ライフサイエンスコーパス: locus coeruleus

1 noradrenergic influences originating in the locus coeruleus.

2 ry nucleus, ventral periaqueductal gray, and locus coeruleus.

3 t not into the ventral tegmental area or the locus coeruleus.

4 ilateral nucleus in the brainstem called the locus coeruleus.

5 disease due to the early degeneration of the locus coeruleus.

6 ei, and noradrenergic input from the nucleus locus coeruleus.

7 phrine transporter (NET) availability in the locus coeruleus.

8 noradrenergic signals that originate in the locus coeruleus.

9 s prepro-galanin messenger RNA levels in the locus coeruleus.

10 od brain barrier, the inferior olive and the locus coeruleus.

11 area X following injections of CTB into the locus coeruleus.

12 t loss of norepinephrine (NE) neurons in the locus coeruleus.

13 e nucleus, Edinger-Westphal nucleus, and the locus coeruleus.

14 ventral thalamus, posterior tuberculum, and locus coeruleus.

15 cleus of the stria terminalis, amygdala, and locus coeruleus.

16 aracterize CO2/H+-sensitive neurons from the locus coeruleus.

17 ry processing through its connections to the locus coeruleus.

18 l arousal state, including the noradrenergic locus coeruleus.

19 < 0.001), red nucleus (-31%; p = 0.03), and locus coeruleus (-17%; p = 0.03).

20 o be triggered by sympathetic stress via the locus coeruleus; [3] sodium salicylate induces an acute

21 y the anterior SNpc (-49%; P < .001) and the locus coeruleus (-37%; P < .05).

22 d with increases in gain and activity in the locus coeruleus (a purported neurophysiological mechanis

23 tively regulate noradrenergic neurons in the locus coeruleus, a brain center implicated in attention,

24 in this issue of Neuron shows that the human locus coeruleus, a brain stem nucleus containing cell bo

25 ation revealed age-dependent degeneration of locus coeruleus, a major player in contextual learning,

26 VLM (RVLM) catecholaminergic neurons contact locus coeruleus, A1, and A2 noradrenergic neurons, and u

27 positive norepinephrine neurons was found in locus coeruleus/A5/A7 noradrenaline cell groups, whereas

28 the number of catecholaminergic cells in the locus coeruleus (A6) and the ventral tegmental area (A10

29 amic neurons were measured before and during locus coeruleus activation in waking animals.

30 ttermates, which was rescued by chemogenetic locus coeruleus activation via designer receptors exclus

31 Locus coeruleus activation was eliminated by intracerebr

32 ry auditory cortex (A1), pairing sounds with locus coeruleus activation.

33 directionally influence pain perception, and locus coeruleus activity mirrors the interaction between

34 activation, a process largely facilitated by locus coeruleus activity.

35 lso elicit phasic changes in neural gain and locus coeruleus activity.

36 he prominent state-modulating actions of the locus coeruleus, additional studies examined: 1) lateral

37 eleased within primary sensory circuits from locus coeruleus afferent fibers can produce a spectrum o

38 duced in the superior vestibular nucleus and locus coeruleus after estradiol replacement; estradiol t

39 s, such as from the prefrontal cortex to the locus coeruleus, alter global arousal levels.

40 Locus coeruleus and A5 inhibition was not seen unless pr

41 nduced loss of norepinephrine neurons in the locus coeruleus and adjoining A5 and A7 noradrenaline ce

42 man tissues confirmed high expression in the locus coeruleus and adrenal gland, but also in sympathet

43 n 2 rs1108580, but only small differences in locus coeruleus and adrenals.

44 omic components of the limbic forebrain, the locus coeruleus and cerebellar Purkinje cells, or for CR

45 ified alpha-syn aggregates in neurons of the locus coeruleus and cingulate cortex.

46 xpression was decreased by phenelzine in the locus coeruleus and decreased by imipramine in the dorsa

47 pression of tyrosine hydroxylase mRNA in the locus coeruleus and decreased pituitary adrenocorticotro

48 Mild neuronal loss was identified in the locus coeruleus and dorsal motor nucleus of the vagus, b

49 ificantly greater BOLD responses in the left locus coeruleus and hypothalamus after placebo compared

50 on of tyrosine hydroxylase is delayed in the locus coeruleus and is markedly deficient in the medulla

51 ggests that aberrant tau accumulation in the locus coeruleus and noradrenergic dysfunction may be a c

52 al area and hindbrain structures such as the locus coeruleus and parabrachial nucleus.

53 the right side compared to left side in the locus coeruleus and parabrachial, superior vestibular, a

54 We made whole-cell recordings from rat locus coeruleus and primary auditory cortex (A1), pairin

55 uctures and neurochemical modulation via the locus coeruleus and raphe nuclei.

56 ns shell, and moderately to medial amygdala, locus coeruleus and solitary tract, consistent with the

57 ed projections from the noradrenergic nuclei locus coeruleus and subcoeruleus, and injections of biot

58 ted the asymmetry of c-Fos expression in the locus coeruleus and supragenualis nucleus, created an as

59 ignificantly reduced NET availability in the locus coeruleus and that greater NET availability in thi

60 mRNA levels, especially in the noradrenergic locus coeruleus and the dorsal raphe nucleus, in paralle

61 m the HSD2 neurons to the forebrain--the pre-locus coeruleus and the innermost region of the external

62 binding potential of NET availability in the locus coeruleus and the severity of PTSD symptoms assess

63 ic antidepressant treatment on brainstem GR, locus coeruleus and ventral tegmental area (VTA) tyrosin

64 he brain that are involved in sleep arousal (locus coeruleus) and preference/aversion (nucleus accumb

65 e pontine noradrenergic cell groups, A5, A6 (locus coeruleus), and A7, provide the only noradrenergic

66 ising a region of interest that includes the locus coeruleus), and cerebellum.

67 dal portions of the hindbrain, including the locus coeruleus, and much later in basolateral amygdala,

68 fied NPS fibers originating in the brainstem locus coeruleus, and projecting to the PVN.

69 ortical structures, including basal ganglia, locus coeruleus, and raphe nuclei (phase II), followed b

70 y little to the catecholamine neurons in the locus coeruleus, and selectively targets the viscerosens

71 This differs from the striatum, locus coeruleus, and spinal cord, where multiple peptida

72 ne nuclei, the dorsal tegmental nucleus, the locus coeruleus, and the reticular formation.

73 Westphal nucleus, the hippocampus, amygdala, locus coeruleus, and the ventral tegmental area.

74 n the substantia nigra pars compacta (SNpc), locus coeruleus, and ventral tegmental area in Parkinson

75 volumes of the anterior and posterior SNpc, locus coeruleus, and ventral tegmental area were determi

76 entral striatum, and nucleus accumbens), the locus coeruleus, and white matter, and deactivation of m

77 l system and of noradrenergic neurons in the locus coeruleus are important pathological features of P

78 PPG(+) neurons in the RTN and locus coeruleus are selectively activated (Fos) followin

79 rainstem in only three distinct regions: the locus coeruleus area, the principal sensory trigeminal n

80 opin-releasing factor (CRF), that render the locus coeruleus arousal system of females more vulnerabl

81 tyrosine hydroxylase gene expression in the locus coeruleus as a measure of central norepinephrine f

82 the noradrenergic fibres originating in the locus coeruleus as an additional source of neurotransmit

83 RVLM catecholaminergic neurons activate the locus coeruleus as well as A1 and A2 noradrenergic neuro

84 lopment was significantly compromised in the locus coeruleus as well.

85 reviously identified as sending axons to the locus coeruleus, as well as from newly identified presyn

86 sustained, high-frequency stimulation of the locus coeruleus at frequencies of 5 Hz and above caused

87 underlying mechanisms and the development of locus coeruleus-based therapies.

88 review is to emphasize the complexity of the locus coeruleus beyond its primary definition as a norep

89 lar potency to morphine-mediated currents in locus coeruleus brain slice preparations.

90 strate distinct modes by which an inhibitory locus coeruleus circuit regulates arousal in the brain.

91 gions including the hypothalamus, raphe, and locus coeruleus, commercial antibodies to LGI1 bound to

92 erations in LCGU, but LCGU was higher in the locus coeruleus compared to quinpirole alone (P<0.05), w

93 hile we have previously detailed the unusual locus coeruleus complex of the tree pangolin, the superi

94 s, variations in regions associated with the locus coeruleus complex, auditory system, and motor, neu

95 Neural activity in the noradrenergic locus coeruleus correlates with periods of wakefulness a

96 Recordings in the locus coeruleus demonstrate two modes of LC-GABA respons

97 immunized mice showed neuronal damage in the locus coeruleus detected by a reduction of average cell

98 ed for histological and behavioural signs of locus coeruleus dysfunction reminiscent of mild cognitiv

99 ional studies examined: 1) lateralization of locus coeruleus efferents to these regions; 2) the topog

100 at a subset of excitatory neurons in the pre-locus coeruleus express prodynorphin, and that these neu

101 nk between pretangle tau accrual and altered locus coeruleus fibre morphology.

102 oss of hippocampal norepinephrine levels and locus coeruleus fibres in the medial entorhinal cortex a

103 equency-dependent, causal relationship among locus coeruleus firing, cortical activity, sleep-to-wake

104 ds to raise noradrenaline levels or increase locus coeruleus function may be of benefit in treating m

105 to sudden sounds in PTSD is associated with locus coeruleus hyperresponsiveness.

106 Locus coeruleus imaging also holds the promise to strati

107 the groundwork to evaluate the potential of locus coeruleus imaging as a biomarker for neurodegenera

108 n with neuropathological biomarkers, in vivo locus coeruleus imaging could help to understand the con

109 yte activation in the ventral portion of the locus coeruleus in immunized mice.

110 compacta and noradrenergic neurons from the locus coeruleus in monkeys performing a task manipulatin

111 ct from the well-documented functions of the locus coeruleus in promoting the stress response, demons

112 unity to quantify structural features of the locus coeruleus in vivo during disease progression.

113 illary area, laterodorsal tegmental nucleus, locus coeruleus, inferior and superior colliculus homolo

114 y projecting novelty signaling system of the locus coeruleus initiates new network representations th

115 tau accrual in the locus coeruleus, loss of locus coeruleus innervation and deficits locus coeruleus

116 stochastic behavioral modes is controlled by locus coeruleus input into ACC.

117 Activation of locus coeruleus inputs, vPAG astrocytes, or vPAG(DA) neu

118 us on how non-invasive in vivo assessment of locus coeruleus integrity can be used for clinical resea

119 ith disease progression, in vivo measures of locus coeruleus integrity could provide new pathophysiol

120 y modulating norepinephrine release from the locus coeruleus into the olfactory bulb.

121 a (SNpc) and of noradrenergic neurons in the locus coeruleus is accompanied with increases in apoptos

122 Here we report that neuronal firing in the locus coeruleus is especially sensitive to environmental

123 These results suggest that the locus coeruleus is finely tuned to regulate organismal a

124 Our results demonstrate that locus coeruleus is highly plastic, leading to substantia

125 x, challenging the long-held belief that the locus coeruleus is the sole source of norepinephrine pro

126 om primary somatosensory cortex and from the locus coeruleus (LC) (the neuromodulatory nucleus releas

127 sing factor (CRF)-mediated increase in tonic locus coeruleus (LC) activity and consequent release of

128 rostimulation, Joshi et al. (2016) show that locus coeruleus (LC) activity closely matches moment-to-

129 ine noradrenergic cell groups, including the locus coeruleus (LC) and A5.

130 medulla (VLM), and to a lower extent, in the locus coeruleus (LC) and Barrington nucleus.

131 The locus coeruleus (LC) and dorsal raphe (DR) are monoamine

132 t from the pontine micturition center (PMC), locus coeruleus (LC) and medial prefrontal cortex (mPFC)

133 Recent findings indicate that the locus coeruleus (LC) and noradrenergic neuromodulation m

134 nt in noradrenergic circuits associated with locus coeruleus (LC) and prefrontal cortex, where emotio

135 ar glutamate transporters (VGLUT 1-3) in the locus coeruleus (LC) and the dorsal raphe nucleus (DRN)

136 Mice with locus coeruleus (LC) area injection of lentivirus encodi

137 monstrated that noradrenergic neurons in the locus coeruleus (LC) corelease noradrenaline and dopamin

138 Recordings from acute slices of rat locus coeruleus (LC) demonstrated that photorelease of L

139 and downstream noradrenergic neurons in the locus coeruleus (LC) during nonrapid eye movement (NREM)

140 um, and these patterns paralleled changes in locus coeruleus (LC) fiber innervation, respectively.

141 ificant loss of noradrenergic neurons in the locus coeruleus (LC) in addition to the loss of dopamine

142 pharmacological inactivation of amygdala and locus coeruleus (LC) in mice.

143 The locus coeruleus (LC) in the pons is the major source of

144 The locus coeruleus (LC) is a dense cluster of neurons that

145 The locus coeruleus (LC) is a major noradrenergic brain nucl

146 The locus coeruleus (LC) is a seemingly singular and compact

147 ave indicated that the noradrenergic nucleus locus coeruleus (LC) is one site at which DYN may contri

148 The brainstem nucleus locus coeruleus (LC) is the primary source of norepineph

149 The brainstem nucleus locus coeruleus (LC) is the sole source of norepinephrin

150 The noradrenergic brain nucleus locus coeruleus (LC) modulates arousal and may have effe

151 We investigated locus coeruleus (LC) modulation of thalamic feature sele

152 le-cell voltage-clamp recordings from KF and locus coeruleus (LC) neurons contained in acute rat brai

153 We found that inhibition and activation of locus coeruleus (LC) neurons decreases and increases fre

154 Loss of noradrenergic locus coeruleus (LC) neurons is a prominent feature of a

155 Activation of noradrenergic locus coeruleus (LC) neurons promotes wakefulness and be

156 Moreover, we determined the role of the locus coeruleus (LC) neurons that project to the basolat

157 Locus coeruleus (LC) neurons, the source of hippocampal

158 In rat locus coeruleus (LC) neurons, tolerance to morphine was

159 by riluzole in the regulation of activity of locus coeruleus (LC) neurons, which provide the major in

160 endomorphin-2, and morphine in rat and mouse locus coeruleus (LC) neurons.

161 Activity of locus coeruleus (LC) noradrenergic neurons was determine

162 ry deficits coupled with degeneration of the locus coeruleus (LC) norepinephrine (NE) neurons.

163 pression in the dorsal raphe (DR) and in the locus coeruleus (LC) of mice lacking orexin receptors in

164 ctrical-stimulation-evoked NE release in the locus coeruleus (LC) of mouse brain slices, looming-evok

165 Here, we examined how neuromodulation via locus coeruleus (LC) projections to HPC area CA1 (LC-CA1

166 The locus coeruleus (LC) projects throughout the brain and s

167 The noradrenergic locus coeruleus (LC) regulates arousal, memory, sympathe

168 Here, we developed an ex vivo locus coeruleus (LC) slice culture system and successful

169 are not fully resolved, they likely involve locus coeruleus (LC) stimulation via the nucleus of the

170 The locus coeruleus (LC) supplies norepinephrine to the brai

171 The brainstem locus coeruleus (LC) supplies norepinephrine to the fore

172 hms and impairment of the noradrenergic (NA)-locus coeruleus (LC) system.

173 ntations increases local NE release from the locus coeruleus (LC) to generate "NE hotspots." At these

174 pha(1)-Adrenoceptors are concentrated in the locus coeruleus (LC) where they appear to regulate vario

175 innervated by NE-containing fibers from the locus coeruleus (LC), a pathway known to modulate state-

176 orphinergic projections terminate within the locus coeruleus (LC), a primary source of norepinephrine

177 at originate from pontine neurons in the A5, locus coeruleus (LC), and A7 cell groups.

178 ves dense noradrenergic (NE) inputs from the locus coeruleus (LC), and the LC-NE system is heavily im

179 nucleus and the norepinephrine (NE) nucleus, locus coeruleus (LC), are integral to a circuit that lin

180 -containing neurons in the brainstem nucleus locus coeruleus (LC), but there is little direct evidenc

181 the raphe nuclei, Edinger-Westphal nucleus, locus coeruleus (LC), lateral parabrachial nucleus, vent

182 The locus coeruleus (LC), or 'blue spot', is a small nucleus

183 ucleus (SON), paraventricular nucleus (PVN), locus coeruleus (LC), rostral raphe pallidus (rRPa), nuc

184 The locus coeruleus (LC), the main source of brain noradrena

185 Goal-directed movement engages the locus coeruleus (LC), the main source of noradrenaline i

186 ave global effects on behavior is within the locus coeruleus (LC), the major brain norepinephrine (NE

187 of action was a priority and focused on the locus coeruleus (LC), the major noradrenergic control ce

188 Degeneration of the locus coeruleus (LC), the major noradrenergic nucleus in

189 ted whether noradrenergic neurons within the locus coeruleus (LC), the major source of forebrain nore

190 visceral states and it provides input to the locus coeruleus (LC), the major source of norepinephrine

191 The locus coeruleus (LC), the origin of noradrenergic modula

192 d mimicked by chemogenetic activation of the locus coeruleus (LC), the source of forebrain norepineph

193 smitter in the brain norepinephrine nucleus, locus coeruleus (LC), to activate this system during str

194 Applying MAPseq to the locus coeruleus (LC), we find that individual LC neurons

195 els of norepinephrine (NE) released from the locus coeruleus (LC), we interpret these results as sugg

196 n the noradrenergic system, particularly the locus coeruleus (LC), which is dysregulated in stress-re

197 Here, we explored whether locus coeruleus (LC)-NE regulates stress-induced changes

198 ng pupil changes to salient stimuli; and the locus coeruleus (LC)-norepinephrine (NE) neuromodulatory

199 The locus coeruleus (LC)-norepinephrine system is a target o

200 of the stress response is activation of the locus coeruleus (LC)-norepinephrine system.

201 nin from the main noradrenergic nucleus, the locus coeruleus (LC).

202 homogeneous cell population in the brainstem locus coeruleus (LC).

203 s the rostral ventromedial medulla (RVM) and locus coeruleus (LC).

204 al hippocampus originate from neurons of the locus coeruleus (LC).

205 5HT), and singly labeled Fos(+) cells in the locus coeruleus (LC).

206 tonomic dysfunction involving the brain stem locus coeruleus (LC).

207 as an astrocytic signalling molecule in the locus coeruleus (LC).

208 es, where they synapse onto neurons near the locus coeruleus (LC).

209 evel-dependent (BOLD) responses in the human locus coeruleus (LC).

210 ave global effects on behavior is within the locus coeruleus (LC).

211 nucleus (Sp5), dorsal raphe nucleus (DR) and locus coeruleus (LC).

212 dium-sized Bar neurons located medial to the locus coeruleus (LC).

213 individual CO2/H+-sensitive neurons from the locus coeruleus (LC).

214 (NE) is produced primarily by neurons in the locus coeruleus (LC).

215 includes early pretangle tau accrual in the locus coeruleus, loss of locus coeruleus innervation and

216 ress-related brain regions (for example, the locus coeruleus, medial amygdala and paraventricular nuc

217 luded: cuneiform/subcuneiform, dorsal raphe, locus coeruleus, median raphe, parabrachial complex, pon

218 hat unclear, although cortical inputs to the locus coeruleus mediating arousal are likely involved.

219 pinal projections observed suggests that the locus coeruleus might have the greatest effect on somato

220 c activation of noradrenergic neurons in the locus coeruleus mimics this shift in reciprocal IL-PL sp

221 could help to understand the contribution of locus coeruleus neurodegeneration to clinical and pathol

222 he degree of collateralization of individual locus coeruleus neurons across these regions.

223 We examined how locus coeruleus neurons are modified by experience and t

224 These results suggest that loss of locus coeruleus neurons contributes to motor dysfunction

225 Although initially unresponsive, locus coeruleus neurons developed and maintained auditor

226 human catecholaminergic substantia nigra and locus coeruleus neurons express MHC-I, and that this mol

227 Cultured mouse locus coeruleus neurons expressing hyperphosphorylation-

228 Desensitization is inhibited in locus coeruleus neurons of mutant mice.

229 Whole-cell recordings from locus coeruleus neurons were made, and the agonist-induc

230 ensitization and one measure of tolerance in locus coeruleus neurons when these phosphorylation-defic

231 When tagged D2 receptors were expressed in locus coeruleus neurons, a desensitizing protocol induce

232 els are a consequence of stress or damage to locus coeruleus neurons.

233 l organization of basal forebrain-projecting locus coeruleus neurons; and 3) the degree of collateral

234 catecholaminergic neurons in the NTS, A5 or Locus Coeruleus, no serotoninergic raphe neurons nor any

235 For example, locus coeruleus noradrenaline (also known as norepinephr

236 h the established effects of invasive VNS on locus coeruleus-noradrenaline signaling, and support tha

237 Arousal responses linked to locus coeruleus noradrenergic (LC-NA) activity affect co

238 Increased tonic activity of locus coeruleus noradrenergic (LC-NE) neurons induces an

239 The locus coeruleus noradrenergic (LC-NE) system is one of t

240 involved in the stress response, as are the locus coeruleus norepinephrine (LC-NE) and dorsal raphe

241 ameter, which are thought to track levels of locus coeruleus norepinephrine activity and neural gain,

242 eous Type Serial Token (ST(2)) model and the Locus Coeruleus-Norepinephrine (LC-NE) model.

243 ponses to stress, in part, by activating the locus coeruleus-norepinephrine (LC-NE) projection system

244 suggests that CRF-mediated activation of the locus coeruleus-norepinephrine (LC-NE) system contribute

245 Because the locus coeruleus-norepinephrine (LC-NE) system is a major

246 The locus coeruleus-norepinephrine (LC-NE) system is a major

247 ive responses to stress are regulated by the locus coeruleus-norepinephrine (LC-NE) system.

248 posit a key modulatory role for the pontine locus coeruleus-norepinephrine (LC-NE) system.

249 ng innovative technologies highlight how the locus coeruleus-norepinephrine system can now be targete

250 nd humans suggests that sensitization of the locus coeruleus-norepinephrine system may underlie behav

251 that a substantial window of opportunity for locus coeruleus/ norepinephrine-based therapeutics exist

252 of locus coeruleus innervation and deficits locus coeruleus/norepinephrine modulated behaviours, doe

253 tional key neural system into the model, the locus coeruleus/norepinephrine system.

254 ts to the ventral attention network from the locus coeruleus/norepinephrine system.

255 loss in the substantia nigra, raphe nuclei, locus coeruleus, nucleus basalis of Meynert and dorsal m

256 gmental area); and later on in the anterior (locus coeruleus/nucleus subcoeruleus) and posterior (vag

257 Analysis of the locus coeruleus of multiple sclerosis and control brains

258 the frontal and temporal cortex, and in the locus coeruleus, of drug users aged > 30 years (all P =

259 several key criteria for a suitable model of locus coeruleus pathology and dysfunction early in Alzhe

260 e identify glutamatergic neurons in the peri-locus coeruleus (periLC(VGLUT2) neurons) as a polysynapt

261 in-sensitive MRI to measure the integrity of locus coeruleus pigmented neurons, and 18F-dihydroxyphen

262 dified by experience and the consequences of locus coeruleus plasticity for cortical representations

263 Locus coeruleus plasticity induced changes in A1 respons

264 ally engage distinct efferent nodes, the pre-locus coeruleus (pLC), and central lateral parabrachial

265 ted brain tissue, particularly in the dorsal locus coeruleus/pons region.

266 BD+ group trended towards a reduced mean MRI locus coeruleus: pons ratio compared to PDRBD- (P = 0.07

267 rvate numerous brain sites including the pre-locus coeruleus (pre-LC) and PB external lateral-inner (

268 eus of the stria terminalis (BSTvl), the pre-locus coeruleus (pre-LC), and the inner division of the

269 hyperphosphorylated tau was detected in the locus coeruleus prior to accrual in the medial entorhina

270 Photolysis in slices of rat locus coeruleus produced a rapid inhibition of the ionic

271 Activation of locus coeruleus projections to the vPAG or vPAG(DA) neur

272 modulatory systems such as the noradrenergic locus coeruleus, providing information about internal st

273 n the caudate putamen (R=0.436, p=0.033) and locus coeruleus (R=0.86; p<0.001).

274 ected) and midbrain with pons, including the locus coeruleus (R2=0.18; P<.01 corrected), which corrob

275 ST), optic tectum, various tegmental nuclei, locus coeruleus, raphe nuclei, reticular nuclei, and the

276 ell as in specific brain regions, namely the locus coeruleus, raphe pallidus, and paraventricular nuc

277 rior raphe nuclei, parabrachial nucleus, pre-locus coeruleus region, NTS, and A1 noradrenergic neuron

278 receptor levels in hippocampus, amygdala and locus coeruleus regions of the brain.

279 reactive neurons of the hypothalamus and the locus coeruleus, respectively.

280 CA cell groups were also located in the locus coeruleus, solitary tract nucleus, and area postre

281 rior colliculi, the parabrachial nuclei, the locus coeruleus, subcoeruleus and periolivary areas, and

282 ind that the activation of the noradrenaline-locus coeruleus system (NOR-LC) during strong fear memor

283 However, direct evidence linking locus coeruleus system hyperactivity to PTSD hyperrespon

284 D participants exhibited larger responses in locus coeruleus (t = 2.60, region of interest familywise

285 Phenelzine increased locus coeruleus TH and imipramine increased dorsal raphe

286 Thus, locus coeruleus TH(+) neurons can mediate post-encoding

287 o the hippocampus, optogenetic activation of locus coeruleus TH(+) neurons mimics the novelty effect,

288 pecially sensitive to environmental novelty, locus coeruleus TH(+) neurons project more profusely tha

289 Surprisingly, two effects of locus coeruleus TH(+) photoactivation are sensitive to h

290 r the acute modulation of neurons in the pre-locus coeruleus that express prodynorphin, and for satia

291 ning neurons in the nucleus raphe magnus and locus coeruleus that project to the spinal cord.

292 Pathological alterations to the locus coeruleus, the major source of noradrenaline in th

293 In neurons of the periphery and locus coeruleus, this up-regulation is associated with a

294 stream of the amygdala via the noradrenergic locus coeruleus to enable threat (fear) learning, specif

295 inputs from the dorsal raphe, median raphe, locus coeruleus, ventral tegmentum and nucleus basalis o

296 In the PTSD group, NET availability in the locus coeruleus was independently positively associated

297 tex or hippocampus, and tau pathology in the locus coeruleus was negatively correlated with noradrene

298 r source of noradrenaline are neurons in the locus coeruleus, we hypothesized that alterations in nor

299 minergic neurons of the substantia nigra and locus coeruleus, which are implicated in neurodegenerati

300 .001) with increased Mn concentration in the locus coeruleus, while decreased Fe was associated with

301 al pons, the PVH projects heavily to the pre-locus coeruleus, yet very little to the catecholamine ne