ライフサイエンスコーパス: liver development

1 ting the relevance of this pathway for human liver development.

2 mbly of the RNA Polymerase II complex during liver development.

3 uct differentiation and morphogenesis during liver development.

4 patobiliary fate decisions during vertebrate liver development.

5 d temporal expression of beta-catenin during liver development.

6 port that Cited2 is required for mouse fetal liver development.

7 ctivity has the opposite effect and enhances liver development.

8 originate from hepatoblasts during embryonic liver development.

9 been shown to be crucial for early embryonic liver development.

10 lo, which exhibits severe defects in gut and liver development.

11 y) we have found a new role for Wt1 in mouse liver development.

12 iferation upon PHx but did not reverse fatty liver development.

13 elial Arnt plays a pivotal role in embryonic liver development.

14 s and organogenesis, especially in embryonic liver development.

15 esis, but are redundant for an early step of liver development.

16 biosynthesis of lipids during early skin and liver development.

17 and in embryonic erythropoiesis during fetal liver development.

18 gate the effect of exogenous FGFs on ex vivo liver development.

19 tes a physiological role of FGF during early liver development.

20 ment that might be crucial for physiological liver development.

21 atenin corresponded to cell proliferation in liver development.

22 s known about the molecular aspects of avian liver development.

23 in regulating growth zone activities during liver development.

24 y examining FGF signaling during early mouse liver development.

25 ular matrices) and TNFalpha is important for liver development.

26 nduced obesity, insulin resistance and fatty liver development.

27 ough activation of the PXR gene during fetal liver development.

28 sed to elucidate the role of beta-catenin in liver development.

29 nzo-p-dioxin as well as regulation of normal liver development.

30 bryos die at mid-gestation from a failure of liver development.

31 in the hepatic diverticulum at the onset of liver development.

32 oma (Rb)-like protein, p107, during prenatal liver development.

33 e the pattern of E2F binding during prenatal liver development.

34 nic day 12.5 and is associated with abnormal liver development.

35 2.8 is the first such factor associated with liver development.

36 ortance of cyclin D1-CDK4 function in normal liver development.

37 uated in order to assess the consequences on liver development.

38 self-renewal and cell fate decisions during liver development.

39 lic homeostasis, and completely blocks fatty liver development.

40 on and protein malnutrition-associated fatty liver development.

41 circadian regulator, Bhlhe40, in programming liver development.

42 tify microRNA (miR)-337-3p as a regulator of liver development.

43 tes previously inaccessible aspects of human liver development.

44 ular competence, which are indispensable for liver development.

45 n growth, yolk utilization, and pancreas and liver development.

46 ignaling, methionine deficiency and impaired liver development.

47 tumor suppressor mechanism during postnatal liver development.

48 about the contribution of Hippo signaling to liver development.

49 to a highly proliferative stage of postnatal liver development.

50 This is a key advance in bioartificial liver development.

51 which differentiate into HSCs and PFs during liver development.

52 tial for normal biliary tubulogenesis during liver development.

53 and a functional receptor instructing early liver development.

54 ue to severe anemia attributed to defects in liver development.

55 that SECs influence HSC localization during liver development.

56 red for Sp1 activation/Mediator during mouse liver development.

57 rotein function antagonistically to regulate liver development.

58 e 10) reduces PIP3 levels and leads to fatty liver development.

59 ng an instructive role of the vasculature in liver development.

60 ere treated with each isomer for 24 h during liver development (52-76 hpf).

61 (TF) widely recognized as a key regulator of liver development, acts as a gatekeeper of pancreatic li

62 he function of MPI and mannose metabolism in liver development and adult liver diseases.

63 -fetoprotein and albumin activation early in liver development and alpha-fetoprotein reactivation dur

64 hepatocyte differentiation during mammalian liver development and also crucial for metabolic regulat

65 ntiation of liver progenitor cells underlies liver development and bile duct formation as well as liv

66 ressing growth factors that are critical for liver development and both the initiation and terminatio

67 5' UTR to promote cell proliferation during liver development and carcinogenesis.

68 se iPS cells retain full potential for fetal liver development and describe a procedure that facilita

69 The hydrogel may prove useful for liver development and disease models, as well as providi

70 utility of zebrafish as a model for studying liver development and disease, and provide valuable tool

71 study, we created an in vitro model of human liver development and disease, physiology, and metabolis

72 for studying the mechanisms underlying human liver development and disease, testing the efficacy and

73 ch, offering innovative methods for studying liver development and disease.

74 put screens, to enhance our understanding of liver development and disease.

75 (PSCs) has transformed the investigation of liver development and disease.

76 ecapitulate hepatic architecture relevant to liver development and disease.

77 ignaling is another important determinant in liver development and function and promotes cell-cell cy

78 relevant concentrations of PFHxS can impair liver development and function in fish, which could have

79 he identified SNPs highlights involvement in liver development and function, lipid metabolism, insuli

80 d targets of miR-30a are known regulators of liver development and function.

81 tial for blastocyst formation and for proper liver development and function.

82 d double mutants did not show any defects in liver development and function.

83 a) is a well established master regulator of liver development and function.

84 of Srebfs and methionine metabolism impacts liver development and function.

85 iched transcription factor, is essential for liver development and function.

86 F-kappaB) plays a critical role during fetal liver development and hepatic oncogenesis.

87 proliferation and survival during embryonic liver development and hepatocellular carcinogenesis.

88 ses of the contribution of HNF-4alpha toward liver development and hepatocyte differentiation.

89 r factor 4alpha (HNF4alpha) is essential for liver development and hepatocyte function.

90 esults identify miR-337-3p as a regulator of liver development and highlight how tight quantitative c

91 eir own lineage maintenance during postnatal liver development and homeostasis.

92 ction, providing an opportunity for studying liver development and host determinants of HCV susceptib

93 A comparison between mouse liver development and human hepatocellular carcinoma (HC

94 As differentially expressed throughout fetal liver development and in adult liver.

95 tivity during hepatocyte differentiation and liver development and in response to drug induction.

96 c mesenchymal cells that play vital roles in liver development and injury.

97 We focused on CRD-BP expression during rat liver development and liver regeneration, because c-myc

98 n vivo remain largely unknown, especially in liver development and liver tumorigenesis.

99 The expression of CYP3A4 changes during liver development and may be affected by the administrat

100 cannabinoid receptor (Cnr) activity disrupts liver development and metabolic function in zebrafish (D

101 We analyzed the cooperation of RB and p53 in liver development and pathogenesis of hepatocellular car

102 n signaling is involved in the regulation of liver development and physiology.

103 critical transcription factor that controls liver development and plays an important role in hepatic

104 This work offers a panoramic view of mouse liver development and provides a rich resource to explor

105 ned to explore differentiation during normal liver development and regeneration after toxic injury.

106 Liver development and regeneration share the requirement

107 t play critical roles at different phases of liver development and regeneration, and underscore the i

108 During liver development and regeneration, hepatocytes undergo

109 signaling is a known regulatory pathway for liver development and regeneration, we studied the role

110 time-dependent role for wnt signaling during liver development and regeneration.

111 catenin signaling plays an important role in liver development and regeneration.

112 e practically dispensable in hepatocytes for liver development and regeneration.

113 t study, we examined PDGFRalpha signaling in liver development and regeneration.

114 hogenesis of other hepatic cell types during liver development and regeneration.

115 transcription factor that controls embryonic liver development and regulates tissue-specific gene exp

116 esults indicate that IKK-beta is crucial for liver development and regulation of NF-kappaB activity a

117 MSCs prevent HFD-induced fatty liver development and restore glycogen storage in hepato

118 examine the localization of YAP during fetal liver development and show that higher levels of YAP are

119 Both repression of AFP during liver development and silencing in the brain, where AFP

120 cting reports about the role of Notch during liver development and suggest that Notch acts by coordin

121 that neither RelA nor TNFR-1 is required for liver development and that RelA protects the embryonic l

122 erlap in the genes and pathways that control liver development and those that regulate liver regenera

123 al polyploidization events occur during both liver development and throughout adult life.

124 stigate the basic mechanisms directing human liver development and to produce cell types for clinical

125 cularly important, possibly through impaired liver development and/or infection in early life, in det

126 ANGPTL3 is expressed early during liver development, and expression is maintained in adult

127 hepatic stem cells from adults, for studying liver development, and for cell therapy based on hepatic

128 nic livers, metabolic genes during postnatal liver development, and growth/inflammation and metabolic

129 Abnormal yolk utilization, brain and liver development, and overall growth were observed in l

130 erved role for Notch signaling in vertebrate liver development, and support the zebrafish as a model

131 regulating Hex, a homeobox gene required for liver development, and the earliest stages of hepatogene

132 Gata4 and Gata6 display an earlier block in liver development, and thus completely lack liver buds.

133 s circulating macrophages and promotes fatty liver development, and ultimately contributes to impaire

134 dentity of miRNAs and their functions during liver development are largely unknown.

135 anscription factors known to be important in liver development are not induced during liver regenerat

136 Moreover, processes that are key to liver development are often co-opted during pathogenesis

137 eta) pathways have been implicated in normal liver development as well as in cancer formation.

138 enin, a key component of the Wnt pathway, in liver development as well as its normal distribution in

139 dynamic patterns of individual miRNAs during liver development, as well as miRNA networks that could

140 delta, and retinoid X receptor beta; and (c) liver development associated with CCAAT/enhancer binding

141 peak expression of beta-catenin during early liver development at Embryonic day 10 (E10)-E12, followe

142 reduced AFP gene expression during embryonic liver development, at a time in which fetal hepatocytes

143 During liver development, bipotent progenitor cells differentia

144 oxylase mRNA is tightly regulated during rat liver development, both temporally and spatially support

145 chanical elements that shape the BC lumen in liver development but also counteract elevated biliary p

146 Polyploidization occurs mainly during liver development, but also in adults with increasing ag

147 SCs) undergo dramatic expansion during fetal liver development, but attempts to expand their numbers

148 cyte nuclear factor 6 (HNF6) is required for liver development, but its role in adult liver metabolis

149 specific Shp deletion protects against fatty liver development by suppressing expression of peroxisom

150 correlates with BC connectivity during mouse liver development, consistent with predicted changes in

151 morphogenesis, suggesting that the defect in liver development contributed to embryonic lethality.

152 sterol 7-hydroxylase mRNA evolves during rat liver development, correlated this with its total liver

153 expressed during the proliferative phase of liver development, correlating with expression of the fi

154 that liver restoration after hepatectomy and liver development differ dramatically with regard to tra

155 ripotent stem cells in hepatology, including liver development, disease modeling, host-pathogen inter

156 ignals appear to initiate distinct phases of liver development during mammalian organogenesis.

157 s research revealed that prometryn decreased liver development during zebrafish embryogenesis.

158 ifferentiation markers showing commitment to liver development, even under conditions that normally s

159 Although during early liver development full-length beta-catenin is the predom

160 and signaling programs precisely coordinate liver development, has begun to elucidate the molecular

161 The hepatic vasculature is essential for liver development, homeostasis and regeneration, yet the

162 t advances in the role of Notch signaling in liver development, homeostasis, and disease.

163 catenin signaling plays pivotal roles during liver development, homeostasis, and regeneration.

164 of the RSPO-LGR4/5-ZNRF3/RNF43 module during liver development, homeostasis, metabolic zonation, rege

165 of hematopoietic Jag1 does not affect fetal liver development; however, Jag1-deficient fetal liver H

166 that HNF3beta plays a critical role in early liver development; however, our studies demonstrate that

167 y and involved in pivotal processes, such as liver development, immunoregulation, regeneration, and a

168 show here that E-cadherin is dispensable for liver development, implying that HNF4alpha regulates add

169 contributes to hepatocyte maturation during liver development in addition to the postnatal activatio

170 s have significant clinical implications for liver development in infants exposed to abnormal estroge

171 Decades of research on liver development in mice and other vertebrates offer va

172 omoters and genes contrasting cerebellum and liver development in mice.

173 We describe failed liver development in response to reduced SMN levels, in

174 t birth and increases during early postnatal liver development in the HBV transgenic mouse model of c

175 ndergoes rapid changes in the pathway toward liver development in utero since it is also the major si

176 se methods usually follow different steps of liver development in vitro, which is time consuming and

177 ough VEGF-A signaling and may play a role in liver development in vivo.

178 indicating the impact of ruminal acidosis on liver development in young calves.

179 However, none reliably mimic human liver development, including parallel formation of hepat

180 est that HBV DNA methylation during neonatal liver development is actively modulated by the relative

181 increased expression during early postnatal liver development is associated with HCC progression in

182 ion and demethylation, whereas in vivo fetal liver development is characterized predominantly by deme

183 During adolescence, liver development is completed and children's livers nor

184 Thus, temporal activation of PDGFRalpha in liver development is important in hepatic morphogenesis.

185 The function of microRNA (miRNA) in liver development is unknown.

186 (AFP), a protein highly induced during fetal liver development, is down-regulated by retinoids in the

187 -enriched factor expressed very early during liver development, is sufficient to confer transcription

188 Cytokinesis can fail during normal postnatal liver development, leading to polyploid hepatocytes.

189 2-OHCHR toxicity that closely coincided with liver development, leading us to hypothesize that differ

190 s are a valuable tool for the study of human liver development, liver injury, and hepatic repopulatio

191 Additionally, defects in liver development may underlie some congenital and perin

192 nd is instrumental for further dissection of liver development, metabolism, and disease.

193 Moreover, aberrations in liver development observed in these mice were identical

194 tion in response to injury without effect on liver development or hepatocyte proliferation.

195 CCN1 is not required for liver development or regeneration, since these processes

196 , such as CYP3A4, is markedly reduced during liver development or regeneration.

197 Introducing concepts critical to liver development, organization, and physiology sets the

198 techniques to establish a timeline for fatty liver development over 20 weeks.

199 ocyte proliferation, which may be crucial in liver development, regeneration following partial hepate

200 t role in hepatic homeostasis, especially in liver development, regeneration, and cancer, and loss of

201 stellate cells, as well as their function in liver development, regeneration, and cancer.

202 eta-catenin activation is observed in normal liver development, regeneration, and liver cancer.

203 ial for hepatocyte entry into mitosis during liver development, regeneration, and liver cancer.

204 ively associated with cellular growth during liver development, regeneration, and oncogenesis but wit

205 s have implications in mechanisms concerning liver development, regeneration, and oncogenesis.

206 and TAZ activation have been associated with liver development, regeneration, and tumorigenesis.

207 ate determination and differentiation during liver development remains unclear.

208 elopment biased to the left and pancreas and liver development restricted to opposing sides of the mi

209 fish embryos to 17beta-estradiol (E2) during liver development significantly decreased hepatocyte-spe

210 ties in Klf6(-/-) mice obfuscate its role in liver development since these two processes are linked i

211 We evaluate the performance of ssNPA on liver development single-cell RNA-seq data, where the co

212 Our work provides fresh insights into liver development, suggesting that microbial-derived cue

213 During liver development, TfR2 was up-regulated and TfR1 was do

214 via enhanced CD36 expression, provoke fatty liver development that in turn leads to hepatic insulin

215 ession and regulation of beta-catenin during liver development that might be crucial for physiologica

216 During and after liver development, the activation of YAP/TAZ induced by

217 We examined, during wild-type fetal liver development, the expression of the Rel family memb

218 During subsequent liver development, the progenitor cells expressed HepPar

219 During liver development, the Ser/Thr phosphorylated RBMY is ex

220 expression parallels c-myc expression during liver development; the protein is present in fetal and n

221 During liver development, there are physiological changes, from

222 bility in DNA methylation state during human liver development, these regions become highly unmethyla

223 FoxA transcription factors are critical for liver development through their pioneering activity, whi

224 role for estrogenic regulation in vertebrate liver development to affect hepatobiliary fate decisions

225 LATS2 are redundantly required during mouse liver development to repress YAP and TAZ in both the bil

226 for changes in methylation during postnatal liver development to test the hypothesis that developmen

227 nts the advantages of zebrafish for studying liver development, underscoring how studies in zebrafish

228 ulation of xenobiotic responses during fetal liver development was analyzed using a fetal hepatocyte

229 Fatty liver development was associated with transcriptional ac

230 The control of liver development was originally defined by classical hi

231 gy to identify genes involved in early mouse liver development we have isolated Praja1, a gene with s

232 ole of APC loss and enhanced Wnt activity in liver development, we examined APC mutant and wnt induci

233 To determine the role of Foxm1b in liver development, we have generated Foxm1b -/- mice tha

234 To discover novel modifiers of liver development, we performed a chemical genetic scree

235 tional gene ablation during a later phase of liver development, we show here that deletion of both Fo

236 lar features to those observed during normal liver development, we sought to investigate the role of

237 AT1), a key enzyme of TG synthesis, in fatty liver development, we studied mice with global and liver

238 jury, 70% partial hepatectomy, and postnatal liver development were used.

239 During postnatal liver development, when transgenic p-21 protein becomes

240 entifying key factors and pathways governing liver development will help elucidate the physiological

241 increase progressively throughout postnatal liver development with maximal viral biosynthesis occurr

242 m1b -/- hepatoblasts contributed to abnormal liver development with significant reduction in the numb