ライフサイエンスコーパス: lymphocyte depletion

1 wo of two mixed cellularity, and two of four lymphocyte depletion).

2 67 (47%) of 143 mixed cellularity, and all 5 lymphocyte depletion.

3 al hospitalization and causes more sustained lymphocyte depletion.

4 of these properties to in vivo CD4-positive lymphocyte depletion.

5 suppression in sepsis by inducing widespread lymphocyte depletion.

6 Some mice showed marked splenic lymphocyte depletion.

7 MS suppression following alemtuzumab-induced lymphocyte depletion.

8 antibody that causes profound and sustained lymphocyte depletion.

9 mmunological deficits because of protein and lymphocyte depletion.

10 the CNS, and rituximab leads to prolonged B-lymphocyte depletion.

11 l transplant patients after treatment with B-lymphocyte depletion.

12 ot recapitulate the viral dynamics of CD8(+) lymphocyte depletion.

13 R3-173 mAb were not associated with effector lymphocyte depletion.

14 251-infected macaques with or without CD8(+) lymphocyte depletion.

15 iciency virus), or iatrogenic (chemotherapy) lymphocyte depletion.

16 tuzumab subjects despite profound, prolonged lymphocyte depletion.

17 occurred concomitantly with acute gut CD4 T-lymphocyte depletion.

18 orrelate with the degree of preceding CD8+ T lymphocyte depletion.

19 B cell levels following chemotherapy-induced lymphocyte depletion.

20 disruption, cell death, and ultimately, CD4+ lymphocyte depletion.

21 lar sclerosis (132), mixed cellularity (34), lymphocyte depletion (2), and unclassified types (5), al

22 l cycling in response to alemtuzumab-induced lymphocyte depletion, a phenomenon that is driven by hig

23 Lymphocyte depletion after subcutaneous alemtuzumab was

24 response in SHIV-immunized monkeys by CD8(+) lymphocyte depletion, an intervention that abrogated SHI

25 ting virus, KU-1, that caused rapid CD4(+) T-lymphocyte depletion and AIDS-like illness in monkeys

26 nic viruses (SHIV-89.6P) inducing rapid CD4+ lymphocyte depletion and AIDS-like illness in rhesus mon

27 s tolerated rituximab well, achieved swift B-lymphocyte depletion and complete clinical remission (ac

28 re being evaluated: hematopoietic chimerism, lymphocyte depletion and costimulation blockade.

29 R) or more experienced irreversible CD4(+) T lymphocyte depletion and developed clinical disease requ

30 IFN-gamma and Irgm1 were 'rescued' from the lymphocyte depletion and greater mortality that occurs i

31 Lymphocyte depletion and high alloantigen load have been

32 ompartments and possible mechanisms of CD4 T-lymphocyte depletion and immune dysfunction in simian AI

33 deaminase activity (ADA) activity results in lymphocyte depletion and in severe combined immunodefici

34 he absence of adenosine deaminase results in lymphocyte depletion and in severe combined immunodefici

35 on, providing a potential mechanism by which lymphocyte depletion and repopulation could reduce the r

36 We observe varying levels of lymphocyte depletion and significant differences in neut

37 l was insensitive to either CD8(+) or CD4(+) lymphocyte depletion and, at necropsy, cell-associated S

38 Global suppression of the immune system via lymphocyte depletion and/or immunosuppressive drugs can

39 spleen, lungs, and regional lymph nodes and lymphocyte depletion and/or lymphocytolysis in the splee

40 5 nodular sclerosis, 16 mixed cellularity, 5 lymphocyte depletion, and 5 unclassified) and in 66% of

41 omic relationship between virus replication, lymphocyte depletion, and cytokine gene expression level

42 39-infected rhesus macaques underwent CD8(+) lymphocyte depletion, and RNA from whole blood was obtai

43 ells in 30 of 35 cases of nodular-sclerosis, lymphocyte-depletion, and mixed-cellularity Hodgkin's di

44 In the case of CDR-OKT4A/hIgG4, neither lymphocyte depletion, antigenic modulation, nor preventi

45 -inclusive regimens has led to studies using lymphocyte depletion as induction and maintenance therap

46 diated effector functions, including T and B lymphocyte depletion, autoimmune hemolytic anemia, and a

47 cells in vivo, with the pattern of CD4(+) T lymphocyte depletion being inextricably linked to chemok

48 ata reveal a differential impact of CD8(+) T lymphocyte depletion between controller and progressor S

49 ffects of rATG may occur not only because of lymphocyte depletion but also enhanced Treg cell number

50 vented SCI-induced glucocorticoid excess and lymphocyte depletion but did not prevent pneumonia.

51 tetraprolin-deficient mice after cytotoxic T lymphocyte depletion, but also in WSX-1/tristetraprolin

52 CD8(+) T-lymphocyte depletion by CD8alpha or CD8beta monoclonal a

53 Cp40 does not alter lymphocyte depletion by rhesus-specific anti-thymocyte g

54 e to tolerance induction seen after subtotal lymphocyte depletion can be attributed to alterations in

55 ystander CD4 T cells is a major mechanism of lymphocyte depletion caused by X4 HIV-1 strains but is o

56 to three consecutive cycles until achieving lymphocyte depletion (CD4(+) count < 200/muL) or progres

57 In peripheral blood, CD8(+) lymphocyte-depletion changed the dynamics of CD4(+) T-ce

58 poptosis induction in the progressive CD4(+)-lymphocyte depletion characteristic of HIV-1 pathogenesi

59 Despite eliciting broader B lymphocyte depletion, continuous combo therapy afforded

60 tion of immunoregulation, rather than simple lymphocyte depletion, contributes to the therapeutic eff

61 Thus, the extent of lymphocyte depletion correlates with the level of viremi

62 Further studies found transitory early B lymphocyte depletion delayed T1D onset in a portion of N

63 infected perinatally with HIV, a pattern of lymphocyte depletion develops that resembles the pattern

64 d (0.03 mg/kg per day), there was a profound lymphocyte depletion down to about 30% of pretransplant

65 In vivo lymphocyte depletion during primary infection resulted i

66 letion, we investigated the effect of CD8(+) lymphocyte depletion during primary SIV infection on CD4

67 udies indicate transient BAFFR-Fc-mediated B lymphocyte depletion elicits long-term T1D protection by

68 Lymphocyte depletion experiments showed that human NK ce

69 T-cell distribution were more important than lymphocyte depletion for controlling the blood cell leve

70 sulted in profound peripheral and lymph node lymphocyte depletion for up to 1 month.

71 B lymphocyte depletion has little effect on bacterial numb

72 B lymphocyte depletion has recently emerged as a promising

73 Here, we conducted CD8(+) T lymphocyte depletion in 15 rhesus macaques (RMs) infecte

74 rmed experiments of in vivo CD4(+) or CD8(+) lymphocyte depletion in 2 nonhuman primate species, rhes

75 ary lymphoid organs associated with profound lymphocyte depletion in blood.

76 CD8(+) lymphocyte depletion in EC monkeys resulted in a dramati

77 e failure as a generalized mechanism for CD4 lymphocyte depletion in HIV-1 infection, as alpha1 circl

78 erential rates of AIDS development and/or T4 lymphocyte depletion in HIV-1-infected individuals remai

79 g HIV infection, and can thus participate in lymphocyte depletion in HIV-infected individuals.

80 CD4+ T lymphocyte depletion in human immunodeficiency virus typ

81 HIV-1 induces apoptosis and leads to CD4+ T-lymphocyte depletion in humans.

82 tly and caused rapid and persistent CD4(+) T-lymphocyte depletion in inoculated rhesus macaques.

83 9.6 into a virus that causes profound CD4+ T-lymphocyte depletion in monkeys.

84 ious phase 2 trials indicated benefit from B-lymphocyte depletion in myalgic encephalomyelitis/chroni

85 Following B lymphocyte depletion in patients with RA, a positive cli

86 This phase 2 study evaluated the role of B-lymphocyte depletion in patients with type 1 diabetes.

87 Antibody-mediated CD8(+) lymphocyte depletion in simian immunodeficiency virus (S

88 (HK/486) (nonlethal) virus and monitored for lymphocyte depletion in the blood, lungs, and lymphoid t

89 Our expectation was that lymphocyte depletion, in conjunction with an augmentatio

90 Perioperative lymphocyte depletion induces allograft tolerance in some

91 on, we previously showed that peritransplant lymphocyte depletion induces rapid memory T cell prolife

92 ipients, and KDIGO guidelines suggest use of lymphocyte-depletion induction when DGF is anticipated.

93 Consideration must be given to use of lymphocyte-depletion induction when the anticipated risk

94 Lymphocyte depletion, intravascular apoptosis, and cytok

95 B lymphocyte depletion is a therapeutic strategy known to

96 However, we report that CD8(+) lymphocyte depletion is also associated with a dramatic

97 es on immune memory and reconstitution after lymphocyte depletion is beginning to be defined.

98 3 + regulatory T cells (Tregs) through CD4 + lymphocyte depletion is being investigated as cancer tre

99 Antibody-mediated lymphocyte depletion is frequently used as induction the

100 Recovery of lymphocyte populations after lymphocyte depletion is implicated in therapeutic immune

101 Immune cell depletion, particularly lymphocyte depletion, is an effective clinical strategy

102 CD8(+) T lymphocyte depletion leads to a relatively homogenous in

103 tory to conventional therapy suggests that B lymphocyte depletion may be a safe, effective, mechanism

104 progression of CNS neuronal injury in a CD8 lymphocyte depletion model of neuroAIDS in SIV-infected

105 This CD8+ lymphocyte depletion model should prove useful in defini

106 Furthermore, during CD8+ lymphocyte depletion, monkeys developed delayed-type hyp

107 croenvironment may account for the selective lymphocyte depletion observed in this model of familial

108 T-lymphocyte depletion of bone marrow grafts compromises e

109 cytes, follicular hyperplasia of the spleen, lymphocyte depletion of mesenteric lymph nodes, intersti

110 ancreatitis, adrenocortical hyperplasia, and lymphocyte depletion of spleen and lymph nodes.

111 d immunodeficiency associated with stringent lymphocyte depletion of the graft appears to strongly pr

112 Liver reperfusion injury is reduced by lymphocyte depletion or activation of adenosine A2A rece

113 ructural proteins but did not cause CD4(+) T-lymphocyte depletion or clinical disease.

114 DA-EPOCH-F/R resulted in lymphocyte depletion (P < .001), which was inversely ass

115 fected cells were highly associated with CD4 lymphocyte depletion (p = 0.00001 and p = 0.003, respect

116 Rituximab leads to prolonged B-lymphocyte depletion, potentially allowing John Cunningh

117 g tolerogenic cytokine administration and/or lymphocyte depletion prior to oral antigen-specific immu

118 CD8(+) lymphocyte depletion prior to SIVmac239 vaginal challeng

119 Antibody-mediated CD8+ T lymphocyte depletion restored tumor growth in MerTK-/- m

120 CD8(+) T lymphocyte depletion resulted in a more prominent increa

121 We show that intestinal lymphocyte depletion results in skewed ISC differentiati

122 In this model, lymphocyte depletion seems to be the best predictor of c

123 e new findings strongly indicate that CD4(+) lymphocyte depletion seen in AIDS is primarily a consequ

124 Also, CD8(+) lymphocyte depletion significantly affected the ability

125 T-lymphocyte depletion studies showed that CD4(+) and CD8(

126 Drugs inducing lymphocyte depletion, such as alemtuzumab, may disrupt t

127 ainst donor blood cells was restored after B lymphocyte depletion, suggesting a direct pathophysiolog

128 control of postchallenge viremia after CD8+ lymphocyte depletion suggests that both humoral and cell

129 ce for the safety and possible efficacy of B lymphocyte depletion therapy in SLE to justify a formal

130 d in nine rhesus monkeys that received CD3 T-lymphocyte depletion therapy with immunotoxin on the day

131 ss the clinical and serologic responses to B lymphocyte depletion therapy with rituximab in patients

132 tal exposure, disease processes, and chronic lymphocyte depletion therapy.

133 -F/R safely provides tumor cytoreduction and lymphocyte depletion, thereby offering a bridge to RIC-a

134 Neither T-lymphocyte depletion (TLD) of the bone marrow nor irradi

135 would provide disease control and result in lymphocyte depletion to facilitate engraftment.

136 icular those specific for donor HLA, after B-lymphocyte depletion treatment in renal transplant recip

137 ously demonstrated that induction therapy by lymphocyte depletion, using alemtuzumab (anti-human CD52

138 l mediator of the inflammatory response, and lymphocyte depletion via apoptosis may be an important m

139 Lymphoid tissue CD8+ T lymphocyte depletion was >99% in three out of four anti-

140 B lymphocyte depletion was attained using combination ther

141 In the 3-day group, lymphocyte depletion was more sustained and initial hosp

142 Lymphocyte depletion was profound in the periphery and s

143 The degree of lymphocyte depletion was proportional to the WBI dose.

144 Lymphocyte depletion was reflected by a decrease in T an

145 HIV-related CD4(+) lymphocyte depletion was strongly associated with microb

146 These CD4(+) and CD8(+) lymphocyte depletions were followed by a largely lineage

147 Histological examination showed diffuse lymphocyte depletion, which was most striking in the CD4

148 both arms was to achieve rapid and effective lymphocyte depletion while simultaneously allowing reduc

149 therefore performed a trial to determine if lymphocyte depletion with alemtuzumab combined with DSG

150 Lymphocyte depletion with antithymocyte globulin (ATG) c

151 , an adenosine deaminase inhibitor, leads to lymphocyte depletion with low risk of myelosuppression.

152 In addition to lymphocyte depletion, with which it was once synonymous,

153 atients treated with 2-CdA showed peripheral lymphocyte depletion without a significant reduction in

154 AIDS is characterized by CD4+ T lymphocyte depletion, yet the mechanisms underlying this