ライフサイエンスコーパス: long-standing

1 e outcome of this application will address a long-standing analytical challenge to achieving fast, co

2 l colours help maintain thermal balance is a long-standing and contested question.

3 nipulate CM ploidy may resolve some of these long-standing and fundamental questions.

4 sformations not observed in nature remains a long-standing and important challenge.

5 iversity in regions that contain mixtures of long-standing and novel plant habitats.

6 for enzymatic processes, which has provoked long-standing and un-concluded conjectures on their rela

7 n of P and M pathways to spatial vision is a long-standing and unresolved issue.

8 itions, indicating an inherent resilience to long-standing anthropogenic pressures such as noise poll

9 a plausible mechanistic explanation for the long-standing appreciation that RAAS inhibitors are bene

10 evelopment is not well understood, despite a long-standing appreciation that various aspects of cytok

11 patients with Parkinson's disease challenges long-standing assumptions about how this disease manifes

12 These results validate long-standing assumptions on the coherent behavior of to

13 ur work reveals the structural basis for the long-standing "barcode" hypothesis and has important imp

14 s biotransformation, liver detoxification, a long-standing barrier in nanomedicine translation, can b

15 This 'segregation bias' is a long-standing biological mystery that may pose challenge

16 eness is generated for local adaptation is a long-standing biological question.

17 y, and energy efficient product recovery are long-standing bioprocess challenges.

18 This work breaks the long-standing bottlenecks limiting materials innovation

19 thus with the whole genome information, is a long-standing but perhaps deceptive mystery.

20 udy was to evaluate the damage present after long-standing but resolved central serous chorioretinopa

21 Given this long-standing but underappreciated challenge in mapping

22 ful and user-friendly catalytic reactions, a long-standing, but elusive goal in Sm(II) chemistry.

23 tifying stabilizing factors in foodwebs is a long standing challenge with wide implications for commu

24 thway at the alpha/beta interface has been a long-standing challenge due to the lack of structural da

25 room-temperature thermoelectrics have been a long-standing challenge due to vanishing electronic entr

26 eneration of devices and technologies, yet a long-standing challenge has been finding materials witho

27 A long-standing challenge in C-H activation is the inabili

28 route to nitrogen-containing molecules is a long-standing challenge in chemical synthesis.

29 l hydroxyl groups in carbohydrates remains a long-standing challenge in chemical synthesis.

30 often lack fundamental information due to a long-standing challenge in ecology: How do we draw robus

31 A long-standing challenge in motor neuroscience is to unde

32 e intriguing structure of tagetitoxin (1), a long-standing challenge in natural product synthesis, ha

33 ive synthesis of trisubstituted alkenes is a long-standing challenge in organic chemistry, due to the

34 However, alkene diamination remains a long-standing challenge in organic synthesis, especially

35 scaffolds from simple precursors, has been a long-standing challenge in organic synthesis.

36 from prochiral starting materials remains a long-standing challenge in organic synthesis.

37 This new attention has served to highlight a long-standing challenge in the field of radical chemistr

38 Direct oxidation of methane to methanol is a long-standing challenge in the heterogeneous catalysis c

39 However, a long-standing challenge is improving their energy densit

40 ess protecting strategy is presented for the long-standing challenge of conducting the palladium-cata

41 ticity of soft polymeric materials remains a long-standing challenge resulting in cyclic hysteresis.

42 hibit chemotherapy resistance, which poses a long-standing challenge to cancer treatment.

43 It has been a long-standing challenge to develop MIECs with both high

44 However, it is a long-standing challenge to harnessing their exceptional

45 ow value materials such as alkenes remains a long-standing challenge to synthetic chemists.

46 acyl-enzyme intermediates, which has been a long-standing challenge when using canonical nucleophile

47 e elastic limit and low density represents a long-standing challenge, because these properties are, i

48 stems for therapeutic biomacromolecules is a long-standing challenge.

49 he required complex micromaterials remains a long-standing challenge.

50 ndustrial wastes and agricultural soils is a long-standing challenge.

51 lates and their higher homologues has been a long-standing challenge.

52 h atomic-level control of dopants has been a long-standing challenge.

53 ic materials and their integration remains a long-standing challenge.

54 loy single-crystal turbine blades has been a long-standing challenge.

55 One of the long standing challenges is the large contribution of si

56 Reductive electrosynthesis has faced long-standing challenges in applications to complex orga

57 One of the long-standing challenges in experimental physics is the

58 deep learning open novel avenues to address long-standing challenges in imaging MS.

59 One of the long-standing challenges to performing electrogenerated

60 th TUS may be beneficial for addressing some long-standing challenges with local drug delivery in can

61 ls are employed to mitigate some of the most long-standing challenges.

62 of viral suppression from 1997 to 2017 in a long-standing community-based cohort study of PWID, the

63 Longevity has been a long-standing concern for hybrid perovskite photovoltaic

64 There is a long-standing concern for the lack of reproducibility of

65 Despite the long-standing connection between these organelles, the f

66 oncept for antenna design allows approaching long-standing contests in radio physics.

67 The present analysis helps resolve some long-standing controversies in the field.

68 rnered many successes and engendered several long-standing controversies regarding the nature of thei

69 ardiac NCC development, thereby clarifying a long-standing controversy in the literature.

70 Intrigued by a long-standing controversy regarding the existence of an

71 enable rapid p53 stabilization and resolve a long-standing controversy surrounding MDM2 auto-degradat

72 neutral to acidic pH values to elucidate the long-standing controversy surrounding the rate-limiting

73 A long-standing conundrum is how mitotic chromosomes can c

74 There is a long-standing debate about whether categories are repres

75 gen environments, these findings reconcile a long-standing debate between paleontologists and geochem

76 These convergent results shed light on the long-standing debate of neural organization of language

77 mation on axon radii, as well as resolve the long-standing debate on whether axon radii can be quanti

78 m the first years of their life has fueled a long-standing debate on whether infants can make the typ

79 This in turn resolves long-standing debate over Mesopotamian chronology in the

80 egalithic contexts in Europe to resolve this long-standing debate.

81 hanisms responsible have been the subject of long-standing debate.

82 l fossil record of marine animals has fueled long-standing debates about diversity change through tim

83 history, ancient DNA has provided answers to long-standing debates about major movements of people an

84 Our results help resolve long-standing debates on the stability, saturation and d

85 There have been long-standing debates regarding whether supervised or un

86 of thousands of deaths each year despite the long-standing deployment of an effective vaccine.

87 However, there has been a long-standing desire to find cheaper and more environmen

88 These results address the long-standing dichotomy of A- versus B-side initial char

89 This resolves a long-standing dilemma about the location and nature of t

90 Implicit in the long-standing disagreements about whether humans' fundam

91 ination of complex materials, and resolves a long-standing dispute concerning the uniqueness of a mod

92 ayans more closely resembled to resolve this long-standing dispute.

93 Thus, our findings necessitate changes to long-standing dogma on mechanisms for LPL inactivation b

94 It is likely linked to the long-standing dogma that the rodent islet has a mantle o

95 This new perspective on tau challenges long-standing dogma.

96 The long-standing effect of obesity-induced changes in SAT w

97 food web theory are two cornerstones of the long-standing effort to understand how species coexist.

98 These findings will help inform long-standing efforts to model HIV-1 transmission and ea

99 onship between these nodule types has been a long-standing enigma for molecular and evolutionary biol

100 It has been a long-standing enigma how different IDRs successfully exe

101 sizes of different species and tissues is a long-standing enigma.

102 e biomedical scientific community to address long-standing ethical and scientific barriers to equitab

103 trophysiological counterpart, except for the long-standing evidence of a relative EEG slowing over th

104 Long-standing evidence supports the importance of mainta

105 me strategy needs to be coordinated with the long-standing, evidence-based tobacco control strategies

106 We were surprised by realizing that, despite long-standing experience, we were making occasional diag

107 We, an international team of scientists with long-standing expertise in SERS, address this issue from

108 This long-standing finding dominates models of estrogen actio

109 drive frequency in natural populations is a long-standing focus of evolutionary research.

110 This long-standing focus on purely automated methods unnecess

111 uch as echolocation in bats and whales, is a long-standing fundamental question.

112 se 1/3 inhibitor) in 5 patients with severe, long-standing GA in an open-label clinical trial.

113 sociation was not observed in eyes with more long-standing GA, which have larger lesion sizes.

114 rough cortical excitability, which fills the long-standing gap between two major directions of resear

115 Our study tackles a long-standing gap in the monarch's annual cycle and high

116 rain on countries around the world, exposing long-standing gaps in public health and exacerbating chr

117 nd recovered language performance has been a long-standing goal for cognitive and clinical neuroscien

118 lation of transcription factor activity is a long-standing goal in drug discovery but hampered by the

119 fector response of CD8(+) T cells has been a long-standing goal in immunology to produce better vacci

120 C(sp(3))-H bonds in organic substrates is a long-standing goal in synthetic chemistry.

121 Realizing such systems has been a long-standing goal in the field of ultracold atoms.

122 of interest during cell division has been a long-standing goal of cell cycle studies.

123 l and temporal variability in LMA has been a long-standing goal of ecological research and is an esse

124 eukaryotic CCDs have been characterized, the long-standing goal of experimentally visualizing a CCD-c

125 rovides a potential avenue for achieving the long-standing goal of imaging beta-cell mass in the clin

126 scales from the macro to the nano remains a long-standing goal of material science.

127 Controlled, localized drug delivery is a long-standing goal of medical research, realization of w

128 A long-standing goal of X-ray crystallography has been to

129 tructure for a catalytic material has been a long-standing goal, but typically an arbitrary active si

130 on a molecular and supramolecular scale is a long-standing goal.

131 eutralizing diverse HIV-1 strains has been a long-standing goal.

132 mune activation and cellular turnover due to long-standing HIV infection with delayed cART initiation

133 This study included 185 women (128 with long-standing HIV infection, 88% under antiretroviral th

134 Long-standing hypotheses regarding the retromer sorting

135 A long standing hypothesis that amyloid-beta drives Alzhei

136 s for the PDC enzyme, but also challenge the long standing hypothesis that PDC is involved in BCAA-de

137 Our findings are consistent with the long-standing hypothesis of dysregulation of the striata

138 Whereas a long-standing hypothesis of the aging literature links c

139 A long-standing hypothesis suggests that hybridization cou

140 hese results provide evidence to support the long-standing hypothesis that IAV's strategy of import a

141 lution to provide evidence in support of the long-standing hypothesis that information integration is

142 Here we probe the long-standing hypothesis that noradrenaline is involved

143 This approach is based on the long-standing hypothesis that PARP inhibition will impai

144 Our data offer direct evidence to support a long-standing hypothesis that protonation of Asp favors

145 ratory divides and genetic breaks supports a long-standing hypothesis that the Tibetan Plateau is a s

146 ular RNA structure provides evidence for the long-standing hypothesis(6-8) that heterogeneity in RNA

147 One long-standing idea is that high-contrast patterns with r

148 gh less frequently, in patients treated with long-standing immunosuppressive therapy, such as in infl

149 However, despite its long-standing importance, it is exceedingly difficult in

150 indings and the laying hen model support the long-standing incessant ovulation hypothesis and cortica

151 Although the personalized approach draws on long-standing influences in clinical psychology, there h

152 evaluate how climate change will alter this long-standing interaction.

153 ease ovulation prior to the end of life is a long-standing interdisciplinary and evolutionary challen

154 r (Phospholamban Foundation), who have had a long-standing interest in cardiac physiology and pathoph

155 There has been long-standing interest in processes underpinning thymus

156 Chemists have had a long-standing interest in reactive intermediates such as

157 -resolution structural determination despite long-standing interest in their role in excitation-contr

158 able narrow atomic transitions, it remains a long-standing interest to develop new schemes to further

159 ted C(60) molecules has been of particularly long-standing interest.

160 on cost, and signal amplification has been a long-standing issue for wearable electronics.

161 In this study, we address the long-standing issue-arising prominently from conceptual

162 One long-standing knowledge gap is the role of nuclear prote

163 Here, we overcome this long-standing limitation by implementing stereo-polarime

164 This approach objectively addresses the long-standing limitations of conventional source imaging

165 important evidence to confirm, and refute, a long-standing maxim in clinical medicine that a 1-unit t

166 The long-standing mechanistic explanation for this adaptive

167 in aging humans is scarce, likely reflecting long-standing methodological challenges in noninvasive a

168 an induce skeletal muscle hypertrophy, and a long standing model in the field indicates that mechanic

169 A long-standing model proposed that MrpC activity is contr

170 In an important correction to a long-standing model, we show Pkn8 and Pkn14 kinase activ

171 The long-standing Monterey Hypothesis uses this excursion to

172 hort, 133 patients (age = 54.2 +/- 9.6) with long-standing multiple sclerosis and 48 healthy controls

173 range metal behavior, elucidating one of the long-standing mysteries of correlated quantum matter.

174 assignment of physisorbed disulfides solve a long-standing mystery and reveal new, dynamic properties

175 This mechanism informs on a long-standing mystery for how few upstream kinase molecu

176 It has been a long-standing mystery how the IDR-mediated mass exchange

177 A long-standing mystery in fungal pathogens of humans is h

178 A long-standing mystery in the field is why vertebrates ha

179 These findings resolve the long-standing mystery of the MMC/PTP and demonstrate tha

180 Our findings thus solve the long-standing mystery of the molecular function of FIT2

181 origins of such strange metals have posed a long-standing mystery.

182 ty health workers to increase accessibility; long-standing nationwide provision of basic health inter

183 This method addresses the long-standing need to accurately genotype medically impo

184 le of newly developed obesity independent of long-standing obesity.

185 tion by this pathway apparently explains the long-standing observation of ethylene accumulation in ox

186 Our results collectively explain the long-standing observation that the attachment of the low

187 The long-standing obstacle to characterizing the vacancy net

188 This answers the long-standing open question about the existence of a fin

189 However, a long-standing open question is how astrocytes regulate n

190 from species' trophic interactions remains a long-standing open question.

191 In the long-standing paradigm for G1/S control, Cdks inactivate

192 eptin scaffolds and barriers have provided a long-standing paradigm for the generation and maintenanc

193 ng and revealed greater complexity regarding long-standing paradigms describing key regulatory steps

194 s in telomere cohesion, which reconciles the long-standing paradox between the role of ARID1A in main

195 eered nanoparticles can be used to reconcile long-standing paradoxes in the anticancer drug delivery.

196 parameters of the f-waves could discriminate long-standing persistent AF (LPeAF) from non-LPeAF.

197 eft atrium size, 54+/-10 mm, with persistent/long-standing persistent AF in 53 (83%)/11 (17%), prior

198 ers showed promising results in a persistent/long-standing persistent AF population.

199 d its effectiveness to CA for persistent and long-standing persistent AF treatment.

200 Patients with persistent or long-standing persistent AF underwent ablation using the

201 al catheter ablation (CA) for persistent and long-standing persistent atrial fibrillation (AF) treatm

202 o the CA for the treatment of persistent and long-standing persistent atrial fibrillation.

203 only ablation trial to substantially include long-standing persistent-AF, that is, 42% patients with

204 ng persistent-AF, that is, 42% patients with long-standing persistent-AF.

205 of Donald Trump was seen as a departure from long-standing political norms.

206 The long-standing popularity of semiconductor photocatalysis

207 The long-standing popularity of thermoelectric materials has

208 his mechanism provides justification for the long-standing practice of management with antibiotic the

209 nts an impediment to the pursuit of numerous long-standing predictions for exotic superconductivity w

210 ore effective treatments for depression is a long-standing primary objective in both psychiatry and t

211 for memorization and retrieval of data is a long-standing problem at the intersection of machine lea

212 metal insertion into aromatic C-C bonds is a long-standing problem critical for development of new ar

213 By doing so, NeuroInfo helps in solving the long-standing problem faced by researchers investigating

214 g the cause of allometric scaling has been a long-standing problem in biology.

215 y to control different cell fates has been a long-standing problem in developmental biology.

216 nship between mental imagery and vision is a long-standing problem in neuroscience.

217 A long-standing problem is how cells that lack one of the

218 nding charge transport in DNA molecules is a long-standing problem of fundamental importance across d

219 ental policy is geared toward addressing the long-standing problem of nutrient overenrichment, these

220 muscle contraction characteristics; (3) the long-standing problem of two disparate patterns of longi

221 This gives a positive solution to a long-standing problem that goes back to Mathias.

222 rganisms maintain cell size homeostasis is a long-standing problem that remains unresolved, especiall

223 Here, we address this long-standing problem with QUEnch-assiSTed Magnetic Reso

224 Our findings solve a long-standing problem, providing a new insight into the

225 be best designed and developed to solve this long-standing problem.

226 ablishing a systemic molecular basis for the long-standing proposed links between redox dysregulation

227 t inhibition of KRAS oncoproteins has been a long-standing pursuit in precision oncology, one establi

228 ormones in a manner that runs counter to the long-standing pursuit of glucagon antagonism.

229 Our work not only explains a long-standing puzzle for an important catalyst but also

230 y on temperature T down to low T have been a long-standing puzzle in condensed matter physics.

231 mechanism provides a possible solution to a long-standing puzzle in the field about the versatility

232 lockade valleys, resolving, along the way, a long-standing puzzle of the experimentally observed fini

233 issue of Blood, Calzavarini et al solve the long-standing puzzle of the function of protein S (PS) t

234 ilar but non-native metal substitutions is a long-standing puzzle.

235 of spin-triplet superconductivity has been a long-standing quest in condensed matter physics since th

236 peration naturally lead to a solution of the long-standing question about complexity-stability parado

237 This result addresses a long-standing question about the molecular mechanisms of

238 A long-standing question has been whether these incipient

239 For thylakoid membranes of higher plants, a long-standing question has been which of the two mobile

240 A long-standing question in ecology is how species interac

241 A long-standing question in HIV-1 gene expression is wheth

242 A long-standing question in infectious disease dynamics co

243 A key, long-standing question in neuroscience is to understand

244 A long-standing question in the field of embryogenesis is

245 In multicellular organisms, a long-standing question is how spatial patterns of distin

246 A long-standing question is whether these areas are shaped

247 arrangements in driving evolution has been a long-standing question of evolutionary biology.

248 These data help to clarify the long-standing question of how MT-4 cells overcome the re

249 with opioid receptor activity, leading to a long-standing question of the significance of this reper

250 .SIGNIFICANCE STATEMENT This work resolves a long-standing question of whether figure-ground segregat

251 plants that do not produce amylose revives a long-standing question of why starch granules contain am

252 ctivity with CO(2), allowing us to address a long-standing question related to Ni-catalyzed carboxyla

253 has mostly been conserved in humans, it is a long-standing question whether the structural analogies

254 How these hubs cross-talk has been a long-standing question, but answers remain elusive.

255 A long-standing question, however, is how such breaks occu

256 activity of AGO3 remains controversial and a long-standing question.

257 e the synthesis of mature peptidoglycan is a long-standing question.

258 out being lost to the environment has been a long-standing question.

259 ation from mRNA localization, we untangled a long-standing question: Are mRNAs directed to P granules

260 ate epithelial progenitors, and help resolve long-standing questions about anatomical relationships b

261 To answer long-standing questions about how plants use and regulat

262 amics in microcrystalline samples, resolving long-standing questions about the connection between non

263 ed to other systems, could help in resolving long-standing questions about the importance of characte

264 Results presented in this work answer long-standing questions about the role of leiomodin in t

265 miology has played a vital role in answering long-standing questions about whether religion is causal

266 KIFC1 may help answer long-standing questions in cellular neuroscience such as

267 We first address long-standing questions regarding the structure of embry

268 crossing over in mice while also addressing long-standing questions related to Holliday junction res

269 udies have proven to be useful for answering long-standing questions.

270 Long-standing radical species have raised noteworthy con

271 e remains a substantial challenge to produce long-standing radicals by light, because of the structur

272 Despite long-standing recognition of the importance of precipita

273 Here, we address this long-standing research gap by systematically testing the

274 Here we review our long-standing research program focused on Xenopus, a fro

275 hinges on reaching a consensus regarding the long-standing rifts in the field.

276 operates at a critical "tipping" point is a long standing scientific question, with evidence from bo

277 angle of a liquid on a solid substrate is a long-standing scientific problem pertinent across physic

278 l analyses performed support the presence of long-standing selective pressures acting against ADHD-as

279 es that photoenzymatic catalysis can address long-standing selectivity challenges in the radical lite

280 ains poorly understood despite extensive and long standing studies. Notwithstanding the growing evide

281 aining (multi)stereogenic centers has been a long-standing synthetic challenge in both academia and i

282 bon monoxide dehydrogenase (CODH) has been a long-standing synthetic challenge thought to be crucial

283 To resolve this long-standing synthetic challenge, we sought to characte

284 Here, we address this long-standing synthetic problem using dual electrocataly

285 aracteristics using data collected through a long-standing, systematic, hospital-based surveillance s

286 Our results confirm long-standing theoretical predictions and bring into foc

287 utational models of decision-making, we test long-standing theories of how groups influence choice.

288 e suggest that there is a need to revise the long-standing theory of proinsulin processing.

289 This result confirms the long-standing theory that masting, a population-level ph

290 results provide an approach that breaks the long-standing trade-off between low energy consumption a

291 aemic cardiac events, or from progression of long-standing underlying heart disease.

292 the film interior to the surface, resolving long-standing unresolved observations of incomplete PAH

293 the analysis of these imaging data sets is a long-standing, unsolved problem.

294 After long-standing use of endocrine therapy and targeted biol

295 Our results provide support for the long-standing view that rates of speciation and morpholo

296 However, there has been a long-standing view that the classically spliced form of

297 rus-tolerant phenotype and link these to the long-standing virus-host coevolution that may have allow

298 y activate prgQ transcription, contrary to a long-standing working model.

299 Sulfur depletion on asteroids is a long-standing, yet unresolved phenomenon that is of fund

300 stance to aminoquinolines and antifolates is long-standing, yet with greatly decreased use of chloroq