ライフサイエンスコーパス: low-affinity

1 e obtained from the parent chelator that has low affinity.

2 ly (U) or d(T) while d(A) polymers bind with low affinity.

3 m a non-ciliary localizing protein (Src) has low affinity.

4 x3) indeed binds to monomeric ubiquitin with low affinity.

5 a nutraceutical, binds SHBG with relatively low affinity.

6 t determines which site has high, medium, or low affinity.

7 hen allergen-specific IgE was absent or only low-affinity.

8 ep binding events, one high-affinity and one low-affinity.

9 ith a high degree of predisposition but with low affinities.

10 While C1q binds to a single Fc with low affinity, a higher avidity stable binding of two or

11 s in EBd-treated patients homozygous for the low-affinity allele.

12 In this study, we humanized three parent low affinity allergic response inhibitor (LARI) mouse an

13 ive contacts in the transition states of the low-affinity ancestral and high-affinity human NCBD/CID

14 nd fast activation, and cis Pro300 SthK with low affinity and slow activation.

15 complexes is complicated by their typically low affinity and variable binding of the SIMs in paralle

16 rketamine blocks NMDA receptor currents with low affinity and weak voltage dependence and is effectiv

17 /lpr mouse, binds autologous IgG2a(a/j) with low affinity, and as a result, AM14 B cells only prolife

18 However, the side effects, low affinity, and poor efficacy of RSK modulators limit

19 bound IgE of the allergic effector cells via low-affinity anti-human IgE Abs with dissociation consta

20 We previously found that mouse low-affinity anti-human IgE mAbs with K(D) in the 10(-6)

21 strate that targeting surface-bound IgE with low-affinity anti-IgE Abs is capable of suppressing alle

22 We demonstrated that these low-affinity anti-IgE mAbs bind to the cell surface-boun

23 llent safety profile, indicating that use of low-affinity anti-IgE mAbs holds promise as a novel ther

24 Instead, the low-affinity anti-IgE mAbs profoundly block human peanut

25 ability of allergic reaction blockade by the low-affinity anti-IgE mAbs was correlated with their cap

26 nker, auristatin as payload at DAR = 4 and a low affinity antibody with effector-reduced Fc.

27 that were antigen independent or induced by low-affinity antigen but not those initiated by high-aff

28 ic cells are soft and promote acquisition of low-affinity antigens through low forces.

29 energies, which predict high-affinity Na(+)-low-affinity aspartate binding, and the experimental res

30 tine lacked agonist activity and displayed a low affinity at both receptors, trans-5'-methylnicotine

31 surface glycans function as initial, usually low-affinity attachment factors, providing a first ancho

32 ns lead us to propose that high-specificity, low-affinity attachment of MERS-CoV to sialoglycans duri

33 that acts as rheostat for the maturation of low-affinity autoreactive cells.

34 cell interactions and efficient selection of low-affinity B cell clones for proliferative clonal expa

35 In aggregate, low-affinity/background sites also contribute to competi

36 cilitate recruitment of naive B cells with a low-affinity BCR into GCs to initiate the process of aff

37 e different, with the former expressing even low-affinity BCRs efficiently capture and present suffic

38 B cells expressing very-low-affinity BCRs formed GCs but were unable to efficien

39 rom high affinity beta2-containing nAChRs to low affinity beta4-containing nAChRs, in addition to the

40 ed deposition rates confirmed the relatively low affinity between plastic surfaces and aluminum-based

41 akly quenched by the same surface due to the low affinity between the GO-coated surface and the relat

42 omplex (PLBs-bacteria) and GOMs and (ii) the low affinity between the same complex and GOMs.

43 allows the determination of binding modes of low affinity binders in the protein-ligand interface and

44 ification of all subjects in high, mixed and low affinity binders.

45 ABs), 3 mixed-affinity binders (MABs), and 3 low-affinity binders (LABs)-were studied with whole-body

46 nding, while no change could be detected for low-affinity binders.

47 ve a value that allows interactions with the low affinity binding site.

48 r between a QD and a molecular probe to even low-affinity binding events at the QD/solvent interface.

49 e substrate, whereas MDDMA and MDTMA adopt a low-affinity binding mode consistent with an inhibitor,

50 ional selection mechanism contrasts with the low-affinity binding mode of 53BP1, and it ensures 53BP1

51 The number of low-affinity binding motifs is significantly depressed i

52 a concentration-driven interaction with the low-affinity binding partner DAB2, finding that this int

53 was associated with loss of hydration water, low-affinity binding released more hydration water.

54 receptor (c-MPL) via steric occlusion of the low-affinity binding site, contributing to perturbation

55 modeled outward-open cleft contribute to one low-affinity binding site, whereas arginine 440 located

56 bind approximately 1.6 thrombin molecules at low-affinity binding sites (Kd = 2.8 muM) and approximat

57 vival oncogene MITF as a model, we show that low-affinity binding sites act as a competitive reservoi

58 cription factor Ultrabithorax (Ubx) utilizes low-affinity binding sites in the Drosophila melanogaste

59 r Irf4 abundance with its recruitment toward low-affinity binding sites within Teff cell cis-regulato

60 nd binding to GPCRs have revealed transient, low-affinity binding sites, termed metastable binding si

61 sion of DBP1 may have been selected to allow low-affinity binding to another receptor on Duffy-null e

62 Domain 4 exhibited low-affinity binding to LRP6 in in vitro binding assays,

63 t the RNA-binding surface allow for high- or low-affinity binding with functional implications.

64 tions to hydration release in both high- and low-affinity binding.

65 t some maintain an additional basal level of low affinity, broad reactivity to diverse epitopes, a ph

66 Low-affinity but highly specific protein-protein interac

67 We therefore expressed a low affinity Ca(2+) indicator (ER-GCaMP6-150) in the ER,

68 eloped novel genetically encoded ER-targeted low-affinity Ca(2+) indicators optimized for examining a

69 Syt1 is a fast-acting, low-affinity Ca(2+) sensor that penetrates membranes upo

70 ty Ca(2+)/Mg(2+) mixed binding sites and two low-affinity Ca(2+)-specific sites.

71 C-terminal acidic region containing multiple low-affinity calcium binding sites.

72 the ciliary transport regulator Arl3, while low-affinity cargo is released by Arl3 and its non-cilia

73 and low-affinity TDBs revealed that only the low-affinity CD3/CLL1 TDB was well tolerated and able to

74 n is orchestrated in lymphoid tissue and how low-affinity cells contribute to host protection remains

75 ators IL-10, TIGIT, GITR, and CTLA4, whereas low-affinity cells displayed increased transcripts for A

76 lective transporter, while NPF6.6 had only a low-affinity chloride transport activity.

77 Although the N-terminal low-affinity CNB domain (CNB-A) was dispensable for the

78 e versus nonspecific as well as high- versus low-affinity cognate DNA binding.

79 iad of residues that respond specifically to low-affinity cognate DNA.

80 murine ETS1 alone and when bound to high-and low-affinity cognate sites or to nonspecific DNA.

81 mpetitors, particularly rapidly dissociating low-affinity competitors.

82 high-affinity and nonspecific complexes, the low-affinity complex represents a unique conformational

83 sically disordered proteins may evolve via a low-affinity complex which is optimized by modulating di

84 h procyanidin B3 and trimer C2 had a similar low-affinity constant at 310 K, both procyanidins were a

85 The low-affinity CopA is suggested to export excess Cu and t

86 trates can suppress phosphorylation of their low affinity counterparts.

87 llowed us to propose that D8 has a high- and low-affinity CS-binding region within its central crevic

88 small tumor burdens was achieved by high- or low-affinity CTL.

89 in, Ctr2, has been proposed to function as a low-affinity Cu transporter, a lysosomal Cu exporter, or

90 differentially expressed genes had multiple, low-affinity CUX1 binding sites, features of analog gene

91 For low-affinity decoys, noise in the level of unbound TF al

92 ites while confronted with a large excess of low-affinity degenerate motifs.

93 li3 and Hand2 uncovered mandibular-specific, low-affinity, 'divergent' Gli-binding motifs (dGBMs).

94 ng residue (Gln-336) specifically recognizes low-affinity DNA and triggers the loss of a distal salt

95 aging of the same targets is performed using low-affinity DNA imaging probes to resolve nanometer-sca

96 Functional evidence increasingly implicates low-affinity DNA recognition by transcription factors as

97 Transcription factors bind low-affinity DNA sequences for only short durations.

98 owever fibrin reversibly binds thrombin with low affinity E-domain sites (KD = 2.8 muM) and high affi

99 After activation, low-affinity effector CD8(+) T cells accumulated at effe

100 The early release of low-affinity effector T cells led to rapid target cell e

101 AREG is a low affinity EGFR ligand, which is upregulated following

102 etermine in vivo the role of amphiregulin, a low-affinity EGFR ligand that is highly upregulated with

103 nals of other moderately injury-upregulated, low-affinity EGFR ligands (epiregulin, epigen, TGFalpha)

104 and revealed the importance of both high and low affinity epitopes for allergic responses.

105 The low-affinity Fcgamma receptors, expressed on immune cell

106 The human-to-mouse low-affinity FcgammaR locus swap engendered hFcgammaRIIA

107 Low-affinity FcgammaR locus-switched mice represent an u

108 f these cells were reduced in PBMCs with the low-affinity FcgammaRIIIa-158F genotype.

109 6(+) macrophages in PMBCs that expressed the low-affinity FcgammaRIIIa.

110 n human PBMCs, especially PBMCs that express low-affinity FcgammaRIIIa.

111 However, polymorphisms in low affinity FcgammaRs have been associated with altered

112 Cells expressing the low-affinity FcgammaRs (FcgammaRII or CD32 and FcgammaRI

113 fingerprinting using a dynamically binding, low-affinity fluorescent antibody fragment differentiate

114 gen-elicited memory T cells can have high or low affinity for cross-reactive allogeneic peptide-MHC,

115 ategies face multiple challenges in terms of low affinity for detection and labelling requirements th

116 ain after systemic drug injections and shows low affinity for DREADDs.

117 affinity for the neurotransmitter ACh and a low affinity for its metabolic product choline.

118 ATPase activity, and nucleotide-independent low affinity for microtubules.

119 inding sites of a protein receptor have only low affinity for monovalent ligands.

120 ikely evade negative selection, due to their low affinity for self-ligands, in the abundance of "publ

121 mice such that thymocytes bearing TCRs with low affinity for self-peptide are not efficiently select

122 alf of the EWS portion of the fusion) showed low affinity for smaller GGAA-microsatellites but instea

123 in these cases suggests that this ligand has low affinity for tau lesions primarily made of straight

124 und the viral capsid, despite an anomalously low affinity for the capsid protein (CA).

125 We also find that galectin-3 has low affinity for the surface layer of osteoarthritic car

126 ne transport protein that has both high- and low-affinity functions.

127 ealed a significant population of relatively low-affinity gamma2 subunit-containing GABAA receptors i

128 tifs blocks it, as does transforming them to low-affinity GCUUG motifs.

129 HxtB was confirmed to be a low affinity glucose transporter, localizing to the plas

130 present together with high affinity ligands, low affinity GSL ligands can contribute significantly to

131 With low-affinity haemoglobin, which predicts low haemoglobin

132 ding restraints of this CC MBS.LZ PKG-Ialpha low-affinity heterotetrameric complex and allow reevalua

133 can engage the human FcgammaRII class of the low-affinity hFcgammaRs, demonstrating that N-linked gly

134 ession of the GS1 isogene Gln-1;2 encoding a low-affinity high-capacity GS1 protein in Arabidopsis (A

135 This high frequency of high- and low-affinity HIP2.5 T cells in the islets potentially re

136 dissociating, e.g., k (off) = 10 minute(-1) low-affinity "hits" through to slowly dissociating e.g.,

137 ly composed of alpha4 and beta2 subunits and low-affinity homomeric nAChRs composed of alpha7 subunit

138 easurements, we find that SdrC is engaged in low-affinity homophilic bonds that promote cell-cell adh

139 h-affinity mature IgA antibodies and whether low-affinity IgA produced by innate-like B cells might a

140 are required for production of high- but not low-affinity IgE and subsequent allergen-induced anaphyl

141 mpaired generation of B cells expressing the low-affinity IgE receptor CD23, which mediates the clear

142 CD23, the low-affinity IgE receptor found on B lymphocytes and oth

143 FcepsilonRI) on mast cells and basophils and low-affinity IgE receptors (FcepsilonRII) on B cells.

144 tion of IgE interactions with both high- and low-affinity IgE receptors, and explains why omalizumab

145 FcepsilonRII is a multifunctional low-affinity IgER that is involved in the pathogenesis o

146 ased production and activation of both CD32 (low affinity IgG receptor) and alphaMss2 integrin.

147 The inhibitory low-affinity IgG Fc-receptor FcgammaRIIB is co-expressed

148 oped a novel mouse strain in which the human low-affinity IgG receptor locus, comprising both activat

149 Intestinal eosinophils expressed low-affinity IgG receptors, and the activating receptor

150 rin in the binding trans configuration and a low affinity in their cis form.

151 we describe mutants with enhanced binding to low-affinity inhibitory human Fcgamma and glycan recepto

152 1d, suggesting different roles for high- and low-affinity iNKT clones in immune regulation.

153 IL-13 cytokine secretion among Ag-stimulated low-affinity iNKT clones.

154 el of IgAN, compared with high-affinity IgA, low-affinity innate-like IgA, formed in the absence of n

155 e-guided mutation allows the generation of a low-affinity INPP5E mutant which loses exclusive ciliary

156 insufficient to induce deletion of high- or low-affinity InsB9-23-reactive CD4(+) T cells; however,

157 We provide evidence of a low affinity interaction with CAR, with modelling sugges

158 and PNKP together and thereby promoting the low-affinity interaction identified here, which then sti

159 Low-affinity interaction of tropomyosin with actin has t

160 The low-affinity interaction site required the highly conser

161 d in an ancestral deuterostome organism as a low-affinity interaction that subsequently evolved into

162 ectin binding to a single glycan ligand is a low-affinity interaction, but the multivalency of galect

163 Gaussia luciferase enzyme robustly detected low affinity interactions and reduced the amount of prot

164 e optimal balance between resolving specific low-affinity interactions and minimizing background or s

165 has the advantages that it is applicable to low-affinity interactions because the complexes are not

166 ocess may, in part, involve enabling crucial low-affinity interactions between Orai1 N-terminus and S

167 It is not clear how brief, low-affinity interactions can drive efficient transcript

168 SCAR with a collagen fibril, with transient, low-affinity interactions initiated by the membrane-dist

169 Profilin and cofilin display transient, low-affinity interactions with phosphoinositide-rich mem

170 hought to modulate neuronal function through low-affinity interactions with proteins, in particular w

171 lly actuated organelles based on multivalent low-affinity interactions.

172 nges that improve reader domain detection of low-affinity interactions.

173 Low-affinity intercellular adhesion may play a role in f

174 riggers heme release from Hb via a flexible, low-affinity interface that forms fleetingly in solution

175 The low affinity leukotriene receptor BLT2 is a receptor inv

176 4 also fully blocked D8 binding to CS-A, the low affinity ligand for D8.

177 ligands directly inhibited signaling by the low affinity ligands BMP-2, BMP-7, and BMP-9.

178 nanodiscs suggest that the participation of low affinity ligands in heteromultivalent binding with G

179 olar side chain of T153 creates a barrier to low-affinity ligands that interact with E149 and A150.

180 cell antigen receptor signaling response to low-affinity ligands.

181 e to peptide recognition, yet the pEF hand's low affinity limits Ca(2+) binding at normal physiologic

182 experiments point to selection of relatively low-affinity MBCs as a mechanism to promote diversity.

183 odes, whereas MDTMA exclusively binds to the low-affinity mode.

184 y useful for the systematic investigation of low affinity molecules with residence times in the micro

185 low copy number can reduce the abundance of low-affinity monoclonal antibody (mAb) epitopes while re

186 We find that pMad/Medea bind at an atypical, low affinity motif in the FMRFa enhancer.

187 achieved through a high-affinity motif and a low-affinity motif within myosin VI.

188 phatidylserine, and phosphatidylcholine, two low-affinity MPP(+) binding sites and one high-affinity

189 of choline acetyltransferase (ChAT) and the low-affinity neurotrophin receptor, p75(NTR) .

190 nistration in rats by the recruitment of the low-affinity neurotrophin receptor, p75NTR, whose activi

191 By contrast, maize NPF6.4 was a low-affinity nitrate transporter with efflux activity.

192 The uncompetitive low-affinity NMDA receptor antagonist, memantine, acutel

193 ertoires of high affinity pathogenic IgE and low affinity non-pathogenic IgE.

194 itination by WWP1 requires the presence of a low-affinity, noncovalent Ub-binding site within the HEC

195 inity (specific analyte) and high-abundance, low-affinity (nonspecific background) binding by measuri

196 ial interactions of the first site result in low-affinity, nonspecific binding; rate-limiting engagem

197 The low affinity observed for GCRho monomers is unusual for

198 ility of glycans in their purified form, the low affinities of GBP-glycan interactions, and limitatio

199 Relatively low affinities of the peptides and poor correlations bet

200 Low affinity of IL-10Rbeta for cytokines has impeded eff

201 s a decline in cellular [ATP]; the unusually low affinity of IP6Ks for ATP compels 5-InsP7 levels to

202 anisotropy of the complex, combined with the low affinity of these interactions, have limited atomic-

203 esistance in B. bacteriovorus depends on the low affinity of this compound for the B. bacteriovorus d

204 ed by ADP-ribose or nicotinamide, indicating low affinity of TNT for these reaction products.

205 which should selectively reduce activity at low-affinity off-target sites.

206 high-affinity event and, in addition to the low-affinity one.

207 ed by IL-2, thereby restricting responses to low-affinity or low-abundance self-antigens even in the

208 osition suggests that substrate binding is a low-affinity, ordered process.

209 We inserted high- and low-affinity OT-I epitopes into IAV and infected mice af

210 gnification was largely sustained by 4CL5, a low-affinity paralog of 4CL1 typically with only minor x

211 assemblies, including those with challenging low-affinity partners, and may facilitate the design of

212 A low affinity peptide ligand behaved, regardless of ligan

213 groove of MHC I, resulting in the release of low-affinity peptide.

214 able in geometry for strong binders than for low-affinity peptides.

215 sPHT2;1 functions as a chloroplast-localized low-affinity Pi transporter that mediates UV tolerance a

216 the chloroplast envelope and functioned as a low-affinity Pi transporter.

217 from the soil, plants have evolved high- and low-affinity Pi transporters and the ability to induce r

218 of the enzyme and Cys303 providing a second, low affinity pigment binding site that is essential for

219 etation of a common BMP signal, conferred by low affinity pMad/Medea binding motifs, can contribute t

220 tic stages comprising two distinct high- and low-affinity populations that differed in affinity by 10

221 Mechanistically, low affinity-primed memory CD8(+) T cells produced more

222 novel mechanism by which CD45 isoforms tune low affinity-primed memory CD8(+) T cells to become pote

223 CD45RB blockade prolonged graft survival in low affinity-primed mice, but not in high affinity-prime

224 n and timing of effector differentiation, as low affinity-primed T cells acquired cytotoxic activity

225 In contrast to high-affinity priming, low-affinity priming elicited fully differentiated memor

226 ng that despite a lower precursor frequency, low-affinity priming is sufficient to generate memory ce

227 Little is known about the effect of low-affinity priming on memory cell generation and funct

228 due specificity, GECX enables the capture of low-affinity protein binding (affibody with Z protein),

229 , a P2ATP-D2ADP species accumulates when the low-affinity proximal sites bind ATP and enable rapid AT

230 Previous work identified a low-affinity Rap1-binding site in the talin-1 F0 domain

231 of its sensitivity and they frequently miss low affinity reader domain interactions.

232 These results reveal LYVE-1 as a low affinity receptor tuned to discriminate between diff

233 ied: the high-affinity receptor BLT1 and the low-affinity receptor BLT2.

234 n mice by targeting CD23 (FcepsilonRII), the low-affinity receptor for IgE on B cells.

235 Increasing evidence suggests that the low-affinity receptor for IgE, CD23, plays an important

236 The low-affinity receptor for IgE, FcepsilonRII (CD23), cont

237 CD23/FcepsilonRII, the low-affinity receptor for IgE, is constitutively express

238 that Mcm10 recruitment occurs via two modes: low affinity recruitment in the absence of CMG assembly

239 rred as strong and weak sites (with high and low affinity, respectively).

240 the binding strength of high-, medium-, and low-affinity RGD-binders.

241 ns led to cooperativity in virus swarms with low-affinity S minority variants sustaining propagation

242 specific binding of a second RR dimer to the low-affinity secondary binding site.

243 tein, has evolved a changed preference for a low-affinity, secondary binding motif.

244 d the structures of representative high- and low-affinity SF3b1 ULM complexes with the Tat-SF1 UHM at

245 high affinity site (3.2 +/- 0.3 uM) and one low affinity site (209 +/- 25 uM).

246 rrent consensus model has Q8H2 oxidized at a low affinity site (QL), passing electrons to a tightly b

247 The ligands bind to a low-affinity site, resulting in altered modulation of P-

248 ft is critical for MPP(+) binding to another low-affinity site.

249 ify the Fe partitioning between the high and low affinity sites as a function of the oxidation state

250 complexes, and that the presence of high and low affinity sites may influence the rate of isotopic ex

251 ding with MPP(+) transport suggests that the low-affinity sites are involved in MPP(+) transport, whe

252 ng to a high-affinity binding site and three low-affinity sites on Tau, accompanied by a change in Ta

253 actor and cofactor concentrations could help low-affinity sites overcome their kinetic inefficiency.

254 Why are the low-affinity sites retained?

255 pha(IIb)beta(3) receptor, converting it to a low affinity state for adhesion and aggregation processe

256 ubsequent conversion of CD11c from a high to low affinity state under fluid shear activated phospho-S

257 The low-affinity state requires Lis1 to also bind to dynein

258 sport mode of YfkE from a high-affinity to a low-affinity state.

259 difference in affinity between the high- and low-affinity states is more compressed in alpha4beta1 (6

260 ic, state-dependent SLC13A5 inhibitors, with low-affinity substrate activity in the absence of citrat

261 ve inhibitor bisindolylmaleimide I displaces low affinity substrates more potently leading to substra

262 substrates and suppressing ubiquitylation of low-affinity substrates.

263 y T cells and XCR1(+) DCs or Tfh cell-prone, low-affinity T cells and SIRPa(+) DCs postinfection with

264 entire CD4+ T-cell repertoire, inclusive of low-affinity T cells missed by tetramers, using a T-cell

265 ors, Eef1e1 and Gbp2, to a higher level than low-affinity T cells.

266 Inherent intermediate- to low-affinity T-cell receptors (TCR) that develop during

267 Infusion of low-affinity T-state PolyhHb led to increased tissue oxy

268 on FcRn binding affinity that increased from low affinity (t1/2 29h), to wild type (t1/2 50h), to hig

269 a general mechanism to facilitate binding to low-affinity targets and that this may be a prevalent fe

270 CTL expressing low-affinity TCR may be effective against lymphoma, and

271 We found that low-affinity TCRs biased mouse naive T cells to become T

272 nder conditions of chronic antigen exposure, low-affinity TCRs preferentially expanded within the TCR

273 y and target cell depletion by the high- and low-affinity TDBs revealed that only the low-affinity CD

274 The low-affinity, tetramer-negative, dodecamer-positive T ce

275 eversibly bind their target can overcome the low affinity that limits reversible fragment screening,

276 strates that thrombin initially binds to the low-affinity thrombin binding sites before preferentiall

277 of two forms of TK with high- (TK(high)) and low-affinity (TK(low)).

278 stions into how organisms might exploit such low affinities to connect their signaling components.

279 th specific partners evolves from an initial low affinity to a higher affinity.

280 ctions that were previously too transient or low affinity to be identified.

281 )-gp130 heterodimer and binds with only very low affinity to mLIFR.

282 GSB were resistant to oxygen and showed a low affinity to sulfide.

283 that the PDZ domain of nNOS binds with very low affinity to the C termini of target proteins, and a

284 ntagonists for CCR1 and CCR3, also bind with low affinity to the closely related receptors CCR2 and C

285 SDA uses two DNA strands that have low affinity to the dapoxyl dye unless hybridized to abu

286 itial fragment hits, which usually bind with low affinity to their target.

287 force accelerates transition from the bent (low affinity) to the extended (high affinity) state.

288 All investigated compounds had low affinity toward P-glycoprotein (P-gp, ABCB1).

289 Considering that Hsp104 is characterized by low affinity towards ATP and is strongly inhibited by ad

290 tro-formed nucleosomes containing a high- or low-affinity TP53 TFBS located at differing translationa

291 ond, discrete and previously uncharacterised low-affinity TPP binding-site was also observed, and hen

292 ptake by plant cells requires both high- and low-affinity transport activities.

293 potentially nonredundant roles for high- and low-affinity Tregs in controlling autoimmunity.

294 We observed that high- and low-affinity Tregs were recruited to the pancreas and co

295 ation for how the activin class accommodates low-affinity type I interactions without the requirement

296 owed in Drosophila melanogaster embryos that low-affinity Ultrabithorax (Ubx)-responsive shavenbaby (

297 er than naive B cells that typically express low-affinity unmutated antibodies.

298 put, with increased oxygen extraction (31.1% low affinity vs. 21.7% normal).

299 Unlike CDC42, an extremely low affinity was determined for the RAC1-GRD interaction

300 the 6-arylpicolinates (halauxifen), and very low affinity was found for picolinic acid-based auxins (