ライフサイエンスコーパス: lymphatic

1 n case of an infection disseminating through lymphatics.

2 Bones do not normally have lymphatics.

3 hat rapamycin can prevent the growth of bone lymphatics.

4 distinct network separated from the external lymphatics.

5 ntial for the development of ventral cardiac lymphatics.

6 o functional communication between the lobar lymphatics.

7 ode (LN)-homing of immune cells via afferent lymphatics.

8 gfr3 transgene rescued partially the cardiac lymphatic abnormalities in compound heterozygotes.

9 However, the mechanisms by which collecting lymphatics adapt to changes in fluid load and how these

10 ated in the lymphatics of CLNs and meningeal lymphatics after SAH.

11 ent study aimed to elucidate whether and how lymphatic anastomosis occurs after lung transplant.

12 es cells of the T cell lineage that seed the lymphatic and blood systems.

13 esence of Lyve-1 positive macrophages in the lymphatic and nonlymphatic regions in the meninges of ra

14 g of chemokine (C-C motif) ligand 21 in lung lymphatics and tertiary lymphoid organ formation, and th

15 owever, owing to the unique structure of the lymphatics and the size-restrictive nature of the lymph

16 M-1(+) high endothelial venules and efferent lymphatics, and had immune profiles consistent with immu

17 However, individuals with generalized lymphatic anomaly (GLA) or Gorham-Stout disease (GSD) de

18 When the meningeal lymphatics are depleted in a mouse model of SAH, the deg

19 ances in understanding the role of meningeal lymphatics as a communicator between the brain and perip

20 of PLVs, along with their function in other lymphatic beds, are warranted.

21 e of Folliculin results in the appearance of lymphatic-biased venous endothelial cells caused by ecto

22 arterial glymphatic transports and meningeal lymphatics by clear depiction of para-arterial, parasinu

23 Although fluid uptake by lymphatic capillaries is a critical attribute of the lym

24 he mesenteric lymph nodes via the mesenteric lymphatic capillaries.

25 and defines the underlying mechanisms of the lymphatic cell environment supporting persistent infecti

26 ssion of K(ATP) channel subunits in distinct lymphatic cell types, and assess the consequences of alt

27 e maintained by virus constantly produced by lymphatic cells in HIV-positive individuals.

28 mor cells in culture, but not that of normal lymphatic cells.

29 s affects the activation and polarization of lymphatic cells.

30 Retroperitoneal lymphatics, cisterna chyli, and thoracic duct were viewe

31 uency, amplitude, or fractional pump flow of lymphatic collectors from two different regions of the m

32 While lymphatic complications, particularly lymphoceles, are n

33 rds the host and the formation of donor-host lymphatic connections at the level of the transplant ana

34 uid load and how these adaptations influence lymphatic contractile activity are unknown.

35 SERCA activator, CDN 1163 partially restored lymphatic contractile activity in MetSyn lymphatic vesse

36 Diminished lymphatic contractile activity in the vessels from the M

37 The intrinsic lymphatic contractile activity is necessary for proper l

38 control vessels, whereas, the reduced MetSyn lymphatic contractile activity was not further diminishe

39 on mutant (GoF) subunits results in profound lymphatic contractile dysfunction and LSM hyperpolarizat

40 nstrate the significance of axial stretch in lymphatic contractile function, suggest that axial stret

41 n of Kir6.1 GoF has essentially no effect on lymphatic contractile function.

42 r SUR2 subunits results in severely impaired lymphatic contractile responses to pinacidil.

43 A computational model of a chain of lymphatic contractile segments incorporating these adapt

44 ir6.1 GoF subunits had negligible effects on lymphatic contraction frequency or amplitude.

45 (GoF) subunit resulted in severely impaired lymphatic contractions and hyperpolarized LSM.

46 Lymphatic contractions play a fundamental role in mainta

47 we determined the mechanisms mediating tumor-lymphatic cross talk.

48 ng of intraventricular and parenchymal (glia-lymphatic) CSF pathways.

49 ytes are described and the recent finding of lymphatic delivery of bile acid-containing nanocarriers

50 We show that bone lymphatics develop in a stepwise manner where regional l

51 model for experimental analysis of meningeal lymphatic development and opens up new avenues for probi

52 a SHF vasculogenic contribution to coronary lymphatic development through a local niche at the base

53 SOX18 and PROX1, central regulators of lymphatic development, are key factors for KSHV genome m

54 The master regulator of lymphatic development, Prox1, bound the promoter of the

55 his an essential model organism for studying lymphatic development, the existence of meningeal lympha

56 diameter (p = 0.007) and lower expression of lymphatic differentiation and function markers (LYVE-1 [

57 understood lymphatic disease associated with lymphatic dilation and leakage.

58 hangiectasia is a rare and poorly understood lymphatic disease associated with lymphatic dilation and

59 virulence mechanisms important for bacterial lymphatic dissemination and show that metastatic strepto

60 r, this work demonstrates that the meningeal lymphatics drain extravasated erythrocytes from CSF into

61 Lymphatic drainage after lung transplantation is establi

62 Promoting meningeal lymphatic drainage and enhancing waste clearance improve

63 erstitium fluid exchange in HFpEF, including lymphatic drainage and the potential osmotic forces exer

64 cept that glymphatic influx and intracranial lymphatic drainage are interconnected.

65 ion) and isovolumetric pressure (above which lymphatic drainage cannot compensate for fluid extravasa

66 our hypothesis that enhancement of meningeal lymphatic drainage could decrease neuroinflammation and

67 val of the heart allografts was dependent on lymphatic drainage from the tolerant lung allograft to t

68 vessels, and functional assays demonstrated lymphatic drainage in the transplanted lung that was com

69 Establishing lung lymphatic drainage is thought to be important for succes

70 Tracers can help visualize the lymphatic drainage patterns and sentinel nodes (SNs) of

71 In literature, no segmental or preferential lymphatic drainage patterns are known to exist.

72 e results show the existence of preferential lymphatic drainage patterns in the murine liver.

73 aphy and in vivo microscopy to delineate the lymphatic drainage patterns of individual liver lobes.

74 dye liver lymphangiography show preferential lymphatic drainage patterns: Right lobe mainly to hepato

75 served hypertonic skin Na(+) excess, but the lymphatic drainage was impaired (isovolumetric pressure

76 s thought to be limited owing to the lack of lymphatic drainage.

77 itial devices enhance volume removal through lymphatic duct decompression.

78 Moreover, we show that pre-existing lymphatic dysfunction before TBI leads to increased neur

79 oth the causes and consequences of meningeal lymphatic dysfunction in TBI and suggest that therapeuti

80 at increased ICP can contribute to meningeal lymphatic dysfunction.

81 licated in diseases, such as xerocytosis and lymphatic dysplasia.

82 ing in vitro effects of soluble MDK on human lymphatic endothelial (HLEC) and melanoma cell prolifera

83 at Tbx1 is activated and required in cardiac lymphatic endothelial cell (LEC) progenitors between E10

84 HA and HS and altered expression of CD44 and lymphatic endothelial cell HA receptor-1, HA receptors o

85 ons in breast cancer, it remains unclear how lymphatic endothelial cell metabolism is altered in the

86 matched donor-derived human dermal blood and lymphatic endothelial cells (BEC and LEC, respectively)

87 ific lymphatics, the cellular origin of bone lymphatic endothelial cells (bLECs) is not known and the

88 ) infection and is thought to originate from lymphatic endothelial cells (LEC).

89 established a new infection model of primary lymphatic endothelial cells (LECs) infected with a lytic

90 Breast cancer cells 'educate' lymphatic endothelial cells (LECs) to support tumor vasc

91 eduction of HIF-2alpha protein expression in lymphatic endothelial cells (LECs).

92 expression of the VEGF-C receptor VEGFR3 in lymphatic endothelial cells (LECs).

93 ial cells from this niche differentiate into lymphatic endothelial cells and, in close association wi

94 FOXC1 knockdown (KD) in human lymphatic endothelial cells increased focal adhesions an

95 umor-associated macrophages, as well as more lymphatic endothelial cells than tumors from PyMT mice.

96 non-neoplastic human primary cell line (lung lymphatic endothelial cells) as a typical normal host ce

97 r KSHV genome maintenance and lytic cycle in lymphatic endothelial cells, supporting Kaposi sarcoma t

98 chemical analyses of the receptor in primary lymphatic endothelial cells, we provide the first eviden

99 ammatory responses in cardiac and peripheral lymphatic endothelial cells.

100 ypes indicated recruitment and activation of lymphatic endothelial cells.Conclusions: A unique popula

101 In contrast, lymphatic endothelial-specific expression of Kir6.1 GoF

102 The drivers of lymphatic endothelium development, SOX18 and PROX1, regu

103 -mediated constraint on LYVE-1 clustering in lymphatic endothelium that tunes the receptor for select

104 In contrast, lymphatic endothelium-specific expression of Kir6.1 GoF

105 cle by PCR, but only Kir6.1 was expressed in lymphatic endothelium.

106 lls and the cellular factors that render the lymphatic environment unique to KSHV life cycle.

107 Lymphatic filariasis (LF) afflicts over 60 million peopl

108 on people are currently at risk of acquiring lymphatic filariasis (LF) in over 52 countries worldwide

109 The global elimination of lymphatic filariasis (LF) is a major focus of the World

110 lymphatic filariasis (LF).

111 rack to achieve their elimination goals (for lymphatic filariasis and trachoma) by 2020 or 2021 and t

112 mens are needed to accelerate elimination of lymphatic filariasis in Africa.

113 luated our methodology using a case study of lymphatic filariasis in Ghana, demonstrating that a geos

114 schistosomiasis, soil-transmitted helminths, lymphatic filariasis, trachoma, onchocerciasis, visceral

115 ndazole, diethylcarbamazine (IDA) regime for Lymphatic Filariasis.

116 ons were chylothorax (n = 19; 76%), cervical lymphatic fistula (n = 2; 8%), and combined chylothorax

117 tinal lymph nodes and there is no interlobar lymphatic flow.

118 The cochlea is filled with two lymphatic fluids.

119 actors: efficient antigen uptake in draining lymphatics from the site of injection, protection of ant

120 Spontaneous contractions of popliteal lymphatics from wild-type (WT) (C57BL/6J) mice, assessed

121 go significant remodeling, with insufficient lymphatic function and/or lymphangiogenesis leading to f

122 d opens up new avenues for probing meningeal lymphatic function in health and disease.

123 ced cardiac dysfunction by improving cardiac lymphatic function, alleviating fibrosis and inflammatio

124 The glia-lymphatic (glymphatic) system facilitates brain fluid cl

125 develop in a stepwise manner where regional lymphatics grow, breach the periosteum and then invade b

126 asma, platelets, and macrophages at sites of lymphatic growth were potential sources of Vegfc.

127 Cs) is not known and the development of bone lymphatics has not been fully characterized.

128 lymphatics, the functional anatomy of liver lymphatics has not been mapped out.

129 atic development, the existence of meningeal lymphatics has not yet been reported in this species.

130 These findings suggest that lymphatics have an overall protective effect in lung inj

131 Meningeal lymphatics have been reported to drain macromolecules an

132 that HIF-2alpha is an important mediator of lymphatic health.

133 Recent studies have suggested that lymphatics help to restore heart function after cardiac

134 ts that HIF-2alpha normally promotes healthy lymphatic homeostasis and raises the exciting possibilit

135 r Gorham-Stout disease (GSD) develop ectopic lymphatics in bone.

136 The recent discovery of meningeal lymphatics in mammals is reshaping our understanding of

137 Here, we describe the development of bone lymphatics in mouse models of GLA and GSD.

138 at rapamycin can suppress the growth of bone lymphatics in our models of GLA and GSD.

139 to study cerebral glymphatics and meningeal lymphatics in patients with reversible cerebral vasocons

140 ent anticancer agent, were studied on cancer-lymphatic interactions.

141 bnormalities of the CLS, and access site for lymphatic interventions (ie, clinically useful examinati

142 giography in the preinterventional workup of lymphatic interventions in patients with thoracic chylou

143 ned a priori were poor differentiation (PD), lymphatic invasion (LI), vascular invasion (VI), and per

144 same cohort, which were pN stage, pT stage, lymphatic invasion, and venous vascular invasion.

145 We also show that the development of bone lymphatics is impaired in mice that lack osteoclasts.

146 cosal invasion is used as a key predictor of lymphatic metastases although data are conflicting on it

147 Lymphatic metastases are closely associated with tumor r

148 l-mesenchymal transition (EMT), and lung and lymphatic metastasis in GC cells.

149 and 3D cultures) and in vivo (mouse lung and lymphatic metastasis models) assays to evaluate the func

150 y due to distant metastasis but not regional lymphatic metastasis.

151 We portray a high-resolution lymphatic metastatic map for CRC by dividing LNMs into p

152 its Kir6.1 and SUR2B were expressed in mouse lymphatic muscle by PCR, but only Kir6.1 was expressed i

153 agen fibers is in the axial direction, while lymphatic muscle cell nuclei and actin fibers are orient

154 ractions, which is associated with damage to lymphatic muscle cells (LMCs), is a biomarker of disease

155 raction of collecting lymphatic vessels, via lymphatic muscle cells and one-way valves, to transport

156 Additionally, insulin resistant lymphatic muscle cells exhibited elevated intracellular

157 rough both PCR and immunostaining that mouse lymphatic muscle cells expressed Ca(v)3.1 and Ca(v)3.2 a

158 in SERCA pump expression and/or activity in lymphatic muscle influences the diminished lymphatic ves

159 a expression and impaired SERCA2 activity in lymphatic muscle.

160 ion and elevated oxidative stress within the lymphatic muscle.

161 SC in mice led to robust growth of blood and lymphatic neovessels and rapid allograft rejection after

162 n-of-function studies, expansion of the lung lymphatic network by transgenic overexpression of Vegfc

163 , we show that zebrafish possess a meningeal lymphatic network comparable to that found in mammals.

164 brosis and fit with a mechanism whereby lung lymphatic network expansion reduces lymph stasis and inc

165 How tumor cells disseminate within the lymphatic network remains largely unknown.

166 east involution, immune avoidance, increased lymphatic network, extracellular matrix remodeling, and

167 sm and musculoskeletal disorders (11% each); lymphatic, neurodevelopmental, cardiovascular, and hemat

168 umber of erythrocytes are accumulated in the lymphatics of CLNs and meningeal lymphatics after SAH.

169 a suggest that the liver, adrenal gland, and lymphatic organs are important sites of EBOV infection a

170 he exclusive producers of CCL22 in secondary lymphatic organs during homeostasis.

171 tokine as a central regulator of immunity in lymphatic organs.

172 in LSM is not an essential component of the lymphatic pacemaker, and does not exert a strong influen

173 Anatomic variations, a lymphatic pathologic abnormality, and interventional acc

174 keletal signaling as a therapeutic target in lymphatic pathologies.

175 hibitor, thapsigargin, significantly reduced lymphatic phasic contractile frequency and amplitude in

176 found that different aspects of the cardiac lymphatic phenotype in Tbx1-Vegfr3 compound heterozygote

177 Overall, we argue the case for lymphatics playing a fundamental role in renal physiolog

178 uences of altered K(ATP) channel activity on lymphatic pump function.

179 he first evidence that SERCA2a modulates the lymphatic pumping activity by regulating phasic contract

180 ecular mechanisms responsible for the weaker lymphatic pumping activity in MetSyn conditions are unkn

181 euptake of tissue-infiltrating immune cells, lymphatics regulate immune responses.

182 and p = 0.012, respectively); residual skin lymphatics showed a larger diameter (p = 0.007) and lowe

183 experiments on isolated rat tail collecting lymphatics showed that the contractile metrics such as c

184 .1 and SUR2B subunits are expressed in mouse lymphatic smooth muscle (LSM) and form functional K(ATP)

185 l, which hyperpolarized both mouse and human lymphatic smooth muscle (LSM).

186 harp intracellular electrode measurements in lymphatic smooth muscle revealed only subtle, but not si

187 although T-type VGCCs are expressed in mouse lymphatic smooth muscle, they do not play a significant

188 of Prox1, a master transcription factor for lymphatic specification.

189 ype VGCC, Ca(v)1.2, completely abolished all lymphatic spontaneous contractions.

190 nsplantation, with more numerous and complex lymphatic sprouting developing thereafter.

191 Likewise, chronic cranial windows provoked lymphatic sprouting.

192 ncephalography electrodes were surrounded by lymphatic sprouts originating from lymphatic vasculature

193 Background Abnormalities of the central lymphatic system (CLS) are increasingly treated by inter

194 pact immunosuppressive therapies have on the lymphatic system and emerging evidence of organ-specific

195 delivery of unmodified LPV to the mesenteric lymphatic system and resulted in undetectable levels of

196 The findings establish the lymphatic system as both a survival niche and conduit to

197 ls, often metastasize regionally through the lymphatic system before metastasizing systemically throu

198 sport, point to a key role of the glymphatic-lymphatic system in clearance of amyloid-beta and other

199 tle is known about the role of the meningeal lymphatic system in HE.

200 Unassisted metastasis through the lymphatic system is a mechanism of dissemination thus fa

201 st that therapeutics targeting the meningeal lymphatic system may offer strategies to treat TBI.

202 antation, and emerging evidence suggests the lymphatic system plays a key role in shaping outcomes.

203 phatic vascular system, it is clear that the lymphatic system plays an integral role in physiology, a

204 The lymphatic system relies on orchestrated contraction of c

205 As such, the glymphatic-lymphatic system represents a new target in combating ne

206 on of ERalpha and impaired regulation of the lymphatic system through the transcription factor prospe

207 ight emerging application areas, such as the lymphatic system, and close the review discussing potent

208 e development and structure of the meningeal lymphatic system, the contribution of this network in ev

209 size of HIV reservoirs within the mesenteric lymphatic system.

210 process is largely taking place through the lymphatic system.

211 etic, parasympathetic, sensory and meningeal lymphatic systems.

212 The potential for mesenteric lymphatic targeting and bioconversion to LPV in physiolo

213 transit, first in afferent and then efferent lymphatics that carry the bacteria through successive dr

214 terest in the development of tissue-specific lymphatics, the cellular origin of bone lymphatic endoth

215 s highlight the importance of organ-specific lymphatics, the functional anatomy of liver lymphatics h

216 e epithelial barrier, the mucosal-associated lymphatic tissues and microbiota.

217 rains the egress of CCR7(+) lymphocytes from lymphatic tissues into the blood, thus resulting in redu

218 essels in lung fibrosis, the contribution of lymphatics to fibrosis is unknown.

219 nsitivity between ventral and dorsal cardiac lymphatics to the effects of altered Tbx1 and Vegfr3 gen

220 ractile amplitude and frequency, but not the lymphatic tone.

221 In different pathological conditions cardiac lymphatics undergo significant remodeling, with insuffic

222 describes a novel technique for quantifying lymphatic valve back-leak.

223 Lymphatic valve defects are one of the major causes of l

224 technique for the quantitative assessment of lymphatic valve function utilizes the servo-null micropr

225 iameter-based method, the competence of each lymphatic valve is challenged over a physiological range

226 thelial-specific deletion impaired postnatal lymphatic valve maturation in mice.

227 ry for the development of lymphatic vessels, lymphatic valves (LVs) and lymphovenous valves (LVVs).

228 fx) ;Cx37(-/-) mice, we tested our method on lymphatic valves displaying a wide range of dysfunction,

229 used to quantify valve function in isolated lymphatic valves from a variety of species.

230 sed for assessing the function of venous and lymphatic valves from various species, including humans.

231 in vivo and that the opening and closing of lymphatic valves leads to significant changes in axial s

232 is review, the molecular characterization of lymphatic vascular development and our understanding of

233 pose that subtle asymptomatic alterations in lymphatic vascular function could underlie the variabili

234 Even without lymphatic vascular injury, the loss of LEC-specific Hif2

235 rstanding of the function and biology of the lymphatic vascular system, it is clear that the lymphati

236 ounded by lymphatic sprouts originating from lymphatic vasculature along the dural sinuses and the mi

237 tors of mechanotransduction in the postnatal lymphatic vasculature and posit cytoskeletal signaling a

238 a pioneering paper showing how the meningeal lymphatic vasculature can be manipulated with VEGF-C to

239 Morphological or functional defects in the lymphatic vasculature have now been uncovered in several

240 ng conventional views about the roles of the lymphatic vasculature in health and disease.

241 The lymphatic vasculature is a unidirectional conduit that r

242 Lymphatic vasculature is an integral part of digestive,

243 Contractile activity in the lymphatic vasculature is essential for maintaining fluid

244 The lymphatic vasculature is involved in the pathogenesis of

245 c capillaries is a critical attribute of the lymphatic vasculature, the barrier function of collectin

246 etween glymphatic activity and the meningeal lymphatic vasculature.

247 Meningeal immunity along with its associated lymphatic vasculatures is widely discussed recently.

248 Loss of popliteal lymphatic vessel (PLV) contractions, which is associated

249 red lymphatic contractile activity in MetSyn lymphatic vessel by increasing phasic contractile freque

250 n lymphatic muscle influences the diminished lymphatic vessel contractions in MetSyn animals.

251 sly shown that TBX1 is required for systemic lymphatic vessel development in prenatal mice and it is

252 We show that the remodelled lymphatic vessel displayed increasing intrinsic contract

253 Lymphatic vessel endothelial hyaluronan receptor 1 (LYVE

254 ifferentiation and function markers (LYVE-1 [lymphatic vessel endothelial hyaluronan receptor 1]: p <

255 d enhanced expression of CXCR3 and increased lymphatic vessel infiltration.

256 l therapeutic target to selectively modulate lymphatic vessel permeability and function.

257 ntial for the development and maintenance of lymphatic vessel valves.

258 HFpEF showed rarefaction of small blood and lymphatic vessels (p = 0.003 and p = 0.012, respectively

259 to highlight and contextualize the roles of lymphatic vessels and lymphangiogenesis in immunobiology

260 to determine whether and where intracranial lymphatic vessels are present.

261 easurements suggest that rat tail collecting lymphatic vessels are under an axial stretch of ~1.24 un

262 It is likely that collecting lymphatic vessels are under axial strain in vivo and tha

263 ificantly better regressed corneal blood and lymphatic vessels at 1 week after the treatment compared

264 eeper that maintains separation of blood and lymphatic vessels by limiting the plasticity of committe

265 Peritumoral lymphatic vessels connect the primary tumor to lymph nod

266 lenvatinib treatment abrogated the increased lymphatic vessels development in the endometriotic lesio

267 Using mesenteric lymphatic vessels from C57BL/6J, Ub-CreER(T2) ;Rasa1(fx/

268 Mesenteric lymphatic vessels from high-fructose diet-induced metabo

269 via crosstalk with surrounding renal cells, lymphatic vessels have been implicated in the progressio

270 oncept along with the discovery of meningeal lymphatic vessels have, in recent years, highlighted tha

271 Lymphatic vessels in meninges drain interstitial fluid i

272 pressor, leads to misconnection of blood and lymphatic vessels in mice and humans.

273 Peripheral lymphatic vessels in patients with HFpEF exhibit structu

274 We did not observe any lymphatic vessels in spinal dura mater.

275 evidence of organ-specific heterogeneity of lymphatic vessels in the context of solid organ transpla

276 Lymphatic vessels in the donor lung exhibited active spr

277 e recently emerged controversial role of the lymphatic vessels in tumor dissemination and cancer immu

278 Although lymphatic vessels initially arise from embryonic veins,

279 culature, the barrier function of collecting lymphatic vessels is also important by ensuring efficien

280 The kidney contains a network of lymphatic vessels that clear fluid, small molecules, and

281 cells including high endothelial venules and lymphatic vessels that resemble secondary lymphoid organ

282 the docking and entry of dendritic cells to lymphatic vessels through selective adhesion to its liga

283 nd skin-inoculated filariae migrated through lymphatic vessels to draining lymph nodes.

284 through sequential lymph nodes and efferent lymphatic vessels to enter the bloodstream.

285 port that Streptococcus pyogenes also hijack lymphatic vessels to escape a local infection site, tran

286 surgery, and its rapid transport through the lymphatic vessels to the SLN is then visualized with dyn

287 is established by active sprouting of donor lymphatic vessels towards the host and the formation of

288 The function of lymphatic vessels within tertiary lymphoid organs remain

289 ry of transplanted lungs demonstrated robust lymphatic vessels, and functional assays demonstrated ly

290 structure composed of fibroblasts, blood and lymphatic vessels, and immune cells.

291 to immune cells to help them find blood and lymphatic vessels, and to endothelial cells to stabilize

292 or PROX1 is necessary for the development of lymphatic vessels, lymphatic valves (LVs) and lymphoveno

293 ession was significantly decreased in MetSyn lymphatic vessels, myosin light chain 20, MLC(20) phosph

294 nents, including cancer-associated blood and lymphatic vessels, pericytes, cancer associated fibrobla

295 dipose hypertrophy, dysfunction of blood and lymphatic vessels, the overall oestrogen dependence and

296 es on orchestrated contraction of collecting lymphatic vessels, via lymphatic muscle cells and one-wa

297 cells to the draining mediastinal LN via the lymphatic vessels, which we term retrograde migration.

298 reast cancer metastasis occurs via blood and lymphatic vessels.

299 roy and regress pathologic corneal blood and lymphatic vessels.

300 regulate contractile function in collecting lymphatic vessels; however, less is known about the role

301 ia L-selectin and actively exit via efferent lymphatics via an S1P dependent mechanism.