ライフサイエンスコーパス: lone

1 A lone 10 min exposure of myoblasts to 1.5 mT amplitude su

2 plied for distinguishing hydrogen-bonded and lone (17)O sites on the surface of silica gel; the one-d

3 Markovnikov directing effect is relieved and lone abstraction is observed, affording the 5-hydroxy-is

4 as to promote a social bond with the group's lone adult male.

5 and 2008, and those with a family history of lone AF (AF without preceding cardiovascular/endocrine d

6 udies conducted using 1,335 individuals with lone AF (cases) and 12,844 unaffected individuals (refer

7 ere identified in all subjects with familial lone AF (n = 33) as well as apparently unaffected family

8 rtery disease without MV disease (n=57), and lone AF (n=35).

9 association in two independent cohorts with lone AF (overall combined odds ratio = 1.52, 95% CI 1.40

10 ntified an association on chromosome 1q21 to lone AF (rs13376333, adjusted odds ratio = 1.56; P = 6.3

11 s, and anatomic remodeling) in patients with lone AF and are strong predictors of recurrent arrhythmi

12 terature are inconsistent so that studies of lone AF are not comparable.

13 Guidelines provide a vague definition of lone AF but do not provide direction about how much or w

14 In the lone AF cohort, 9 rare missense variants and 1 splice si

15 and 35.8%), increased, and the prevalence of lone AF decreased.

16 The IRRs for lone AF given an affected first- or second-degree relati

17 techniques have improved, the prevalence of lone AF has fallen.

18 Patients with lone AF have impaired myocardial energetics and subtle L

19 The IRR for lone AF in persons aged <40 years given a first-degree r

20 (AF) before age 60 years is associated with lone AF in relatives.

21 the intervening years is that definitions of lone AF in the literature are inconsistent so that studi

22 A family history of lone AF is associated with substantial risk of lone AF,

23 experience with the CMP in the treatment of lone AF over 2 decades and compares the original cut-and

24 Little is known about BNP in lone AF patients undergoing arrhythmia ablation.

25 predictive ability for thromboembolism among lone AF patients.

26 Risk In Communities Study, Cleveland Clinic Lone AF Study, Cardiovascular Health Study, and Rotterda

27 We followed up 726 patients with lone AF undergoing first-time arrhythmia ablation.

28 IRR for lone AF was 6.24 (95% CI: 2.59 to 15.0), given at least

29 We hypothesized that early-onset lone AF was associated with genetic variation in SCN5A.

30 TS3-associated variants in the patients with lone AF was much higher than expected, compared with the

31 therefore, recommended that use of the term "lone AF" be avoided.

32 In addition, the term "lone AF" is not invariably useful in making treatment de

33 ical variables (including age, hypertension, lone AF) failed to significantly predict response to AAD

34 es mellitus, or obstructive sleep apnea (ie, lone AF) undergoing ablation and 25 matched control subj

35 other cardiovascular disease or dysfunction (lone AF).

36 Tc intervals was stronger for the outcome of lone AF, as evidenced by a hazard ratio of 2.32 (95% con

37 In a cohort of patients with early-onset lone AF, we identified a high prevalence of SCN5A mutati

38 ne AF is associated with substantial risk of lone AF, with the strongest risks associated with young

39 sms for AF in patients categorized as having lone AF.

40 strongest with respect to the development of lone AF.

41 developed AF, of whom 1,467 (14%) developed lone AF.

42 actors may play a role in the development of lone AF.

43 CNN3), that associate with either typical or lone AF.

44 least 2 first-degree relatives affected with lone AF.

45 s of at least certain types of patients with lone AF.

46 nistic overlap between LQTS3 and early-onset lone AF.

47 -up, 9,507 persons were identified as having lone AF.

48 ere followed up until the first diagnosis of lone AF.

49 s sequenced in 192 patients with early-onset lone AF.

50 sk of recurrent arrhythmia after ablation of lone AF.

51 identify common genetic variants underlying lone AF.

52 dy of 345 patients initially diagnosed with "lone" AF between 1992 and 2007.

53 (2)DS(2)-VASc score reliably identified the "lone" AF patients who were at "truly low risk" for throm

54 risk stratification schemes in a cohort of "lone" AF patients with a 12-year follow-up.

55 F ablation only or AF+AFL ablation than with lone AFL ablation.

56 growth modes are achieved which result in a lone Ag structure emanating from a single (100) Au facet

57 cated rare variants in 25 different genes in lone and familial atrial fibrillation (AF) using linkage

58 s with AS-CA (grade: 1 to 3) than those with lone AS (24.5% vs. 13.9%; p = 0.05).

59 AS-CA survival post-TAVR did not differ from lone AS (p = 0.36).

60 eristics and outcomes of AS-CA compared with lone AS.

61 d whether an individual's risk of developing lone atrial fibrillation (AF) before age 60 years is ass

62 Lone atrial fibrillation (AF) may reflect a subclinical

63 BNP) is abnormally elevated in patients with lone atrial fibrillation (AF).

64 perimental study investigating patients with lone atrial fibrillation identified six novel mutations

65 The historical origin of the term "lone atrial fibrillation" (AF) predates by 60 years our

66 helpers produced more direct offspring than lone breeders, some while still subordinate but most aft

67 that promotes cell-cell interaction, limits lone cell movement, and slows swarm expansion.

68 nsufficient for them to replace culture as a lone diagnostic test.

69 The best lone disease predictor was Concavity Min (Marfan syndrom

70 n to be significantly more emissive than the lone dye, with a concentration-independent emission and

71 explained by assuming the association of the lone electron pair at sulfur to the Co-alkyne complexes.

72 r is of the conventional type, involving the lone electron pair of an oxygen donor, the latter is per

73 ics and OP identification confirmed that the lone electron pair of the amine-N is the predominant sit

74 caused by an n -> pai* interaction between a lone electron pair of the oxygen atom of the spiroketal

75 The lone electron pair revealed on Na and the negative Lapla

76 Specifically, orbital ordering and lone electron pair stereochemical activity compete, givi

77 different types of hyperconjugation between lone electron pairs of nitrogen atoms and sigma*C-N orbi

78 n-shell structure with a single bond and two lone electrons on each terminal atom (biradical).

79 d nitrogen to form silylamines stands as the lone example of a catalytic reaction involving N(2) to f

80 M >/= 5.5 have not been identified, with the lone exception of an M = 6.9 quake remotely triggered by

81 The lone factor for twinning dependent on grain size is the

82 Lone females or males suffer similar rates of predation,

83 semen was collected and cryopreserved from a lone, fertile, CHS carrier male.

84 tion in atrial fibrillation, with studies in lone forms of the arrhythmia suggesting a traditional mo

85 and further evolution that may differentiate lone from pack predators.

86 tallographic data reveal arginine 183 as the lone H-bond-donating residue in the distal pocket.

87 The pK(a) of the lone histidine residue in the peptide, which is likely r

88 via receiver domain phosphorylation) in this lone hunting bacterium, demonstrating divergence from it

89 Stimulation of the lone inhibitory FgammacR, FcgammaRIIB, also has adverse

90 ion of methylation in the heart, enriched in lone intergenic CpGs and depleted from CpG islands aroun

91 DAGK) and undecaprenol kinase (UDPK) are the lone members of a family of multispan membrane enzymes t

92 P1-type paralogues (CRWN1, 2, and 3) and the lone NMCP2-type paralogue, CRWN4.

93 s preferentially the twix hydrogens over the lone ones.

94 ants, in 9 genes, previously associated with lone or familial AF.

95 Rare variants previously implicated in lone or familial forms of AF present on the exome chip a

96 II [R/X = Ph/BH(3) (4), t-Bu/BH(3) (5), t-Bu/lone pair (10)].

97 --> sigma* orbital delocalization between a lone pair (n) of a (thio)amide donor and the antibonding

98 ong HB, involves charge transfer between the lone pair (n) of Y, and the sigma* orbital of E-X as emp

99 low-lying dark state, involving the nitrogen lone pair (nNpi*), does significantly participate in the

100 pair donors, and the sigma*Xe-O orbitals are lone pair acceptors.

101 ergy difference between the frontier silicon lone pair and 3p orbitals.

102 d the electron-rich character of the carbene lone pair and also enhanced the CO(2) binding energy to

103 bilizing interaction between a nitrogen atom lone pair and an aromatic sulfur system (nN --> sigma*S-

104 an be used to raise the energy of the anchor lone pair and increase conductance.

105 directional dipoles of the endocyclic oxygen lone pair and of the highly polar axial Si-O bond.

106 onic effects (repulsion between the nitrogen lone pair and polarized C-Pd bond at C2-/C6-positions an

107 icated weak interaction between the nitrogen lone pair and proximal radical center in angular 5,6-die

108 cceptor substituents delocalize the nitrogen lone pair and stabilize the reactant state of 2-azetines

109 lized by an interaction between the nitrogen lone pair and the vacant pi* orbital.

110 ning pH-responsive species, namely, an amine lone pair as the electron donor and a cationic ring of m

111 d molecular orbital (HOMO)-with a Ge-centred lone pair as the HOMO-1.

112 ve electron-sharing bonds R-E-R and only one lone pair at atom E.

113 The sigma-lone pair at the divalent carbon is the HOMO of these sp

114 ly, resulting from the delocalization of the lone pair at the nucleophilic center, a sigma CC bond, a

115 of the bonding was attributed to the reduced lone pair bond weakening effect, LPBWE, upon substitutio

116 bond with one water molecule at the nitrogen lone pair but only weakly N-H donating hydrogen bonds.

117 Lone pair cations like Pb(2+) are extensively utilized t

118 ereochemical activity due to the Sn(2+) s(2) lone pair causes a crystallographically hidden, locally

119 plexes, increasing the energy of the N(beta) lone pair decreases the ligand-to-metal CT (LMCT) energy

120 en atoms in these cases are valence electron lone pair donors, and the sigma*Xe-O orbitals are lone p

121 confirmation of unusual features including a lone pair effect on (3)J(PH), the negative coupling cons

122 ontrary to common wisdom, fluorine is a good lone pair electron donor toward geminal sigma bonds.

123 Here we make use of the lone pair electrons found in most of 2D metal chalcogeni

124 The key role played by lone pair electrons in achieving this high efficiency in

125 The lone pair electrons of an ortho-triazolo substituent pla

126 teract with the gold nanofingers through the lone pair electrons of pyridyl nitrogens, not through de

127 d to be dependent on the availability of the lone pair electrons of the pendant groups.

128 Stable s(2) lone pair electrons on heavy main-group elements in thei

129 l, and the excitation primarily derives from lone pair electrons on the oxygen atom of water molecule

130 tributed to sigma-donation of the isocyanide lone pair electrons to the surface.

131 tween the radical alpha-C-H and the nitrogen lone pair followed by hydrogen abstraction within the co

132 ble stability due to the delocalisation of a lone pair from a planar phosphorus centre into the vacan

133 hown by quantum mechanical calculations, its lone pair having an energy significantly lower than that

134 Thus, going from the sp(3)-hybrid lone pair in common sulfonamides to the sp-like lone pai

135 and manifold originating from the hybridized lone pair in nitrogen orbitals of the Phthalocyanine rin

136 on, a long range, weak interaction between a lone pair in the oxygen atom of the carbonyl group and a

137 addition, we analyze the role of a carbanion lone pair in the rearrangement step, concluding that it

138 e pair in common sulfonamides to the sp-like lone pair in the smallest Paquette's sultam resulted in

139 in the acylated catalyst and an appropriate lone pair in the substrate.

140 ron-donor amine moiety converts the nitrogen lone pair into a sigma bond and the HOMO into a lower-ly

141 the delocalization of the endocyclic oxygen lone pair into the antibonding sigma*((C-X)) orbital or

142 t is due to delocalization of the phosphorus lone pair into the vacant p-orbital at germanium.

143 is larger for 2 than for 1, whereas no extra lone pair is available in 2.

144 stituent and inward rotation of the nitrogen lone pair is preferred.

145 s found that the s-character of the nitrogen lone pair is the most important factor defining properti

146 iated with a dominant donation from a p-type lone pair localized on one of two iodine atoms, the sigm

147 ipolar interactions, while others implicated lone pair n->pai* orbital delocalisation.

148 dinated gallium(I) centers possessing both a lone pair of electrons and a vacant orbital, reminiscent

149 dicoordinate aluminum center features both a lone pair of electrons and an unoccupied 3p orbital, thu

150 MO is a Ge-C bonding combination between the lone pair of electrons on the germanium atom and the C-N

151 The lone pair of electrons on the silicon atom of (carbene)S

152 , which show that pyridinic defects retain a lone pair of electrons that are capable of binding CO2.

153 on(II) atom with an energetically high lying lone pair of electrons that is shown to be accessible fo

154 The donor oxygen donates a lone pair of electrons to the sigma* orbital of acceptor

155 omplexes in which gold(I) coordinates to the lone pair of oxygen.

156 ive interaction of the trityl group with the lone pair of the enamine nitrogen is supported by the fi

157 n involves coordination of the SmI(2) to the lone pair of the nitrile nitrogen followed by an inner s

158 "ortho effect" (conformational alignment of lone pair of the ortho alkoxy oxygen or the nitrogen in

159 i))-sigma*CC interactions between the p-type lone pair of the terminal oxygen and adjacent unfilled C

160 -donation is better represented by an oxygen lone pair on flat sites, whereas it is delocalized on bo

161 state of the drug shows a highly delocalized lone pair on the amine nitrogen of the melphalan, which

162 ansfer (ET) via nucleophilic attack by its N lone pair on the C of CO(2), and finally (c) proton tran

163 tead: the nucleophilic attack of the carbene lone pair on the imino nitrogen (pathway "a") or on the

164 calculations revealed that the stereoactive lone pair on the Pb(2+) cation is critical to producing

165 he double substitution, R155K/D168A, and the lone pair on the quinoxaline in grazoprevir.

166 The lone pair orbitals on the iodines mix to give a high-ene

167 c potential minimum, observed at the carbene lone pair region of NHC (V(min1)) as well as at the carb

168 a strong trans substantiating effect through lone pair repulsion.

169 We show that lone pair stereochemical activity due to the Sn(2+) s(2)

170 ic potential minimum (V(min)) at the carbene lone pair suggested that annelation of heterocycle to a

171 rotations, and the propensity for the Pb(2+) lone pair to express its stereochemistry.

172 d relatively weak pi donation from the amide lone pair to platinum and supports a 14-electron assignm

173 These calculations reveal that the lone pair type orbitals on the halogen-bonded anion gove

174 y increasing orbital overlap of the nitrogen lone pair with the incipient oxyallyl cation, is coupled

175 he sigma-hole on bromobenzene (BrPh) and the lone pair(s) of Pz significantly lowers the energies of

176 anism involves Cu(II) binding to the amide N lone pair, decoupling it from >N-C horizontal lineO reso

177 and various types of halogen bond acceptors (lone pair, pi and sigma bonds).

178 ation energy (E(aroma)), strength of carbene lone pair, proton affinity, and CuCl binding energy.

179 For cases where steric, lone pair-cation, and cation-pi effects have been invoke

180 Electronegative but lone pair-donating groups NR2, OR, and F stabilize the c

181 nt pyrazine and quinoxaline units involves a lone pair-heteroarene interaction which is much stronger

182 witterionic transition states facilitated by lone pair-LUMO interactions between the migrating R grou

183 Such contacts may be of either the lone pair-pai (lp-pai) or the OH-pai type, in nature.

184 oin ring of Gh is stabilized by noncanonical lone pair-pai and CH-pai interactions, as well as hydrog

185 olar-pai, hydrophobic-pai, anion-pai and the lone pair-pai interactions.

186 st favorable interactions are sp(2)O-sp(2)C (lone pair-pai, presumably n-pai*), sp(2)C-sp(2)C (pai-pa

187 this selectivity reversal is the result of a lone pair-pi interaction between the substrate ligated b

188 PYCH dihedral angle theta (Y = O, N, C) and lone pair-PYC dihedral angle omega shows similar theta,o

189 a dark state (nOpi*) involving the carbonyl lone pair.

190 eactivity owing to the presence of the Nbeta lone pair.

191 sight on the localization of the carbanionic lone pair.

192 izontal lineN(alpha) pi bond and the N(beta) lone pair.

193 nic vibration of Cl atoms induced by a 3s(2) lone pair.

194 as one-electron oxidants on the sulfinate S lone pair.

195 idal coordination with a highly stereoactive lone pair.

196 The C-H...pai, pai...pai, and lone pair...pai noncovalent interactions (NCIs) between

197 t-enhanced reactivity of nucleophiles with a lone-pair adjacent to the attacking center-was recently

198 e central Si(0) atom, i.e., an sp(0.41)-type lone-pair and a delocalized p lone-pair.

199 two lone pairs of electrons (one sigma-type lone-pair and one 3p(Ge) lone-pair) on the zerovalent Ge

200 ymmetry coordination environments favored by lone-pair cations.

201 demonstrates the large non-Karplus effect of lone-pair conformation on vicinal phosphorus-hydrogen co

202 und to rely on lactone acidification through lone-pair delocalization, which leads to extremely rapid

203 rom Fe(III)-N-O bending, which is induced by lone-pair donation to the N(NO) atom.

204 absence of a net charge, covalent bonds, or lone-pair donor groups.

205 he shift to be associated with the loss of a lone-pair donor interaction from the distal histidine th

206 ctric phase transition ascribed to the 6s(2) lone-pair effects of Bi(3+) at around 135 K, and a long-

207 ransfer transition involving donation of the lone-pair electron density on both Sb(III) and Sn(II) to

208 However, for substituents that stabilize by lone-pair electron donation, such as N or O centers, the

209 .82-0.85) and the NBO energy of the nitrogen lone-pair electrons of amines (N = 59, R(2) values of 0.

210 nergy, occupied orbitals associated with the lone-pair electrons on oxygen.

211 Owing to the presence of lone-pair electrons on the phosphorus atom, TPP is also

212 ressure-induced delocalization of non-bonded lone-pair electrons to sp(3)d(2) hybridization in two-di

213 with (n-1)d(10)ns(0), d(0), or stereoactive lone-pair electrons.

214 ond acidity and basicity, polarizability and lone-pair electrons.

215 become competitive with the commonly favored lone-pair interaction whenever the carbonyl group carrie

216 e of distinctly coexisting weak covalent and lone-pair interactions, give rise to cooperative structu

217 r of chalcogenides (and, in principle, other lone-pair materials) by studying prototypical telluride

218 volving an antibonding, b(1), combination of lone-pair MOs, occur in forming all (CO)(2n) molecules f

219 an antibonding, b(1g) combination of carbon lone-pair orbitals in four CO molecules and the b(2g) an

220 f the oxyallyl LUMO with the carbonyl pi and lone-pair orbitals, making this reaction "hemipseudoperi

221 ate geometries that minimize the unfavorable lone-pair repulsion between neighboring nitrogen atoms a

222 The associated lone-pair stabilization of the transition state by Ox pr

223 Stabilization of the TS through N(lone-pair) -> sigma*(C-C) "negative hyperconjugation" in

224 ons (one sigma-type lone-pair and one 3p(Ge) lone-pair) on the zerovalent Ge atom.

225 he alpha-C-H sigma* orbital and a heteroatom lone-pair, increasing the C-H BDE and destabilizing the

226 sly unconsidered multicenter "hyperbonding" (lone-pair-antibonding-orbital) interactions elucidates n

227 ined rings, electronegative substituents, or lone-pair-bearing heteronuclei.

228 This is particularly problematic for lone-pair-rich, semiconducting materials, such as phase-

229 sp(0.41)-type lone-pair and a delocalized p lone-pair.

230 Current interest in lone-pair...pai (lp...pai) interactions is gaining momen

231 e opposed by the Pauli repulsion between the lone pairs (n) of O(i-1) and the bonding orbital (pi) of

232 z trajectory, involves delocalization of the lone pairs (n) of the oxygen (O(i-1)) of a peptide bond

233 to minimize interactions between the oxygen lone pairs and the pi electrons.

234 ducts of the p-block elements with available lone pairs and/or polarized carbon-element pai-bonds are

235 mides, and esters, and particularly when the lone pairs are engaged in orthogonal hydrogen bonding (h

236 spectrum despite the fact that the nitrogen lone pairs are held in a perpendicular geometry that wou

237 re divalent E(0) compounds which possess two lone pairs at E.

238 of stable and isolable species that bear two lone pairs at the same C center, i.e., geminal dianions,

239 nerates the favored diastereomer, the oxygen lone pairs from the substituent are closer to the cation

240 ased on the simple orbital mixing model, the lone pairs in a pair of neutral directly connected heter

241 The exo directed lone pairs in the latter are able to scavenge Lewis acid

242 part, stabilized by delocalization of the N lone pairs into the vacant p-orbital at carbon (or a hea

243 rescent (RTP) organic materials have O- or N-lone pairs leading to low lying (n, pai*) and (pai, pai*

244 BO) analysis of 3 unambiguously exhibits two lone pairs of electrons (one sigma-type lone-pair and on

245 gma orbital by two, adjacent, sp(2) nitrogen lone pairs of electrons and stabilization of the carbene

246 isomer only, in which the orientation of the lone pairs of electrons at phosphorus favors this coordi

247 peculiar electronic structure of 3 with two lone pairs of electrons at the Ge atom.

248 The presence of two lone pairs of electrons on each P atom in the silylene-s

249 ked three-dimensional structures wherein the lone pairs of electrons on oxygen and nitrogen are orien

250 ich include n-pi* interactions involving the lone pairs of electrons on water oxygen atoms and the an

251 of H(2)O(2), the parent peroxide, where the lone pairs of oxygen are not involved in strongly stabil

252 nteraction of two donor protons with the two lone pairs of oxygen.

253 Rather, the fluorine lone pairs of the CF(4) often act as an electron donor i

254 at a rearrangement to one sigma bond and two lone pairs on sulfur is usually more favorable.

255 The latter bears two highly localized lone pairs on the phosphorus atom due to the LSi horizon

256 fect at present is hyperconjugation from the lone pairs on the ring heteroatom to the antibonding orb

257 is of DFT calculations, to the twisting of N lone pairs out of conjugation with the carbonyl pi orbit

258 abilized by charge transfers from the N or O lone pairs to the quinone's pi* orbitals.

259 on produces electron-rich heterocycles (four lone pairs) and features homoatomic sigma-bond heterolys

260 nto the chemical-bonding network, as well as lone pairs, of the prototypical PCM, Ge2 Sb2 Te5 (GST).

261 ridines that operate with hydrogen bonds and lone pairs, respectively.

262 Electronegative substituents with lone pairs, such as halogen and oxygen, thus appear to d

263 5 s from simple triarylboranes which have no lone pairs.

264 sity comprised of the three valence electron lone pairs.

265 ixing of the orbitals occupied by the oxygen lone pairs.

266 ly pairwise electronic behavior of bonds and lone pairs.

267 Orbital analysis, showing two perpendicular lone-pairs of electrons on the central Si(0) atom, i.e.,

268 ergistic effect of two types of stereoactive lone-pairs on Sb(III) and Sn(II) is critical for the cha

269 y family disadvantage (indicated by poverty, lone parenthood, teenage parenthood, household joblessne

270 tating the localization of the remaining two lone pi-electrons on each of the end atoms, therefore in

271 ation is a more singular encounter between a lone predator and prey; contact is always via the piliat

272 We show that lone proteins and complex subunits failing to assemble i

273 ges (AMs) and epithelial cells (ECs) are the lone resident lung cells positioned to respond to pathog

274 cular) had a worse prognosis than those with lone RV (p < 0.0001).

275 o predict the observed risk in patients with lone RV but underestimated the risk in those with LV inv

276 for the estimation of risk in patients with lone-RV presentation but underestimated the risk when LV

277 CAVI is the lone secreted CA and exists in both saliva and the gastr

278 obilities in transistors made with Te as the lone semiconductor or from Te-organic multilayer semicon

279 at is, the generation of two triplets from a lone singlet state-has recently resurfaced as a promisin

280 cell-to-cell transmission, viruses behave as lone soldiers.

281 We find that lone SR K(+) -channels from Tric-a KO mice have a lower

282 When lone SR K(+) -channels were incorporated into bilayers,

283 States and has been related to bites of the lone star tick (Amblyomma americanum).

284 was used to characterize the IgE response to lone star tick proteins administered through the skin of

285 hat largely conforms to the territory of the lone star tick.

286 Here we report for the first time that adult lone star ticks, Amblyomma americanum, also actively dri

287 ed in paradigms that involve searching for a lone target in a cluttered array or natural scene.

288 in APH-1 serves as a scaffold, anchoring the lone transmembrane helix from nicastrin and supporting t

289 arsely expressed in most cells and, although lone TRIC-B channels exhibit low Po, the high Po levels

290 er the interaction of QCN with TbHK1, as the lone Trp residue (Trp-177) was quenched under all condit

291 The strategy easily distinguishes lone-tumbling molecules versus nanoentities of various s

292 TWA and MA when compared with patients with lone TWA (median, 37 [interquartile range, 26-61] versus

293 mains in different formats suggests that the lone Vbeta sequence controls the sensitivity and a major

294 ial 'dark side' to conditional cooperation ('lone wolf effect') and draw implications for the adoptio

295 imental games confirm the existence of both 'lone wolf' defectors and 'good shepherd' cooperators, an

296 ndition their actions on others' behaviour, 'lone wolf' defectors undermine initial cooperation encou

297 The model predicts that the 'lone wolf' effect is stronger than the 'good shepherd' e

298 d 'good shepherd' cooperators, and that the 'lone wolf'effect is stronger in the context of organ don

299 uilding design and access, communication and lone working, provision of equipment and consumables, an

300 In contrast, our results show that Dpo4, the lone Y-family DNA polymerase in S. solfataricus, can fai