ライフサイエンスコーパス: liver mitochondria

1 mitate oxidation by isolated hepatocytes and liver mitochondria.

2 etic acid (DOPAC) in isolated hamster or rat liver mitochondria.

3 red to as mtMYH, has been purified from calf liver mitochondria.

4 n during 5-HT metabolism in isolated hamster liver mitochondria.

5 selectively localized in highly purified rat liver mitochondria.

6 sely affects the respiratory activity of rat liver mitochondria.

7 roximately 0.5 kD) in the matrix of isolated liver mitochondria.

8 ted to homogeneity from Percoll-purified rat liver mitochondria.

9 nd DA metabolism in isolated hamster and rat liver mitochondria.

10 d to ethanol, far in excess of that in adult liver mitochondria.

11 he permeability transition pore of heart and liver mitochondria.

12 e activity and the MMPT were measured in rat liver mitochondria.

13 cribe a novel approach to quantifying OAA in liver mitochondria.

14 tle to no effect on mtH(2)O(2) production by liver mitochondria.

15 and blocks mitochondrial pyruvate carrier in liver mitochondria.

16 s a key participant of ceramide formation in liver mitochondria.

17 findings, based upon their studies of mouse liver mitochondria.

18 roblasts, HEK293 cells, and murine heart and liver mitochondria.

19 e claim that a NOS isoform exists within rat liver mitochondria.

20 ansition (MPT) were assessed in isolated rat liver mitochondria.

21 g proteins derived from HeLa cells and mouse liver mitochondria.

22 pecific, because no decrease was observed in liver mitochondria.

23 ith mastoparan, an inducer of the MPT in rat liver mitochondria.

24 the metabolism of 10-HCO-THF by isolated rat liver mitochondria.

25 er membranes derived from swollen/shrunk rat liver mitochondria.

26 Isolated rat liver mitochondria (0.5 mg/ml) were incubated in multiwe

27 s, slightly enhanced respiration in isolated liver mitochondria (30.8% compared with control), lower

28 In isolated rat liver mitochondria, a cGMP analogue in the presence of a

29 dicate that increased levels of HNE in fetal liver mitochondria after maternal ethanol consumption re

30 l was to investigate whether HBV might alter liver mitochondria also in humans, and the resulting mit

31 y active state 3 respiration in AdN-depleted liver mitochondria, although further accumulation of AdN

32 nsition (MPT) pore opening in isolated mouse liver mitochondria, an effect that was prevented complet

33 major mH(2)O(2) supplier in male and female liver mitochondria and 2) KGDH can form mH(2)O(2) when l

34 e chose to readdress this question using rat liver mitochondria and employing a variety of assays tha

35 We also induce dANM for mouse liver mitochondria and envision that the separation mech

36 substrates of beta-oxidation in isolated rat liver mitochondria and hence are expected to yield 5,7-d

37 f tetraoleoyl-CL to tetralinoleoyl-CL in rat liver mitochondria and identified the intermediates lino

38 sm and lipid oxidation, is induced in fasted liver mitochondria and implicated in metabolic syndrome.

39 question by measuring K+ flux in intact rat liver mitochondria and in liposomes containing KATP chan

40 rt and oxidative phosphorylation in isolated liver mitochondria and in the cultured murine hepatoma c

41 modulates oxidative phosphorylation in mouse liver mitochondria and intact hepatocyte cell lines.

42 brain nonsynaptosomal mitochondria and mouse liver mitochondria and mitoplast fractions derived from

43 ltransferase (GPAT) was determined using rat liver mitochondria and mutagenized recombinant rat GPAT

44 t fractionation, ultrapure, never frozen rat liver mitochondria and submitochondrial particles were o

45 For instance, liver mitochondria are a vital source of gluconeogenic p

46 atory showed that isolated, intact adult rat liver mitochondria are able to oxidize the 3-carbon of s

47 These studies confirm that liver mitochondria are early targets of injury during en

48 chondria and 2) KGDH can form mH(2)O(2) when liver mitochondria are energized with fatty acids but on

49 cute ethanol exposure in which HNE levels in liver mitochondria are strikingly increased.

50 In the liver, mitochondria are exposed to different concentrati

51 (MT) localizes in the intermembrane space of liver mitochondria as well as in the cytosol and nucleus

52 r ion trap-mass spectrometry analyses of rat liver mitochondria as well as submitochondrial particles

53 GD3 directly induces the PT in isolated rat liver mitochondria at 30-100 microM in the presence of e

54 re we show that CBS proteins were present in liver mitochondria at a low level under normoxia conditi

55 idated using mouse cortical synaptosomes and liver mitochondria attached to XF24 V7 cell culture micr

56 In liver mitochondria, BAD resides in a functional holoenzy

57 Our aims were to determine if liver mitochondria become resistant to the MPT during ch

58 on in t-butyl hydroperoxide-stimulated fetal liver mitochondria, but not in adult mitochondria.

59 and an anti-mtGPAT immunoreactive protein in liver mitochondria, but not in microsomes.

60 he mtUDG activity did not change with age in liver mitochondria, but there was a small increase in ac

61 In prohibitin-competent mice, elongation of liver mitochondria by expression of L-OPA1Delta resulted

62 The permeability transition pore of rat liver mitochondria can be closed by chelating free Ca2+,

63 and extent were normal in isolated Mfn2(-/-) liver mitochondria, consistent with the finding that acu

64 s, the P/O ratios obtained with isolated rat liver mitochondria consistently exceed 2.5 with NAD-link

65 l-related decreases in COX activity found in liver mitochondria could be attributable to HNE adduct f

66 Respiration by liver mitochondria energized at complex II by succinate

67 he overall activity of the CU in cardiac and liver mitochondria, even at the highest estimated values

68 gest KGDH is the main mH(2)O(2) generator in liver mitochondria, even when fatty acids are used as fu

69 Here we report that liver mitochondria exhibit ceramide formation from sphin

70 Percoll-purified rat liver mitochondria exhibited a negligible contamination

71 asuring oxygen consumption rates in isolated liver mitochondria exposed to physiologically relevant c

72 Immunoblot analysis of mouse liver mitochondria failed to detect AQP8 expression, wit

73 Respiratory control index values on rat liver mitochondria for this series suggested uncoupling

74 Isolated liver mitochondria from alcohol-treated mice had a great

75 l swelling and calcium retention in isolated liver mitochondria from C57BL/6J (wild-type) and Ppif(-/

76 uding analytical parameters, from a study of liver mitochondria from control and diabetic rats are pr

77 Additionally, liver mitochondria from ethanol-fed rats containing high

78 In contrast, liver mitochondria from fed and fasted mice expressed li

79 Liver mitochondria from homozygous mutant mice, with a c

80 Liver mitochondria from iPLA(2)gamma(-/-) mice were mark

81 KMV inhibited mH(2)O(2) production in liver mitochondria from male and female mice oxidizing m

82 rtially rescued oxidative phosphorylation in liver mitochondria from mice fed a high-fat diet.

83 s suggested the presence of a second GPAT in liver mitochondria from mtGPAT(-/-) mice.

84 Liver mitochondria from PY plus LPS or PY plus TNF-alpha

85 mitoKATP-mediated K+ flux in both heart and liver mitochondria from rat.

86 In this study we examined the properties of liver mitochondria from transgenic mice expressing HCV c

87 Liver mitochondria from transgenic mice expressing the H

88 y accelerated Ca(2+)-induced mPTP opening in liver mitochondria from wild-type mice.

89 dienoyl-CoA reductase (EC 1.3.1.34) from rat liver mitochondria has been investigated.

90 We also report that highly purified liver mitochondria have ceramidase, reverse ceramidase,

91 active proteins in wild type and mtGPAT(-/-) liver mitochondria have different isoelectric points.

92 In liver mitochondria, imeglimin redirects substrate flows

93 bited calcium-induced AIF release from mouse liver mitochondria, implicating the involvement of an en

94 y examines the effect of alcohol exposure on liver mitochondria in a rat model and explores the inter

95 responsible for the accumulation of AdNs in liver mitochondria in a strictly Ca(2+)-dependent way wi

96 mitoylcarnitine-supported respiration of rat liver mitochondria in concentration-dependent and time-d

97 Here, we show that liver mitochondria in fasting mice adapt to the demand o

98 ase in oxidative phosphorylation observed in liver mitochondria in response to glucagon and Ca(2+)-mo

99 yze changes in lysine acetylation from mouse liver mitochondria in the absence of SIRT3.

100 PCs and PSs in lipid extracts from isolated liver mitochondria in two different rat strains.

101 d that ribosomes stably bind to purified rat liver mitochondria in vitro.

102 inhibitor of Ca2+-stimulated respiration of liver mitochondria in vitro.

103 AdN content, state 3 respiration and CRC in liver mitochondria in wild type but not in SCaMC-3-KO mi

104 istent with this concept, H2O2 production by liver mitochondria increases from 5 minutes to 3 hours a

105 During fasting, NAD in liver mitochondria increases, thereby triggering SIRT5 d

106 e activity was also observed in isolated rat liver mitochondria incubated with alpha-TOS and tBOOH.

107 expressing HCV core protein, and from normal liver mitochondria incubated with recombinant core prote

108 Brain and liver mitochondria isolated by a discontinuous Percoll g

109 susceptibility to the calcium-induced MPT in liver mitochondria isolated from a knock-in HD mouse mod

110 In contrast, liver mitochondria isolated from iNOS-/- mice fed ethano

111 onents of the electron transport chain using liver mitochondria isolated from male and female C57BL6N

112 Using mouse liver mitochondria isolated from ogg1(-/-) mice, we show

113 antisera against various subfractions of rat liver mitochondria (mitoplast, inner membrane, intermemb

114 Mn-SOD expression and activity of Ad.SOD2 in liver mitochondria of infected animals was increased nea

115 This effect is also seen in liver mitochondria of RSV-fed animals (50 mg/kg/day).

116 e level of total glutathione was 30% less in liver mitochondria of the Sod2(-/+) mice.

117 r, the levels of ceramide were dissimilar in liver mitochondria of WT and NCDase KO mice.

118 SOD1 specifically in spinal cord, but not in liver, mitochondria of SOD1 mice and patients.

119 her is associated with the outer membrane of liver mitochondria (OM cyt b5).

120 inhibitor of the permeability transition in liver mitochondria, only protects against neuronal injur

121 lity transition or cytochrome c release from liver mitochondria or GCDC-induced mitochondrial depolar

122 Using rat liver mitochondria, our data demonstrate that calcium-me

123 mH(2)O(2) generation in both male and female liver mitochondria oxidizing palmitoyl-carnitine.

124 However, liver mitochondria possess alternative anabolic pathways

125 ion (109% compared with control) in isolated liver mitochondria, probably due to increased levels of

126 dependent increases in oxidant production by liver mitochondria promote the induction of antioxidant

127 ificantly decreased respiratory rates in rat liver mitochondria relative to untreated controls, compl

128 r carnitine) as CPT I in skeletal muscle and liver mitochondria, respectively.

129 globin and nitrite to isolated rat heart and liver mitochondria resulted in the inhibition of respira

130 Protease treatment of rat liver mitochondria revealed that GPAT has a membrane-pro

131 ot affect the State 4Deltapsi of RBM and rat liver mitochondria (RLM).

132 tochondria in PC12 cells and of isolated rat liver mitochondria showed that hypoxia induced depolariz

133 In isolated mouse liver mitochondria, SR4 similarly increased oxygen consu

134 GST release) and NAPQI toxicity in isolated liver mitochondria (succinate dehydrogenase inactivation

135 Experiments on lysates from rat liver mitochondria suggest the ratio MB/cytochrome c is

136 Studies with isolated mouse liver mitochondria suggested that [Dmt1,dnsDap4]DALDA ta

137 el of the mPT in populations of isolated rat liver mitochondria that quantitatively describes Ca(2+)-

138 esent study identified a crucial node in the liver mitochondria that regulates fasting-induced glucon

139 Rottlerin increased the QO2 of isolated rat liver mitochondria to a level similar to that produced w

140 tAPE, we purified the APE activity from beef liver mitochondria to near homogeneity, and showed that

141 were characterized by exposing isolated rat liver mitochondria to physiological and pathological rat

142 Liver mitochondria undergo dynamic alterations following

143 ake, even though ruthenium red-inhibited rat liver mitochondria undergo rapid pore opening under anal

144 on monoamine metabolism in isolated hamster liver mitochondria using 5-HT as the substrate.

145 Finally, Western blot analyses of rat liver mitochondria, using NOS (neuronal or endothelial)

146 In liver mitochondria, VWR increased both maximal oxidative

147 itionally, mtH(2)O(2) generation in isolated liver mitochondria was almost abolished when MitoSNO was

148 ory function of isolated skeletal muscle and liver mitochondria was assayed.

149 We found that the GSH content of isolated liver mitochondria was diminished by >/=50% in GGT(-/-)

150 Similarly, peroxidase activity of murine liver mitochondria was high with FFA-OOH.

151 ed by the 2,4-dienoyl-CoA reductase from rat liver mitochondria was investigated.

152 might be linked, respiration of isolated rat liver mitochondria was measured after addition of Zn(2+)

153 se (CPS)-1, a protein primarily localized to liver mitochondria, was found to be present in high conc

154 atory control ratios (RCRs) of GGT(-/-) mice liver mitochondria were </=60% those of wild-type mice p

155 Intact and swelling bovine heart and rat liver mitochondria were examined with an excitation wave

156 nd, recombinant SCAD activity and antigen in liver mitochondria were found up to 7-fold of normal con

157 em mass spectrometry, respectively, when rat liver mitochondria were incubated with elaidoyl-CoA but

158 s end, changes in H(2)O(2) production by rat liver mitochondria were monitored at different rates of

159 Hepatocytes and liver mitochondria were obtained from bile duct-ligated

160 Rat liver mitochondria were purified by differential and Per

161 Extracts of isolated rat liver mitochondria were subjected to blue native polyacr

162 ate production was confirmed in isolated rat liver mitochondria where formate production from serine,

163 so be efficiently imported into isolated rat liver mitochondria, where it is processed to its native

164 idation (FAO) proteins were less abundant in liver mitochondria, whereas FAO protein content was indu

165 PHOS subunits were coordinately increased in liver mitochondria, whereas mitochondria of other tissue

166 ificant degradation of mtDNA in isolated rat liver mitochondria, whereas the same concentration of dy

167 We identified NEIL1 in liver mitochondria, which could account for the residual

168 Nnt inhibition in liver mitochondria, which do not require substrates to d

169 mounts of the ROS hydrogen peroxide, whereas liver mitochondria, which express a different Ant isofor

170 heir genomes and isolated a protein from rat liver mitochondria with 8-oxoguanine (8-oxodG) DNA glyco

171 Moreover, incubation of respiring rat liver mitochondria with [(14)C]cytidine diphosphate lead

172 Incubating mouse liver mitochondria with an HCV core (100 ng/mg) in vitro

173 such as tetraethylammonium and lysine by rat liver mitochondria with EC50 = 11-15 microM.

174 Incubation of intact liver mitochondria with physiological, micromolar concen

175 lts uncover a Goldilocks effect of Ca(2+) on liver mitochondria, with specific "just right" concentra

176 ange inhibits mtH(2)O(2) by ~50% in isolated liver mitochondria without disrupting respiration, where