ライフサイエンスコーパス: loneliness

1 , 3-12, with higher score indicating greater loneliness).

2 ly sensitive to subjective social isolation (loneliness).

3 d 3-9, with higher scores indicating greater loneliness).

4 ocial isolation and mortality is mediated by loneliness.

5 the association between the pSTS volume and loneliness.

6 an important role in shaping an individual's loneliness.

7 e well-being and of subjective well-being on loneliness.

8 both have an effect on an individual's final loneliness.

9 h associated with a 21-24% increased risk of loneliness.

10 he UCLA-3 item scale indicating considerable loneliness.

11 participants experienced moderate to severe loneliness.

12 y (frailty phenotype), social isolation, and loneliness.

13 of depression, anxiety, mental wellbeing and loneliness.

14 associated with 15% and 21% greater risk of loneliness.

15 oms, anxiety symptoms, life satisfaction and loneliness.

16 elevant measures to discriminate people with loneliness.

17 spitalisation regardless of social isolation/loneliness.

18 nd quality of life and a smaller increase in loneliness.

19 ents that are associated with a reduction in loneliness.

20 ions targeting SA might be adopted to reduce loneliness.

21 with loneliness and 2.16 (2.05-2.27) without loneliness.

22 and decreased perceived social handicap and loneliness.

23 might be sufficient to influence feelings of loneliness.

24 lar, community identification on feelings of loneliness.

25 ors in the odds of reporting moderate-severe loneliness.

26 evidence of a genetic predisposition toward loneliness.

27 closeness to each target and their own trait loneliness.

28 rn societies are experiencing an epidemic of loneliness.

29 sing, the effect of both BMI and body fat on loneliness.

30 m the first genome-wide association study of loneliness.

31 across a variety of diseases exacerbated by loneliness.

32 ses in PA were associated with reductions in loneliness 1 year later.

33 state anger (2.23%; P = 0.03), and possibly loneliness (1.21%; P = 0.06), but not cynical hostility

34 seline (1.42 [1.10-1.83]) and an increase in loneliness (1.50 [1.18-1.90]) raised the risk of develop

35 ), anxiety (2.23 [1.72-2.89]; p<0.0001), and loneliness (1.52 [1.26-1.84]; p<0.0001) than people with

36 , Self-realization, and Pleasure scale), and loneliness (3-item Revised University of California, Los

37 Frailty prevalence was 3.38%, loneliness 4.75% and social isolation 9.04%.

38 ial species, humans deprived of contact find loneliness a potentially distressing condition.

39 nclude that genetic risk factors for MDD and loneliness act pleiotropically to increase CAD risk in f

40 also to the current acculturation stress and loneliness affected by neighborhood social cohesion.

41 Perceived social isolation, or loneliness, affects physical and mental health, cognitiv

42 t being alone experience a steep increase in loneliness after spending time alone in daily life, wher

43 dings suggest that individual differences in loneliness among older adults are correlated with indivi

44 lence symptoms of psychological distress and loneliness among US adults during the coronavirus diseas

45 hout social isolation, 2.14 (1.92-2.38) with loneliness and 2.16 (2.05-2.27) without loneliness.

46 were identified between genetic liability to loneliness and 20 out of the 26 specific diseases, inclu

47 Hunger, thirst, loneliness and ambition determine the reward value of fo

48 ins partly mediated the relationship between loneliness and cardiovascular diseases, stroke and morta

49 est meta-analysis on the association between loneliness and dementia (k = 21 samples, N = 608,561) an

50 Robots provide benefits such as relieving loneliness and enabling communication.

51 We estimated the chip heritability of loneliness and examined coheritability between lonelines

52 Those without kin report higher rates of loneliness and experience elevated risks of chronic illn

53 stand the nature of the relationship between loneliness and health.

54 Higher CRP predicted higher subsequent loneliness and higher loneliness predicted elevated CRP.

55 gn and tailor social interventions to reduce loneliness and improve mental health in general.

56 ies deficient in participants who experience loneliness and in many psychopathologies.

57 present experiences is critical for reducing loneliness and increasing social contact and that removi

58 e and a three-item scale were used to assess loneliness and isolation levels, respectively.

59 k for future studies of the genetic basis of loneliness and its relationship to mental and physical h

60 etter understand the genetic architecture of loneliness and its relationship with associated outcomes

61 ficant associations and interactions between loneliness and latent factors for the amygdala and the h

62 rpinnings and disease mechanisms involved in loneliness and may enhance early detection and intervent

63 d effect modifier of the association between loneliness and memory aging.

64 However, whether the associations between loneliness and multiple diseases are consistent with cau

65 The coheritability between loneliness and neuroticism may reflect the role of negat

66 accounted for 14% of the association between loneliness and pain.

67 Analysis showed that current loneliness and physical activity were associated with ea

68 (GWP) to explore global associations between loneliness and physical pain, while accounting for healt

69 for the genetic correlation between MDD and loneliness and re-computed polygenic scores.

70 neliness and examined coheritability between loneliness and several personality and psychiatric trait

71 Given phenotypical overlaps between loneliness and social anxiety (SA), cognitive-behavioral

72 naire revealed significantly lower levels of loneliness and social anxiety when in the social VR plat

73 ambulatory assessments were used to measure loneliness and social contact in daily life.

74 ng; by fostering equanimity with feelings of loneliness and social disconnect, acceptance-skills trai

75 dverse outcomes, but the association between loneliness and social isolation and adverse outcomes was

76 Loneliness and social isolation are a growing public hea

77 Loneliness and social isolation have been identified as

78 Although loneliness and social isolation have been linked to an i

79 Developing interventions for loneliness and subjective well-being could have substant

80 back of fairly substantial magnitude between loneliness and subjective well-being.

81 A significant additive interaction between loneliness and the degree of risk factor control on the

82 ence on the cognitive processes underpinning loneliness and the psychological and behavioral effects

83 cted sustained psychological wellbeing, less loneliness, and a lower incidence of new chronic disease

84 bute to the development of social isolation, loneliness, and consequent cognitive decline and depress

85 search on the link between social isolation, loneliness, and health outcomes in later life, including

86 There was no significant change in loneliness, and mean degree of loneliness during the stu

87 ive symptoms, bipolar disorder, neuroticism, loneliness, and mental health-related socioeconomic and

88 lated to age, neighbourhood deprivation, and loneliness, and positively related to partnership status

89 to life evaluation, but health, care giving, loneliness, and smoking are relatively stronger predicto

90 l, there may be a loop between inflammation, loneliness, and social engagement.

91 that the Covid-19 pandemic caused increased loneliness, anxiety and greater social isolation due to

92 Estimates of loneliness, anxiety, anger, and depression also increase

93 ession (aOR = 2.58, 95% CI = 1.46-4.56), and loneliness (aOR = 2.86, 95% CI = 1.75-4.67).

94 sion, (aOR = 6.96, 95% CI = 3.80-12.74), and loneliness (aOR = 6.91, 95% CI = 3.38-13.00).

95 Both social isolation and loneliness are associated with increased mortality, but

96 Major depressive disorder (MDD) and loneliness are phenotypically and genetically correlated

97 Findings suggest that emotional and social loneliness are related to different aspects of FEP, unde

98 Isolation and loneliness are related to various aspects of health.

99 easurement and environmental determinants of loneliness are well understood, but its genetic basis is

100 rrying about family or friends overseas, and loneliness as post-migration stressors.

101 We conclude that loneliness, as defined in this study, is a modestly heri

102 Main Outcomes and Measures: Loneliness, as determined by the 3-item UCLA Loneliness

103 Loneliness-associated genes derived primarily from plasm

104 , which resonates with anecdotal findings of loneliness-associated hyperphagia in humans.

105 er associative network shows more consistent loneliness associations in grey matter volume than other

106 ontrast, E-Risk Study participants reporting loneliness at age 18 did not show any elevated markers o

107 Dunedin Study participants who reported loneliness at age 38 or age 45 had elevated suPAR at age

108 In BRHS, a higher level of loneliness at baseline (1.42 [1.10-1.83]) and an increas

109 from 1996 to 2004, participants experiencing loneliness at one time point, two time points, and >=thr

110 " neural self-representation in the mPFC, as loneliness attenuated the similarity between self and ot

111 reductions from pre- to post-intervention in loneliness (b = -0.24, p = 0.016) and negative emotions

112 t [beta = 0.51; 95% CI, 0.44-0.58] and lower loneliness [beta = -0.41; 95% CI, -0.48 to -0.33]), cond

113 s studies have estimated the heritability of loneliness between 37 and 55% using twins and family-bas

114 in quality of life, anxiety/depression, and loneliness between patients and age-matched and sex-matc

115 of sleepiness lead to social withdrawal and loneliness, both risk factors for mental and physical il

116 e of social support that not only alleviates loneliness but also buffers its negative effects on heal

117 n about the neural processes associated with loneliness (but see [12-14]).

118 Among diabetes patients, loneliness, but not social isolation scale, is associate

119 , Monitor+Accept training reduced daily-life loneliness by 22% (d = 0.44, P = 0.0001) and increased s

120 ciated with genetic risk factors for MDD and loneliness by conducting a phenome-wide association stud

121 iness, (ii) a range of covariates, and (iii) loneliness by covariate interactions with latent brain v

122 time-invariant and time-variant confounders (loneliness: coef = - 0.06, 95% CI - 0.09 to - 0.02; dome

123 en was significantly associated with greater loneliness: compared with individuals in the amyloid-neg

124 ndom forest classification model showed that loneliness contributed to discriminate individuals with

125 iobank participants aged 38 to 73 years with loneliness data and without a diagnosis of PD at baselin

126 athy-oriented telephone call program reduced loneliness, depression, and anxiety compared with the co

127 lack of social support, adverse life events, loneliness, depression, generalized anxiety, panic, soci

128 Given the complex interplay between loneliness, depressive symptomatology, and SCD, more res

129 1.48 for the top quintile of isolation), but loneliness did not (hazard ratio 0.92, 95% confidence in

130 therefore assessed the relationship between loneliness, different aspects of social isolation, and p

131 Loneliness, domestic isolation and social disengagement

132 ant change in loneliness, and mean degree of loneliness during the study was robustly associated with

133 areas of chronic dysphoria (e.g., anger and loneliness/emptiness) and interpersonal symptoms reflect

134 a higher power may offer protection against loneliness even when individuals are physically alone.

135 h deviation from a person's typical level of loneliness (for vigorous intensity, mean deviation [MD]

136 Associations with loneliness, friendship relationship quality, and perceiv

137 o examine the association between cumulative loneliness from 1996 to 2004 and all-cause mortality fro

138 Compared to those who never reported loneliness from 1996 to 2004, participants experiencing

139 anxiety might be promising to reduce chronic loneliness given a close link between both constructs.

140 iety, cultural activity, volunteering), less loneliness, greater prosperity (wealth, income), better

141 Loneliness has been shown to longitudinally predict subj

142 ubstrate for the negative affective state of loneliness has remained elusive.

143 Frailty, social isolation, and loneliness have individually been associated with advers

144 , complex socio-emotional functioning (e.g., loneliness, helping behavior, abusive behavior, and char

145 ere performed to examine associations of (i) loneliness, (ii) a range of covariates, and (iii) loneli

146 Although both isolation and loneliness impair quality of life and well-being, effort

147 al amyloid burden is associated with greater loneliness in cognitively normal older adults.

148 mean age = 54.9), we test for signatures of loneliness in grey matter morphology, intrinsic function

149 nown about structural cerebral correlates of loneliness in healthy older adults.

150 As part of the Helping Alleviate Loneliness in Hong Kong Older Adults (HEAL-HOA) dual ran

151 (PiB-PET), was examined in association with loneliness in linear regression models adjusting for age

152 Cumulative loneliness in mid-to-later life may thus be a mortality

153 Ample evidence indicates that loneliness in old age is associated with poor bodily and

154 disease (AD) genes (that was correlated with loneliness in this sample, although gene expression anal

155 rted falls relative to one point increase in loneliness independent of socio-demographic factors (HR:

156 (SMD, 0.25; 95% CI, 0.04 to 0.45) but not in loneliness interventions.

157 Loneliness is a complex biological trait that has been a

158 itively normal older adults, suggesting that loneliness is a neuropsychiatric symptom relevant to pre

159 Loneliness is a perceived state of social and emotional

160 large correlational literature suggests that loneliness is a prospective risk factor for MD; correlat

161 Loneliness is a risk factor for depression and other ill

162 the emotion of loneliness, susceptibility to loneliness is a stable trait that varies across individu

163 Loneliness is associated with an increased risk of late-

164 er, the extent to which emotional and social loneliness is associated with FEP has not been examined.

165 Loneliness is associated with impaired mental and physic

166 Loneliness is increasingly prevalent in modern societies

167 Loneliness is more strongly associated with mortality th

168 ing of neurobiological mechanisms underlying loneliness is needed to identify potential intervention

169 and neurobiological factors associated with loneliness is needed to identify which specific mechanis

170 However, its relationship with isolation and loneliness is not well understood.

171 Loneliness is the distressing feeling associated with th

172 Although the experience of loneliness is universally human, some people report expe

173 h indicates that perceived social isolation (loneliness) is a risk factor for morbidity and mortality

174 risk associated with perceived isolation, or loneliness, is not well understood.

175 role for DRN dopamine neurons in mediating a loneliness-like state.

176 The loneliness-linked neurobiological profiles converge on a

177 h amyloid burden (amyloid-positive group) to loneliness (lonely group) using logistic regression, con

178 tly clear: perceived social isolation (i.e., loneliness) may be the most potent threat to survival an

179 mon factor contributing to SIB, neuroticism, loneliness, MDD, and ASD, weakly correlated with a secon

180 ffects regression model analyses showed that loneliness measured by the UCLA Loneliness Scale was sig

181 leus accumbens from donors (N=26) with known loneliness measures.

182 hypothesized that individual differences in loneliness might be reflected in the structure of the br

183 We hypothesized that loneliness might occur in association with elevated cort

184 inese adults completed validated measures of loneliness, mindfulness, and depressive symptoms.

185 rmance (Short Physical Performance Battery), loneliness (modified UCLA Loneliness Scale), and isolati

186 g, less depression, low social isolation and loneliness, more close relationships, better self-rated

187 entified strong genetic correlations between loneliness, neuroticism, and a scale of 'depressive symp

188 re resettlement related stressors, including loneliness (odds ratio 1.17, 95% CI 1.05-1.28 for PTSD a

189 In adjusted models, loneliness (odds ratio [OR], 0.85; 95% CI, 0.73-0.99), l

190 magnitude and persistence of the effects of loneliness on subjective well-being and of subjective we

191 ty, and empathy independently contributed to loneliness, only basic social perception skills mediated

192 ted, focusing on a particular aspect such as loneliness or insecurity, but failing to account for the

193 Also, the interactions of loneliness or isolation with the degree of risk factor c

194 ores), whereas self-reported measures (e.g., loneliness or life satisfaction) are equally well explai

195 Co-occurrence of frailty and loneliness or social isolation was most common in partic

196 r before baseline, and have complete data on loneliness or social isolation.

197 r (OR, 2.07; 95% CI, 1.23-3.46), prepandemic loneliness (OR, 1.28; 95% CI, 1.09-1.49), and lower prep

198 is discussed because stress, lack of sleep, loneliness, or lack of exercise each impair EFs.

199 nual intervals and a more nuanced measure of loneliness, our findings suggest significant within-pers

200 es to identify risk variants for MD and used loneliness outcome data from UK Biobank.

201 and spiritual well-being (P < .05) and more loneliness (P < .05) than both survivors and controls.

202 ne educators experience substantial rates of loneliness, particularly among minority groups, at level

203 mputing genetic correlations and by building loneliness polygenic scores in an independent sample of

204 In contrast, higher loneliness predicted declines in PA.

205 cted higher subsequent loneliness and higher loneliness predicted elevated CRP.

206 However, veterans with preexisting loneliness, psychiatric distress, and lower purpose in l

207 Depression, anxiety, loneliness, quality of life, sleep quality, and amount o

208 mmediately after the call, they repeated the loneliness questionnaire.

209 ive controls, had the largest effect size on loneliness reduction (-1.86; 95% CI, -3.14 to -0.59; I2

210 'Loneliness' refers to the perceived social isolation tri

211 ur understanding of how social isolation and loneliness relate to cognitive decline and may contribut

212 cal expressions of loneliness to clarify how loneliness relates to dementia.

213 The polygenic score unique to loneliness remained associated with CAD (OR 1.09, 95% CI

214 on behavior and health, the neural basis of loneliness remains elusive.

215 her their effects are independent or whether loneliness represents the emotional pathway through whic

216 increase in the polygenic scores for MDD and loneliness, respectively.

217 al inactivity (RR, 1.07; 95% CI, 1.04-1.11), loneliness (RR, 1.07; 95% CI, 1.02-1.12), and economic d

218 quartile: RR, 1.46; 95% CI, 1.18-1.81), and loneliness (RR, 1.32; 95% CI, 1.08-1.61) were each assoc

219 Prior-day feelings of loneliness, sadness, threat, and lack of control were as

220 Loneliness, as determined by the 3-item UCLA Loneliness Scale (possible range, 3-12, with higher scor

221 indicating favorable influence); and 3-item Loneliness Scale (scored 3-9, with higher scores indicat

222 showed that loneliness measured by the UCLA Loneliness Scale was significantly reduced in the behavi

223 vised University of California, Los Angeles, loneliness scale) were tested before and during the COVI

224 formance Battery), loneliness (modified UCLA Loneliness Scale), and isolation considered in three way

225 re measured using the PHQ-9, GAD-7, and UCLA Loneliness scale, respectively.

226 -item Patient Health Questionnaire, and UCLA Loneliness Scale-Short form, respectively.

227 was 1.230 (0.209), and the mean (SD) UCLA-3 loneliness score was 5.3 (1.8).

228 ted for women with high social isolation and loneliness scores (midpoint of the upper half of the dis

229 ndividuals in low-touch relationships having loneliness scores more comparable to single participants

230 analyses showed that individuals with higher loneliness scores tended to have smaller gray matter vol

231 ) are far less important than mental health (loneliness), sensory function (hearing), mobility, and b

232 However, whether SA and loneliness share the same underlying neurocognitive mech

233 o (sHR) 1.30, 95% CI: 1.03-1.63) and chronic loneliness (sHR 1.58, 1.12-2.23), as well as chronic soc

234 stigate the longitudinal association between loneliness, social isolation and falls amongst older adu

235 Frailty and loneliness/social isolation affect individuals across a

236 should target people living with frailty or loneliness/social isolation, regardless of age.

237 onal impairment among those with fluctuating loneliness (sub-hazard ratio (sHR) 1.30, 95% CI: 1.03-1.

238 this study assessed the relationship between loneliness subtypes and FEP in 75 PWH (mean age = 59.4;

239 scoring the need for interventions targeting loneliness subtypes to improve FEP deficits and social-e

240 nships can transiently induce the emotion of loneliness, susceptibility to loneliness is a stable tra

241 Anxiety, depression, and loneliness symptoms were assessed using the 2-item Gener

242 s of momentary social anxiety, paranoia, and loneliness ten times per day for six consecutive days.

243 Girls experienced steeper increases in loneliness than boys (P < 0.0001).

244 man, some people report experiencing greater loneliness than others.

245 = 1.53, 95% CI 1.02-2.23) had higher odds of loneliness than their counterparts.

246 ore strongly to the subjective experience of loneliness than to objective social network size.

247 onditions including depression, anxiety, and loneliness that can negatively impact diabetes outcomes.

248 cial isolation generates an aversive state ('loneliness') that motivates social seeking and heightens

249 te associations between momentary feeling of loneliness, the social environment (i.e. overcrowding, s

250 ors such as marital status and age influence loneliness, there is also compelling evidence of a genet

251 nd poorer antibody responses was mediated by loneliness; those reporting lower social cohesion also r

252 proteomic signatures of social isolation and loneliness through proteome-wide association study and p

253 nome-wide association study meta-analysis of loneliness to 511 280 subjects, and detect 19 significan

254 biological and psychological expressions of loneliness to clarify how loneliness relates to dementia

255 onnect, acceptance-skills training may allow loneliness to dissipate and encourage greater engagement

256 -reported isolation (a three-item scale) and loneliness (two questions).

257 of social defeat (U=109, z=-2.09, P=.04) and loneliness (U=87.5, z=-2.72, P=<.001) than did healthy c

258 sult of information bias due to differential loneliness underreporting by gender.

259 d hazard ratio for mortality risk related to loneliness was 1.38 (95% CI 1.30-1.47), which reduced to

260 A standard questionnaire measure of loneliness was administered also.

261 Loneliness was assessed with a 5-item scale at baseline

262 Loneliness was associated with 1710 differentially expre

263 lthough HL participants showed increased SA, loneliness was associated with a response pattern clearl

264 phic and lifestyle factors, and morbidities, loneliness was associated with an increased risk of a ho

265 A genetic predisposition toward loneliness was associated with cardiovascular, psychiatr

266 finding predicted, we further confirmed that loneliness was associated with difficulty in processing

267 During a median 12.2-year follow-up, loneliness was associated with greater risks in 13 of 14

268 Loneliness was associated with lower level of cognition

269 Emotional loneliness was associated with reduced neutral bias (r=-

270 Most notably, in mPFC, loneliness was associated with reduced representational

271 isolation with mortality was unchanged when loneliness was included in the model.

272 Importantly, low loneliness was linked to an Own Age Bias for novel happy

273 prodromal syndrome, when stratified by time, loneliness was not associated with risk for incident PD

274 However, the effect of loneliness was not independent of demographic characteri

275 Genetic liability to loneliness was only potentially causally associated with

276 study also established that higher levels of loneliness was positively associated with the incidence

277 , the association of high amyloid burden and loneliness was stronger in APOEepsilon4 carriers than in

278 in whom autopsy of the brain was performed, loneliness was unrelated to summary measures of AD patho

279 ple experiencing perceived social isolation (loneliness), we conducted integrative analyses of leukoc

280 Continuous scores of social isolation and loneliness were analyzed.

281 In ARIC, polygenic scores for MDD and loneliness were associated with hazard ratios of 1.07 (9

282 Both social isolation and loneliness were associated with increased mortality.

283 ss deaths due to each category of cumulative loneliness were calculated.

284 Polygenic scores for MDD and loneliness were developed for each person using previous

285 r results indicate that, if interventions on loneliness were made 1 and 2 years prior to assessing fi

286 worry about COVID-19, perceived stress, and loneliness were measured at study baseline early in the

287 Depression, anxiety, and loneliness were measured using the PHQ-9, GAD-7, and UCL

288 Depressive symptoms, anxiety and loneliness were not associated with GrimAge2 or DunedinP

289 we investigated whether social cohesion and loneliness were predictive of antibody response to a sin

290 CHRNA4, IL-1A, CRHR1, MTHFR, DRD2, APOE) and loneliness were replicated (p>0.05), despite our much la

291 loss is associated with social isolation and loneliness, which are known to negatively impact mental

292 g lower social cohesion also reported higher loneliness, which in turn was associated with lower anti

293 on to the potential expansion of older adult loneliness, which is increasingly considered a threat to

294 he UK Biobank to examine the associations of loneliness with a wide range of non-overlapping diseases

295 tions, this review suggests relationships of loneliness with altered structure and function in specif

296 Relevance: We report a novel association of loneliness with cortical amyloid burden in cognitively n

297 ich the associations of social isolation and loneliness with mortality were attributable to differenc

298 The associations of social isolation and loneliness with premature mortality are well known, but

299 ouch in a relationship and the expression of loneliness, with individuals in low-touch relationships

300 ndardized effect = -0.13) to assessing final loneliness would both have an effect on an individual's