ライフサイエンスコーパス: lymphotoxin-alpha

1 TNFKO mice, which express the TNFR1 ligand, lymphotoxin alpha.

2 of two test antibodies, humAb4D5-8 and anti-lymphotoxin alpha.

3 40+) and produce IL-6, IL-10, TNF-alpha, and lymphotoxin-alpha.

4 affinity of poxvirus TNFRs for TNFalpha over lymphotoxin-alpha.

5 activation on macrophages by T cell-derived lymphotoxin alpha(1)beta(2) controls proinflammatory res

6 different cytotoxic TNF family ligands: TNF, lymphotoxin-alpha(1)beta(2), Fas ligand, and TNF-related

7 tic deletion of lymphotoxin beta receptor or lymphotoxin alpha abrogated development of lymphatic ves

8 t al report that Reed-Sternberg cell-derived lymphotoxin-alpha activates endothelial cells to enhance

9 because TNFR knockout (KO), TNF KO, and TNF/lymphotoxin alpha and beta triple KO mice showed 2- to 3

10 ceptor expressed by T lymphocytes (LIGHT) or lymphotoxin alpha and BTLA.

11 model decreased the muscle protein levels of lymphotoxin alpha and Il17a by 32% and 42%, respectively

12 ss I MHC disparity and form independently of lymphotoxin alpha and lymphotoxin beta receptor pathways

13 ember, BALM, unique to fish; 3) orthologs of lymphotoxins alpha and beta were not clearly identified

14 ontribute to splenic organization, including lymphotoxins alpha and beta.

15 rdiaI infarction with the LTA gene (encoding lymphotoxin-alpha), and a follow-up study found that an

16 interleukin (IL)-9, IL-13, IL-5, IL-4, IL-6, lymphotoxin alpha, and granulocyte-macrophage colony-sti

17 ts and effector molecules (interferon gamma, lymphotoxin alpha, and myxovirus resistance 1) were redu

18 238] and TNFA [-308]), the gene that encodes lymphotoxin-alpha, and alleles of the TNF-alpha microsat

19 ion of BM B cells is dependent on TNF-alpha, lymphotoxin-alpha, and both TNF receptors, TNFR1-p55 and

20 files with differential production of CD40L, lymphotoxin-alpha, and interferon-gamma.

21 h as tumor necrosis factor alpha (TNFalpha), lymphotoxin-alpha, and lipopolysaccharide.

22 e canonical TNF-related cytokines, LIGHT and Lymphotoxin-alpha, and the Ig-related membrane proteins,

23 al kinase activation and secretion of IL-10, lymphotoxin-alpha, and TNF-alpha were partially blocked.

24 uired for development of the MZ, i.e., muMT, lymphotoxin-alpha, and TNFR1.

25 Thus, TNF-alpha and lymphotoxin-alpha are required for loss of BM B lineage

26 onses, the conventional TNF ligand LIGHT and lymphotoxin alpha, as well as herpes simplex virus glyco

27 ear if soluble LT alpha 3, and/or cell-bound lymphotoxin-alpha beta (LT alpha beta) mediate these dev

28 The lymphotoxin-alpha beta complex (LT alpha beta) is found

29 he woodchuck tumor necrosis factor (TNF) and lymphotoxin-alpha, -beta (LT-alpha, -beta) cDNAs, genes

30 s the lymphorganogenic cytokines/chemokines, lymphotoxin-alpha/-beta, CCL19, CCL20, CCL21, and CXCL13

31 nct from regions where the ligands LIGHT and lymphotoxin-alpha bound HVEM.

32 recruitment was independent of L-selectin or lymphotoxin-alpha but required CCR7 expression.

33 king either lymphotoxin beta receptor or the lymphotoxin alpha-chain, and there was minimal overlap b

34 s in infection by and immunity to rotavirus, lymphotoxin alpha-deficient (LTalpha(-/-)) mice that lac

35 Lymphotoxin alpha-deficient (LTalpha-/-) mice show drama

36 Lymphotoxin alpha-deficient (LTalpha-/-) mice, which lac

37 ne the role of lymph node in CNV, we lasered lymphotoxin alpha-deficient mice (LTalpha-/-) and measur

38 We demonstrate in this report that lymphotoxin alpha-deficient mice develop CD8(+) T cells

39 es of transitional B cells in splenectomized lymphotoxin alpha-deficient mice that lack all secondary

40 Lymphotoxin- alpha-deficient (LTalpha(-/-)) mice have no

41 Lymphotoxin-alpha-deficient (LT-alpha-/-) mice manifest

42 Neutralization of IL-17 in CCR7(-/-) or in lymphotoxin-alpha-deficient animals specifically inhibit

43 Lymphotoxin-alpha-deficient mice infected with RSV were

44 CD8(+) RTEs efficiently populated the gut of lymphotoxin-alpha-deficient mice, which lack lymphoid or

45 egins, ftILCPs accumulate at PP anlagen in a lymphotoxin-alpha-dependent manner.

46 gene (TNF-308) and the +250 site within the lymphotoxin-alpha gene (LT alpha+250) on the risk of pro

47 The tumor necrosis factor gene (TNF) and lymphotoxin-alpha gene (LTA) have long attracted attenti

48 TNF-beta that is encoded by lymphotoxin-alpha gene (LTA) regulates adhesion molecule

49 t underwent splenectomy or were deficient in lymphotoxin alpha generated hepatic ABCs despite the lac

50 Polymorphisms in the TNF-alpha and lymphotoxin alpha genes influence TNF-alpha production.

51 on and by polymorphisms in the TNF-alpha and lymphotoxin alpha genes.

52 xpression, as infected mice deficient of TNF/lymphotoxin-alpha genes did not demonstrate attenuated c

53 40 to induce expression of CD23, ICAM-1, and lymphotoxin-alpha genes in B cells.

54 onsiveness to fish oil appeared unrelated to lymphotoxin alpha genotype.

55 ype was 6 times more frequent than the other lymphotoxin alpha genotypes among responsive individuals

56 examined the relation between TNF-alpha and lymphotoxin alpha genotypes and the ability of dietary f

57 Anti-lymphotoxin alpha has fast nonspecific clearance in cyno

58 -19, with central roles for IL-7, IL-15, and lymphotoxin-alpha in COVID-19 respiratory failure.

59 vided insight into pathogenesis, implicating lymphotoxin-alpha in multiple sclerosis.

60 e show that persistently increased levels of lymphotoxin-alpha in the cerebral meninges can give rise

61 IL-17 acted by promoting lymphotoxin-alpha-independent expression of the chemokin

62 Stereotaxic injections of recombinant lymphotoxin-alpha into the rat meninges led to acute men

63 c variation at the human LTA locus, encoding lymphotoxin-alpha, is associated with susceptibility to

64 ng wild-type control mice and splenectomized lymphotoxin alpha knockout (LT) mice deficient in SLOs a

65 Lymphotoxin alpha knockout mice lacking Peyer's patches

66 Injection of a lymphotoxin-alpha lentiviral vector into the cortical me

67 Lymphotoxin alpha (LT alpha)-deficient mice revealed cri

68 ntenance in germinal centers is dependent on lymphotoxin alpha (LT-alpha) and LT-beta signaling compo

69 In mice deficient in either lymphotoxin alpha (LT-alpha) or type I tumor necrosis fa

70 Although lymphotoxin-alpha (LT alpha) has been shown to be requir

71 Lymphotoxin-alpha (LT alpha) has recently been demonstra

72 Human lymphotoxin-alpha (LT alpha) is found in a secreted form

73 ols were genotyped for six biallelic TNF and lymphotoxin-alpha (LT alpha) polymorphisms and eight cla

74 Mice deficient in lymphotoxin-alpha (LT alpha-/- mice) have no lymph nodes

75 We identify surface lymphotoxin-alpha (LT-alpha) as common to T(H)0, T(H)1 a

76 In mice deficient in either lymphotoxin-alpha (LT-alpha) or the type I tumor necrosi

77 is factor receptor-associated factor family, lymphotoxin-alpha (LT-alpha), and a membrane-associated

78 Using lymphotoxin-alpha-(LT-alpha)-, TNF-alpha-, or TNFRp55-de

79 e polymorphism (SNP) haplotype involving the lymphotoxin alpha (LTA) and tumor necrosis factor (TNF)

80 se hypersensitive sites corresponding to the lymphotoxin alpha (LTA) and tumour necrosis factor (TNF)

81 modified by a functional polymorphism in the lymphotoxin alpha (LTA) gene (LTA C+80A, where the CC ge

82 We now demonstrate a critical role for lymphotoxin alpha (LTA) in the pathogenesis of Sjogren's

83 were determined for polymorphisms in the TNF/lymphotoxin alpha (LTA) region.

84 in B cells (lkappaBL), inhibitor-like 1 and lymphotoxin alpha (LTA), in relation to nutritional iron

85 within a 4.5-kb region encompassing TNF and lymphotoxin alpha (LTA).

86 olymorphisms in the TNF -308G>A (rs1800629), lymphotoxin-alpha (LTA) 252A>G (rs909253), IL10 -3575T>A

87 We identified lymphotoxin-alpha (LTA) as the causative factor for auto

88 The TNF-alpha (TNF) and lymphotoxin-alpha (LTA) genes belong to the TNF gene sup

89 The proinflammatory cytokine lymphotoxin-alpha (LTA) is thought to contribute to the

90 n separated by sex, a variant in intron 1 of lymphotoxin-alpha (LTA), a gene adjacent to TNF, was ass

91 ide, the cytokine tumor necrosis factor beta/lymphotoxin-alpha (LTA), and heat-killed bacteria.

92 ndertaken, and the pro-inflammatory cytokine lymphotoxin-alpha (LTA), and its key ligand galectin-2 (

93 n TNFSFs appear in shark genomes, except for lymphotoxin-alpha (LTA; TNFSF1) and TNF (TNFSF2), and CD

94 at HVEM binds two cellular ligands, secreted lymphotoxin alpha (LTalpha) and LIGHT, a new member of t

95 Lymphotoxin alpha (LTalpha) can exist in soluble form an

96 We show that targeted mutation of the lymphotoxin alpha (LTalpha) gene efficiently rescued tum

97 pendent, TNFR1-mediated death in response to lymphotoxin alpha (LTalpha) homotrimers.

98 contrast, the role of the related cyto-kine lymphotoxin alpha (LTalpha) in CM has been overlooked.

99 The importance of lymphotoxin alpha (LTalpha) in lymphoid organogenesis is

100 sized the role of type 1 IFN (IFN-alpha) and lymphotoxin alpha (LTalpha) in the pathogenesis of the d

101 chanistically, ES enhanced the expression of lymphotoxin alpha (LTalpha) on Tregs after transplantati

102 Lymphotoxin alpha (LTalpha) signals via tumor necrosis f

103 n of tumor necrosis factor alpha (TNFalpha), lymphotoxin alpha (LTalpha), and multiple components of

104 Tumor necrosis factor alpha (TNFalpha) and lymphotoxin alpha (LTalpha, originally TNFbeta) are pote

105 ECT CrmD cysteine-rich region bound TNF and lymphotoxin-alpha (LTalpha) and blocked their in vitro c

106 the injection of lentiviral vectors for the lymphotoxin-alpha (LTalpha) and interferon-gamma (IFNgam

107 d membrane extracts detected the presence of Lymphotoxin-alpha (LTalpha) but not tumor necrosis facto

108 association between genetic variants in the lymphotoxin-alpha (LTalpha) gene and leprosy.

109 udy, we show in vitro that HRS cells secrete lymphotoxin-alpha (LTalpha) which acts on endothelial ce

110 Lymphotoxin-alpha (LTalpha)(-/-) and LTbetaR(-/-) mice s

111 Lymphotoxin-alpha (LTalpha), a cytokine crucial for deve

112 of tumor necrosis factor (TNF) superfamily, lymphotoxin-alpha (LTalpha), also interacts with HVEM.

113 Lymphotoxin-alpha (LTalpha), lymphotoxin-beta (LTbeta),

114 enes, including interferon-gamma (IFNgamma), lymphotoxin-alpha (LTalpha), tumor necrosis factor-alpha

115 However, besides TNF, etanercept also blocks lymphotoxin-alpha (LTalpha), which has no clear therapeu

116 phoid organs, NALT develops independently of lymphotoxin-alpha (LTalpha).

117 Lymphotoxin-alpha(-/-) (LTalpha(-/-)) mice are thought t

118 TNF/LTalpha/LTbeta (tumor necrosis factor/lymphotoxin-alpha/lymphotoxin-beta) triple knockout (KO)

119 nhanced C5aR expression in the brains of TNF/lymphotoxin-alpha -/- mice and in normal animals even in

120 the genes for TNF and lymphotoxin-alpha (TNF/lymphotoxin-alpha -/- mice) showed significantly attenua

121 mmune response by reversing the LN defect in lymphotoxin-alpha(-/)- mice, thereby restoring the capac

122 Similar results were obtained in lymphotoxin alpha-/- mice, which lacked peripheral lymph

123 proteome analysis links vaccine efficacy to lymphotoxin-alpha, mucosal DC-10, and chemokine (C-C mot

124 receptors that share the HVEM ligands LIGHT, Lymphotoxin-alpha, or BTLA.

125 Our results show that chronic lymphotoxin-alpha overexpression alone is sufficient to

126 Lymphotoxin-alpha plays a key role in lymphoid organ dev

127 induced by CD4(+) thymocytes via CD80/86 and lymphotoxin-alpha signals.

128 on, since mice lacking the genes for TNF and lymphotoxin-alpha (TNF/lymphotoxin-alpha -/- mice) showe

129 ocument a novel link between IL-12Rbeta2 and lymphotoxin-alpha, TNF-alpha, and IFN-gamma expression,

130 vated T cells and impaired overexpression of lymphotoxin-alpha, TNF-alpha, and IFN-gamma in the brain

131 hisms in the TNF-alpha (TNF*1 and TNF*2) and lymphotoxin alpha (TNFB*1 and TNFB*2) genes were determi

132 selectively binds and inhibits TNF/TNFR1 and lymphotoxin-alpha/TNFR1 signaling with good affinity and