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1 ty, autoantibody production, and substantial lymphoproliferation.
2 is necessary for development of HCV-related lymphoproliferation.
3 t also causes massive double-negative T-cell lymphoproliferation.
4 m autoimmune diabetes without causing T-cell lymphoproliferation.
5 orm infection on host cytokine responses and lymphoproliferation.
6 negatively associated with rubella-specific lymphoproliferation.
7 who developed an Epstein-Barr virus-related lymphoproliferation.
8 itive patients who exhibit envelope-specific lymphoproliferation.
9 on in vitro does not preclude HIV-1-specific lymphoproliferation.
10 ormed to determine the cell type involved in lymphoproliferation.
11 cells are mainly responsible for preventing lymphoproliferation.
12 er monocytes to downregulate mitogen-induced lymphoproliferation.
13 bute to the costimulation of virally induced lymphoproliferation.
14 ion of PCD and in the inhibition of in vitro lymphoproliferation.
15 gement of the BCR in these cells, leading to lymphoproliferation.
16 ctions, hyperinflammation, autoimmunity, and lymphoproliferation.
17 combined immunodeficiency (CID), atopy, and lymphoproliferation.
18 esents as autoimmunity, inflammation, and/or lymphoproliferation.
19 ceptibility to infections, autoimmunity, and lymphoproliferation.
20 nfections, herpes viremia, autoimmunity, and lymphoproliferation.
21 matory markers, frequency of infections, and lymphoproliferation.
22 s than unlikely ALPS and had higher rates of lymphoproliferation.
23 entify high-risk patients and diagnose early lymphoproliferation.
24 ciency strongly correlated with intensity of lymphoproliferation.
25 a long-term risk of AA amyloidosis and overt lymphoproliferation.
26 lation, providing a mechanism for the T cell lymphoproliferation.
27 markers and were unable to induce allogeneic lymphoproliferation.
28 l dysfunction, perhaps related to EBV-driven lymphoproliferation.
29 isms, impaired production of antibodies, and lymphoproliferation.
30 st patients died of infection or progressive lymphoproliferation.
31 ify high-risk patients and to diagnose early lymphoproliferation.
32 confirmed the clonal B-cell nature of these lymphoproliferations.
33 tic target for treatment of some EBV-induced lymphoproliferations.
34 munodeficiency, we studied 39 EBV-associated lymphoproliferations (10 benign, 29 malignant) from four
35 the high frequency of autoimmunity (57.4%), lymphoproliferation (52.4%), noninfectious enteropathy (
36 ocyte responses at diagnosis, as measured by lymphoproliferation (7/7) or cytokine flow cytometry (3/
37 inhibition led to a reduction in spontaneous lymphoproliferation, a key ex vivo correlate of the immu
39 ity locus Nba2 causes dramatic B cell and PC lymphoproliferation, accelerated autoantibody production
40 PS) is characterized by chronic nonmalignant lymphoproliferation, accumulation of double-negative T c
41 ng precursor to neoplastic high-grade B-cell lymphoproliferation among people with HIV, especially fo
42 ng (a) H-TdR incorporation for inhibition of lymphoproliferation and (b) flow cytometry to analyze fo
43 ify the mTOR pathway as a major regulator of lymphoproliferation and aberrant differentiation in ALPS
44 At 4 mo of age, both groups showed extensive lymphoproliferation and aberrant T cell formation, altho
45 e Fas signaling, resulting in chronic benign lymphoproliferation and accumulation of TCRalphabeta(+)
47 had an impaired ability to induce allogeneic lymphoproliferation and activated autologous memory CD4+
51 vo depletion of normal Thy-1+ cells restores lymphoproliferation and autoantibody production in such
57 We found that expression of MC159 led to lymphoproliferation and autoimmunity as exemplified by T
63 le for infectious agents in the induction of lymphoproliferation and B cell autoimmunity in MRL-lpr m
64 pport an etiological role for HCV in causing lymphoproliferation and causing non-Hodgkin lymphoma.
67 monstrated suppression of adenovirus-induced lymphoproliferation and cytokine responses (interleukin-
70 y role for dietary exposure in the extent of lymphoproliferation and development of nephritis in this
71 port on 13 individuals from 10 families with lymphoproliferation and early-onset solid-organ autoimmu
74 pr.H-2(d) mice, both types of mice developed lymphoproliferation and exhibited elevated levels of IgG
76 TLA4Ig treatment of CTLA-4 -/- mice prevents lymphoproliferation and fatal multiorgan tissue damage i
78 ymph nodes (MLN), and spleen were assayed by lymphoproliferation and flow cytometry for the expressio
79 ogical activity of each subset, expressed as lymphoproliferation and gamma interferon (IFN-gamma) pro
80 atients without clinically detectable B-cell lymphoproliferation and generates many large B-cell clon
82 ovide insight into mechanisms of EBV-induced lymphoproliferation and identify potential therapeutic i
84 with this haplotype demonstrated higher mean lymphoproliferation and IFN-gamma secretion than did cel
87 eviously shown to be important in preventing lymphoproliferation and immunodeficiency following infec
88 eficiency syndrome (MAIDS), characterized by lymphoproliferation and immunodeficiency in susceptible
90 of virus-specific T cells and occurrence of lymphoproliferation and inflammatory autoimmune disease
92 tvaccination H3(Beijing/32) HA (H3)-specific lymphoproliferation and interleukin (IL)-2, IL-10, and i
93 on of autoreactive T and B cells, leading to lymphoproliferation and lupus-like autoantibody producti
94 infection of BALB beta2m-/- mice results in lymphoproliferation and lymphoma, providing a valuable t
97 exogenous sphingolipids cause inhibition of lymphoproliferation and PCD by two separate and distinct
99 Mice homozygous for the lpr gene develop lymphoproliferation and produce autoantibodies closely r
100 polyclonal lymphocyte activation leading to lymphoproliferation and severe autoimmune nephritis with
101 )CD25(+) regulatory T cells, exhibit massive lymphoproliferation and severe inflammatory infiltration
102 ty similar to that shown in vitro, including lymphoproliferation and stimulation of interleukin-6 sec
103 This paradigm is based on the extensive lymphoproliferation and systemic autoimmunity in mice an
104 ses induced by NP DNA, which included robust lymphoproliferation and Th1-type cytokine secretion (hig
105 significantly down-regulated antigen-induced lymphoproliferation and the expression of interleukin-12
106 ontrols, BEL dose-dependently inhibited both lymphoproliferation and Treg generation in human leukocy
107 activation of T cells (LAT) show progressive lymphoproliferation and ultimately die at 4-6 mo age.
110 s influences the phenotype of the developing lymphoproliferations and potentially the severity of dis
112 logical changes in lymphoid organs, abnormal lymphoproliferation, and a greatly increased incidence o
113 on that leads to abnormalities of apoptosis, lymphoproliferation, and a lupus-like autoimmune disease
115 es with immunodeficiency coupled with atopy, lymphoproliferation, and cytokine overproduction harbori
116 s, antibody-dependent cellular cytotoxicity, lymphoproliferation, and cytotoxic CD8+ T cell activity
117 patients displayed multiorgan autoimmunity, lymphoproliferation, and delayed-onset mycobacterial dis
120 r protein) cause a syndrome of autoimmunity, lymphoproliferation, and humoral immune deficiency.
123 stations-allergy, autoimmunity/inflammation, lymphoproliferation, and malignancies-are known to exist
124 fects of immunosuppression on EBV-associated lymphoproliferation, and may be an essential technique f
125 e dysregulation manifesting as autoimmunity, lymphoproliferation, and organ inflammation and thereby
126 Knocking out CTLA4 in mice causes lethal lymphoproliferation, and polymorphisms in human CTLA4 ar
128 ns of SNPs with measles-specific antibodies, lymphoproliferation, and secreted cytokines were determi
129 mmatory arthropathy, intermittent polyclonal lymphoproliferation, and significant chronic kidney dise
131 in delayed-type hypersensitivity responses, lymphoproliferation, and spontaneous apoptosis and with
133 tissue, in Epstein-Barr virus (EBV)-induced lymphoproliferations, and in malignant lymphomas with sp
136 ar lymphocytic leukemias (T-LGLs) are clonal lymphoproliferations arising from either natural killer
138 d the activation of autoreactive T cells and lymphoproliferation as well as production of autoantibod
139 repeat RT-PCR, nested DNA PCR, western blot, lymphoproliferation assay, cytotoxic T-cell lysis, CD8-d
143 chronic stimulation of the immune system and lymphoproliferation associated with storage of glucocere
145 s for one such subject revealed Env-specific lymphoproliferation at 11 DPI but no detectable Env-spec
146 family presenting with EBV-associated B-cell lymphoproliferation at an early age (12, 7(1/2), and 14
149 iciency for the IFN-RI surprisingly worsened lymphoproliferation, autoantibody production, and end or
150 e array of immune-mediated disease including lymphoproliferation, autoimmune cytopenias, and multisys
151 apoptosis of lymphocytes is characterized by lymphoproliferation, autoimmunity, but also an increased
152 linical manifestations including infections, lymphoproliferation, autoimmunity, enteropathy, bronchie
153 nt recipients are at high risk of EBV-driven lymphoproliferation because they lack EBV-specific memor
154 s to be required for uncontrolled aggressive lymphoproliferation, because none of the IL-15Ralpha(-/-
156 which was initially attributed to excessive lymphoproliferation but is now ascribed to the absence o
158 e that overexpression of this locus leads to lymphoproliferation, but no experimental proof that dysr
159 e sensitivity of peripheral monitoring for B lymphoproliferation, but the dramatic reduction in PTLD
160 volved in the pathogenesis of several B cell lymphoproliferations, but the precise contribution it ma
161 induced tolerance and double-negative T-cell lymphoproliferation can be uncoupled from each other.
162 tic cows, demonstrating that the spontaneous lymphoproliferation characteristic of BLV-induced persis
163 gnificantly exacerbated the skin disease and lymphoproliferation characteristic of MRL/lpr mice.
164 factor pathway by EBV may contribute to the lymphoproliferation characteristic of type III latency.
166 biopsy revealed an Epstein-Barr virus-driven lymphoproliferation consistent with a polymorphic posttr
168 ayed type hypersensitivity (DTH) and in vivo lymphoproliferation correlated with MMc levels, suggesti
169 E7 and/or L1-specific WIL, as determined by lymphoproliferation, could be isolated from more than 75
172 deleted region (CDR) changed the spectrum of lymphoproliferations developing in CDR- versus MDR-delet
173 e resulting FADD mutant mice did not develop lymphoproliferation diseases, unlike Fas-deficient mice.
174 immune regulatory disorder characterized by lymphoproliferation, dysgammaglobulinemia, and multiorga
175 munodeficiency associated with erythroderma, lymphoproliferation, elevated IgE, and hyperactive oligo
176 the Notch1 intracellular domain resulted in lymphoproliferation, exacerbated T(H)1 responses and aut
178 man immunodeficiency virus-negative atypical lymphoproliferations expressing large amounts of the lat
179 and conventional MRL-lpr mice were noted in lymphoproliferation, flow cytometric analysis of lymph n
181 noculated intradermally into wild type (wt), lymphoproliferation gene (lpr) (Fas deficient), or gener
184 dies, 77% of patients with envelope-specific lymphoproliferation have undetectable anti-CD4bd antibod
186 mber of immunopathologic sequelae, including lymphoproliferation, hypergammaglobulinemia, and overt s
189 o 8 weeks after infection by the criteria of lymphoproliferation, impaired proliferative responses to
191 motes rather than inhibits Bcr-Abl-induced B lymphoproliferation in a murine model where BM cells fro
194 rom CTLA-4(-/-) mice engrafted and prevented lymphoproliferation in an in vivo murine model of CTLA-4
198 IgM(+) memory B cells as a general target of lymphoproliferation in HCV(+) patients, affecting appare
199 , our findings suggest that autoimmunity and lymphoproliferation in IL-2Ralpha-/- mice can result fro
202 with increased susceptibility to EBV-induced lymphoproliferation in patients associated with hypomorp
203 sensitivity responses and decreased in vitro lymphoproliferation in response to specific antigens hav
204 This approach accomplishes the control of lymphoproliferation in severe forms as well as the minim
206 the marked decrease seen in mitogen-induced lymphoproliferation in the presence of infected monocyte
209 skin test to tuberculin, and antigen-induced lymphoproliferation in vitro were markedly suppressed in
211 recapitulates the spectrum of CLL-associated lymphoproliferations in humans, including CLL, CD5(+) mo
216 differential diagnosis of extranodal T-cell lymphoproliferations, including those in immunosuppresse
217 by the production of anti-nucleolar IgG Abs, lymphoproliferation, increased serum levels of IgG1 and
218 by the production of antinucleolar IgG Abs, lymphoproliferation, increased serum levels of IgG1/IgE
219 constitutively active Raf transgene enhanced lymphoproliferation, indicating a role for the Ras-MAPK
221 ignificantly increased Ag85b-specific T cell lymphoproliferation, interferon (IFN)-gamma secretion, I
223 T3 mutations may distinguish truly malignant lymphoproliferations involving T and NK cells from react
224 Epstein-Barr virus (EBV)-associated B-cell lymphoproliferation is a life-threatening complication a
229 ninfected, nonpregnant mice, suggesting that lymphoproliferation is not a good indicator of the antim
232 was sufficient to trigger aggressive B-cell lymphoproliferation, leading to early postnatal lethalit
233 TLA-4 die at an age of 2-3 wk due to massive lymphoproliferation, leading to lymphocytic infiltration
234 homozygous gld mutations cause age-dependent lymphoproliferation, limiting the gld mutation to one al
238 ween this syndrome and that in mice with the lymphoproliferation (lpr) phenotype or the generalized-l
240 tween intrinsic B cell reactivity and lethal lymphoproliferation, lymphomagenesis, and autoinflammati
241 -nonbinding CTLA-4 mutant delayed the lethal lymphoproliferation observed in CTLA-4-deficient mice.
242 prevents all features characteristic of the lymphoproliferation observed in CTLA-4-deficient mice.
243 rlier occurrence of autoantibodies; a higher lymphoproliferation of B and T cells; and an earlier ons
244 ular lymphocyte (T-LGL) leukemia is a clonal lymphoproliferation of cytotoxic T cells (CTLs) associat
245 ular lymphocyte leukemia is a chronic clonal lymphoproliferation of cytotoxic T cells often associate
246 phocyte (T-LGL) leukemia is a chronic clonal lymphoproliferation of cytotoxic T cells often associate
247 eukemia (T-LGLL) is characterized by chronic lymphoproliferation of cytotoxic T lymphocytes (CTLs) an
248 a (T-LGL) is characterized by chronic clonal lymphoproliferation of cytotoxic T lymphocytes (CTLs).
251 on 2 patients demonstrated that spontaneous lymphoproliferation of PBLs was present but decreased re
254 erum antibodies to Chlamydia and significant lymphoproliferation of T-cells following stimulation wit
255 ion at 11 DPI but no detectable Env-specific lymphoproliferation or ex vivo gamma interferon (IFN-gam
257 ctive immune disorders such as autoimmunity, lymphoproliferation, or atopy, but this coincidence is r
258 ey did not develop spontaneous autoimmunity, lymphoproliferation, or germinal center expansion althou
259 favorable impact on immune cell subsets and lymphoproliferation over placebo in patients with APDS o
260 ss-switched memory B cells and propensity to lymphoproliferation (P = .002) in patients with CVID.
261 esponses that trended higher than Dryvax for lymphoproliferation (P = .06), but lower for IFN-gamma E
264 that, at least in NZB, the autoimmunity and lymphoproliferation phenotypes are not linked geneticall
265 ts also emphasize the importance of IL-6 for lymphoproliferation, possibly through induction of IL-2R
268 essing gp160/LAMP had greater gp160-specific lymphoproliferation responses and higher titers of anti-
270 entity in which a bone marrow clonal B-cell lymphoproliferation results in autoimmune hemolytic anem
272 L13, SPP1), activated B-cell subtype (MUM1), lymphoproliferation (SPP1, TCL1A, CHI3L1), aggressive cl
274 liferation and, in older mice, clonal B cell lymphoproliferation, suggesting that the DZ inertial cel
275 matologic illness involving cytokine-induced lymphoproliferation, systemic inflammation, cytopenias,
277 expressing T and B cell lymphomas, including lymphoproliferations that emerged spontaneously after EB
279 Unexpectedly, there was no progression of lymphoproliferation through 24 weeks, even though immune
283 autoimmune disease manifestations, including lymphoproliferation, vasculitis, glomerulonephritis, and
284 velop an autoimmune disease characterized by lymphoproliferation, vasculitis, glomerulonephritis, aut
287 d monitoring strategy detecting peripheral B lymphoproliferation was effective in the early diagnosis
291 (purified protein derivative [PPD])-induced lymphoproliferation was markedly impaired in vaccinated
293 atory features were present in all patients: lymphoproliferation was the most common manifestation (7
295 mice in that the number of CLL among B-cell lymphoproliferations was significantly elevated in the f
296 nd NF-kappaB activation, IL-2 secretion, and lymphoproliferation were inhibited by fish oil feeding.
297 ells and peripheral tissues played a role in lymphoproliferation, whereas the skin disease phenotype
299 early onset and aggressive polyclonal T cell lymphoproliferation with concomitant B cell expansion an
300 eatment, all patients showed amelioration of lymphoproliferation with lymph node sizes and spleen vol