ライフサイエンスコーパス: local anesthetic

1 transsulcular probing (TSP) after injecting local anesthetic.

2 sensitive anatomy, and monitor the spread of local anesthetic.

3 eural toxicity in association with high-dose local anesthetic.

4 s inhibited by bupivacaine, a tertiary amine local anesthetic.

5 f 47 patients who initially were not given a local anesthetic.

6 ly obtained to measure concentrations of the local anesthetic.

7 using paravertebral block supplemented with local anesthetic.

8 m to improve outcome, unlike the intrathecal local anesthetics.

9 and neostigmine to potentiate the effects of local anesthetics.

10 as the ability to potentiate the effects of local anesthetics.

11 ed to the increased interest in their use as local anesthetics.

12 ne, that potentiates the effect of delivered local anesthetics.

13 nnel that is also inhibited by extracellular local anesthetics.

14 bing the physicochemical properties of novel local anesthetics.

15 bitors are used clinically as analgesics and local anesthetics.

16 loped to directly measure log k'(w) of eight local anesthetics.

17 king phenomenon reminiscent of the action of local anesthetics.

18 ally inaccessible from extracellular charged local anesthetics.

19 the major cause of the inhibition of FAAT by local anesthetics.

20 BTX binding is inhibited allosterically by local anesthetics.

21 ed with various substances, especially other local anesthetics.

22 the additivity of the effect of general and local anesthetics.

23 ardiotoxicity caused by low and high-potency local anesthetics.

24 monitor needle placement and application of local anesthetics.

25 reduces the sensitivity of receptors to the local anesthetic [2-(triethylamino)-N-(2,6-dimethylpheny

26 Our results support a reinterpretation of local anesthetic action whereby lidocaine functions as a

27 affect fast-inactivation, slow-inactivation, local anesthetic action, and batrachotoxin (BTX) action.

28 imply that the modulated receptor theory of local anesthetic action, which confines local anesthetic

29 are the key determinants of isoform-specific local anesthetic action.

30 ex, indicating that they did not result from local anesthetic actions of cocaine.

31 amine, a calcium channel blocker, has potent local anesthetic activity in vivo and in vitro.

32 tions with a reduction in the total doses of local anesthetic administered.

33 uch rare complications after subconjunctival local anesthetics administration.

34 The results show that the investigated local anesthetics affect thermal thresholds to a differe

35 gineered mutation at an interaction site for local anesthetic agents (F1760A) partially attenuated th

36 citable cells, and are molecular targets for local anesthetic agents and intracellular free Ca(2+) ([

37 thod for measuring the hydrophobicity of the local anesthetic agents in the unionized form.

38 ly dependent on a known interaction site for local anesthetic agents.

39 that general anesthetics, barbiturates, and local anesthetics all display the same effect on melting

40 For example, the local anesthetics ambroxol and lidocaine block both Na(V

41 Local anesthetic amount, surgical field size, and the op

42 ures have been solved, exhibit modulation by local anesthetic and anti-epileptic agents, allowing mol

43 Lidocaine is a widely used local anesthetic and antiarrhythmic drug that is believe

44 We used lidocaine, a local anesthetic and antiarrhythmic drug, to probe the r

45 We also examine recent studies of local anesthetic and antiepileptic drug binding to a sod

46 cy-dependent manner, which were abolished by local anesthetic and selective A-fiber blockade.

47 A standardized amount of local anesthetic and similar extent and duration of surg

48 Fluoroscopically guided injections of local anesthetic and steroid in the foot and ankle can i

49 ients, fluoroscopically guided injections of local anesthetic and steroid into the foot and ankle wer

50 small eyelid incision (8-13 mm) include less local anesthetic and tissue distortion, less ecchymosis

51 ed by needle sticks (Ns) for the delivery of local anesthetic and/or scaling and root planing (SRP) i

52 tivity than the site occupied by traditional local anesthetics and anticonvulsants.

53 ree mutations had strong effects on block by local anesthetics and anticonvulsants.

54 e lacosamide receptor overlaps receptors for local anesthetics and batrachotoxin.

55 A class of ligands, including galanthamine, local anesthetics and certain toxins, interact with nACh

56 ients randomized to receive a TAP block with local anesthetics and dexamethasone, PILA with dexametha

57 escribes the anti-inflammatory properties of local anesthetics and discusses the benefits seen when u

58 esuscitation from intravascular injection of local anesthetics and institutional procedures to positi

59 considered much less cardiotoxic than other local anesthetics and is used commonly as infusions for

60 n reverse cardiac pharmacotoxicity caused by local anesthetics and other lipophilic drugs.

61 r other small molecule inhibitors, including local anesthetics and TTX.

62 ients reported that bad taste, receiving the local anesthetic, and excessive fluid in the mouth were

63 positively charged small molecule used as a local anesthetic, and planar supported lipid bilayers (S

64 ng preoperative oral sedation (diazepam) and local anesthetic, and the second using local anesthetic

65 ystemic toxicity, local tissue toxicity from local anesthetics, and inflammation.

66 Local anesthetic antiarrhythmic drugs block Na+ channels

67 Local anesthetic antiarrhythmic drugs block voltage-gate

68 use-dependent Na channel inhibitors used as local anesthetic, antiarrhythmic, and anticonvulsant dru

69 -gated sodium channels are inhibited by many local anesthetics, antiarrhythmics, and antiepileptic dr

70 ffects of analgesic, sedative, beta-blocker, local anesthetic, antiemetic, and obstetric medications.

71 Local anesthetics are a group of drugs defined by their

72 teresting and promising areas where systemic local anesthetics are being implemented.

73 Local anesthetics are commonly administered to prevent t

74 Local anesthetics are drugs which have many potentially

75 Local anesthetics are known to inhibit neuronal fast ant

76 Local anesthetics are used in a wide range of clinical s

77 ely, it is the correct peri-neural spread of local anesthetic around a nerve that provides safe, effe

78 The use of EMLA (eutectic mixture of local anesthetics; Astra USA, Westborough, MA) cream (li

79 orrelate linearly with the solubility of the local anesthetic bases in medium chain triglycerides and

80 rmacodynamic response of cutaneously applied local anesthetic bases, this study was conducted to char

81 Channel block by the neutral local anesthetic benzocaine is unaffected by the distrib

82 Xenopus laevis oocytes, whereas the neutral local anesthetic, benzocaine, does not, suggesting that

83 Administration of a long-acting local anesthetic between the mesh and the peritoneum sig

84 y of local anesthetic action, which confines local anesthetic binding effects to the channel pore, sh

85 titutions of the amino acids at the putative local anesthetic binding site (i.e., F1760, N1765, Y1767

86 The local anesthetic binding site in I1G1(M) is indistinguis

87 ing site on hNav1.5 differs from that of the local anesthetic binding site.

88 u1-Y401C/F1579A), which altered the putative local anesthetic binding site.

89 ion mutations in amino acids at the putative local anesthetic binding sites.

90 WT SoCal5 and SoCal5 with the local anesthetics binding site mutated (F1760A) could be

91 isoindoline carboxamides interacted with the local anesthetics binding site.

92 lasting increase in phosphorylation, and (3) local anesthetic block of the injected paw reversibly bl

93 ilter region as a structural determinant for local anesthetic block.

94 of the mutant hNav1.5 channels compared with local anesthetic block.

95 Local anesthetics block neurons, but are also potent ant

96 Local anesthetic blocks under image intensifier or CT gu

97 arge when peripheral inputs are disrupted by local anesthetic blocks with lidocaine (LID).

98 e inhibited by Zn2+ (IC50 = 175 microM), the local anesthetic bupivacaine (IC50 = 68 microM), and the

99 iently reduced the free concentration of the local anesthetic bupivacaine in 0.9% NaCl.

100 ellular application of the membrane-permeant local anesthetic bupivacaine selectively inhibited G pro

101 ls remained highly sensitive to block by the local anesthetic bupivacaine, unlike several other BTX-r

102 ated by electrospinning, with or without the local anesthetic bupivacaine.

103 After mesh placement, a long-acting local anesthetic (bupivacaine hydrochloride, 0.50%) or p

104 we examined whether a single injection of a local anesthetic (bupivacaine) into the cingulum bundle

105 Coincubation with local anesthetics but not tetrodotoxin attenuated compou

106 creases the [Ca(2+)](i) in the brain and its local anesthetic, but neither its catecholaminergic nor

107 block of hNav1.5 channels similar to that of local anesthetics, but the location of the prenylamine b

108 in contrast to the mostly positively charged local anesthetics, but their open/inactivated-state bloc

109 vidence remains mixed, but it is likely that local anesthetic cardiotoxicity primarily arises from a

110 use and best treatment of LAST (particularly local anesthetic cardiotoxicity) remain unclear.

111 Local anesthetics cause muscle necrosis, followed by reg

112 ed Na+ channels are the molecular targets of local anesthetics, class I antiarrhythmic drugs, and som

113 t determinant of the block of Na+ channel by local anesthetic-class drugs.

114 Local anesthetics, commonly used for treating cardiac ar

115 onselective cation channels are inhibited by local anesthetic compounds through an undefined mechanis

116 n = 8) or lidocaine (2%, n = 4), an internal local anesthetic control, or intravenous phenylephrine (

117 onal shake-flask method was obtained for the local anesthetics, demonstrating the reliability of the

118 l access pathway for the membrane-impermeant local anesthetic derivative QX-222 into the internal ves

119 local anesthesia has long been a key goal in local anesthetic development.

120 resent study tests this prediction using the local anesthetic dibucaine as a probe.

121 We conclude that the charged form of local anesthetics directly and reversibly inhibits kines

122 Local anesthetics do not penetrate readily through human

123 Ultrasound guidance may aid in reduction in local anesthetic dose, anatomical evaluation and avoidan

124 f molecular mechanisms of antiarrhythmic and local anesthetic drug interactions with hNa(V)1.5 and wi

125 rated the deactivation of NsVBa, whereas the local anesthetic drug lidocaine was shown to antagonize

126 Use of enantiomeric local anesthetic drugs permits a safer and wider range o

127 study the interactions of antiarrhythmic and local anesthetic drugs with hNa(V)1.5.

128 s define cardiac-specific external paths for local anesthetic drugs.

129 e channel's inner pore overlap with those of local anesthetic drugs.

130 rall discomfort of patients and the need for local anesthetic during caries removal and subsequent re

131 antagonist into the ventricular system or a local anesthetic effect caused by infusion of the antago

132 aine is complicated, however, by an apparent local anesthetic effect of the drug.

133 ypomotility following cocaine seemed to be a local anesthetic effect, because it was mimicked by 50-2

134 Local anesthetics effectively suppress pain sensation, b

135 perties, and of lidocaine, which has similar local anesthetic effects as cocaine but is devoid of cat

136 Time- and voltage-dependent local anesthetic effects on sodium (Na) currents are gen

137 ium channels and has potent and long-lasting local anesthetic effects when tested in two pain assays

138 ckade of afferent input from the injury with local anesthetic elicits conditioned place preference, a

139 We have developed a local anesthetic-eluting suture system which would combi

140 Lidocaine is one of the most common local anesthetics employed for adulteration of illicit c

141 Patients undergoing local anesthetic endovenous thermal ablation were random

142 nation mutations and studies of block by the local anesthetic etidocaine favored the conclusion that

143 ion I409A in IS6 reduced the affinity of the local anesthetic etidocaine for the inactivated state by

144 7c89, 4030w92, and 619c89 as well as for the local anesthetic etidocaine.

145 the affinity of inactivated channels for the local anesthetic etidocaine.

146 ater number of patients (p < 0.05) requested local anesthetic for the tooth subjected to the control

147 detomidine enhanced the efficacy of released local anesthetics, greatly increasing the number of trig

148 logic anesthetic, many ester-and amide-based local anesthetics have been developed for a variety of s

149 Local anesthetics have many beneficial properties, and p

150 Given that site 2 neurotoxins and local anesthetics have nonidentical but overlapping bind

151 Local anesthetics have similar chemical structure but di

152 In the modified in vitro motility assay, local anesthetics immediately and reversibly stopped the

153 Bupivacaine is the indicated local anesthetic in caudal, epidural, and spinal anesthe

154 od for measuring the hydrophobicity of eight local anesthetics in current clinical use.

155 Dosing studies of local anesthetics in peripheral nerve blockade suggest t

156 The choice of local anesthetics in regional anesthesia depends on desi

157 Local anesthetics in the form of creams, gels and sprays

158 The trend toward smaller doses of local anesthetics in ultrasound-guided regional anesthes

159 ion has emerged as an effective treatment of local anesthetic-induced cardiac arrest, but its therape

160 lipid emulsion as an effective treatment of local anesthetic-induced cardiac arrest.

161 The results suggest that local anesthetic-induced convulsive seizures are mediate

162 n and application, and proper preparation of local anesthetic infusate solutions are all considered e

163 gies for the relationship between continuous local anesthetic infusion volume and concentration as we

164 ral strategies such as continuous ambulatory local anesthetic infusions and adjuvants that may potent

165 We propose that membrane-permeant local anesthetics inhibit GIRK channels by antagonizing

166 These results fine tune our understanding of local anesthetic inhibition of voltage-gated sodium chan

167 Local anesthetic injection at the surgical site, though

168 When local anesthetic injection immediately preceded the doxo

169 in into the eyelid of rabbits 2 days after a local anesthetic injury, perhaps exploiting the toxic ef

170 We also determine whether prenylamine and local anesthetics interact with a common binding site on

171 The amine in local anesthetics interacts with the charged selectivity

172 investigate the efficacy of intraperitoneal local anesthetic (IPLA) on pain after acute laparoscopic

173 istent evidence that epidural analgesia with local anesthetics is associated with faster resolution o

174 The subconjunctival anesthesia with local anesthetics is considered as a low-risk procedure

175 Eutectic mixture of local anesthetics is currently the most frequently presc

176 Knowledge of the pharmacology of local anesthetics is essential for their safe use and se

177 Acute toxicity to cocaine and other local anesthetics is manifested in central nervous syste

178 Thus, the thermodynamic behavior of local anesthetics is very similar to that of general ane

179 obenzoic acid that finds an application as a local anesthetic, is found to adopt in its protonated fo

180 involving the use of opioid and non-opioid (local anesthetics, ketamine, acetaminophen, and non-ster

181 tested whether mibefradil interacts with the local anesthetic (LA) binding site, which includes resid

182 ) of the S5-S6 linkers in channel gating and local anesthetic (LA) block using site-directed cysteine

183 dues of I-S6 and II-S6 in channel gating and local anesthetic (LA) block was investigated using the c

184 -gated sodium (Na+) channels are targets for local anesthetic (LA) drugs that bind in the inner pore

185 h-frequency discharges of excitable cells by local anesthetics (LA) is largely determined by drug-ind

186 Local anesthetics (LAs) are noncompetitive antagonists o

187 channels in their open conformation, whereas local anesthetics (LAs) block Na(+) conductance.

188 these channels to open persistently, whereas local anesthetics (LAs) block Na(+) conductance.

189 Local anesthetics (LAs) block voltage-gated Na+ channels

190 Most local anesthetics (LAs) elicit use-dependent inhibition

191 The effects of local anesthetics (LAs) on G protein-mediated responses

192 ed Na(+) channels are the primary targets of local anesthetics (LAs).

193 -gated Na+ channels are a primary target for local anesthetics (LAs).

194 ed trials comparing epidural analgesia (with local anesthetics, lasting for >/= 24 hours postoperativ

195 In Experiment 2, the local anesthetic lidocaine (2%) was infused (0.5 microl)

196 caudal arcuate nucleus by microinjecting the local anesthetic lidocaine (2%; 0.1 or 0.3 microl) bilat

197 To test this, the local anesthetic lidocaine (2%; 0.5 microl) was microinj

198 e not mimicked by repeated injections of the local anesthetic lidocaine and were not observed in neur

199 The local anesthetic lidocaine appears to be able to access

200 Although the local anesthetic lidocaine modulates inflammatory proces

201 mcinolone, and methylprednisolone) and three local anesthetics (lidocaine, ropivacaine, and bupivacai

202 Microinjections of local anesthetics, lidocaine (100 microg) and procaine (

203 A) in a cream, and (iii) the analysis of the local anesthetics, lidocaine and prilocaine, in a gel an

204 hibition by aryl sulfonamides and by classic local anesthetics might show an interaction mediated by

205 er-reviewed literature regarding the role of local anesthetics, NSAIDs, gabapentinoids, and acetamino

206 We investigated the direct effect of local anesthetics on kinesin, using both in vitro motili

207 e effect of tetracaine aerosol inhalation, a local anesthetic, on lung volume decrements, rapid shall

208 n the spectrum of pharmacodynamic actions of local anesthetics, on comparison of pharmacodynamic and

209 ) and local anesthetic, and the second using local anesthetic only.

210 onset time.The addition of clonidine to the local anesthetic opioid mixtures seems to produce analge

211 responses to cytokines in addition to their local anesthetic or antiarrhythmic properties.

212 requested additional epidural bolus doses of local anesthetic (P=0.01).

213 study was conducted to characterize various local anesthetics pharmacodynamically by measuring therm

214 ther ultrasound-guided foam sclerotherapy or local anesthetic phlebectomy.

215 phosphate and preperitoneal instillation of local anesthetic (PILA) with dexamethasone vs control on

216 proved suitable for characterization of the local anesthetics, possibly because cold receptors are l

217 ) and were not mimicked by injections of the local anesthetic procaine (800 mm).

218 We injected the local anesthetic procaine [15, 17, 18] into the mushroom

219 ffects of medial septal microinfusion of the local anesthetic, procaine (MS Pro), on hippocampal neur

220 saxitoxin (STX), a compound with ultrapotent local anesthetic properties but little or no cytotoxicit

221 Because it has been reported that local anesthetic properties may influence the reinforcin

222 amine uptake inhibitors, we investigated the local anesthetic properties of cocaethylene as well as i

223 aine (except for serotonin increases) but no local anesthetic properties, and of lidocaine, which has

224 ed tetrodotoxin (TTX), which has ultrapotent local anesthetic properties.

225 oxic effects of antidepressants when used as local anesthetics proved this to be the case.

226 n be also blocked by the membrane-impermeant local anesthetic QX via external paths not present in sk

227 A local anesthetic QX-314 injected at the end of Phase 2 b

228 veals sensitivity to inhibition by a charged local anesthetic, QX-314, applied extracellularly.

229 dium action potentials were blocked with the local anesthetic QX314.

230 Membrane-impermeant quaternary amine local anesthetics QX314 and QX222 can access their bindi

231 nt of hydrophobicity and has been applied to local anesthetics recently.

232 of open Na(+) channels is via the conserved local anesthetic receptor albeit with a relatively slow

233 A F1579K mutation at the local anesthetic receptor of inactivation-deficient Nav1

234 s containing lysine substitutions within the local anesthetic receptor region at residues F1760 or N1

235 nonidentical molecular determinants with the local anesthetic receptor site in transmembrane segment

236 I1760, F1764, and Y1771, which form part of local anesthetic receptor site in transmembrane segment

237 These results suggest that the local anesthetic receptor site is formed primarily by re

238 pared with wild-type by the mutations at the local anesthetic receptor site.

239 Thus, lubeluzole likely binds to the local anesthetic receptor through its phenoxy-propranol-

240 -inactivated state by binding at or near the local anesthetic receptor within the sodium channel pore

241 identical, or allosterically coupled, to the local anesthetic receptor.

242 endence, suggesting that A-core binds to the local anesthetic receptor.

243 1771A) channels, which reduce block by other local anesthetics, reduced high-affinity block of inacti

244 graphy allows for reduction of the volume of local anesthetic required to accomplish a nerve block, r

245 reduction in the amount or concentration of local anesthetic required to produce perioperative analg

246 gional neural blockade in combination with a local anesthetic results in increased duration of sensor

247 However, "chase" with free local anesthetic site inhibitors increased the rate of d

248 n VGSCs, both of which can be bound by known local anesthetic site inhibitors.

249 Unlike cationic derivatives of local anesthetic sodium channel blockers like QX-314, th

250 y have similar properties with regard to the local anesthetics solubility as the stratum corneum lipi

251 Local anesthetic solutions aerosolized onto skin-harvest

252 Local anesthetic solutions frequently contain vasoconstr

253 e are now able to use very low concentration local anesthetic solutions with a reduction in the total

254 Unlike previous local anesthetics studied, the strongest effect was obse

255 rent use for measuring the hydrophobicity of local anesthetics suffer from a number of limitations an

256 d eliminates the inhibition by extracellular local anesthetics, suggesting that the pore-loop complex

257 t for neonates, and guide us to safer use of local anesthetics suitable for neonates with their pharm

258 ith increases in use of regional anesthesia, local anesthetic systemic toxicity (LAST) has been a top

259 unt for the apparent enhanced sensitivity to local anesthetic systemic toxicity during pregnancy.

260 Strategies to reduce the risk of local anesthetic systemic toxicity should be employed wh

261 th apparent success early in the spectrum of local anesthetic systemic toxicity to preempt cardiac ar

262 can result in high plasma concentrations and local anesthetic systemic toxicity.

263 rmed the efficacy of lipid resuscitation for local anesthetic systemic toxicity.

264 Antiarrhythmics, anticonvulsants, and local anesthetics target voltage-gated sodium channels,

265 In some experiments, the local anesthetic tetracaine (10 microg) was then microin

266 romolecular prodrug (P407-CM-T) in which the local anesthetic tetracaine (T) is attached to the polym

267 Interestingly, the potency of the local anesthetic tetracaine for the inhibition of alpha3

268 In the single-molecule motility assay, the local anesthetic tetracaine inhibited the motility of in

269 amily of voltage-gated ion channels, and the local anesthetic tetracaine is known to block CNG channe

270 Co-infusion of the local anesthetic tetracaine with duodenal lipids abolish

271 Interactions of the local anesthetic tetracaine with unilamellar vesicles ma

272 ng mating can be prevented by injection of a local anesthetic (tetracaine) in the cloacal region prio

273 (azithromycin), antifungal (tolnaftate), and local anesthetic (tetracaine), were examined.

274 c sodium (Na) currents are more sensitive to local anesthetics than brain or skeletal muscle Na curre

275 ifiers contain an intrapore-binding site for local anesthetic that is normally inaccessible from extr

276 The amount of the local anesthetic that was injected was then recorded, as

277 stem toxicity are unwanted side-effects from local anesthetics that cannot be attributed to the inhib

278 Injectable local anesthetics that would last for many days could ha

279 lthough antidepressants indeed act as potent local anesthetics, their use in the clinical setting can

280 anesthetics as well as modifying injectable local anesthetic to decrease the pain of local infiltrat

281 pecific issues of nerve damage, treatment of local anesthetic toxicity with lipid solutions and preve

282 n neurologic assessment and the potential of local anesthetic toxicity.

283 Even with co-administration of local anesthetics, traditional injection still causes pa

284 Local anesthetic use in gynecologic laparoscopy appears

285 First, the effect of lidocaine, a local anesthetic used for human skin biopsy, on B. burgd

286 te or placebo) was injected per cartridge of local anesthetic used.

287 ural volume extension enhances the spread of local anesthetics using a combined spinal-epidural techn

288 ants (122) received one or two cartridges of local anesthetic/vasoconstrictor prior to dental treatme

289 More information is becoming available on local anesthetic volume and concentration relationships

290 inal anesthesia; considerations in selecting local anesthetic volume, concentration, and mass in peri

291 A local anesthetic was applied to the third finger of the

292 8-fold, whereas that of bupivacaine, a known local anesthetic, was reduced by as much as 68-fold comp

293 be a fundamental physicochemical property of local anesthetics, was in the past obtained by octanol/b

294 y phase HPLC column, the log k'(w) values of local anesthetics were determined by measuring the capac

295 has been conducted with the use of systemic local anesthetics when considering their cost effectiven

296 lurane effect was attenuated by lidocaine, a local anesthetic with anti-inflammatory property.

297 ed by procaine (PRO 5 mg/kg), a short-acting local anesthetic with negligible effect on the DA transp

298 t antidepressants exhibit many properties of local anesthetics with an extended duration of action.

299 The introduction of long acting local anesthetics with better safety profile as well as

300 inical and scientific interest in developing local anesthetics with prolonged durations of effect fro