ライフサイエンスコーパス: long before

1 introduction into the African population not long before 1959.

2 iles at three stages of disease progression: long before (2 months of age), immediately before (5 mon

3 stors from African Yoruban ancestors started long before 50,000 years ago and give information about

4 a progressive autoimmune disease that starts long before a clinical diagnosis is made.

5 in a functional impairment of CD4(+) T cells long before a quantitative decline in circulating CD4(+)

6 f major depression associated with ACS began long before ACS and therefore were not caused by ACS.

7 m signaling and synaptic transmission system long before AD histopathology onset.

8 These vulnerabilities begin long before adulthood, providing opportunities to change

9 44 weeks) and is seen throughout the cochlea long before age-related changes in thresholds or hair ce

10 the visual stimulus frequently being encoded long before an upcoming saccade.

11 Conversely, thermal preference can arise long before, and remain long after, the harmful effects

12 as evident even at a very early age in mice, long before any clinical symptoms arose.

13 s within an hour or two of cohesin cleavage, long before any decline in ecdysone receptor could be de

14 og, two "utility" species, were domesticated long before any food crops or livestock species, and tha

15 rs coincident with the development of IR and long before any measurable change in carotid intima-medi

16 al evidence of a photo-induced cell response long before any morphological cues.

17 balance and modulate each other's activities long before any mutually exclusive silencing occurs.

18 evident microvascular morphological changes long before any pathological manifestation.

19 f communities and change ecosystem processes long before any species are extirpated from communities.

20 provide a marker to screen cigarette smokers long before any symptoms of bladder cancer are present.

21 concentrations may alter astrocyte function long before any visible symptoms of the disease are obse

22 n of crystallin PTMs begins before birth and long before ARC presents, we postulate that the lens pro

23 w that macrophages arrive at the lesion site long before axon fragmentation, much earlier than previo

24 Long before bacteria infected humans, they infected amoe

25 ese expression levels declined precipitously long before bleaching itself was evident, suggesting tha

26 etected in Ca isotope data after about 1 wk, long before bone mineral density has changed enough to b

27 of community spread and healthcare exposures long before BSI diagnosis.

28 resulting in indirect socioeconomic impacts long before built infrastructure is directly impacted by

29 ay have engaged this function independently, long before cadherins arrived on the scene.

30 ts closely mimic persistent HPV16 infection, long before carcinogenesis sets in.

31 unity to characterize early arterial disease long before cardiovascular complications present.

32 ction occurs during early-stage HIV disease, long before CD4 T cell counts fall below critical levels

33 Long before chondrogenesis, suc/et-1 mutant embryos have

34 immune network dysregulation in individuals long before clinical asthma diagnosis.

35 It is highly probable that BCCs enter the BM long before clinical detection.

36 flammatory phenotype in the microvasculature long before clinical disease is evident.

37 he gut microbiome and metabolome might begin long before clinical onset of IHD.

38 t these autoreactive T-cells can be detected long before clinical onset of the disease.

39 ss, which, in nontransplant patients, occurs long before clinical presentation.

40 ble to detect mutations emerging in patients long before clinical relapse.

41 uld identify mothers at risk of preeclampsia long before clinical symptoms manifest themselves.

42 nce: Alzheimer disease (AD) pathology starts long before clinical symptoms manifest, and there is no

43 ng the earliest phases of neurodegeneration, long before commitment to cell death.

44 Our findings suggest that metabolic factors long before conception can increase asthma risk and that

45 Assume that long before Cryogenian Snowballs, diverse supra- and per

46 rdiovascular gender differences are apparent long before CVDs appear in men and women, and improved u

47 ter mitochondrial membrane, which take place long before cytochrome c is released from mitochondria i

48 ersible" DAergic synaptic dysfunction occurs long before DAergic neuron loss.

49 nopause, female mice exhibit ovarian failure long before death because of chronological age and subse

50 We examined how long before death patients enrolled in hospice programs.

51 ndful of species, females cease reproduction long before death, highlighting an apparent evolutionary

52 Long before dementia is diagnosed, there is a progressiv

53 a predisposition toward cancer development, long before detectable tumors are formed, is a key to th

54 arise early in tumor development, sometimes long before diagnosis.

55 motoneurons that occur by 10 d after birth, long before disease onset.

56 in cell processes as well as the perikaryon long before DNA fragmentation and cell death and therefo

57 ltivated tomatoes, arose in tomato germplasm long before domestication; (4) extant accessions of L. e

58 rf allele to improve plant height in sorghum long before efforts to introduce Green Revolution-style

59 e cells define the exit points by stage 12+, long before either motor or sensory axons have grown thr

60 underwent receptor-mediated internalization long before endosomal fusion, thus minimizing the surfac

61 ll as advance directives should be addressed long before enteral feeding or assistive ventilatory sup

62 n by inorganic catalysts and energy sources, long before enzymes or genes existed.

63 a collapsed at approximately 800 years B.P., long before European contact.

64 mary glands in which cyclin E is deregulated long before evidence of malignancy.

65 on of continents by subaerial microbial mats long before evolution of land plants in the Phanerozoic

66 Motor behaviors are often planned long before execution but only released after specific s

67 d at exocytic sites are associated with DCVs long before exocytosis, and near the time of membrane fu

68 value can also be badly biased when measured long before exposure initiation.

69 oping fetus is exposed to a source of prions long before exposure to the infectious agent during and

70 usly undetected early gene modules expressed long before fate determination although being clearly as

71 shows that Solanaceae were well diversified long before final Gondwanan breakup.

72 changes in DNA methylation begin in the SAM long before germ cell differentiation to protect the gen

73 tively the stem rust resistance protein RPG1 long before haustoria formation.

74 y of human hepatocytes stained HDAg-positive long before HBV spreading was completed, confirming that

75 er, nifII, was expressed in vegetative cells long before heterocysts formed.

76 imate-triggered extinction trends that began long before hominins evolved suitable hunting capabiliti

77 a critical region for peach evolution since long before human presence, much less agriculture.

78 Long before infants reach, crawl or walk, they explore t

79 replicate and accumulate in lymphoid tissues long before infection spreads to the central nervous sys

80 imonidazole binding significantly at 7 days, long before inflammation and necrosis could be detected.

81 rly in the second and third decades of life, long before ischemic heart disease becomes clinically ap

82 membranes rich in trans-Golgi network (TGN) long before it becomes available for re-esterification a

83 the bullseye boundary position is specified long before it becomes visible.

84 fter treatment, anticipating drug resistance long before it was clinically manifest.

85 ggesting CWS management has been in practice long before its first mention in historical documents.

86 kinematics of self-generated limb movements long before M1 develops its capacity to drive movements

87 ormationally rich representation of movement long before M1 develops its motor functionality.SIGNIFIC

88 seases to be detected at the molecular level long before macroscopic symptoms appear.

89 y very early in the course of SIV infection, long before marked declines in peripheral CD4(+) T cell

90 es (IIS) in epilepsy at just 5 weeks of age, long before memory impairments or beta-amyloid depositio

91 s underlying skeletal fragility that operate long before menopause.

92 in the common ancestor of fungi and animals long before mesoderm appeared.

93 Long before Meta II decays into the aporeceptor opsin an

94 acute (LPS) and chronic (ethanol) stresses, long before more-dramatic fibrotic changes to the liver

95 Taken together, we have shown that long before morphological changes occur in the shoot api

96 genes that showed marked decreases in levels long before morphological damage could be readily ascert

97 kage and intestinal inflammation, take place long before motor disorders.

98 deficits occur as early as 18 years of age, long before motor manifestations of HD.

99 The evidence that the environment acts long before MS becomes clinically evident is well establ

100 r the MBP gene in the early developing brain long before myelination and especially in the pioneer co

101 operties declined sharply at anaphase onset, long before natural disassembly.

102 Mitochondrial fission by NO occurs long before neurite injury and neuronal cell death.

103 date have involved administration of agents long before onset of symptoms, which cannot currently be

104 erm cells are eliminated during development, long before oogenesis or spermatogenesis.

105 A discordant origin of traits long before or after the origin of the putative coevolut

106 regional communication networks that existed long before other major innovations such as agriculture,

107 process, which we term 'cistauosis', appears long before other tauopathy.

108 All reefs were substantially degraded long before outbreaks of coral disease and bleaching.

109 treatment of diabetes and its complications long before overt disease develops.

110 Metabolic changes often occur long before pathologies manifest and treatment becomes c

111 eine, declines rapidly after APAP ingestion, long before patients are admitted to the clinic with sym

112 d reduction in LV functional cardiac indices long before PE development.

113 Brown Norway (BN/SsNHsd) rat as a DNA source long before plans for rat genome sequencing had been lau

114 y be pro-epileptogenic at the soluble stage, long before plaque deposition.

115 ssure may require reduction of lead exposure long before pregnancy.

116 nity leaders, employee groups and the media, long before protocol implementation, is essential.

117 netic diagnosis might be made early in life, long before recognisable neuropsychiatric disorders have

118 nase enzyme activities become oxygen-limited long before respiration.

119 endemic coronavirus which emerged in humans long before SARS-CoV-2.

120 Long before seizures, coincident with loss of inhibitory

121 proliferating human mammary epithelial cells long before senescence.

122 Although Abeta levels become abnormal long before severe cognitive impairments appear, increas

123 del also shows that autocatalysis takes over long before significant amounts of olefins are formed, t

124 is pathology is manifested in memory defects long before significant plaque deposition.

125 onset of the phenotype, which in turn occurs long before specific neurodegeneration can be detected.

126 As SpOtx appears long before SpGsc transcription is activated, we propose

127 egy, as well as determine the visual outcome long before surgery occurs.

128 ow telomere length regulates gene expression long before telomeres become short enough to produce a D

129 gen-derived as well as environmental signals long before Th17 cells have sensed bacterial invasion.

130 n primary visual and primary auditory cortex long before thalamocortical synapse formation, but that

131 ighly conserved and was probably established long before that of double-stranded DNA viruses infectin

132 but they were likely used in Asian medicine long before that.

133 hat admixture occurred early on each island, long before the 18(th)-century massive TAST deportations

134 Long before the 5 November US presidential election, I h

135 and microglial activation in graft deposits long before the accumulation of alpha-synuclein patholog

136 et of neuromuscular denervation, which began long before the activation of cell death proteins in SOD

137 a common ancestor of great apes and humans, long before the advent of modern humans.

138 d as gain medium for lasers since the 1960s, long before the advent of today's organic electronic dev

139 at M form KSHV likely existed in this region long before the AIDS epidemic.

140 xpressed IAG from the first larval stage on, long before the androgenic gland primordia begin to diff

141 -related decrease in neurogenesis is evident long before the animals become aged.

142 ns form early during the refolding reaction, long before the appearance of native tailspike.

143 esults in the formation of cellular patches, long before the appearance of tumors, that are visualize

144 rsity in chronic infection could be detected long before the appearance of viral escape mutations in

145 eak in sea-ice-related feedbacks that occurs long before the Arctic becomes ice-free in summer.

146 ntigen within 90 min of antigen inoculation, long before the arrival of dendritic cells from skin.

147 olithic technology were active in Madagascar long before the arrival of farmers and herders and befor

148 ops in temperature, stressing the ecosystems long before the bolide impact delivered its final blow a

149 t with growing evidence that sponges evolved long before the Cambrian explosion approximately 542 mil

150 Long before the cause was discovered, peptic ulcers were

151 losed marine basin, was affected by land use long before the changes of the Industrial Era.

152 nment problem-action selection signals occur long before the consequent dopamine reinforcement signal

153 ls in a species-typical manner might develop long before the coordinated behavior is demanded of the

154 chromatin organization, all become apparent long before the cortical release and the nuclear import

155 viability as the pH went <6, which happened long before the culture reached saturation.

156 Pathways to extinction start long before the death of the last individual.

157 Mast cells have existed long before the development of adaptive immunity, althou

158 PBC often suffer from a variety of symptoms long before the development of cirrhosis that include is

159 ncing the early growth of transformed cells, long before the development of clinical cancer.

160 ions differ in selective pressures on clones long before the development of clinically apparent chron

161 Bone metastasis is a multistage process: long before the development of clinically detectable met

162 ryonic vertebrate heart begins pumping blood long before the development of discernable chambers and

163 e soon after activation of the transgene and long before the development of lung pathology.

164 topoietic stem cells and exhibit dysfunction long before the development of lung pathology.

165 ic dissemination of tumor cells often begins long before the development of overt metastases, reveali

166 through inflammatory and neuroretinal stages long before the development of vascular lesions represen

167 les can be traced back 5,000 years, or more, long before the development of written traditions.

168 MAbs predict the diagnosis of complicated CD long before the diagnosis of disease, recognize uniquely

169 most pronounced when this variation occurred long before the diagnosis.

170 fferences between the sexes begin to develop long before the differentiation of Sertoli cells, includ

171 ementally through mammaliaform evolution and long before the differentiation of the living mammal gro

172 Long before the discovery of cytokines as immune system

173 In the early 19th century, long before the discovery of the dinosaurs, scientists a

174 ion originated early in the history of life, long before the diversification of cyanobacteria and oth

175 ade of tortoises became extinct that evolved long before the dodo or the Rodrigues solitaire, two oth

176 an-Silurian transition (~444 million years), long before the earliest reported vascular plant fossil,

177 During development, long before the emergence of disease symptoms, the funct

178 ore the radiation of the Laverania subgenus, long before the emergence of P. falciparum.

179 a common ancestor that probably existed not long before the emergence of the cartilaginous fish.

180 ches a threshold level (or bound), sometimes long before the end of stimulus.

181 across trials, with most labels stabilizing long before the end of training and then being used cons

182 ersonalized approaches to treatment, ideally long before the end stage is reached.

183 timulation resting level, which was attained long before the endoplasmic reticulum Ca2+ store had bee

184 nce of the FtsZ1 and FtsZ2 families occurred long before the evolution of land plants, preceding the

185 ins evolved in ancient marine microorganisms long before the evolution of land plants.

186 e present in central and northwestern Europe long before the extinction of late Neanderthals in south

187 in the area where exudative MNV will develop long before the exudation, accelerating significantly in

188 libut brain already at the time of hatching, long before the eyes are functional.

189 is well established by the day after birth, long before the final target zone is discernible within

190 rged as a stable and widespread way of life, long before the first evidence for domesticated plants o

191 response to stress under normal conditions, long before the formation of a cancerous lesion.

192 Cylindraspis commenced in the mid-Oligocene, long before the formation of the Mascarene Islands.

193 m was bioavailable in the mid-Archaean ocean long before the Great Oxidation Event.

194 supports a pathway to extinction that began long before the Holocene, when the combination of coolin

195 g ancestral gene resurrection, we show that, long before the hormone evolved, the receptor's affinity

196 isease initiation/progression in human cells long before the induction of a critical DNA damage respo

197 As encoding genes for 5S rRNA was detectable long before the injected DNAs had time to reconstitute i

198 deoxynucleotides into newly synthesized DNA, long before the lack of pyrimidine nucleoside triphospha

199 n medical education implemented in Ann Arbor long before the landmark Flexner Report on Medical Educa

200 iated with pre-angiosperm plants that appear long before the later, iterative associations between an

201 ons resulted in rapid decline of thresholds, long before the loss of most photoreceptors, which was e

202 ecause infected cells express viral antigens long before the macroscopic signs of infection scored in

203 the non-image-forming pathway is functional long before the mainstream image-forming pathway during

204 ersely alter the cardiovascular risk profile long before the manifestation of clinical disease.

205 c responses were demonstrated experimentally long before the mechanisms responsible were elucidated.

206 aptations evolved independently in dinosaurs long before the modern bird radiation and provides a not

207 Long before the morphological effects of NT-3 appeared,

208 ondary structure, but without tight packing, long before the native state.

209 proach to modulate early pathologic pathways long before the occurrence of vision loss among patients

210 vascular hyperpermeability (CVH) was induced long before the onset of angiogenesis in a modified, in

211 nal peak within 15 min after light exposure, long before the onset of cell division.

212 from synapses early in the disease process, long before the onset of classical AD pathology.

213 regnancy, even at 13 to 16 weeks' gestation (long before the onset of clinical disease); their gestat

214 in system-level circuits of the human brain, long before the onset of cognitive symptoms.

215 in aqueous solutions as volume is decreased long before the onset of crystallization by in situ time

216 Many PAAI effects influence phenotypes long before the onset of detectable age-dependent change

217 ic inflammation and autoimmunity in RA begin long before the onset of detectable joint inflammation.

218 metabolic rate for glucose, which may begin long before the onset of histopathological or clinical f

219 ccupied seasonally dry heterogenous habitats long before the onset of late Neogene aridity.

220 ize in most chloroplasts from mature leaves, long before the onset of leaf senescence.

221 aled a marked degeneration of callosal axons long before the onset of motor symptoms.

222 poised in a near-eruptive equilibrium state long before the onset of the 2004-05 eruption.

223 the hallmark of type 2 diabetes and develops long before the onset of the disease.

224 Insulin resistance (IR) is present long before the onset of type 2 diabetes and results not

225 that often trace back to evolutionary events long before the origin of humans.

226 of inflammation, on postimmunization day 5, long before the peak of inflammation on day 14.

227 nd the blood of acutely infected chimpanzees long before the peak of T cell infiltration and most of

228 fect the embryo shortly after fertilization, long before the placenta is established.

229 for both targeted and nontargeted infections long before the policy was implemented.

230 on for the smooth ride and other characters, long before the PRPF breed was established.

231 ng that non-image-forming perception emerged long before the radiation of present vertebrate lines an

232 Long before the recent thrust of scientific research on

233 ion of HIV-1 in west-central Africa occurred long before the recognized AIDS pandemic.

234 nducible resistance phenotype within 5 days, long before the recommended 14-day extended incubation.

235 nsic feature of the oropharyngeal epithelium long before the region becomes innervated.

236 dapted to high-altitude hypoxic environments long before the regional arrival of modern Homo sapiens.

237 a time scale of only 1 millisecond, that is, long before the remnant can collapse into a black hole.

238 atmospheric oxygenation and climatic cooling long before the rise of forests, although earlier CO(2)

239 Although animal breeding was practiced long before the science of genetics and the relevant dis

240 h site the first double-strand break is made long before the second.

241 The ancestral AL gene emerged long before the separation of human and chimpanzee ances

242 uit brain structures, which begin to develop long before the skill manifests and exhibit rapid develo

243 rences are most obvious at postnatal day 15, long before the start of the critical period, indicating

244 SC concentration of oral samples was reached long before the sulfide detector fully responded.

245 change projections (sometimes >10 000 muatm) long before the term 'ocean acidification' was coined, w

246 arrest is initiated during a critical period long before the time at which fusion normally occurs.

247 experimental tetanus when injected into mice long before the toxin.

248 n occurs within 5 minutes after irradiation, long before the translocation of RAP80 to IRIF.

249 bacteria may also tailor the host's response long before the virus has infected the airway.

250 exposure in 10 control windows, each 7 days long, before the exacerbation.

251 rized genetically as regulators of Hox loci, long before their catalytic functions were recognized.

252 ths in intermediate hosts often stop growing long before their growth is limited by host resources, a

253 ronments for breeding during the Cretaceous, long before their modern descendants.

254 in the atmosphere was likely to have ceased long before their ultimate disappearance from the rock r

255 that he believed that ancestral forms 'lived long before' their first fossil representatives.

256 ar under selective conditions in some clones long before there is any sign of neoplastic change in th

257 g in infancy and continuing throughout life, long before there were more advanced linguistic features

258 ology has now come of age and it will not be long before these formulations assume a prominent role i

259 mpact marine ecosystems in the coming years, long before these interventions can be developed.

260 Evidence suggests that some flaps become long before they are cleaved, and that this cleavage inv

261 ETR2 mRNAs are expressed in geranium florets long before they are receptive to pollination and transc

262 ation process that is almost two cell cycles long before they become competent to function as microtu

263 ted to become bullwhip neurons are generated long before they begin to differentiate and that their s

264 n members of the same species was recognized long before they could be identified.

265 hemionus) excrete CWD prions in their faeces long before they develop clinical signs of prion disease

266 as mice display various malignant properties long before they develop tumors in vivo.

267 owed their behaviors when they were infants, long before they had been diagnosed as autistic.

268 t adjacent fascicles proximally in the limb, long before they reached the muscle.

269 ns of patients with clinically relevant ILD, long before they require antifibrotics.

270 Long before this goal is achieved, and sometimes at the

271 neage between 230 and 250 million years ago, long before this lineage gave rise to the first birds.

272 ould argue that others have grappled with it long before us, such as, for instance, social media, to

273 9 but also in responding to future pandemics long before vaccines or drugs are developed.

274 18 months; soluble Abeta levels are elevated long before vascular deposition takes place in this mode

275 early during the development of the oocyte, long before vitellogenesis begins.

276 iformly, causing hippocampal memory deficits long before wide-spread brain degeneration becomes evide

277 nal zone of the embryo at the 64-cell stage, long before zygotic transcription starts.