ライフサイエンスコーパス: lymphoid progenitor

1 reversion event having occurred in a common lymphoid progenitor.

2 developmental stage that precedes the common lymphoid progenitor.

3 ells depleted HSCs but not myeloerythroid or lymphoid progenitors.

4 ) production at the expense of erythroid and lymphoid progenitors.

5 ting a differentiation bottleneck for common lymphoid progenitors.

6 for the efficient generation of bone marrow lymphoid progenitors.

7 ate lymphocyte that derives from bone marrow lymphoid progenitors.

8 nitors, hematopoietic stem cells, and common lymphoid progenitors.

9 study that NH cells derive from bone marrow lymphoid progenitors.

10 a critical role in the development of common lymphoid progenitors.

11 ate into progressively restricted myeloid or lymphoid progenitors.

12 s indispensable for T lineage development of lymphoid progenitors.

13 ial expression of p16(Ink4a) and Arf in aged lymphoid progenitors.

14 n the number and proportion of bone marrow B-lymphoid progenitors.

15 xpressing TEL-AML1 either ubiquitously or in lymphoid progenitors.

16 et of cytokine-induced lineage conversion in lymphoid progenitors.

17 smacytoid dendritic cells (PDCs) derive from lymphoid progenitors.

18 hese very rare niches and expansion of donor lymphoid progenitors.

19 oped into lymphoid lineage-restricted common lymphoid progenitors.

20 failed to generate the earliest myeloid and lymphoid progenitors.

21 on of E2a/Pbx1 has been reported in cultured lymphoid progenitors.

22 exploited to isolate and characterize fetal lymphoid progenitors.

23 DC can develop from both myeloid and lymphoid progenitors.

24 with loss of p16(INK4a)p14(ARF) to transform lymphoid progenitors.

25 ge to promote the development of multipotent lymphoid progenitors.

26 -2RG and JAK3 in normal development of human lymphoid progenitors.

27 homeostasis of hematopoietic stem cells and lymphoid progenitors.

28 pulating activity, HSC quiescence and common lymphoid progenitors.

29 alizing osteoblasts has no effect on HSCs or lymphoid progenitors.

30 avors the recruitment of bone marrow-derived lymphoid progenitors.

31 sulting from the malignant transformation of lymphoid progenitors.

32 r-successor relationships between EILPs, all-lymphoid progenitors (ALPs), and ILC precursors (ILCps).

33 t progenitors (LMPPs) differentiate into all lymphoid progenitors (ALPs).

34 lineage-committed myeloid, T lymphoid, and B lymphoid progenitors also results in AML, T-ALL, and B-A

35 ILCs derive from common lymphoid progenitors, although the transcriptional pathw

36 te lymphoid progenitor, common helper innate lymphoid progenitor and innate lymphoid cell progenitor

37 tal intermediate between the upstream common lymphoid progenitor and the downstream NKP, previously a

38 phoid-primed multipotent progenitors, common lymphoid progenitors and B cell progenitors, normal expr

39 In contrast to MPP, common lymphoid progenitors and B lineage cell numbers were sig

40 nied by induction of apoptosis of leukemic B-lymphoid progenitors and by long-term animal survival, s

41 ng, multipotent progenitors, including early lymphoid progenitors and CD62L(+) cells previously descr

42 Clonogenic common lymphoid progenitors and clonogenic common myeloid proge

43 Moreover, early lymphoid progenitors and common lymphoid progenitors pro

44 a developmental intermediates such as common lymphoid progenitors and common myeloid progenitors, rec

45 their downstream progenitors such as common lymphoid progenitors and common myeloid progenitors.

46 iesis was unaffected, and bone marrow common lymphoid progenitors and hematopoietic stem cells were e

47 rodimer that stimulates the growth of common lymphoid progenitors and immature B and T lymphoid cells

48 -C motif) ligand 12) regulates both HSCs and lymphoid progenitors and is expressed by all of these st

49 RAG-1(+) early lymphoid progenitors and Lin(-)Sca-1(+)cKit(Lo)IL-7Ralph

50 ontributes to reduced growth and survival of lymphoid progenitors and makes them refractory to malign

51 In bone marrow from mutant mice, common lymphoid progenitors and pre-pro-B cells appeared normal

52 inhibition impaired proliferation of common lymphoid progenitors and pre-pro-B cells but not pro-B c

53 atelet lineage bias, increased generation of lymphoid progenitors and rebalanced HSC lineage output i

54 ls comprise a distinct niche that supports B-lymphoid progenitors and retains HPCs in the bone marrow

55 s depends on sequential interactions between lymphoid progenitors and stromal cells in discrete regio

56 In common lymphoid progenitors and T-cells Firre exerts a cis-acti

57 was a 10-fold reduction in committed PreproB-lymphoid progenitors and the functional B-cell potential

58 ing proteins, is expressed in multipotential lymphoid progenitors and throughout the T lineage.

59 resulting in reduced cell survival of common lymphoid progenitors and thymocytes at the double-negati

60 otential of downstream committed myeloid and lymphoid progenitors and with their ability to give rise

61 progenitors in both the bone marrow (common lymphoid progenitor) and thymus (proT1) maintain a laten

62 leukocyte counts, early depletion of common lymphoid progenitors, and a monocytic bias in comparison

63 TLR9 is highly expressed on lymphoid progenitors, and culture studies revealed that

64 id progenitors, characterized immature multi-lymphoid progenitors, and detected progressive DNA methy

65 l capacity to generate committed myeloid and lymphoid progenitors, and diminished lymphoid potential.

66 m cells, early lymphocyte precursors, common lymphoid progenitors, and early T lineage progenitors ar

67 l receptor-less allogeneic T cells, expanded lymphoid progenitors, and induced pluripotent stem cell

68 esis at the single cell level: HSPCs, common lymphoid progenitors, and mature B cells.

69 Multipotent progenitors, early lymphoid progenitors, and the here-defined myeloid proge

70 We can now appreciate that new lymphoid progenitors are drawn from a heterogeneous coll

71 enerated exists, and a new appreciation that lymphoid progenitors are protean and able to alter their

72 rikingly, ectopic GATA-1 reprogrammed common lymphoid progenitors as well as granulocyte/monocyte (GM

73 sults in a severe reduction in Flk2+, IL-7R+ lymphoid progenitors as well as impaired expression of E

74 ed, we show that ILC2 generation from common lymphoid progenitors, as well as ILC2 homeostasis and cy

75 differentiation pathway between conventional lymphoid progenitors, B1P, and mature B1 lymphocytes.

76 fate-restriction events that occur as common lymphoid progenitors become committed to each of the ILC

77 progenitors that colonize the thymus, while lymphoid progenitors become specialized in the productio

78 receptor CCR9 by a subset of MPP and common lymphoid progenitors but not hemopoietic stem cells.

79 cl12 from osteoblasts depleted certain early lymphoid progenitors but not HSCs or myeloerythroid prog

80 onstitutive HPC mobilization and a loss of B-lymphoid progenitors, but HSC function is normal.

81 e observed expression of the IL-7R on common lymphoid progenitors, but not ETPs, results in different

82 Finally, we demonstrate that lymphoid progenitors, but not myeloid-erythroid progenit

83 lony-forming unit assays show suppression of lymphoid progenitors by each PAH within 6 h but a subseq

84 ing during B cell programming of multipotent lymphoid progenitors by restricting chromatin accessibil

85 the natural selective advantage conferred on lymphoid progenitors by the expression of normal gamma(c

86 Because lymphoid progenitors can give rise to natural killer (NK

87 ipotent progenitors and preferential loss of lymphoid progenitors caused by markedly increased p53-me

88 ction of hematopoietic stem cells and common lymphoid progenitors causing a severely depleted acquire

89 Bone marrow normal lymphoid progenitors (CD19+, CD10+, and/or CD34+) are ex

90 d binding of Hoxa9 to the flt3 promoter in a lymphoid progenitor cell line.

91 of Orp3 results in an aberrant expansion of lymphoid progenitor cells and a high penetrance formatio

92 ls, T cells, natural killer cells and common lymphoid progenitor cells and an enhanced myeloid output

93 ) increases the levels of bone marrow common lymphoid progenitor cells and cytotoxic CD8(+) tumor-inf

94 IL-7R is first expressed on common lymphoid progenitor cells and is not detected on primiti

95 Common lymphoid progenitor cells and M2 macrophages were found

96 and Peyer's patches development by targeting lymphoid progenitor cells during fetal and adult life.

97 s required for the formation of the earliest lymphoid progenitor cells in the marrow, but that the ma

98 fter Notch signaling, whereas Hes1-deficient lymphoid progenitor cells required additional cytokine s

99 the absence of EBF, 'expandable' and clonal lymphoid progenitor cells retained considerable myeloid

100 The expression of Pax5 commits common lymphoid progenitor cells to B-lymphoid lineage differen

101 hoblastic leukaemia, a malignant disorder of lymphoid progenitor cells, affects both children and adu

102 on leads to reduced apoptosis of myeloid and lymphoid progenitor cells, and a propensity to develop a

103 ILC2s develop in the bone marrow from common lymphoid progenitor cells, but little is known about how

104 rt-purified mouse bone marrow-derived common lymphoid progenitor cells, early thymic progenitors (ETP

105 Here we found that in lymphoid progenitor cells, the chromatin remodeler Brg1

106 s obtained with specified common myeloid and lymphoid progenitor cells.

107 te development and can be detected in common lymphoid progenitor cells.

108 tor cells and the bone marrow-derived common lymphoid progenitor cells.

109 ted at CpG residues among fetal liver common lymphoid progenitor cells.

110 specific DNA methylation between myeloid and lymphoid progenitors, characterized immature multi-lymph

111 which defines the common helper-like innate lymphoid progenitor (ChILP), but not cytokine signaling.

112 ST2) in ILC2p and common helper-like innate lymphoid progenitors (CHILP), at least partially through

113 Our data suggest that common lymphoid progenitor (CLP) cells could be responsible for

114 otypic changes of reporter-expressing common lymphoid progenitor (CLP) cells in the bone marrow when

115 poietic stem cell (HSC) expansion and common lymphoid progenitor (CLP) depletion in a model of chroni

116 XO1-deficient mice is arrested in the common lymphoid progenitor (CLP) LY6D(+) cell stage.

117 t with multilineage progenitor (MLP), common lymphoid progenitor (CLP), and B lineage-restricted pre-

118 NFIL3 was required in the common lymphoid progenitor (CLP), and was essential for the dif

119 decreased the numbers of MPP-derived common lymphoid progenitor (CLP), common myeloid progenitor (CM

120 hese developmental intermediates, the common lymphoid progenitor (CLP), which can give rise to T cell

121 The number of common lymphoid progenitors (CLP) and their pre-pro-B and pro-B

122 ere was heterogeneity among canonical common lymphoid progenitors (CLP) in bone marrow.

123 ipotent progenitors (MPP) switch into common lymphoid progenitors (CLP) or common myeloid progenitors

124 ed multipotential progenitors (LMPP), common lymphoid progenitors (CLP), and B/T cell precursors.

125 in renders functionally defined HSCs, common lymphoid progenitors (CLP), and precursor B-lymphocytes

126 y reported that two subpopulations of common lymphoid progenitors, CLP-1 and CLP-2, coexist in the BM

127 Strikingly, >50% hGM-CSFR+ common lymphoid progenitors (CLPs) and >20% hGM-CSFR+ pro-T cel

128 generate fewer than normal numbers of common lymphoid progenitors (CLPs) and common myeloid progenito

129 hopenia and substantial reductions of common lymphoid progenitors (CLPs) and lymphoid precursors, in

130 CD11a was critical for generation of common lymphoid progenitors (CLPs) and lymphoid-primed multipot

131 using highly enriched populations of common lymphoid progenitors (CLPs) and MPs from the bone marrow

132 putative thymus seeding populations, common lymphoid progenitors (CLPs) and multipotent progenitors

133 ) subset is predominantly composed of common lymphoid progenitors (CLPs) and multipotent progenitors.

134 oint when NK progenitors develop from common lymphoid progenitors (CLPs) and that E4bp4 must be expre

135 Common lymphoid progenitors (CLPs) are descended from HSCs, and

136 Common lymphoid progenitors (CLPs) are lymphoid-lineage-committ

137 Common lymphoid progenitors (CLPs) are the first bone marrow pr

138 D)J recombinase is active as early as common lymphoid progenitors (CLPs) but not in the upstream prog

139 Common lymphoid progenitors (CLPs) clonally produce both B- and

140 ut not lymphoid genes, whereas single common lymphoid progenitors (CLPs) coexpress T and B lymphoid b

141 We now show that common lymphoid progenitors (CLPs) from mice with active HSV-1

142 h hematopoietic stem cells (HSCs) and common lymphoid progenitors (CLPs) from neonates and adults gen

143 Rac1 and Rac2 inhibited production of common lymphoid progenitors (CLPs) in bone marrow and suppresse

144 topoietic progenitor cells (LSKs) and common lymphoid progenitors (CLPs) in bone marrow.

145 he thymus are thought to develop from common lymphoid progenitors (CLPs) in the bone marrow (BM).

146 onic stem (ES) cells fail to generate common lymphoid progenitors (CLPs) resulting in a complete lack

147 In the fetal liver, a subset of common lymphoid progenitors (CLPs) that expresses the integrin

148 that the extrathymic precursors were common lymphoid progenitors (CLPs) that included CD19(-), B220(

149 The number of common lymphoid progenitors (CLPs) were not affected; however,

150 the proliferation of pre-pro-B cells, common lymphoid progenitors (CLPs), and colony-forming unit (CF

151 HSCs, multipotent progenitors (MPPs), common lymphoid progenitors (CLPs), and common myeloid progenit

152 00-fold toward cells with features of common lymphoid progenitors (CLPs), and lymphoid differentiatio

153 ocyte-erythrocyte progenitors (MEPs), common lymphoid progenitors (CLPs), and pro-T and pro-B cells.

154 sites throughout the genome for MPPs, common lymphoid progenitors (CLPs), common myeloid progenitors

155 ed common myeloid progenitors (CMPs), common lymphoid progenitors (CLPs), granulocyte-macrophage prog

156 th common myeloid progenitors (CMPs), common lymphoid progenitors (CLPs), granulocyte-macrophage prog

157 ineage-committed progenitors, such as common lymphoid progenitors (CLPs), maintain a latent myeloid d

158 We found that both the common lymphoid progenitors (CLPs), shown here and elsewhere to

159 f lin(-)Sca1(low)kit(low)IL7Ralpha(+) common lymphoid progenitors (CLPs), their cloning efficiency in

160 in MPPs reduced differentiation into common lymphoid progenitors (CLPs), which decreased lymphopoies

161 ion of low numbers of highly purified common lymphoid progenitors (CLPs)-a rare population of lymphoi

162 early B lineage differentiation from common lymphoid progenitors (CLPs).

163 re multipotent progenitors (MPPs) and common lymphoid progenitors (CLPs).

164 priate induction of Gata1 in HSCs and common lymphoid progenitors (CLPs).

165 3 ligand (FL) in pDC development from common lymphoid progenitors (CLPs).

166 the alpha-lymphoid progenitor, early innate lymphoid progenitor, common helper innate lymphoid proge

167 much greater competitive advantage to old B-lymphoid progenitors compared with young progenitors, co

168 Although alterations in the lymphoid progenitor content of aged mouse bone marrow (B

169 Common lymphoid progenitors could not be identified in the circ

170 eage-committed pro-B cells and multipotent B-lymphoid progenitors, decline in aged C57BL/6 mice.

171 duces apoptosis of murine and human leukemic lymphoid progenitors, decreases the activation of Rho GT

172 Impaired lymphoid progenitor development led to deficiencies of B

173 ion of PTPMT1 from myeloid, T lymphoid, or B lymphoid progenitors did not cause any defects in lineag

174 ic T lineage-committed cells, whereas common lymphoid progenitors did not.

175 m cell transplant recipients, CAR-expressing lymphoid progenitors differentiated into CAR-induced kil

176 hts into differentiation of murine and human lymphoid progenitors driven by synthetic CAR transgene e

177 ted to innate lymphoid lineages in the alpha-lymphoid progenitor, early innate lymphoid progenitor, c

178 Early innate lymphoid progenitors (EILPs) have recently been identifi

179 ll factor 1-positive (TCF-1(+)) early innate lymphoid progenitors (EILPs), which we named 'specified

180 Stem cells and early lymphoid progenitors (ELPs), but not prolymphocytes, wer

181 Mbd3/NuRD therefore controls the fate of lymphoid progenitors, ensuring appropriate production of

182 However, Suz12-deficient B-lymphoid progenitors exhibit enhanced serial clonogenici

183 Finally, we demonstrate that Gata3 mutant lymphoid progenitors exhibit neither increased apoptosis

184 Lymphoid progenitors exhibit severe growth defects durin

185 Ebf1-deficient lymphoid progenitors exhibited increased T cell lineage

186 For T cell production, lymphoid progenitors exit the BM and home to the thymus

187 escribed lymphoid progenitors such as common lymphoid progenitors express TdT and relatively high lev

188 Lymphoid progenitors expressing a Notch-resistant E2A mu

189 /Y79A) for use in retroviral transduction of lymphoid progenitors for comparison with CD3gammawt.

190 d Lin(-)Sca-1(+)cKit(Lo)IL-7Ralpha(+) common lymphoid progenitors from adult marrow efficiently gener

191 NFalpha mediates the depletion of late-stage lymphoid progenitors from bone marrow in many inflammato

192 lectin+ progenitors (LSP), as well as common lymphoid progenitors from C57BL6-Thy1.1-RAG-1/GFP mouse

193 Although lymphoid progenitors from Ebf1 or Pax5 heterozygote mice

194 therefore an effective marker for separating lymphoid progenitors from myeloid progenitors and hemato

195 development depends on continuous import of lymphoid progenitors from the bone marrow.

196 Whereas the characterization of B lymphoid progenitors has been facilitated by the identif

197 cannot generate early thymocytes from common lymphoid progenitors has thus far precluded investigatio

198 However, unlike in vivo expanded CML B-lymphoid progenitors, hematopoietic stem cells, or multi

199 PU.1 disruption in common lymphoid progenitors, however, did not prevent their B-c

200 Although we know they develop from a common lymphoid progenitor in the bone marrow (BM), the specifi

201 d, most previously identified RAG-1(+) early lymphoid progenitors in bone marrow and all lymphoid-aff

202 ls that support hematopoietic stem cells and lymphoid progenitors in bone marrow.

203 sses of CD19(+) B cells and more primitive B-lymphoid progenitors in bone marrow.

204 IKDCs developed from lymphoid progenitors in culture but, unlike pDCs, were n

205 rated the thymus and were superior to common lymphoid progenitors in magnitude and frequency of thymi

206 yte development, deletion of Arid1a in early lymphoid progenitors in mice resulted in a pronounced de

207 strate that LRF is key for instructing early lymphoid progenitors in mice to develop into B lineage c

208 Flt3 ligand (Flt3L) promotes survival of lymphoid progenitors in the bone marrow and differentiat

209 and extend from hematopoietic stem cells and lymphoid progenitors in the bone marrow and thymus to ma

210 These cells arise from lymphoid progenitors in the bone marrow and, under the c

211 Recent research suggests that lymphoid progenitors in the bone marrow comprise a heter

212 er a selective advantage on undifferentiated lymphoid progenitors in the bone marrow of gammaretrovir

213 ) animals, we found that the number of early lymphoid progenitors in the bone marrow was significantl

214 ILC2s arise from common lymphoid progenitors in the bone marrow, are dependent o

215 at all newly made ILCs originate from common lymphoid progenitors in the bone marrow.

216 ll progenitors in the fetal liver and common lymphoid progenitors in the bone marrow.

217 ion of B/NK bipotent precursors among common lymphoid progenitors in the fetal liver and the bone mar

218 iciency enhances BCR/ABL transformation of B-lymphoid progenitors in vitro and accelerates disease pr

219 ently suppresses BCR/ABL transformation of B-lymphoid progenitors in vitro and BCR/ABL-induced B-ALL

220 s (DCs) can be derived from both myeloid and lymphoid progenitors in vivo.

221 uch as common myeloid progenitors and common lymphoid progenitors, increase the production of immune

222 ed for the in vivo differentiation of common lymphoid progenitors into ILC lineage-restricted cells.

223 gammadelta cells after adoptive transfer of lymphoid progenitors into newborn recipients.

224 rt that Bmi1 transforms and reprograms CML B-lymphoid progenitors into stem cell leukemia (Scl) promo

225 functional B-cell potential of HSC and early lymphoid progenitor is severely impaired, in tandem with

226 ved pDCs in conditions where the function of lymphoid progenitors is impaired or compromised.

227 the differentiation potential of myeloid and lymphoid progenitors leading to development of acute mye

228 itor (Lin-Sca1+Kit+ Flt3+) as well as common lymphoid progenitor (Lin-Sca1+CD117(lo)CD127+) pools.

229 in(-)Sca-1(+)c-Kit(Hi)Thy1.1(-)L-selectin(+) lymphoid progenitors (LSPs) were the best source.

230 cyte-macrophage progenitors (GMPs) and multi-lymphoid progenitors (MLPs) - were functionally and tran

231 -primed multipotential progenitors and early lymphoid progenitor numbers are maintained, but there wa

232 h the anti-oxidant N-acetylcysteine restored lymphoid progenitor numbers to that of Paf(+/+) mice.

233 : HSCs occupy a perivascular niche and early lymphoid progenitors occupy an endosteal niche.

234 isparity in B and T cell expansion from this lymphoid progenitor population and suggest that it conta

235 d-type or mutated signaling molecule, into a lymphoid progenitor population by retroviral infection.

236 eage(-)Sca-1(+)c-Kit(-) (LSK(-)) cells are a lymphoid progenitor population that expands in the splee

237 ular features of primitive hematopoietic and lymphoid progenitors, potentially leading to novel thera

238 oliferation and/or differentiation of common lymphoid progenitors, pre-pro-B cells, and hematopoietic

239 way, Mbd3/NuRD protects the multipotency of lymphoid progenitors, preventing B cell-programming tran

240 raction of periostin with alpha(v)beta(3) on lymphoid progenitors probably provides both proliferativ

241 eover, early lymphoid progenitors and common lymphoid progenitors produced significant numbers of per

242 ematopoietic stem cells did not alter common lymphoid progenitor production but severely reduced proB

243 Constitutive NOTCH signaling in lymphoid progenitors promotes the development of immatur

244 hESC-derived lymphoid progenitors provide a novel means to characteri

245 c, but nonphysiologic, myeloid potentials of lymphoid progenitors, providing an explanation for contr

246 for specification as well as expansion of B-lymphoid progenitors, providing increased insight into t

247 Therefore, RAG-1+ early lymphoid progenitors (RAG-1+ ELP), and CD62L/L-selectin+

248 Lymphoid progenitors rapidly down-regulated RAG-1, and s

249 eam multipotent progenitors (MPP) and common lymphoid progenitors rapidly generated T cells following

250 Development of lymphoid progenitors requires a coordinated regulation o

251 fferentiation of hematopoietic stem cells to lymphoid progenitors requires Ikaros-dependent lineage p

252 particularly inhibited the proliferation of lymphoid progenitors, resulting in decreased production

253 own-regulation of p16(Ink4a) and Arf in aged lymphoid progenitors reverted the senescent phenotype an

254 inhibits B lymphopoiesis by acting on early lymphoid progenitors, S100A9 inhibits B lymphopoiesis by

255 on signatures of E2A- and HEB-ablated common lymphoid progenitors significantly overlap.

256 ended to hematopoietic stem cells and common lymphoid progenitors, spared T cells and enhanced the su

257 is completely blocked at the LY6D(-) common lymphoid progenitor stage.

258 f the B-lymphoid compartment after the early lymphoid progenitor stage.

259 However, whereas previously described lymphoid progenitors such as common lymphoid progenitors

260 during early phases of ex vivo generation of lymphoid progenitors suppressed BCL11B, leading to suppr

261 these data identify a population of atypical lymphoid progenitors that differentiate into B lymphocyt

262 tion factor PU.1 regulates the generation of lymphoid progenitors that express Flk2 and IL-7R.

263 tic effects were maintained with infusion of lymphoid progenitors that lack myeloid potential and wer

264 Furthermore, unlike common lymphoid progenitors that readily generate B cells upon

265 d C/EBPalpha while reducing EBF and Pax-5 in lymphoid progenitors that then generated myeloid cells.

266 m dose-dependent reduction in thymic cKit(+) lymphoid progenitors that was maintained throughout life

267 RC2 normally restricts the self-renewal of B-lymphoid progenitors, the disruption of which contribute

268 Mbd3/NuRD-deficient lymphoid progenitors therefore prematurely activate a B

269 se ILCs are derived downstream of the common lymphoid progenitor through lineage-restricted progenito

270 or that blocks B lymphopoiesis at the common lymphoid progenitor to preproB cell stage.

271 pocyte-derived factor occurred at the common lymphoid progenitor to preproB cell stage.

272 e inhibitors abrogated the response of early lymphoid progenitors to adiponectin in stromal cell-cont

273 sion of huPax5 during the induction of early lymphoid progenitors to B-lineage-committed cells can fi

274 differentiation requirements, and also drove lymphoid progenitors to become dendritic cells.

275 n occur between the gene products, preparing lymphoid progenitors to respond to environmental cues.

276 nal circuitry required for the commitment of lymphoid progenitors to the ILC lineage.

277 ic host induces a preferential commitment of lymphoid progenitors to the T lineage and results in a r

278 id-primed multipotent progenitors and common lymphoid progenitors to the thymus decreases more than 1

279 The recruitment of lymphoid progenitors to the thymus is essential to susta

280 CXCR4 in facilitating localization of early lymphoid progenitors to tissue regions of the thymus, wh

281 Also, unlike adults, fetal lymphoid progenitors transiently expressed endothelial c

282 ILCs arise from lymphoid progenitors undergoing lineage restriction and

283 The loss of lymphoid progenitors was likely due the increased levels

284 fferentiation potential of HNF1A(-/-) common lymphoid progenitors was severely impaired in vitro, and

285 16(INK4a) tumor suppressor in murine T- or B-lymphoid progenitors, we report that ablation of p16(INK

286 nt myeloid but not lymphoid cells, as common lymphoid progenitors were decreased, and peripheral lymp

287 w progenitor numbers were preserved, while B lymphoid progenitors were decreased.

288 , revealing how substantial numbers of early lymphoid progenitors were discarded or neglected in prev

289 inoic acid (ATRA)-treated C57BL6 mice, while lymphoid progenitors were reduced.

290 All B lymphoid progenitors were targets of ATRA in culture and

291 on, operative in both fetal and adult common lymphoid progenitors, where T cell potential is selectiv

292 ILCs are generated from common lymphoid progenitors, which are subsequently committed t

293 e bone marrow and differentiated from common lymphoid progenitors, which indicates they are distinct,

294 c stem cells in the bone marrow give rise to lymphoid progenitors, which subsequently differentiate i

295 for the generation of CCR9-expressing early lymphoid progenitors, which were the most efficient prog

296 sustained in serial transplants and produced lymphoid progenitors with low levels of the E47 transcri

297 71 selectively expanded CD34(+)CD45(+)CD7(+) lymphoid progenitors with NK cell potential, and increas

298 s completed PU.1-initiated transformation of lymphoid progenitors with URE deletion.

299 Moreover, when derived from aged mice, lymphoid progenitors within every population examined ex

300 y that led to marked depletion of very early lymphoid progenitors without affecting RAG2/GFP(+) CMPs