ライフサイエンスコーパス: lung water

1 ravenous beta-agonists reduces extravascular lung water.

2 roton density quantified to give an index of lung water.

3 permeability and contralateral extravascular lung water.

4 d and by direct measurement of extravascular lung water.

5 3/group) were used to assess lesion size and lung water.

6 166 mL increase in nonindexed extravascular lung water.

7 to record the value of indexed extravascular lung water.

8 monary blood volume index, and extravascular lung water.

9 be assessed by measurement of extravascular lung water.

10 ular lung water, and predicted extravascular lung water.

11 94) was larger than for actual extravascular lung water (0.72; confidence interval, 0.53-0.91), this

12 under the curve for predicted extravascular lung water (0.8; confidence interval, 0.65-0.94) was lar

13 ydrochloric acid showed higher extravascular lung water (1,424 +/- 419 vs. 574 +/- 195 ml; P < 0.001)

14 re was also a significant decrease in excess lung water, a measure of pulmonary edema (145 +/- 50 vs

15 .10 for sCR1; 3.59+/-0.08 for sCR1+HB), less lung water accumulation (5.46+/-0.28% for unmodified; 2.

16 to 3 ml/kg significantly reduced the rate of lung water accumulation from 690 microl/h to 310 microl/

17 s indicated a more than twofold reduction in lung water accumulation in AQP1 (-/-) vs. (+/+) mice in

18 lower wet-to-dry lung weight ratios and less lung water accumulation in the KGF group.

19 irectly attenuate pulmonary vascular leak or lung water accumulation.

20 emodynamics, blood gases, cardiac output, or lung water accumulation.

21 ssion model, the ratio between extravascular lung water and end-expiratory lung volume was significan

22 a and has been shown to reduce extravascular lung water and improve lung function in mouse, rat, and

23 Recruitment maneuvers reduced extravascular lung water and lung endothelial injury as measured by pr

24 Extravascular lung water and other markers of lung injury were measure

25 rmine the relationship between extravascular lung water and other markers of lung injury, and to exam

26 stress syndrome (ARDS) reduced extravascular lung water and plateau airway pressure.

27 Regional lung water and pulmonary blood flow were assessed by pos

28 At necropsy, lung water and surfactant function (Wilhelmy balance) we

29 R-/- and beta1AR+/+/beta2AR-/- mice had more lung water and worse survival from this form of acute lu

30 elial permeability to protein, extravascular lung water, and airway tone.

31 tio, oxygenation index, actual extravascular lung water, and predicted extravascular lung water.

32 with hypertonic saline and mannitol on total lung water, as well as on cerebral edema.

33 id more slowly than control littermates, but lung water at 12 h (wet/dry = 5.5) was nearly normal (we

34 the salbutamol group had significantly lower lung water at Day 7 than the placebo group (9.2 +/- 6 vs

35 regression analysis, predicted extravascular lung water but not actual extravascular lung water was a

36 We measured the regional distribution of lung water concentration (LWC) and PBF with PET in 9 pat

37 Measurements of regional PBF and lung water concentration (LWC) using positron emission t

38 to measure fractional pulmonary blood flow, lung water concentration (LWC), and the pulmonary transc

39 dose of OA, developed a similar increase in lung water concentration as the group given OA alone, bu

40 rterial blood pressure, hypoxemia, increased lung water concentration, and an altered intrapulmonary

41 olus injection of E. coli endotoxin elevated lung water content (33% +/- 5%; p < .01 vs. sham control

42 ttenuation of stroke-associated increases in lung water content (r=-.647) CONCLUSIONS: Bowel, lung, a

43 ed magnetic resonance imaging to investigate lung water content and distribution in 16 preterm (24-31

44 Lung water content and distribution were compared betwee

45 congestion with cardiac filling pressures or lung water content has shown most impact to decrease hos

46 nary transvascular protein permeability, and lung water content in response to LPS.

47 Total lung water content in these animals was not different fr

48 animal model of large ischemic stroke, total lung water content increases, which is likely neurogenic

49 We conclude that lung water content is higher in preterm than in term inf

50 Lung water content was increased significantly in rats s

51 ous bolus followed by a continuous infusion, lung water content was significantly reduced with hypert

52 Stroke-associated increases in lung water content were attenuated with 7.5% hypertonic

53 d prefemoral lymph flow and protein content, lung water content, abdominal and thoracic fluid and pro

54 360 +/- 23 mOsm/L) significantly attenuated lung water content.

55 The change in extravascular lung water correlated to baseline cardiac index (r = 0.1

56 tern consistent with increased extravascular lung water (diffuse, bilateral, symmetrical, homogeneous

57 ctual body weight for indexing extravascular lung water does not lead to independence of height, weig

58 In addition, the increase in extravascular lung water during VILI development contributed to the ob

59 tly every 6 hours, we recorded extravascular lung water, end-expiratory lung volume, lung strain, res

60 ed lung injury in terms of the extravascular lung water (EVLW) content, filtration coefficient (Kfc),

61 Measurements of extravascular lung water (EVLW) correlate to the degree of pulmonary e

62 hat it could be improved using extravascular lung water (EVLWi) and plasma biomarkers of acute lung i

63 nificantly the accumulation of extravascular lung water evoked by 6-hour exposure to endotoxin.

64 proves the predictive value of extravascular lung water for survival and correlation with markers of

65 ctive apneas (OAs) in humans, but no data on lung water, gas exchange, filling pressure, or cardiac o

66 r in patients with a change in extravascular lung water >/= 10% than in patients with a change in ext

67 A change in extravascular lung water >/= 10% was predicted by baseline cardiac ind

68 redictive values for change in extravascular lung water >/= 10% were evaluated.

69 d to prediction of a change in extravascular lung water >/= 10%, independent of the presence of sepsi

70 and patients with a change in extravascular lung water >/= 10%.

71 Traditionally, extravascular lung water has been indexed to actual body weight (mL/kg

72 undance that may contribute to regulation of lung water homeostasis.

73 f aqueous humor and cerebrospinal fluid, and lung water homeostasis.

74 in-induced lung injury reduced extravascular lung water, improved lung endothelial barrier permeabili

75 ng, or for the accumulation of extravascular lung water in the injured lung.

76 required for the physiological clearance of lung water in the neonatal or adult lung, or for the acc

77 volume group, as was decreased extravascular lung water in the uninstilled lung in the low tidal volu

78 Extravascular lung water increase during fluid loading in the critical

79 Extravascular lung water increased in 17 of 22 liberally resuscitated

80 Extravascular lung water increased to only 180 +/- 30 microL with salm

81 Extravascular lung water increased with positive perioperative fluid b

82 uced acute lung injury with increased excess lung water, increased lung vascular and lung epithelial

83 chemic stroke, we tested the hypotheses that lung water increases following cerebral ischemia and det

84 tients with a maximum value of extravascular lung water index >21 mL/kg and 43% in the remaining pati

85 A maximum value of extravascular lung water index >21 mL/kg predicted day-28 mortality wi

86 rome episode (maximum value of extravascular lung water index and maximum value of pulmonary vascular

87 [t-test] for maximum value of extravascular lung water index and median [interquartile range]: 4.4 [

88 associated with an increase in extravascular lung water index and pulmonary vascular permeability ind

89 The maximum values of extravascular lung water index and pulmonary vascular permeability ind

90 Extravascular lung water index and pulmonary vascular permeability ind

91 Extravascular lung water index and pulmonary vascular permeability ind

92 We tested whether extravascular lung water index and pulmonary vascular permeability ind

93 There was no difference in extravascular lung water index between those who progressed to acute l

94 An extravascular lung water index cutoff value on day 1 of 10 mL/kg had a

95 Extravascular lung water index had a moderate sensitivity of 65% and s

96 Elevated extravascular lung water index is a feature of early acute lung injury

97 The mean extravascular lung water index on day 1 for patients who progressed to

98 ate analyses, maximum value of extravascular lung water index or maximum value of pulmonary vascular

99 Furthermore, extravascular lung water index predicts progression to acute lung inju

100 Global end-diastolic index, extravascular lung water index, and stroke volume index were also over

101 x, global end-diastolic index, extravascular lung water index, and stroke volume index, especially wh

102 Extravascular lung water index, dead space fraction, PaO2/FIO2, and ot

103 tested whether the changes in extravascular lung water indexed for ideal body weight could detect we

104 An increase in extravascular lung water indexed for ideal body weight greater than or

105 g spontaneous breathing trial, extravascular lung water indexed for ideal body weight increased only

106 e 0.89 (95% CI, 0.78-0.99) for extravascular lung water indexed for ideal body weight, 0.97 (0.93-1.0

107 artery occlusion pressure, the extravascular lung water indexed for ideal body weight, plasma B-type

108 ing trial-induced increases in extravascular lung water indexed for ideal body weight, plasma protein

109 Associations between extravascular lung water indexed to predicted body weight and pulmonar

110 tients, 132 patients (88%) had extravascular lung water indexed to predicted body weight and pulmonar

111 Peak values for extravascular lung water indexed to predicted body weight and pulmonar

112 Extravascular lung water indexed to predicted body weight and pulmonar

113 assessed the accuracy of peak extravascular lung water indexed to predicted body weight and pulmonar

114 Extravascular lung water indexed to predicted body weight and pulmonar

115 We aimed to evaluate whether extravascular lung water indexed to predicted body weight and pulmonar

116 Extravascular lung water indexed to predicted body weight effectively

117 Perioperative extravascular lung water indexed to predicted body weight is an early

118 Extravascular lung water indexed to predicted body weight was associat

119 nary vascular permeability and extravascular lung water indexes were significantly lower in i-NE grou

120 Early measurement of predicted extravascular lung water is a better predictor than actual extravascul

121 Increased extravascular lung water is a feature of early acute respiratory distr

122 Extravascular lung water is a quantitative marker of the amount of flu

123 ttenuation of stroke-associated increases in lung water is dependent on achieving a target serum osmo

124 Increasing extravascular lung water is further reflected by a decrease of PaO2/FI

125 ween patients with a change in extravascular lung water <10% and patients with a change in extravascu

126 n in patients with a change in extravascular lung water <10%.

127 its for fluid resuscitation of extravascular lung water (<10 mL/kg) and global end-diastolic volume i

128 It is largely unknown why extravascular lung water may increase during fluid loading in the crit

129 Extravascular lung water may prove valuable for diagnosing reperfusion

130 tested the prognostic value of extravascular lung water measured by a simple, well validated ultrasou

131 We explored extravascular lung water measured by single-indicator transpulmonary t

132 The primary endpoint was extravascular lung water measured by thermodilution (PiCCO) at Day 7.

133 Extravascular lung water (measured with radiolabeled erythrocytes) was

134 Extravascular lung water measurement may be valuable for diagnosing re

135 Accurate extravascular lung water measurements were obtained after pulmonary en

136 an IL-2 (10(6) U IV per rat, n = 6) elevated lung water, myeloperoxidase activity, and protein accumu

137 ody weight, females had a mean extravascular lung water of 9.1 (SD=3.1, range: 5-23) mL/kg and males

138 monary shunting, and increased extravascular lung water (p < .05 compared with baseline).

139 0.001; adjusted R2, 0.18) and extravascular lung water (p < 0.001; adjusted R2, 0.11).

140 dicated that EVLWp, Vd/Vt, and extravascular lung water (p = .0005, .009, and .013, respectively) but

141 e I and type II alveolar epithelial cells to lung water permeability, Pf was measured by stopped-flow

142 To determine whether extravascular lung water predicts survival in patients with early acut

143 short-term changes of indexed extravascular lung water secondary to bronchoalveolar lavage.

144 ronchoalveolar lavage, indexed extravascular lung water significantly increased from 12 +/- 4 to 15 +

145 semiquantitative assessment of extravascular lung water through B-lines.

146 Our data suggest that indexing extravascular lung water to height is superior to weight-based methods

147 a better predictor than actual extravascular lung water to identify patients at risk for death in acu

148 Indexing extravascular lung water to predicted body weight, instead of actual b

149 Despite their role in osmotically driven lung water transport, aquaporins are not required for th

150 onance cine imaging and echocardiography and lung water using magnetic resonance proton density mappi

151 A baseline predicted extravascular lung water value of 16 mL/kg predicted intensive care un

152 Extravascular lung water values were significantly higher in patients

153 s the clinical significance of extravascular lung water variations after pulmonary endarterectomy.

154 ular lung water but not actual extravascular lung water was a predictor of mortality with an odds rat

155 This decrease in lung water was accompanied by a 2.4-fold increase in the

156 Extravascular lung water was indexed to predicted body weight (EVLWPBW

157 Extravascular lung water was measured using the PiCCO system.

158 r lavage, the value of indexed extravascular lung water was significantly different from the baseline

159 ry, and to examine if indexing extravascular lung water with predicted body weight (EVLWp) strengthen