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1  through the covalent attachment of lipoate (lipoylation).
2 s that are responsible for bacterial protein lipoylation.
3 on and independent of traditional N-terminal lipoylation.
4 cid levels and drastically decreases protein lipoylation.
5 (173) mutants, only E170Q mutation prevented lipoylation.
6  these pathways leads to diminished cellular lipoylation.
7 lix 3 are essential for both cuproptosis and lipoylation.
8 duction, is critical for maintaining protein lipoylation, a conserved lipid modification necessary fo
9                                      Protein lipoylation, a crucial post-translational modification (
10 as an upstream regulator of cellular protein lipoylation, a mitochondrial lipid-based post-translatio
11 LIAS, promoting its role in cellular protein lipoylation, a process essential in maintaining cell via
12                                      Protein lipoylation, a vital lysine post-translational modificat
13 ontain two different routes of mitochondrial lipoylation, an arrangement that has not been described
14 lighting ABHD11 as a regulator of functional lipoylation and 2-OG metabolism.
15 ct on both mitochondrial activities, protein lipoylation and glycine metabolism, causing combined def
16 etic evidence to support the linkage between lipoylation and ion homeostasis in plants.
17     This review focuses on the mechanisms of lipoylation and its significant impact on cell metabolis
18 nd correspondingly varying levels of protein lipoylation and metabolic activity.
19 he mtFAS pathway, thereby sustaining protein lipoylation and mitochondrial oxidative metabolism.
20 ion system and establish a crosstalk between lipoylation and mono-ADP-ribosylation.
21 nstructed, has a consensus motif (LTG C) for lipoylation and signal peptide cleavage.
22 sorder, optic neuropathy, defects in protein lipoylation, and reduced mitochondrial oxidative phospho
23 gest that FDX1's roles in cuproptosis and in lipoylation are both structurally and functionally linke
24                           We also identified lipoylation as a target of the toxic antitumor copper io
25 we show that FDX1 directly regulates protein lipoylation by binding the lipoyl synthase (LIAS) enzyme
26 ur study demonstrates that increased protein lipoylation can alleviate DKD through metabolic and ener
27     The intricate relationship among protein lipoylation, cellular energy metabolism, and cuproptosis
28 ative damage but did not reverse the protein lipoylation defect.
29      Efficient restoration of lipoylation in lipoylation deficiency cell states using either chemical
30 A) and LipL2, restored lipoate scavenging in lipoylation-deficient bacteria, indicating that Plasmodi
31  a wild-type strain robustly outcompeted the lipoylation-deficient mutant in a murine model of lister
32  this missense LIPT1 allele recapitulate the lipoylation-deficient phenotype and exhibit impaired pro
33 anifested through the regulation of the four lipoylation-dependent enzymes ultimately resulting in lo
34  potential therapeutic strategy for treating lipoylation disorders.
35                                   Inhibiting lipoylation, either through genetic LIPT1 knockout or a
36                                              Lipoylation emerged as a key metabolic target for radios
37 dy investigated the potential of recombinant lipoylation enzymes lipoate activating enzyme and lipoyl
38 erized function of mtFAS, as mutants lacking lipoylation have an intact ETC.
39                     Engineered lplA restored lipoylation in all tested lipoylation null cell models,
40 er protein synthase is not vital for protein lipoylation in Arabidopsis (Arabidopsis thaliana) and do
41 's ability to induce cuproptosis and support lipoylation in cells, despite retaining full enzymatic a
42 yl domain, is sufficient to prevent aberrant lipoylation in E.coli.
43                             Prevention of L1 lipoylation in K46AE2 removed this competitive L1 role a
44                     Efficient restoration of lipoylation in lipoylation deficiency cell states using
45  of either FDX1 or lipoyl synthase KO cells, lipoylation in these same cells is not rescued, arguing
46               We propose a model for protein lipoylation in which Lip2, Lip3, Lip5, and Gcv3 function
47                           Similar to protein lipoylation in yeast, LIP2 likely also transfers octanoy
48 from the target for biotinylation to one for lipoylation, in vivo and in vitro.
49                             Mechanistically, lipoylation inhibition increased 2-hydroxyglutarate, lea
50 , either through genetic LIPT1 knockout or a lipoylation inhibitor (CPI-613), enhanced tumor control
51 that a target of lipoylation is required for lipoylation is a novel result.
52               Demonstration that a target of lipoylation is required for lipoylation is a novel resul
53                          Maintaining protein lipoylation is vital for cell metabolism.
54 ally, GCV3, encoding the H protein target of lipoylation, is itself absolutely required for lipoylati
55 ered lplA in lipoylation null cells restored lipoylation levels, cellular respiration, and growth in
56 or with alanines substituted at the sites of lipoylation (Lys-46 in L1 or Lys-173 in L2).
57                              Redox-dependent lipoylation may regulate processes such as central metab
58 LA and LIP2 together provide a basal protein lipoylation network to plants that is similar to that in
59 ered lplA restored lipoylation in all tested lipoylation null cell models, mimicking defects in mitoc
60     Overexpression of the engineered lplA in lipoylation null cells restored lipoylation levels, cell
61                                              Lipoylation occurs via a novel redox-gated mechanism tha
62               LIP2 and LIP5 are required for lipoylation of all three mitochondrial target proteins:
63 which supports the Fe-S-dependent process of lipoylation of components of multiple key enzyme complex
64 ate-protein ligase homolog, is necessary for lipoylation of Lat1 and Kgd2, and the enzymatic activity
65 poylation, is itself absolutely required for lipoylation of Lat1 and Kgd2.
66 ient medium results in substantially reduced lipoylation of mitochondrial (but not apicoplast) protei
67                         Thus, the incomplete lipoylation of mitochondrial proteins in mtacp mutants,
68 rized plant morphology, slow growth, reduced lipoylation of mitochondrial proteins, and the hyperaccu
69                   Patients were deficient in lipoylation of mitochondrial proteins.
70                                      Whereas lipoylation of PDC-E2 is essential for enzymatic activit
71 recursors required for the posttranslational lipoylation of pyruvate and alpha-ketoglutarate dehydrog
72 nown as a key enzyme in plastids to catalyze lipoylation of pyruvate dehydrogenase complex for de nov
73 a rapid increase in 2-OG levels by impairing lipoylation of the 2-OG dehydrogenase complex (OGDHc)-th
74  fatty acid synthase system, namely depleted lipoylation of the H subunit of the photorespiratory enz
75 de in the mitochondrion and it catalyses the lipoylation of the H-protein; however, we show that LipL
76 orm of the domain become less flexible after lipoylation of the lysine residue.
77 iency in photorespiration due to the reduced lipoylation of the photorespiratory glycine decarboxylas
78 pyogenes, the activity is dependent on prior lipoylation of the target protein and can be reversed by
79  and bile acids, Vitamin A/D metabolism, and lipoylation of tricarboxylic acid (TCA) cycle enzymes.
80  a DeltalipL mutant, in which the endogenous lipoylation pathway of E2 subunits is blocked, showed gr
81 novo synthesis of precursors for the protein lipoylation pathway plays a vital role in maintenance of
82               The presence of an alternative lipoylation pathway that utilizes exogenous free lipoate
83 , we uncover a redox sensitive mitochondrial lipoylation pathway, dependent on the mitochondrial hydr
84 t mutants affected in different steps of the lipoylation pathway, indicating functional overlap.
85 anoyl-ACP precursor required for the protein lipoylation pathway.
86 precursor required for the essential protein lipoylation pathway.
87  biosynthesis and haem biosynthesis, the two lipoylation pathways of P. falciparum might be attractiv
88 Plasmodium falciparum possesses two distinct lipoylation pathways that are found in separate subcellu
89        Bacillus subtilis possess two protein lipoylation pathways: biosynthesis and scavenging.
90                 The observation of decreased lipoylation raises the possibility of a potential therap
91 luster biosynthesis (BOLA3 KO), and specific lipoylation-regulating enzymes (FDX1 [ferredoxin 1], LIA
92  mitochondrial lipoylation, while apicoplast lipoylation relies on biosynthesis.
93 n encoded by GCSH has a dual role in protein lipoylation required for bioenergetic enzymes including
94 d octanoyl moieties were translocated to the lipoylation site on the acceptor protein.
95 ts a 2-fold axis of quasi-symmetry, with the lipoylation site, Lys43, located at the tip of an expose
96 PDC in place of lipoic acid by the exogenous lipoylation system; the relative levels of lipoic acid a
97 mplexes appears to be independent of protein lipoylation, the best characterized function of mtFAS, a
98 e of utilizing exogenous lipoic acid for the lipoylation Therefore, host-derived lipoic acid may be i
99 al cysteine and therefore being incapable of lipoylation via a thioether linkage, the mutant protein
100 alysis of the role of these genes in protein lipoylation, we conclude that only one pathway for de no
101  release, and promotes mitochondrial protein lipoylation, which is directly targeted by the released
102 that lipoate scavenging drives mitochondrial lipoylation, while apicoplast lipoylation relies on bios

 
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