ライフサイエンスコーパス: long-term plasticity

1 y, AMPA receptors regulate genes involved in long-term plasticity.

2 es and an increase in threshold for inducing long-term plasticity.

3 nt molecular cascades for the maintenance of long-term plasticity.

4 for FMRP in synaptic growth, structure, and long-term plasticity.

5 y of transcription factors known to regulate long-term plasticity.

6 ivation of specific kinase isoforms sustains long-term plasticity.

7 ication of cellular properties that underlie long-term plasticity.

8 s identify which dopamine event is to induce long-term plasticity.

9 ding a link to alphaRIM-dependent short- and long-term plasticity.

10 l assemblies in a state favorable to enhance long-term plasticity.

11 ynthetic synapse with ionic polymer-mediated long-term plasticity.

12 d, and discuss how this activity might drive long-term plasticity.

13 tablishing a commonality with other forms of long-term plasticity.

14 zones, and altered synaptic transmission and long-term plasticity.

15 risynaptic receptors that mediate short- and long-term plasticity.

16 synaptic regulation of synaptic strength and long-term plasticity.

17 uired during the induction and expression of long-term plasticity.

18 tion, which is impossible to explain through long-term plasticity.

19 ion of Rac1 partially reverses their altered long-term plasticity.

20 active zone protein required for presynaptic long-term plasticity.

21 tsynaptic changes underlying dysfunctions in long-term plasticity.

22 motoneuronal inspiratory drive currents and long-term plasticity.

23 ll as provide an instructive signal to guide long-term plasticity.

24 VR, and suggests that MVR can be modified by long-term plasticity.

25 d, a time of known neuronal vulnerability to long-term plasticity.

26 different capacities for both short-term and long-term plasticities.

27 to be a powerful inducement to compensatory long-term plasticity, a mechanism that can explain the l

28 x controls behaviorally relevant presynaptic long-term plasticity, also observed in the mammalian bra

29 lear to what extent cerebellar networks show long-term plasticity and accompanied changes in cortical

30 frontal cortex and working memory but not of long-term plasticity and cytoarchitecture.

31 and potentiation), as well as alterations in long-term plasticity and dendritic spine stability.

32 ted by loss of Epac2 activity; however, both long-term plasticity and forskolin-mediated potentiation

33 population is critical for the formation of long-term plasticity and memory and is achieved by mecha

34 d in regulating gene expression required for long-term plasticity and memory.

35 local translation occurs at synapses during long-term plasticity and requires trans-synaptic signals

36 Dystonia was moreover associated with less long-term plasticity and slower synaptic depression.

37 philin (Spn) and Syd-1, controls presynaptic long-term plasticity and the maintenance of olfactory me

38 h their recent or remote use (short-term and long-term plasticity) and the action of extracellular me

39 rain, mediating numerous forms of short- and long-term plasticity, and having strong influences on sy

40 exhibits exquisite temperature sensitivity, long-term plasticity, and the ability to transform therm

41 have shown that even the earliest phases of long-term plasticity are accompanied by the rapid recrui

42 different forms of presynaptic PKA-dependent long-term plasticity are normal.

43 m plasticity) and developmental acclimation (long-term plasticity) are positively correlated, suggest

44 The consideration of long-term plasticity as a fixed change in amplitude corr

45 unclear whether it can be used for producing long-term plasticity as needed to modify circuit functio

46 n release probability and altered short- and long-term plasticity as present in RIM1alpha(-/-) mice r

47 This differential effect may be prodromic to long-term plasticity, as postsynaptic sensitivity is mom

48 ase pathways contribute to opposing forms of long-term plasticity at a central synapse.

49 one synapse can facilitate the induction of long-term plasticity at another synapse.

50 synaptic strength is malleable, induction of long-term plasticity at distinct inhibitory synapses and

51 support the notion that presynaptic forms of long-term plasticity at excitatory and inhibitory synaps

52 lation of spine actin cytoskeleton and gates long-term plasticity at excitatory synapses in cortical

53 hippocampus-dependent contextual memory and long-term plasticity at mossy fiber synapses.

54 ex spike pattern, and promote short-term and long-term plasticity at parallel fiber synapses in a man

55 IFICANCE STATEMENT Differences in short- and long-term plasticity at Schaffer collateral (SC) synapse

56 Here, we show that long-term plasticity at subthalamo-nigral glutamatergic

57 Bidirectional long-term plasticity at the corticostriatal synapse has

58 that Golgi cells show cell-specific forms of long-term plasticity at their excitatory synapses, that

59 These alterations involved localized long-term plasticity because increases were highly selec

60 irs synaptic vesicle priming and presynaptic long-term plasticity, but is not lethal.

61 Excitatory and inhibitory synapses show long-term plasticity, but spike timing-dependent plastic

62 es show distinct forms of activity-dependent long-term plasticity, but the underlying mechanisms rema

63 ting presynaptic Ca(2+) channels and induces long-term plasticity by decreasing cellular cAMP levels.

64 Here we show how coordinated long-term plasticity calibrates populations of excitator

65 processes in the human neocortex, and their long-term plasticity can alter the discharging cortical

66 tantly, abnormalities in both short-term and long-term plasticity can be reversed by the introduction

67 Long-term plasticity can differ from short-term in recru

68 nhibitory microcircuitry might contribute to long-term plasticity capable of sculpting direct and ind

69 play a role in the neuronal cell damage and long-term plasticity changes associated with SE.

70 y may play a role in epileptogenesis and the long-term plasticity changes associated with the develop

71 opment of symptomatic epilepsy is a model of long-term plasticity changes in the central nervous syst

72 In the cerebellum, for example, long-term plasticity contributes to eyelid conditioning

73 Cortical long-term plasticity depends on firing rate, spike timin

74 made between MLIs and Purkinje cells exhibit long term plasticity following fear conditioning.

75 esynaptic, protein kinase A (PKA)-dependent, long-term plasticity has been described in numerous brai

76 n of AMPAR synthesis, synaptic function, and long-term plasticity, important for hippocampal-dependen

77 vices demonstrate promising trends for short/long term plasticity in the order of ms/minutes, respect

78 ked if intracellular tetanization can induce long-term plasticity in auditory cortex.

79 ine both the sign and timing requirements of long-term plasticity in interneurons.

80 upled to the production of ATP, and reflects long-term plasticity in metabolic capacity.

81 Moreover, this complex mediates short- and long-term plasticity in response to bursts of action pot

82 for inhibitory GABAergic synapses to exhibit long-term plasticity in response to changes in neuronal

83 owing nicotine treatment during adolescence, long-term plasticity in response to timed presynaptic an

84 Long-term plasticity in sensory systems is usually conce

85 also show that visual sequences can lead to long-term plasticity in some circumstances.

86 protein kinase A (PKA) triggers presynaptic long-term plasticity in synapses such as cerebellar para

87 eceptor-independent LTD is the major form of long-term plasticity in the anterior cingulate cortex (A

88 This novel form of long-term plasticity in the avian auditory brainstem may

89 patial learning and synaptic integration and long-term plasticity in the distal dendrites of hippocam

90 s of PV-IN microcircuits to input gating and long-term plasticity in the fear system remain unknown.

91 y double knockout (DKO) mice showed abnormal long-term plasticity in the hippocampal CA1 region toget

92 festing in reduced synaptic transmission and long-term plasticity in the hippocampus.

93 eld, can trigger IEG expression required for long-term plasticity in the hippocampus.

94 longed darkness (light-history) may regulate long-term plasticity in the kinetics of the cone-HC path

95 sets the rules for the induction of synaptic long-term plasticity in the LHb.

96 modification of synaptic transmission during long-term plasticity in the mammalian hippocampus remain

97 modification of synaptic transmission during long-term plasticity in the mammalian hippocampus.

98 sis controls neurotransmitter release during long-term plasticity in the mature mammalian brain.

99 Nonetheless, no NA-gated mechanism of long-term plasticity in the OB has ever been directly ob

100 fects of activation of nAChRs by nicotine on long-term plasticity in the songbird zebra finch, which

101 ic active zone, is essential for presynaptic long-term plasticity in these synapses and is phosphoryl

102 nputs into the NAc, as well as for affecting long-term plasticity in this structure.

103 on) enabling a comparison between short- and long-term plasticity in traits.

104 rmore, activity- and NMDA-receptor-dependent long-term plasticity increased this resonance frequency

105 suitable for controlling the polarity of MF long-term plasticity induced by joint presynaptic and po

106 ver, much less is known about heterosynaptic long-term plasticity induced by mGluRs at inhibitory syn

107 short form]) is an important mediator of the long-term plasticity induced in brain by chronic exposur

108 Hebbian-type long-term plasticity introduces intrinsic positive feedb

109 Modification of synaptic transmission in long-term plasticity is a complex process involving many

110 Dopamine-dependent long-term plasticity is believed to be a cellular mechan

111 missed when only postsynaptic expression of long-term plasticity is considered, and suggest an exper

112 receptors (NMDARs) controls the direction of long-term plasticity is currently disputed.

113 by femtosecond laser ablation, we show that long-term plasticity is encoded as shifts in the operati

114 and whether i-LTD, similar to other forms of long-term plasticity, is important for learning and memo

115 CREB-binding protein (CBP) cause deficits in long-term plasticity, learning, and memory.

116 nase C (PKC) contribute to the expression of long-term plasticity, little is known about how constitu

117 memory by prolonging CaMKII activity during long-term plasticity (LTP) and learning but also represe

118 ely prevented the suppression of hippocampal long-term plasticity (LTP) by Abeta.

119 fiber-Purkinje cell synapse and induction of long-term plasticity (LTP) in M1, leading to transient o

120 This mechanism for long-term plasticity may be quite general: cAMP also act

121 a shift of astrocyte-mediated short-term and long-term plasticity mechanisms towards synaptic potenti

122 eased when PR is elevated by both short- and long-term plasticity mechanisms.

123 m synaptic plasticity, we adapted a model of long-term plasticity, more specifically spike-timing-dep

124 pared the role of pT286 among three forms of long-term plasticity (NMDAR-dependent LTP and LTD, and m

125 enable a direct emulation of both short- and long-term plasticity of biological synapses, representin

126 eurons in the somatosensory cortex triggered long-term plasticity of circuits (LTPc), resulting in th

127 d goal-directed actions, and can also modify long-term plasticity of corticostriatal synapses.

128 rnus (GPi) neuronal activity, and short- and long-term plasticity of direct pathway projections.

129 pendent asymmetry, as well as for short- and long-term plasticity of electrical synapses.

130 lts reveal a new form of activity-dependent, long-term plasticity of endocannabinoid signaling at per

131 This activity-dependent, long-term plasticity of endocannabinoid signaling was sp

132 mmunity and have recently been implicated in long-term plasticity of excitatory synaptic transmission

133 l a critical role of eCBs in controlling the long-term plasticity of glutamate synapses in VTA DA neu

134 However, their role in modulating the long-term plasticity of glutamate synapses of VTA dopami

135 GABAergic inhibition of principal cells and long-term plasticity of glutamateric recruitment of inhi

136 duction of epileptiform activity, but shifts long-term plasticity of hippocampal synapses in favor of

137 Therefore, we studied long-term plasticity of inhibitory inputs to TC cells in

138 ty with sensory-evoked CF inputs can trigger long-term plasticity of inhibitory responses in PCs.

139 Long-term plasticity of motor output and synaptic streng

140 Coordinated long-term plasticity of nearby excitatory synaptic input

141 receptor activation elicits a bidirectional long-term plasticity of NMDA receptor-mediated synaptic

142 small RNAs and present a role for miR-124 in long-term plasticity of synapses in the mature nervous s

143 and signaling molecules and thereby support long-term plasticity of synaptic contacts.

144 ellum, where they are involved in short- and long-term plasticity of synaptic responses.

145 U stimulation has a potential for recovering long-term plasticity of thalamocortical synapses in the

146 ng a selective transition from short-term to long-term plasticity of the biological synapse is presen

147 We demonstrated that such [Mg2+]i-dependent long-term plasticity of the electrical synapse can be ad

148 However, long-term plasticity of the VLE connections and how the

149 on dopamine-dependent shaping of prefrontal long-term plasticity often appear inconsistent and, alto

150 arning and changes in hippocampal short- and long-term plasticity (paired-pulse depression, synaptic

151 e introduce a theoretical framework in which long-term plasticity performs an optimization of the pos

152 nstrate that Satb2 is critically involved in long-term plasticity processes in the adult forebrain th

153 ns with distinct morphologies and short- and long-term plasticities project to these diverse targets.

154 ular interest, mechanisms of both short- and long-term plasticity remain autonomous at these divergen

155 olecular and cellular events associated with long-term plasticity remain hampered in Drosophila by th

156 Long-term plasticity requires new transcription, indicat

157 ed whether these synapses show mechanisms of long-term plasticity similar to those found at principal

158 s a major regulator of synaptic strength and long-term plasticity, suggesting that O-GlcNAcylation of

159 Here we describe a form of long-term plasticity that regulates the spontaneous firi

160 We investigate dopaminergic modulation of long-term plasticity through a multicompartment Hodgkin-

161 Long-term plasticity typically relies on postsynaptic NM

162 at Schaffer-collateral excitatory terminals, long-term plasticity under various recording conditions

163 anges in synaptic strength may contribute to long-term plasticity underlying classical conditioning.

164 c strength are well established as mediating long-term plasticity underlying learning and memory, but

165 Synapse-specific long-term plasticity underlying memory involves the targ

166 decline of short-term adaptation and rise of long-term plasticity up the visual processing hierarchy.

167 etween GluN2B and alphaCaMKII have a role in long-term plasticity via the control of ERK1/2 signaling

168 dying regulation of Arc, a gene required for long-term plasticity, we uncovered a new role for AMPA r

169 Key features of biological synapses, such as long-term plasticity with heterogeneity, including long-

170 ing of optogenetically evoked EPSCs revealed long-term plasticity with opposite outcomes at the pInsC

171 ve degeneration pathways, thereby permitting long-term plasticity without risking neurodegeneration.