ライフサイエンスコーパス: liver-specific

1 ptional repression of AFP gene by ZBTB20 was liver-specific.

2 Whereas liver-specific 11beta-HSD1 KO mice developed a full Cush

3 mal1 in Apoe(-/-) and Ldlr(-/-) mice and its liver-specific ablation in Apoe(-/-) (L-Bmal1(-/-)Apoe(-

4 e have generated a combined mouse model with liver-specific ablation of GHR in which we restored live

5 Liver-specific ablation of LKB1 causes increased glucose

6 Liver-specific ablation of Mfn2 in mice provoked inflamm

7 Here we now show that constitutive liver-specific ablation of Notch signaling, or its acute

8 Liver-specific ablation of p31(comet) causes insulin res

9 neogenesis, we provide genetic evidence that liver-specific ablation of SIK2 alone has no effect on g

10 In mice, congenital liver-specific ablation of the GH receptor (GHR) results

11 Liver-specific ablation of the IR (L-Insulin Receptor KO

12 Liver-specific ablation of three FoxOs (L-FoxO1,3,4) pre

13 Here, we show that liver-specific ablation of X-box binding protein 1 (XBP1

14 liver function, suggesting the need for more liver-specific ACLF criteria.

15 Liver-specific Acox1 knockout (Acox1-LKO) protected mice

16 Administration as an inactive prodrug with liver-specific action compared with other INS-sensitive

17 Liver-specific adhesion molecules CXCR6 and CD49a have b

18 Liver-specific adropin knockout (LAdrKO) mice exhibit in

19 uper IDOL [sIDOL]) in C57Bl/6J mice from the liver-specific albumin promoter (L-sIDOL transgenics).

20 In the present study, we used liver-specific (albumin-Cre) LKB1 knockout mice (LKB1(-/

21 Aldh2-deficient mice, and to examine whether liver-specific ALDH2 inhibition can prevent alcohol-seek

22 y EIG to identify A1CF as a key regulator of liver-specific alternative splicing, supporting this fin

23 Additionally, liver-specific AMPK alpha1 and alpha2 subunit KO and WT

24 NMP in wild type (alpha1alpha2(lox/lox)) and liver-specific AMPK knock-out mice (alpha1alpha2(lox/lox

25 Liver-specific AMPK knockout aggravated liver damage in

26 To test the role of the liver, specific and exclusive deletion of hepatic CB1 re

27 Liver-specific and adipose-specific Tmem127 deletion par

28 Such downregulation of GRK2 levels is liver-specific and can be rapidly reversed by refeeding.

29 as to evaluate the most current evidence for liver-specific and metabolic effects of microbiome-targe

30 Incidence risk ratios for liver-specific and overall mortality for NAFLD were 1.94

31 s, and is associated with increased rates of liver-specific and overall mortality.

32 Interestingly, liver specific Ant2 knockout mice are leaner and resista

33 ating a fertile field for the development of liver-specific autoimmunity.

34 on-induced increases in blood ketone levels, liver-specific autophagy-deficiency significantly attenu

35 esponse was able to inhibit proliferation of liver-specific autoreactive T cells and prevent AIH.

36 Liver-specific beta-catenin knockout (beta-Catenin-LKO)

37 ciency in diet-induced obesity, we generated liver-specific BIM-knockout (BLKO) mice.

38 Here we used both Bmal1(-/-) and acute liver-specific Bmal1-depleted mice to study the role of

39 Here, using heterozygous BRD7 knockout and liver-specific BRD7 knockout mouse models, we report tha

40 Furthermore, the liver-specific BVRA KO mice exhibited increased plasma g

41 Interestingly, liver-specific BVRA KO mice had increased GSK3beta activ

42 ethylnitrosamine (DEN)-induced HCCs, whereas liver-specific c-Fos expression leads to reversible prem

43 PNPLA3 failed to localize to hepatic LDs in liver-specific Cgi-58 knockout (KO) mice.

44 Animals with a liver-specific cIAP1 and total cIAP2 deficiency efficien

45 n signalling triggers the association of the liver-specific class II PI3K isoform gamma (PI3K-C2gamma

46 Liver-specific Clk2 knockout mice fed a high-fat diet ex

47 rolaemic, and that COMMD1-deficient dogs and liver-specific Commd1 knockout mice have elevated plasma

48 the deleterious effects of MET deletion, the liver-specific conditional loss of Egfr facilitated rath

49 Notably, liver-specific constitutive activation of HIF-2alpha, bu

50 Wild-type and liver-specific constitutively activated human AHR transg

51 halamus after repeated administration of the liver-specific contrast agent gadoxetic acid.

52 ive copper overload caused by mutations in a liver-specific copper-transporting ATPase, ATP7B.

53 Here, by studying the liver-specific Cpr-null (LCN) mouse, we examined whether

54 and pro-inflammatory cytokines than the non-liver-specific CXCR6- fraction.

55 Liver-specific cyclin D1 deficiency protected obese/diab

56 lipidemia in aged and young mice by inducing liver-specific degradation of the LDL (low-density lipop

57 We generated mice with either liver-specific deletion (Ppp1r3b(Delta)(hep) ) or liver-

58 using in vivo isotope tracing, we show that liver-specific deletion of Acly in mice is unable to sup

59 We developed mice with liver-specific deletion of ALR (ALR-L-KO) using the albu

60 We created mice with liver-specific deletion of ALR to study its function.

61 We developed mice with liver-specific deletion of ALR, and showed that it is re

62 with defective hepatic metabolism due to the liver-specific deletion of cytochrome P450 oxidoreductas

63 We used mice with liver-specific deletion of Fak and investigated the role

64 As such, global or liver-specific deletion of FcRn results in resistance to

65 Liver-specific deletion of Foxo1 (L-IRFoxo1DKO) rescues

66 egradation of CUGBP1, we generated mice with liver-specific deletion of Gank.

67 al mediator of hepatic lipid metabolism, and liver-specific deletion of HDAC3 leads to fatty liver.

68 Hepatic TG was also decreased by liver-specific deletion of Hig2 in mice with floxed Hig2

69 It is well established that liver-specific deletion of Insig1 leads to higher hepati

70 xpression in MYC-driven hepatoblastomas, and liver-specific deletion of Lin28a/b reduced tumor burden

71 Here we show that liver-specific deletion of LRPPRC causes liver-specific

72 Liver-specific deletion of MKP-1 enhances gluconeogenesi

73 Moreover, mice with liver-specific deletion of MPC2 were protected from deve

74 dicted by the results of previously reported liver-specific deletion of murine Pcyt1a.

75 Liver-specific deletion of Prmt1 reduced gluconeogenic c

76 cer, we created a mouse model with biallelic liver-specific deletion of Pten and Grp78 mediated by Al

77 We show here that liver-specific deletion of Pten, which leads to activati

78 Liver-specific deletion of RALY alters hepatic lipid con

79 Using knockdown or liver-specific deletion of Sab, we aimed to elucidate th

80 We compared mice with liver-specific deletion of Sirt1 (Sirt1LKO) mice with th

81 fasted C57BL/6J mice (control) and mice with liver-specific deletion of STARD1 (Stard1(DeltaHep)), SA

82 Accordingly, liver-specific deletion of the autophagy gene Atg7 incre

83 hepatic metabolism, we generated mice with a liver-specific deletion of the Mfn1 gene (Mfn1LKO) and m

84 lized complex genetic manipulations to drive liver-specific deletion of the Rbpj gene in conjunction

85 atic function of Them2, we created mice with liver-specific deletion of Them2 (L-Them2(-/-) ).

86 Here, we evaluated mice harboring a liver-specific deletion of Trib1 (Trib1_LSKO) to elucida

87 er disease and dyslipidemia similar to HDAC3 liver-specific deletion.

88 roduction, we analyzed mouse lines harboring liver-specific deletions of genes encoding HIF-prolyl-hy

89 This can be circumvented by liver-specific delivery of a rho kinase inhibitor to eff

90 uggest potential application of Lac-GLN as a liver-specific delivery vehicle for anti-miR therapy.

91 Liver-specific depletion of AMOTL2 enlarged mouse liver

92 Here we show that liver-specific depletion of nuclear receptors RORalpha a

93 Liver-specific depletion of RetSat in dietary obese mice

94 Conversely, liver-specific depletion of the nuclear forms of SREBPs,

95 diabetes, or metabolic syndrome, as well as liver-specific disorders such as fatty liver, nonalcohol

96 ound C57BL/6J-C3H mice, as well as mice with liver-specific disruption of Ezh1 and/or Ezh2, at postna

97 Finally, control mice and mice with liver-specific disruption of Nr1h4 (liver FXR-knockout m

98 To address this, we generated the liver-specific dominant-negative (DN) TCF7L2 (TCF7L2DN)

99 Mice lacking E2f7 and E2f8 in the liver (liver-specific E2f7/E2f8 knockout; LKO) were recently re

100 nctionally characterize a previously unknown liver-specific enhancer-promoter element in the wild-typ

101 transcription factors, are retained more at liver-specific enhancers than at promoters and ubiquitou

102 The different levels of liver-specific enzyme elevation, hepatic inflammation, a

103 c liver disease as measured by elevations of liver-specific enzymes and/or by histopathology.

104 s and transient elevation of serum levels of liver-specific enzymes indicative for a hepatic inflamma

105 examine the consequence of effect of chronic liver-specific expression of a dominant-active form of I

106 Two previous studies of liver-specific expression of constitutive active IKK2 (I

107 Furthermore, liver-specific expression of constitutively active FoxO1

108 Liver-specific expression of dominant-active IDOL is ass

109 the liver, we generated transgenic mice with liver-specific expression of luciferase and performed bi

110 Adenovirus-mediated liver-specific expression of SIRT1 or a phosphor-defecti

111 We show that liver-specific expression of the intracellular domain of

112 humanized HAEIII mouse models with inducible liver-specific expression of Thr309Lys-mutated FXII exhi

113 Liver-specific expression of wild-type or a DNA-binding-

114 ansgenic expression system by combination of liver-specific expression, mifepristone induction and Cr

115 Here we demonstrate that mice with global or liver-specific FcRn deletion exhibit hypoalbuminemia, al

116 and ovariectomized (OVX) female control and liver-specific Foxo1 knockout (L-F1KO) mice and sought t

117 cholesterol diet (HFC)-on wildtype (WT) and liver-specific Foxo1/3/4 triple knockout mice (LTKO).

118 r housekeeping/cellular maintenance genes or liver-specific functions.

119 ion in hepatocytes and lead to inhibition of liver-specific functions.

120 steatosis, both of which were reproduced by liver-specific G0S2 knockdown.

121 In other studies, using adult liver-specific G6pc-deficient mice at both pre-tumor and

122 Liver-specific G6pc-knockout (L-G6pc(-/-) ) mice were tr

123 aller livers with fewer hepatocytes, reduced liver-specific gene expression and proliferation.

124 improved morphological organization, higher liver-specific gene expression levels, increased metabol

125 fibronectin promoted albumin production and liver-specific gene expression of Huh-7.5 cells, compare

126 The resultant hiPSC-EB-HLCs expressed liver-specific genes, secreted hepatic proteins such as

127 Here, we show by generation of liver-specific Gln synthetase (GS)-deficient mice that G

128 fy LPS- and ActivinA-induced upregulation of liver specific glucocorticoid receptor and Smad2/3 repor

129 e that accumulate G6P in the liver, that is, liver-specific glucose-6-phosphatase knockout (L-G6pc(-/

130 Liver-specific gp78/AMFR genetic ablation results in fun

131 ry genes we performed nanostring analysis on liver-specific GR knockout (LGRKO) mice in the presence

132 nce of ammonia homeostasis and establish the liver-specific GS KO mouse as a model with which to stud

133 Liver-specific GS-deficient mice showed increased locomo

134 se production in hepatocytes isolated from a liver-specific GSD Ia mouse model (L-G6pc(-/-) mice) and

135 nce can be completely prevented in mice with liver-specific HCLS1-associated protein X-1 (HAX-1) inac

136 Liver tissues from mice with liver-specific hemizygous disruption of Ppargc1a placed

137 Mice with liver-specific hemizygous or homozygous disruption of Pp

138 We also find a highly significant excess of liver-specific heteroplasmies involving nonsynonymous ch

139 t on hepatic HIF-1 because mice deficient in liver-specific HIF-1alpha experience hyperoxia-induced d

140 wild-type animals but are reduced by 60% in liver-specific HIF-1alpha knockout mice treated with DMO

141 Interestingly, mice with liver-specific Hig2 deletion also display improved gluco

142 Liver-specific Hnf4a knockout mice exhibited a 90% decre

143 Mice with liver-specific homozygous or heterozygous Arid1a loss we

144 However, ectopic expression of liver-specific human microRNA 122 (miR-122) further boos

145 rast to this established mode of action, the liver-specific human miR-122 binds at two sites within t

146 nocarcinoma mouse model, Hi-Myc mice, with a liver-specific IGF-1 transgenic mouse model (HIT) to inc

147 cytes, sinusoidal endothelial, stellate, and liver-specific immune cells were released into perfusate

148 w, we summarise the current understanding of liver-specific immune responses and provide an outlook o

149 -gene inborn errors that selectively disrupt liver-specific immunity.

150 er induced by a high-fat diet (HFD), whereas liver-specific IMP2 overexpression results in steatosis.

151 Using liver-specific inactivation in mice, we show that the TA

152 Liver-specific inactivation of Bmal1 led to elevated pla

153 ting megamitochondria formation in mice with liver-specific inactivation of Drp1 was further confirme

154 Liver-specific inactivation or global null-mutation of C

155 Our data further suggest that liver-specific increase in SOX9 levels is a potential th

156 hat liver-specific deletion of LRPPRC causes liver-specific increases of YAP and P27 and decreases of

157 Conversely, liver-specific inducible CEACAM1 expression prevented hy

158 uring several key features of PBC, including liver-specific inflammation focused on portal tract area

159 g insulin effects in the liver, we generated liver-specific insulin receptor knockout (LIRKO) and IR/

160 To this end, we used the liver-specific insulin receptor knockout (LIRKO) mouse,

161 ion in response to insulin resistance in the liver-specific insulin receptor knockout (LIRKO) mouse.

162 Their selective, liver-specific insulin resistance was associated with in

163 Finally, in obese mice with liver-specific IRE1alpha deficiency, reconstitution of I

164 y regulates mRNA and protein expression of a liver specific isoform of Insig-2, Insig-2a, which in tu

165 In this issue, Webb et al. show that the liver-specific isoform of phosphofructokinase-1 forms fi

166 Liver-specific JNK1/2 deletion led to tumor reduction an

167 Studies in liver-specific Klf15-knockout mice suggested a non-hepat

168 ron homeostasis, we generated fetuses with a liver-specific knock-in of fpnC326Y or knockout of the h

169 Furthermore, transient liver-specific knockdown of LPCAT3 in mice affected PPAR

170 In murine models, liver-specific knockdown of TRAP80 ameliorated liver ste

171 are downregulated in hepatocytes from GCN5L1 liver specific knockout mice and their upstream regulato

172 Here we compare a liver-specific knockout (KO) mouse model with total KO m

173 Mice with liver-specific knockout (KO) of the insulin receptor (IR

174 Our data show that Sesn3 liver-specific knockout mice exhibit insulin resistance

175 Using AMPK liver-specific knockout mice, we demonstrate that the Se

176 c polyploidy, we examined livers from Dicer1 liver-specific knockout mice, which are devoid of mature

177 stasis and tumor development, we created two liver-specific knockout mouse models with the deletion o

178 n, we inhibit hepatic lipogenesis in mice by liver-specific knockout of acetyl-CoA carboxylase (ACC)

179 howed that high-fat-diet (HFD)-fed mice with liver-specific knockout of both AMPK catalytic alpha1 an

180 ng, using mice and primary hepatoblasts with liver-specific knockout of Lats1 and Lats2 kinase, the d

181 Liver-specific knockout of murine Bruce impaired ATR act

182 Knockdown or liver-specific knockout of Sab abrogated this effect and

183 Liver-specific knockout or adenovirus-mediated overexpre

184 DIO FGF21 liver-specific knockout, but not FGF21 adipose-specific

185 9a8-inducible global-knockout (ZIP8-iKO) and liver-specific-knockout (ZIP8-LSKO) mice and observed ma

186 We assessed LR in liver-specific knockouts of Wntless (Wls-LKO), a protein

187 atocytes from E4bp4(flox/flox) but not E4bp4 liver-specific KO (E4bp4-LKO) mice.

188 We show that the liver-specific KO mice fully recapitulate the severe iro

189 messenger RNA, while, conversely, mice with liver-specific KO of Arrdc3 (L-Arrdc3 KO) have increased

190 Likewise, mice harboring liver-specific Lats2 conditional knockout (Lats2-CKO) di

191 Strikingly, we found that liver-specific lincRNA gene promoters are more highly sp

192 Liver-specific lipin-1 deficiency in mice exacerbates th

193 d healthy controls (n = 23), we discovered a liver-specific lncRNA (RP11-484N16.1) on chromosome 18 t

194 We found that MCD diet-fed, liver-specific LRH-1 knockout mice (Lrh-1(-/-) ) do not

195 We studied liver-specific Lrp5/6 KO (Lrp-LKO) mice where Wnt-signal

196 Application of CCL-1 to mice with liver-specific luciferase expression in a diet-induced m

197 endothelial cells that together imprint the liver-specific macrophage identity.

198 ynbiotics was associated with improvement in liver-specific markers of hepatic inflammation, LSM, and

199 This confirmed that liver-specific MDSC programing was comprehensive but rev

200 Hepatic stellate cells are liver-specific mesenchymal cells that play vital roles i

201 be suitable to maintain better vitality and liver-specific metabolic functions.

202 vation status of key signaling pathways, and liver-specific metabolic reprogramming in HBV-related HC

203 reduction in mitochondrial iron observed in liver-specific Mfrn1/2-knockout animals.

204 regulated in different malignancies, whereas liver-specific microRNA (miR)-122, a bona fide tumor sup

205 C virus (HCV) replication is dependent on a liver-specific microRNA (miRNA), miR-122.

206 ion of hepatitis C virus, which requires the liver-specific microRNA (miRNA)-122, the interactions of

207 The abundant, liver-specific microRNA miR-122 forms extensive base-pai

208 The liver-specific microRNA, miR-122, is an essential host f

209 lls support the entire HCV life cycle if the liver-specific microRNA, miR-122, is expressed along wit

210 The liver-specific microRNA, miR-122, stabilizes hepatitis C

211 tive-sense RNA virus that interacts with the liver-specific microRNA, miR-122.

212 As the liver-specific microRNA-122 (miR-122) is required for HC

213 aviviridae family, recruits two molecules of liver-specific microRNA-122 (miR-122) to the 5' end of i

214 epatitis C virus (HCV) uniquely requires the liver-specific microRNA-122 for replication, yet global

215 The liver-specific miR-122 binds within the HCV 5' untransla

216 ntly, the mortality rates of male and female liver-specific miR-122 knockout (LKO) mice were signific

217 passenger strand of the abundantly expressed liver-specific miR-122.

218 cterized the primary transcript of the human liver-specific MIR122 using Northern blot, quantitative

219 MicroRNA-122, an abundant and conserved liver-specific miRNA, regulates hepatic metabolism and f

220 nd horizontally transferred a mature form of liver-specific miRNA-122.

221 e outcomes, including overall mortality, and liver-specific morbidity and mortality, respectively.

222 Liver-specific mortality and overall mortality among NAF

223 ty rate of 25.56 per 1000 person-years and a liver-specific mortality rate of 11.77 per 1000 person-y

224 Liver-specific mortality values were calculated.

225 d CREBH processing and apoA-IV expression in liver-specific MTP knock-out mice.

226 We report that liver-specific Mttp knockout mice (Mttp-LKO) exhibit bot

227 Its replication is dependent upon a small, liver-specific noncoding RNA, miR-122.

228 Liver-specific Nrf1 (NF-E2-p45-related factor 1) knockou

229 or this phenotype, we generated an inducible liver-specific Nrf1 knockout mouse line using animals ha

230 At the whole animal level, the liver-specific overexpression of fortilin reduced PRX1 p

231 Conversely, liver-specific overexpression of GSNOR in obese mice mar

232 By contrast, liver-specific overexpression of human ZIP8 (adeno-assoc

233 Global or liver-specific overexpression of miR-26a in mice fed a h

234 Conversely, the liver-specific overexpression of Ppp1r3b enhanced hepati

235 -specific deletion (Ppp1r3b(Delta)(hep) ) or liver-specific overexpression of Ppp1r3b The Ppp1r3b del

236 In mice, liver-specific overexpression of TRIB1 lowers plasma lip

237 arks 99% of hepatic stellate cells (HSCs), a liver-specific pericyte population, to demonstrate that

238 The gene encoding the liver-specific peroxisomal enzyme alanine:glyoxylate ami

239 g to regression of the fibrotic phenotype in liver-specific Phb1 knockout mice.

240 hepatocyte viability and maintenance of the liver-specific phenotype in vitro.

241 tabolism and systemic glycemic control using liver-specific Plin5-deficient mice (Plin5(LKO) ).

242 iet-induced type 2 diabetes mouse models and liver-specific Prmt1 deficiency drastically ameliorated

243 er replaced the entire B domain and a hybrid liver-specific promoter (HLP) mediated 10-fold higher hF

244 vector consisting of a bioengineered capsid, liver-specific promoter and factor IX Padua (factor IX-R

245 xylase (Pah) complementary DNA (cDNA) from a liver-specific promoter coupled to a de novo designed he

246 fish expressing nitroreductase (NTR) under a liver-specific promoter damaged the organ within 24 hour

247 deno-associated virus-5 (AAV5) vector with a liver-specific promoter driving expression of a codon-op

248 HS-CRM8 is introduced upstream of a minimal liver-specific promoter in an adenoassociated virus (AAV

249 therefore performed IUGT of AAV5 or -8 with liver-specific promoter-1 encoding either human coagulat

250 e IL-12 or luciferase under the control of a liver-specific promoter.

251 otype 8 vector expressing feline IDUA from a liver-specific promoter.

252 -transferrin (ProINS-Tf) fusion protein as a liver-specific protein prodrug to achieve a glucose-lowe

253 We suppressed the expression of a liver-specific protein, cell death-inducing DFFA-like ef

254 binding by liver transcription factors than liver-specific protein-coding gene promoters.

255 al, tumor thrombus, genetic profile, and the liver-specific proteome.

256 In liver-specific Pten(-/-) mice shortly after induction of

257 We quantified liver-specific rates of hepatic gluconeogenesis and subs

258 Viral-mediated liver-specific RB deletion in vivo led to the induction

259 nstructive in human disease, we compared our liver-specific RB-loss gene signature to existing profil

260 3 binding and targeted the mutated RSPO to a liver specific receptor, ASGR1.

261 nockout mice, and Sult1e1 knockout mice with liver-specific reconstitution of SULT1E1 expression to b

262 This suggests the lack of common liver-specific reference probes for both S. lateralis an

263 se-free survival, lung-specific relapse, and liver-specific relapse.

264 We generated a liver-specific Repin1 knockout mouse (LRep1(-/-)) and sy

265 enic conditions, leading to hepatosteatosis; liver-specific restoration of XBP1s reverses the defects

266 Viable constitutive and tamoxifen inducible liver-specific RNase H1 knockout mice that expressed no

267 Similar observations were made in liver-specific RORgamma-deficient mice.

268 monstrates that despite reduced lipogenesis, liver specific SCD1 deficiency activates the mechanistic

269 Using liver-specific SCD1 knockout (LKO) mice fed a high-carbo

270 Consistent with the higher BAFF levels, liver-specific selection of the focused BCR IgH repertoi

271 These pathologies are suppressed by liver-specific Sestrin2 reconstitution, mTORC1 inhibitio

272 hagy into a destructive force in mammals, as liver-specific Sgk knockout mice demonstrate marked enha

273 Mechanistically, we demonstrate that liver-specific Shp deletion protects against fatty liver

274 ith hepatic polyploidy, miR-122 is the first liver-specific signal identified; our data demonstrate t

275 Liver-specific SIRT1 knockout (SIRT1 LKO) mice and their

276 al component of NR treatment was revealed in liver-specific Sirt1 knockout mice (Sirt1(hep-/-) ), whe

277 by rimonabant or JD5037 in wild-type but not liver-specific Sirt1(-/-) (Sirt1-LKO) mice, to levels ob

278 We performed partial hepatectomy in WT and liver-specific Sirt1-deficient mice and analyzed the exp

279 ese levels in the brain, blood, and liver of liver-specific Slc30a10 knockouts were only minimally el

280 T3 in control of Gadd45b was confirmed using liver-specific Stat3-null mice.

281 Liver-specific STS induction or estrogen/estrogen sulfat

282 ular membrane, and induction of autoreactive liver-specific T cells was detected.

283 Liver-specific TBC1D15 deficiency or non-p-NUMB expressi

284 epatic gluconeogenesis, a recent study using liver-specific Tcf7l2(-/-) mice suggested the opposite.

285 an alternate cancer model, we have generated liver-specific, Tet-on-inducible transgenic lines expres

286 (ogen) deposition was abolished in mice with liver-specific tissue factor deficiency, pinpointing the

287 s have implications for our understanding of liver-specific tolerance and autoimmunity and for the de

288 In-vivo, liver specific Tp53 loss increases the conversion of 5-F

289 ctivator involved in energy metabolism and a liver-specific transcription factor, respectively.

290 nscription factor binding occupancy of three liver-specific transcription factors between crosses of

291 Although several liver-specific transcription factors have been identifie

292 s accessible in chromatin and allowing other liver-specific transcription factors to bind and stimula

293 After identifying a digital signature of 10 liver-specific transcripts, we used a cross-validated lo

294 sms of Sestrin 3 (Sesn3), we generated Sesn3 liver-specific transgenic and knockout mice.

295 Liver-specific transgenic reconstitution of SULT1E1 in S

296 Moreover, using liver-specific TRbeta1-KO mice, we demonstrate that hypo

297 ORC1) in whole-body physiology, we generated liver-specific Tsc1 (L-Tsc1 KO) knockout mice.

298 nderstand in vivo functions of WWOX, we used liver-specific Wwox(hep-/-) and total Wwox(-/-) mice mod

299 Liver-specific Xbp1 knockout mice (Xbp1(LKO)) and Xbp1(f

300 However, liver-specific Zip14 KO mice exhibit decreased manganese