12/15Lo) knockout were protected similarly

48 es encoding 12-lipoxygenase (arachidonate 12-lipoxygenase, 12S type [Alox12]) or 12/15-lipoxygenase (

49 Here, we show that 13-lipoxygenase (13-LOX) accomplishes a key role in the des

50 Exploiting a series of 13-lipoxygenase (13-lox) mutants in Arabidopsis (Arabidopsi

51 Four 13-lipoxygenases (13-LOXs) produce JA precursors in Arabido

52 we report that synergistic activities of 15-lipoxygenase (15-LO) and secreted phospholipase A(2) (sP

53 us studies have suggested that activating 15-lipoxygenase (15-LOX) is a promising strategy to interve

54 turated phosphatidylethanolamines (PE) by 15-lipoxygenases (15-LO) that normally use free polyunsatur

55 The enzyme 15-lipoxygenase-2 (15-LOX-2) is highly expressed in large a

56 EGCs expressed 15-lipoxygenase-2 and produced high levels of 15-HETE, whic

57 rease, trypsin inhibitor, lipoxygenase-1 and lipoxygenase-3 activities were investigated.

58 complete inactivation of lipoxygenase-1 and lipoxygenase-3, regardless of the moisture contents of t

59 lving mediator concentrations, including the lipoxygenase 5-derived 13-series resolvin (RvT)2, RvT4,

60 Arachidonate-5-lipoxygenase (5-LO) activity and increased leukotriene B

61 mmatory leukotrienes (LTs) are produced by 5-lipoxygenase (5-LO) aided by 5-LO-activating protein (FL

62 on analysis to observe the organization of 5-lipoxygenase (5-LO) and 5-lipoxygenase-activating protei

63 The enzymes 5-lipoxygenase (5-LO) and glycogen synthase kinase (GSK)-3

64 C), but they also suppress the activity of 5-lipoxygenase (5-LO) at clinically feasible concentration

65 nases (COX), and leukotrienes, produced by 5-lipoxygenase (5-LO) have been implicated in cancer progr

66 5-Lipoxygenase (5-LO) is a protein widely distributed in t

67 The enzyme 5-lipoxygenase (5-LO) is key in the synthesis of leukotrie

68 5-Lipoxygenase (5-LO) is the key enzyme in leukotriene bio

69 Lipid mediators derived from 5-lipoxygenase (5-LO) metabolism can activate both pro- an

70 t developed compounds primarily target the 5-lipoxygenase (5-LO) or the cyclooxygenase (COX) pathways

71 oinflammatory cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LO) pathways and concurrently reduces an

72 hough Alox5 expression and the presence of 5-lipoxygenase (5-LO) protein in BMDMs was observed, the a

73 flammatory mediator produced by the enzyme 5-lipoxygenase (5-LO), is associated with the development

74 ng prostaglandin E2 synthase (mPGES)-1 and 5-lipoxygenase (5-LO), key enzymes linking inflammation wi

75 5-Lipoxygenase (5-LO)-activating protein (FLAP) inhibitors

76 tant to both airway remodeling [TGF-beta1, 5-lipoxygenase (5-LO)] and airway-hyperresponsiveness (AHR

77 ducts of the biosynthetic crossover of the 5-lipoxygenase (5-LOX) and cyclooxygenase-2 (COX-2) pathwa

78 Merging of 5-lipoxygenase (5-LOX) and soluble epoxide hydrolase (sEH)

79 Potential pro-inflammatory 5-lipoxygenase (5-LOX) inhibition potential (IC50 0.76-0.9

80 pharmacological and genetic inhibition of 5-lipoxygenase (5-Lox) on cell proliferation, apoptosis an

81 oxidized to proinflammatory eicosanoids by 5-lipoxygenase (5-LOX) on the nuclear envelope.

82 cifically the cyclooxygenase-2 (COX-2) and 5-lipoxygenase (5-LOX) pathways, participate in the induct

83 inhibitors of the cyclooxygenase (COX) and 5-lipoxygenase (5-LOX) pathways.

84 We reported earlier that arachidonate 5-lipoxygenase (5-Lox) plays an important role in the surv

85 nic acid in a 2-step reaction catalyzed by 5-lipoxygenase (5-LOX) requiring the formation of 5-HPETE

86 Propofol attenuated the production of 5-lipoxygenase (5-LOX)-related arachidonic acid (AA) deriv

87 eved through intracellular localization of 5-lipoxygenase (5-LOX): nuclear 5-LOX favors the biosynthe

88 Here, we evaluated the role of 5-lipoxygenase (5LO) and its chemotactic metabolite leukot

89 5-Lipoxygenase (5LO) is a key enzyme in leukotriene (LT) b

90 rovide in vitro experimental evidence that 5-Lipoxygenase (5LO) is as an endogenous regulator for GSA

91 5-Lipoxygenase (5LO) is upregulated in Alzheimer's disease

92 tress up-regulates the ALOX5 gene product, 5-lipoxygenase (5LO), herein we investigated its role in m

93 Two members of the 9-lipoxygenase (9-LOX) oxylipin pathway, 9-hydroxyoctadeca

94 nal mechanistic studies, we demonstrate that lipoxygenases act cell autonomously within neurons to re

95 5-Lipoxygenase activating protein (FLAP) inhibitors attenu

96 drug discovery program in search of novel 5-lipoxygenase activating protein (FLAP) inhibitors focuse

97 5-Lipoxygenase activating protein (FLAP) plays a critical

98 nase (ALOX5) and its partner, arachidonate 5-lipoxygenase-activating protein (ALOX5AP), are involved.

99 of a novel series of oxadiazole-containing 5-lipoxygenase-activating protein (FLAP) inhibitors are de

100 organization of 5-lipoxygenase (5-LO) and 5-lipoxygenase-activating protein (FLAP) into higher order

101 proteins, coactosin-like protein (CLP) and 5-lipoxygenase-activating protein (FLAP), can support 5LO

102 rable clinical profiles, especially the five-lipoxygenase-activating protein inhibitor, MK-591, inhib

103 5-Lipoxygenase-activating protein rescues activity of 5-li

104 serine proteinases, histamine 4-receptor, 5-lipoxygenase-activating protein, 15-lipoxygenase-1, pros

105 e pronounced effect on trypsin inhibitor and lipoxygenase activities of soaked soybeans as compared t

106 ties through inhibiting cyclooxygenase-2 and lipoxygenase activities, particularly in TBW sprouts.

107 ions (i.e., 11-HETE), this may indicate that lipoxygenase activity and lipid peroxidation are increas

108 n AERD may lead to dysregulated control of 5-lipoxygenase activity by PGE(2), whereas adherent platel

109 Inhibition of 15-lipoxygenase activity reduced PD1n-3 DPA and augmented i

110 ties through inhibiting cyclooxygenase-2 and lipoxygenase activity.

111 n in the presence of copper ions and inhibit lipoxygenase activity.

112 and a shift in soluble epoxide hydrolase and lipoxygenase activity.

113 erol, citronellol, and terpineol, as well as lipoxygenases activity-derived compounds, were evaluated

114 ever, the remaining activities of lipase and lipoxygenase after 30 min steam autoclaving were 6.25% a

115 rogen, the residual activities of lipase and lipoxygenase after the same time of atmospheric cold pla

116 ator (SPM) biosynthetic enzymes arachidonate lipoxygenase (ALOX) 12 and ALOX15 and up-regulated the p

117 significantly increased arachidonic acid 12-lipoxygenase (ALOX12) expression and elevated levels of

118 ' analysis, we identified an arachidonate 12-lipoxygenase (ALOX12)-12-hydroxyeicosatetraenoic acid (1

119 peroxidase 4 (GPX4) and arachidonic acid 15-lipoxygenase (ALOX15) are antagonizing enzymes in the me

120 d the potential of targeting arachidonate 15-lipoxygenase (ALOX15) in treating alcoholic liver diseas

121 12-lipoxygenase, 12S type [Alox12]) or 12/15-lipoxygenase (Alox15) to compare the influence of each g

122 ith the expression levels of arachidonate 15-lipoxygenase (ALOX15), and SAT1-induced ferroptosis is s

123 with elevated expression of arachidonate 15-lipoxygenase (ALOX15).

124 mined that the gene encoding arachidonate 15-lipoxygenase (Alox15/15-LO) is essential for the surviva

125 leukotriene-generating enzyme arachidonate 5-lipoxygenase (Alox5) abrogates neutrophil pro-metastatic

126 om the same pathway, in which arachidonate 5-lipoxygenase (ALOX5) and its partner, arachidonate 5-lip

127 us HIV-X4 remarkably increase arachidonate 5-lipoxygenase (ALOX5) expression.

128 the Sp1-binding motif in the arachidonate 5-lipoxygenase (ALOX5) gene promoter (either 5/5, 5/x, or

129 leukocytes through dual oxidase (Duox) and 5-lipoxygenase (Alox5a).

130 icago lineage, nodule-specific Polycystin-1, Lipoxygenase, Alpha Toxin (PLAT) domain proteins (NPDs)

131 M. truncatula nodule-specific polycystin-1, lipoxygenase, alpha-toxin (PLAT) domain-encoding gene, M

132 Plant and animal lipoxygenases also contain a 100-150-amino acid N-termin

133 es revealed that betalains interact with the lipoxygenase amino acids involved in substrate binding a

134 12-Lipoxygenase and 12/15-lipoxygenase are related but dist

135 Silencing of lipoxygenase pathways (5-lipoxygenase and 12/15-lipoxygenase), which are importan

136 xpression of the SPM biosynthetic enzymes 12-lipoxygenase and 15-lipoxygenase.

137 4 plasma cells; and abundant arachidonate 15-lipoxygenase and 25-hydroxyvitamin D-1 alpha hydroxylase

138 idylethanolamine, increased expression of 15-lipoxygenase and acyl-CoA synthetase long-chain family m

139 enzymes under acid-stress (Terfezia claveryi lipoxygenase and Agaricus bisporus tyrosinase).

140 Intravenous anesthetic propofol binds to 5-lipoxygenase and attenuates leukotriene B4 production.

141 olites and enzyme transcripts involving both lipoxygenase and cyclooxygenase pathways are increased i

142 Possibly targeting specific lipoxygenase and cyclooxygenase pathways that are activa

143 nzymes involved in the biochemical response (lipoxygenase and cyclooxygenase).

144 H2O2; and was able to inhibit phospholipase, lipoxygenase and cyclooxygenase, three pro-inflammatory

145 Roles of 5-lipoxygenase and cyclooxygenase-2 in the biosynthesis of

146 Among eicosanoids, lipoxygenase and cytochrome p450 products performed best

147 es (>1.5-fold expression) in arachidonate 15-lipoxygenase and gamma-glutamyltransferase transcripts w

148 am cell differentiation markers including 15-lipoxygenase and lectin-type oxidized LDL receptor-1 bot

149 3 and the leukotriene-synthesizing enzymes 5-lipoxygenase and leukotriene-C4-synthase.

150 Many major lipoxygenase and minor non-lipoxygenase-generated compou

151 he pro-inflammatory enzymes (ciclooxygenase, lipoxygenase and phospholipase A2).

152 bitory activity of pro-inflammatory enzymes (lipoxygenase and phospholipase) was described.

153 5-lipoxygenase-1 (h-15-LOX-1) is a mammalian lipoxygenase and plays an important role in several infl

154 Both the activity of lipoxygenase and the free radical populations in PPIs we

155 e differential increases in oxylipin-pathway lipoxygenases and auxin-responsive transcript levels in

156 t 12-LOX, excellent selectivity over related lipoxygenases and cyclooxygenases, and possess favorable

157 xisting PH and resulted in downregulation of lipoxygenases and insulin-like growth factor-1 receptor.

158 t, yet iconic C-H activation enzyme classes, lipoxygenases and prokaryotic alcohol dehydrogenases.

159 the role of the intracellular polycystin-1, lipoxygenase, and alpha-toxin (PLAT) signature domain of

160 tients had a lower level of expression of 12-lipoxygenase ( approximately 30%) and reduced MaR1 (LAP

161 al genetic deletion of the genes encoding 12-lipoxygenase (arachidonate 12-lipoxygenase, 12S type [Al

162 ing AMPK abolished cellular production of 15-lipoxygenase arachidonic acid metabolites in IL-4-stimul

163 12-Lipoxygenase and 12/15-lipoxygenase are related but distinct enzymes that are e

164 Lipoxygenases are enzymes that catalyze the oxygenation

165 They found that lipoxygenases are like Transformer toys, being converted

166 Lipoxygenases are widespread enzymes found in virtually

167 thanolamine-specific phospholipase D, and 12-lipoxygenase, as well as type I metabotropic glutamate r

168 macological blockade of either iPLA2gamma or lipoxygenases attenuated mPTP opening in failing hearts.

169 e developed for the cyclooxygenase (COX) and lipoxygenase branches of arachidonic acid metabolism, an

170 -mediated expression of three defense genes, lipoxygenase, catalase 3 and polygalacturonase-inhibitor

171 generated from the direct cyclooxygenase- or lipoxygenase-catalyzed oxidation of 2-arachidonoyl-lysop

172 requisite for life on dry land, requires the lipoxygenase-catalyzed oxidation of the essential fatty

173 ity of fat destabilizing enzymes (lipase and lipoxygenase), contaminants heavy metals (As, Cd, Pb, an

174 ated serum LTB4 and synovial expression of 5-lipoxygenase correlated with increased disease severity

175 isoprostanoid levels, with dysregulation of lipoxygenases, cytokines, and metabolite-sensing recepto

176 sma gas, the residual activity of lipase and lipoxygenase decreased to 42.50% and 87.72%, respectivel

177 5-Lipoxygenase-deficient (5-LOX(-/-)) mice, which display

178 LI and isolated monocytes produced RvD2 in a lipoxygenase-dependent manner.

179 ce by repressing an interleukin-1- and 12/15-lipoxygenase-dependent neutrophil recruitment cascade th

180 t date were characterised by an abundance of lipoxygenase derived compounds, norisoprenoids and sulfu

181 malaxation levels hindered the formation of lipoxygenase derived volatiles (hexanal, 1-hexanol, (Z)-

182 Lipoxin A4 (LXA4), an endogenous lipoxygenase-derived eicosanoid mediator, has potent dua

183 n of alveolar macrophages by arachidonate 15-lipoxygenase-derived eicosanoids to express chemokines t

184 ants to release volatile compounds comprised lipoxygenase-derived green leaf volatiles and a number o

185 Similarly, 5, 12-, and 15-lipoxygenase-derived hydroxy-PUFAs as well as those form

186 ulant phospholipid surface enriched in 12/15-lipoxygenase-derived hydroxyeicosatetraenoic acid-phosph

187 on included an increase in concentrations of lipoxygenase-derived metabolites [12(S)-HETE, 15(S)-HETE

188 ouse DRG neurons lacking expression of 12/15-lipoxygenase display protection of axons in this context

189 fluence pro-inflammatory, cyclooxygenase and lipoxygenase eicosanoid products.

190 in configuration is examined for the soybean lipoxygenase enzyme.

191 a-alkynyl arachidonic acid were reacted with lipoxygenase enzymes that introduce oxygen at different

192 2 (PHKG2) regulation of iron availability to lipoxygenase enzymes, which in turn drive ferroptosis th

193 are the substrates for lipid peroxidation by lipoxygenase enzymes.

194 s, including metabolites of cyclooxygenases, lipoxygenases, epoxygenases, and other sources.

195 utathione peroxidase 4P< 0.01] and increased lipoxygenase expression (arachidonate 12-lipoxygenaseP<

196 lipoxygenase (12-LOX), a member of a nonheme lipoxygenase family of dioxygenases.

197 Recently we cloned two catalase-lipoxygenase fusion protein genes (a and b) from the cor

198 In corals a catalase-lipoxygenase fusion protein transforms arachidonic acid

199 Many major lipoxygenase and minor non-lipoxygenase-generated compounds were shown to have disc

200 oxylipids are formed through oxygenation by lipoxygenases (i.e., 5-, 12-, and 15-HETE, and 15- hydro

201 oleic acid co-oxidation initiated by soybean lipoxygenase in a micelle system.

202 rom 2 groups of enzymes, cyclooxygenases and lipoxygenases, inhibit [and the omega-6 (n-6) LC-PUFA me

203 on (27%), NO production (20%), ROS (32%) and lipoxygenase inhibition (IC50=31.24muM) compared to FS.

204 The IC50 value for lipoxygenase inhibition was almost twice as low after el

205 ed using LPS treated RAW 264.7 cell line and lipoxygenase inhibition.

206 , and treatment of these mice with the 12/15-lipoxygenase inhibitor ML-351 rescued the dysglycemic ph

207 ction observed in various settings following lipoxygenase inhibitor treatment.

208 that were abrogated by anti-PlGF Ab or the 5-lipoxygenase inhibitor zileuton.

209 mized to receive vehicle or baicalein (12/15-lipoxygenase inhibitor) at 10-15 minutes postinjury.

210 Multiple structurally distinct lipoxygenase inhibitors as well as mouse DRG neurons lac

211 transcripts, a polyketide synthase and three lipoxygenases (involved in the synthesis of secondary me

212 Wheat lipoxygenase is very weakly active compared to the other

213 Oxidation of the linoleate moiety by lipoxygenases is proposed to facilitate enzymatic cleava

214 um-independent phospholipase A2, 12/15 and 5-lipoxygenase) is expressed in mouse submandibular glands

215 Phospholipase A2/5-lipoxygenase/leukotriene-B4 (PLA2/5-LOX/LTB4) axis is an

216 eonatally sensitized mice showed increased 5-lipoxygenase levels, whereas adult mice expressed more g

217 mal recessive congenital ichthyoses; and (v) lipoxygenases, lipase activity, and LIPN co-localize wit

218 P failed to decrease the parasitic load in 5-lipoxygenase (LO)-deficient macrophages.

219 e previously reported the infection of C3H 5-lipoxygenase (LO)-deficient mice with Borrelia burgdorfe

220 The faba bean exhibited high lipase and lipoxygenase (LOX) activities, with pH optima being 8.0

221 ies attributed this impairment to reduced 15-lipoxygenase (LOX) activity rather than altered DHA cell

222 ity to scavenge free radicals and to inhibit lipoxygenase (LOX) activity.

223 ies to scavenge free radicals and to inhibit lipoxygenase (LOX) activity.

224 rane-bound arachidonic acid, stimulating the lipoxygenase (LOX) and COX pathways also amplified by MY

225 ition, inhibiting phospholipase A2 (PLA2) or lipoxygenase (Lox) blocks chemotaxis towards low concent

226 n enzymes including cyclooxygenase (COX) and lipoxygenase (LOX) has revealed far lower values.

227 ization of the key SPM biosynthetic enzyme 5-lipoxygenase (LOX) in vascular cells.

228 In Arabidopsis, NAE18:2 may be oxidized by lipoxygenase (LOX) or hydrolyzed by fatty acid amide hyd

229 obtained ex vivo, and further evidence that lipoxygenase (LOX) pathway contributes to volatile produ

230 synthesized across the cyclooxygenase (COX), lipoxygenase (LOX), and cytochrome P450 (CYP450) pathway

231 he first enzyme of the oxylipin pathway, the lipoxygenase (LOX), leading to a faster accumulation of

232 nzyme group, including cyclooxygenase (COX), lipoxygenase (LOX), or cytochrome P450 (CYP).

233 ienes by targeting cyclooxygenases (COXs), 5-lipoxygenase (LOX), or the 5-LOX-activating protein (FLA

234 Lipoxygenase (LOX)-catalysed degradation of polyunsatura

235 mpus, partly through the activation of 12/15-lipoxygenase (LOX)/12-HETE signaling, altering neuronal

236 Lipoxygenases (LOX) are non-heme metal enzymes, which ox

237 he increased expression of genes encoding 13-lipoxygenases (LOXs) and phospholipase A-Igamma3 (At1g51

238 Human lipoxygenases (LOXs) are a family of iron-containing enz

239 ling elicits anti-inflammatory responses, 15-lipoxygenase may either support or inhibit inflammatory

240 anched beans also had decreased abundance of lipoxygenase (mean fold-change -13.1), an enzyme respons

241 pathway that results from accumulation of 15-lipoxygenase-mediated lipid oxidation products, specific

242 The lipoxygenase-mediated pathway stimulates the production

243 verge into a cyclooxygenase 2-mediated and a lipoxygenase-mediated route.

244 Here, we determined that 12/15-lipoxygenase-meditated (12/15-LO-mediated) enzymatic lip

245 results suggest that the concentrations of 5-lipoxygenase metabolites of arachidonic acid, 5-hydroxye

246 Cyclooxygenase and lipoxygenase metabolites prostaglandin E2 (vasodilator)

247 ghest prediction of overall preterm birth by lipoxygenase metabolites using random forest (AUC = 0.83

248 s revealed increased arachidonic acid and 12-lipoxygenase metabolites.

249 We show that a maize 13-lipoxygenase mutant, lox10, colonized by the wild-type T

250 ase-activating protein rescues activity of 5-lipoxygenase mutations that delay nuclear membrane assoc

251 d to have some effect on the inhibition of 5-lipoxygenase, no cytotoxicity against RAW 264.7 macropha

252 Retinal ganglion cell axons from 12/15-lipoxygenase-null mice were similarly protected from deg

253 ALOX15 (12/15-lipoxygenase) orthologs have been implicated in maturati

254 The human 12/15-lipoxygenase orthologue, ALOX12, is expressed in cavitar

255 nes such as SOD (superoxide dismutase), LOX (lipoxygenase), PAL (phenylalanine ammonia lyase), and PR

256 ssociated proteins, resveratrol synthase, 9s-lipoxygenase, pathogenesis-related proteins were identif

257 detailed picture of volatile products of the lipoxygenase pathway (mainly C6-aldehydes) and of glucos

258 vating protein (FLAP) inhibitors attenuate 5-lipoxygenase pathway activity and reduce the production

259 a NF-kappaB, eicosanoid biosynthesis via the lipoxygenase pathway and IL-2 biosynthesis (all P < .01)

260 uced formation of reaction products from the lipoxygenase pathway and less pronounced fruitiness and

261 of proinflammatory lipid mediators of the 5-lipoxygenase pathway are significantly higher in MIAC th

262 Lipoxygenase pathway is confirmed as an important biosyn

263 ntrolled cortical impact, suggesting that 15-lipoxygenase pathway might be a valuable therapeutic tar

264 pression profiles of eleven key genes in the lipoxygenase pathway, and both expression profiles and V

265 nd is primarily biosynthesized via the 12(S)-lipoxygenase pathway.

266 aled a dramatic increase in epoxygenase- and lipoxygenase-pathway-derived lipid mediators in spontane

267 Silencing of lipoxygenase pathways (5-lipoxygenase and 12/15-lipoxyge

268 tored eicosanoids in cyclooxygenase-1 and 12-lipoxygenase pathways.

269 ted through the impact on cyclooxygenase and lipoxygenase pathways.

270 series of endogenous plant enzymes, such as lipoxygenases, peroxidases and glycosidases, including m

271 ein b, establishing its role in cleaving the lipoxygenase product 8R-hydroperoxy-eicosatetraenoic aci

272 The 12-lipoxygenase product hepoxilin A3 mediates the migration

273 ,14-eicosatetraenoic acid (5-oxo-ETE) is a 5-lipoxygenase product that acts via the selective OXE rec

274 ,14-eicosatetraenoic acid (5-oxo-ETE) is a 5-lipoxygenase product that is a potent granulocyte chemoa

275 ic isoflurane attenuated the production of 5-lipoxygenase products and IL-10 and reduced CD11b and in

276 rall capacity of whole blood to synthesize 5-lipoxygenase products; these genotype-related changes in

277 putum supernatant concentrations of selected lipoxygenases products: 5-,12-,15-hydroxyeicosatetraenoi

278 c brain injury, and whether inhibition of 15-lipoxygenase provided neuroprotection.

279 with the lipid degrading enzymes, lipase and lipoxygenase, resulting in a relatively short shelf life

280 Lipoxygenases retain their catalytic ability upon immobi

281 The enzyme soybean lipoxygenase (SLO) has served as a prototype for hydroge

282 Soybean lipoxygenase (SLO) has served as a prototype for underst

283 pical nonadiabatic tunneling system, soybean lipoxygenase (SLO), it has remained unclear whether the

284 ve kinetic isotope effects (KIE) for soybean lipoxygenase (sLOX) oxygenation of linoleic acid (LA, 18

285 een determined at pH 6.5 for three different lipoxygenases, soybean, horse bean and wheat and compare

286 injections of 15-HETE or an inhibitor of 15-lipoxygenase (the enzyme that produces 15-HETE); colons

287 In lipoxygenases, the topologically conserved C-terminal do

288 ahexaenoic acid was converted by platelet 12-lipoxygenase to 13S,14S-epoxy-maresin, which was further

289 ylation was mediated by an upregulation of 5-lipoxygenase via cdk5 kinase pathway activation.

290 In summary, we found that PUFA oxidation by lipoxygenases via a PHKG2-dependent iron pool is necessa

291 cyclooxygenases-1 and -2 (COX-1/COX-2), and lipoxygenase was determined.

292 Finally, 5-lipoxygenase was discovered as an additional molecular t

293 reaction catalysed by soybean and horse bean lipoxygenases was observed with 2,6-di-tert-butyl-4-meth

294 ncreatic lipase, acetylcholinesterase and 15-lipoxygenase were performed.

295 oxygenase pathways (5-lipoxygenase and 12/15-lipoxygenase), which are important enzymes for specializ

296 lished through immobilization of the enzyme, lipoxygenase, which catalyzes the production of redox ac

297 SHV miRNA cluster probably targets enzyme 15-lipoxygenase, which is involved in lipoxin A4 synthesis.

298 duced by inhibitors of cyclooxygenase and 12-lipoxygenase, which metabolize arachidonic acid to gener

299 ein conformation upon interaction of soybean lipoxygenase with a fatty acid surrogate, oleyl sulfate

300 resulted as the most potent inactivators of lipoxygenase, with IC50 values of 41.4 and 40.1muM, resp