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1 ttenuated EEEV variants have been applied as live EEEV vaccines.
2 vaccines and most other strategies involving live virus vaccines.
3 ing immunization of a 78-year-old woman with live zoster vaccine.
4 design of a safe alternative to the existing live smallpox vaccine.
5 th -19% (95% CI, -113 to 33; P=0.55) for the live attenuated vaccine.
6 culated for the inactivated vaccines and the live attenuated vaccine.
7 ping a safe and potentially more efficacious live attenuated vaccine.
8 l tropism of a virus is a new approach for a live attenuated vaccine.
9 o understand virus biology and develop novel live attenuated vaccines.
10 n vivo and supports targeting the SH gene in live attenuated vaccines.
11 ations are good candidates for the design of live attenuated vaccines.
12 r antiviral discovery and development of new live attenuated vaccines.
13 use of non-toxigenic C. difficile strains as live attenuated vaccines.
14 ty and activity is a strategy for generating live-attenuated vaccines.
15 ize may be more informative on the safety of live-attenuated vaccines.
16 option as safe, immunogenic, and protective live-attenuated vaccines.
17 ortant determinants of the immunogenicity of live-virus oral vaccines.
18 l adjuvants and licensed vaccines, including live attenuated BCG vaccine.
19 should improve the safety and efficacy of a live attenuated RSV vaccine.
20 athology is a key correlate of the safety of live mycobacterial vaccines.
21 value of including such a mutation in future live attenuated RSV vaccines.
22 eviously exposed to DENV4 infections or to a live attenuated DENV4 vaccine.
23 d may translate into improved manufacture of live-attenuated hRSV vaccines.
24 ects against virulent challenges, similar to live L. monocytogenes vaccines.
25 on polio vaccines and, eventually, for other live-attenuated viral vaccines.
26 lenge model to better evaluate the candidate live attenuated dengue vaccines.
27 une responses elicited by vaccination with a live attenuated type II vaccine.
28 have emerged about the effectiveness of the live attenuated influenza vaccine.
29 H2N2), the backbone of the licensed seasonal live attenuated influenza vaccine.
30 oing testing, including genetically modified live-attenuated parasite vaccines.
31 ide novel targets for the rational design of live attenuated flavivirus vaccine.
32 safe and effective platform for creation of live attenuated RNA viral vaccines.
33 he rational development of other efficacious live attenuated flavivirus vaccines.
34 nstrating that this mutant is an attenuated, live, transmission-blocking vaccine.
35 development of safe, stable, and protective live-attenuated arenavirus vaccines.
36 vaccine as well as further reduce costs for live-attenuated oral polio vaccines.
37 enic influenza virus and immunization with a live attenuated influenza virus vaccine.
38 hallenge the level of protection provided by live attenuated oral rotavirus vaccines.
39 ter randomized controlled trial [cRCT]) used live attenuated influenza vaccine, 11 (7 cRCTs) used ina
40 Here we report maternal vaccination using a live-attenuated ZIKV vaccine (3'UTR-Delta10-LAV) in a pr
42 natural infection and strategies to develop live attenuated vaccines against flaviviral species.IMPO
43 s study may aid in the design of efficacious live attenuated vaccines against PEDV, as well as other
45 A similar approach may guide the design of live-attenuated vaccines against Lassa and other arenavi
46 ly good target for developing antivirals and live-attenuated viral vaccines against deadly arenavirus
49 4 T cell responses elicited by a tetravalent live attenuated dengue vaccine and show that they resemb
50 ile platform for the clinical development of live attenuated HCMV-vectored vaccines and immunotherapi
51 confirmed in 210 (18%) of 1173 recipients of live attenuated influenza vaccine and 105 (18%) of place
52 dren were randomly assigned, 1174 to receive live attenuated influenza vaccine and 587 to receive pla
53 or the observed reduced effectiveness of the live attenuated influenza vaccine and highlight the unde
55 sible association between revaccination with live attenuated vaccines and off-target infections are n
56 hlight the distinct evolutionary dynamics of live attenuated virus vaccines and have important implic
57 r quality control of new lots of the current live-attenuated vaccine and provide insight for the rati
58 nform the development of rationally-designed live-attenuated vaccines and antivirals for control of o
59 applied to current commercial PRRSV modified live-virus (MLV) vaccines and other candidate vaccines.
60 women (n = 44) were immunized with high-dose live attenuated VZV vaccine, and we assessed the express
61 to wild-type CHIKV, two CHIKV vaccines, or a live-attenuated MAYV vaccine, and challenged with MAYV.
62 rts superseded by a final report, studies of live-attenuated vaccine, and studies of prepandemic seas
71 isease in high-mortality settings means that live oral rotavirus vaccines are still likely to provide
72 ger studies of intradermal administration of live, attenuated zoster vaccine are needed to provide co
73 sidering rotavirus vaccine introduction that live, oral rotavirus vaccines are effective in high-chil
75 ults suggest that EHV-1 KyA may be used as a live attenuated EHV-1 vaccine as well as a prophylactic
76 ion may serve as a novel approach to develop live attenuated vaccines as well as antiviral drugs for
77 tivity can lead to the development of novel, live attenuated vaccines, as well as antiviral drugs for
78 ong children whose last vaccine received was live compared with inactivated vaccine, as well as concu
79 l vaccines are typically not as efficient as live attenuated or inactivated vaccines at inducing prot
82 al, we assessed the efficacy and safety of a live attenuated influenza vaccine based on Russian-deriv
83 consideration should be taken when designing live attenuated vaccines based on deletions of nonstruct
84 se findings provide a pathway for developing live attenuated virus vaccines based on engineering the
87 y exposed to DENV and was immunized with the live attenuated tetravalent vaccine Butantan-DV, develop
89 excellent safety profile and high stability, live-attenuated CDV vaccines can retain residual virulen
95 mice and highlights the potential role of a live-attenuated MAYV vaccine candidate in host's protect
97 ra from a phase 2 clinical trial of Takeda's live-attenuated tetravalent dengue vaccine candidate (TA
100 that further development of this promising, live-attenuated ZIKV vaccine candidate is warranted.
102 rational development of safe and protective live attenuated vaccine candidates based on genome reorg
103 tical information for the rational design of live attenuated vaccine candidates for other viral hemor
104 thylation as a target for rational design of live attenuated vaccine candidates for RSV and perhaps o
105 This strategy may be useful for generating live attenuated vaccine candidates that prevent disease
106 ified deISGylase activity for development of live attenuated vaccine candidates, and ISG15 as a novel
111 y stable, highly attenuated, and immunogenic live virus vaccine candidates for RSV.IMPORTANCE Despite
112 bility of a CD-based approach for developing live-attenuated vaccine candidates against human-pathoge
113 tion and provides an approach for generating live-attenuated vaccine candidates for emerging coronavi
116 or the rational design of second-generation, live-attenuated, recombinant JEV vaccine candidates.
117 91, respectively) and for those who received live and inactivated vaccines concurrently compared with
118 ate that pneumococcal conjugate vaccines and live attenuated rotavirus vaccines confer 19.7% (95% con
119 ation and the immune response to single-dose live oral cholera vaccine CVD 103-HgR in Malian adults.
120 to receive three injections of recombinant, live, attenuated, tetravalent dengue vaccine (CYD-TDV) o
121 as developed a chimeric yellow fever-dengue, live-attenuated, tetravalent dengue vaccine (CYD-TDV) th
124 demonstrated the efficacy of a recombinant, live-attenuated dengue vaccine (Dengvaxia) over the firs
125 e asked if we could improve an NS1-truncated live attenuated influenza vaccine developed for poultry
126 People exposed to serotype 4 infections or a live attenuated serotype 4 vaccine developed neutralizin
129 ach to the development of safe and effective live attenuated vaccines directed against VEEV and other
130 ach to the development of safe and effective live attenuated vaccines directed against VEEV and perha
131 ants receiving the monovalent or tetravalent live attenuated DENV vaccine (DLAV), developed by the U.
133 id a combination of a commercially available live fowl poxvirus vaccine expressing the H5 influenza v
135 rtance of the production capabilities of the live attenuated influenza vaccine for pandemic preparedn
136 ade an interim recommendation not to use the live attenuated influenza vaccine for the 2016-2017 infl
138 rstanding may also enable the development of live attenuated vaccines for both RSV and other members
141 JUNV), indicating the potential of TCRV as a live-attenuated vaccine for the treatment of Argentine h
142 NV vaccine constructs use the E protein in a live attenuated vaccine format, utilizing a backbone der
144 ses (CoVs), and the inactivation of nsp16 in live attenuated vaccines has been attempted for several
150 ompared with inactivated alone or concurrent live and inactivated vaccines (HR, 0.50; 95% confidence
153 Taken together, our data indicate that a live attenuated HSV-2 vaccine impaired for infection of
154 n could improve the safety and efficacy of a live attenuated RSV vaccine.IMPORTANCE RSV binds to the
156 a large body of evidence on the efficacy of live oral rotavirus vaccines in different settings, but
157 assess the dynamics of genetic reversion of live poliovirus vaccine in humans, we studied molecular
158 nitiated a pilot introduction of the Rotarix live, oral rotavirus vaccine in all public health facili
159 hese results raise concerns about the use of live-attenuated HSV-2 vaccines in high HSV-1 prevalence
160 adjuvanted inactivated vaccine, but not the live-attenuated vaccine, induced a substantial serum IgG
161 1 envelope (Env) antigens (Ag) for more long-lived, efficacious HIV-1 vaccine-induced B-cell response
163 V biology, including human host-pathogen and live, attenuated vaccine interactions; host and cell typ
167 vaccines.IMPORTANCE The genetic stability of live viral vaccines is important for safety and efficacy
169 tant to prevent the spread of disease, and a live-attenuated MP-12 vaccine is currently the only vacc
171 Rs.IMPORTANCE A chimeric yellow fever-dengue live-attenuated tetravalent vaccine is now being markete
172 rse genetics techniques, we have developed a live-attenuated CIV vaccine (LACIV) for the prevention o
173 e safety and immunogenicity of an avian H5N2 live attenuated influenza vaccine (LAIV H5N2) in healthy
175 al efficacy and safety of a Russian-backbone live attenuated influenza vaccine (LAIV) at two field si
176 omized, placebo-controlled clinical trial of live attenuated influenza vaccine (LAIV) in children age
178 Whether vaccinating children with intranasal live attenuated influenza vaccine (LAIV) is more effecti
184 on Practices recommended preferential use of live attenuated influenza vaccine (LAIV) over inactivate
186 onses in tonsils and saliva after intranasal live attenuated influenza vaccine (LAIV) vaccination in
187 s of inactivated influenza vaccine (IIV) and live attenuated influenza vaccine (LAIV) were tested by
190 dose of either trivalent, Russian-backbone, live, attenuated influenza vaccine (LAIV) or placebo.
192 tivated influenza vaccine (TIV) or trivalent live-attenuated influenza vaccine (LAIV) in Thailand.
193 ent 2009 pandemic influenza A(H1N1) virus or live-attenuated influenza vaccine (LAIV) or who had labo
194 l of inactivated influenza vaccine (IIV) and live-attenuated influenza vaccine (LAIV) performed durin
196 Here, we report the interactions between live-attenuated influenza vaccine (LAIV), successive pne
197 mbinant, temperature-sensitive H3N8 CIV as a live-attenuated influenza vaccine (LAIV), which was atte
199 vated influenza vaccine [TIV] vs. intranasal live, attenuated influenza vaccine [LAIV]) was postulate
200 months and the effectiveness of quadrivalent live attenuated influenza vaccine (LAIV4) among children
201 ccines (IIV3) and a nasal spray, tetravalent live-attenuated influenza vaccine (LAIV4) were used in p
205 pproach to generate safer and more efficient live-attenuated influenza virus vaccines (LAIVs) based o
206 completion, and the chances that one or more live attenuated tetravalent vaccines (LATVs) will be int
212 ve immunity in individuals unable to receive live, attenuated vaccines may have employment implicatio
215 gimens included a chimeric H8/1, intranasal, live-attenuated vaccine on day 1 followed by a non-adjuv
217 forts include high vaccination coverage with live oral polio vaccine (OPV), surveillance for acute fl
224 logy of TCRV and also its potential use as a live-attenuated vaccine or a vaccine vector for the trea
225 f TCRV and to explore its potential use as a live-attenuated vaccine or a vaccine vector for the trea
227 Vi-tetanus-toxoid conjugate vaccine (Vi-TT), live oral Ty21a vaccine, or an experimental vaccine (M01
228 ated a candidate A/Anhui/2013(H7N9) pandemic live attenuated influenza vaccine (pLAIV) in healthy adu
231 us, opening the possibility for its use as a live-attenuated vaccine platform for ZIKV and other clin
233 didates in clinical testing are all based on live-virus vaccine platforms and struggle to induce bala
235 ls spanning the past 28 years, opposition to live-attenuated HSV vaccines predicated on unfounded saf
236 ght substantially improve the performance of live pediatric RSV vaccines presently being developed.
237 ere Shan et al. show that a single dose of a live-attenuated Zika vaccine prevents infection, testis
238 In 2013 England and Wales began to fund a live attenuated influenza vaccine programme for individu
239 ummary, our data indicate that attenuated or live viral vaccines promote cytokine-induced memory-like
240 es.IMPORTANCE Effectiveness of NS1-truncated live attenuated influenza vaccines relies heavily on the
243 CD8(+) T cell responses elicited by a dengue live attenuated virus (DLAV) vaccine resemble those obse
244 role of breast milk secretor status on oral live-attenuated rotavirus vaccine response in breastfed
246 While RABV vaccines are inactivated, the live-attenuated CDV vaccines retain residual virulence f
251 This has implications for the design of live attenuated HPIV3 vaccines; specifically, the antibo
254 d-generation Candid#1 vaccine.IMPORTANCE The live-attenuated Candid#1 vaccine strain of Junin virus i
255 generated a reverse genetics system for the live-attenuated MV vaccine strain Edmonston-Zagreb (EZ),
256 tibility of the glycoprotein of the Candid#1 live-attenuated vaccine strain of JUNV in MACV replicati
258 , we developed nonreverting, nonreplicating, live attenuated uracil auxotroph vaccine strains in the
261 er, the risk of vaccine-induced disease with live-attenuated vaccines strongly limits their use.
264 ldren following immunization with intranasal live attenuated influenza vaccine, suggesting a common r
265 he efficacy, safety, and immunogenicity of a live attenuated tetravalent dengue vaccine (TAK-003) in
267 sults of vaccinating mice with a new type of live attenuated HSV-2 vaccine that is impaired for infec
268 that might be deleted for the development of live attenuated vaccines that would be safer to use in s
269 enetic engineering now enables the design of live viral vaccines that are potentially transmissible.
270 nal Institutes of Health (NIH) has developed live attenuated vaccines to each of the 4 serotypes of d
271 ica serovar Enteritidis DeltaguaBA DeltaclpX live oral vaccines to protect mice against a highly leth
273 member of the poxvirus family, was used as a live-virus vaccine to eradicate smallpox worldwide and h
274 etermine the ability of a single dose of the live attenuated tetravalent dengue vaccine TV003 to indu
277 -mumps-rubella-varicella vaccine (MMRV), one live attenuated varicella vaccine (V) dose given after o
278 use of heterologous flavivirus species as a live attenuated vaccine vector is not likely to generate
279 nstrating the feasibility of using TCRV as a live-attenuated vaccine vector for the treatment of JUNV
280 ammarenaviruses, for their implementation as live-attenuated vaccines or vaccine vectors.IMPORTANCE T
282 The A(H1N1)pdm09 virus strain used in the live attenuated influenza vaccine was changed for the 20
285 fective (95% CI, 47 to 70; P<0.001), and the live attenuated vaccine was not observed to be effective
286 t the stalk and catalytic domains of NA as a live attenuated vaccine was shown to confer a strong IAV
287 he 2016-2017 A(H1N1)pdm09 strain used in the live attenuated vaccine was unchanged from 2015-2016, th
289 ruses and human infections, new candidate H5 live attenuated vaccines were developed by using two dif
290 rinary RVF vaccine in the United States is a live-attenuated MP-12 vaccine, which is conditionally li
292 erpes zoster (HZ) vaccine is superior to the live attenuated HZ vaccine, with an efficacy >90% agains
293 means to increase the antibody response to a live attenuated HPIV3 vaccine without affecting viral re
295 cohort of 80 individuals immunized with the live attenuated yellow fever vaccine (YFV-17D) by sampli
297 on against herpes zoster (HZ) induced by the live attenuated zoster vaccine Zostavax (ZVL) wanes with