ライフサイエンスコーパス: lysine acetyltransferase

1 fs for interacting with and activating three lysine acetyltransferases.

2 the nucleus in human cell lines and binds to lysine acetyltransferase 2A (KAT2A, also known as GCN5)

3 H3K9ac, cholangiocytes predominantly express Lysine Acetyltransferases 2A (KAT2A).

4 Here, we report that the lysine acetyltransferases 2A and 2B (KAT2A/2B, also call

5 increased H3K9Ac through recruitment of the lysine acetyltransferase 2B (KAT2B) and WD repeat-contai

6 1 degradation was mediated by an NO/p38-MAPK/lysine acetyltransferase 5-dependent mechanism.

7 The lysine acetyltransferase 6 (KAT6) histone acetyltransfer

8 MOZ, MORF, and HBO1, which are also known as lysine acetyltransferase 6A (KAT6A), KAT6B, and KAT7, re

9 heterozygous truncating mutations in KAT6B (lysine acetyltransferase 6B, formerly known as MYST4 and

10 t-chain family member 2 (ACSS2) coupled with lysine acetyltransferase 7 (KAT7) modulates beta-hydroxy

11 K (lysine) acetyltransferase 8 (KAT8), an important compone

12 K(lysine) acetyltransferase 8 (KAT8, also known as MOF) me

13 and long-lasting) activation of two distinct lysine acetyltransferase activities along with the ERK/M

14 glucosamine (O-GlcNAc) hydrolase and cryptic lysine acetyltransferase activities.

15 estigated short- and long-term regulation of lysine acetyltransferase activity and the ERK/mitogen-ac

16 P-ZNF384 fusions resulted in loss of histone lysine acetyltransferase activity in a dominant-negative

17 usal relationship between ERK activation and lysine acetyltransferase activity in insular cortex.

18 ence that these TFs, in conjunction with the lysine acetyltransferase activity of p300/CBP, facilitat

19 RVBs are required for the lysine acetyltransferase activity of TIP60.com but not f

20 Both proteins display acetyl-CoA:lysine acetyltransferase activity, can interact with and

21 selective small molecule inhibitors of their lysine acetyltransferase activity, we validate CBP/p300

22 The Mtb Rv2170 protein shows lysine acetyltransferase activity, which is capable of p

23 The KAT8 gene encodes a lysine acetyltransferase and represents the catalyticall

24 ules, therapeutics targeting the activity of lysine acetyltransferases and lysine deacetylase enzymes

25 Nuclear receptors use lysine acetyltransferases and lysine deacetylases (KDACs

26 The MYST protein lysine acetyltransferases are evolutionarily conserved t

27 The MYST family of lysine acetyltransferases are transcriptional regulators

28 tightly regulated by two ER-based acetyl-CoA:lysine acetyltransferases, ATase1 and ATase2.

29 We now demonstrate that the lysine acetyltransferases cAMP-response element-binding

30 The lysine acetyltransferases CBP and p300 function as princ

31 es a reaction mechanism different from other lysine acetyltransferases characterized to date.

32 NuA4 is the only essential lysine acetyltransferase complex in Saccharomyces cerevi

33 that may also function independently of the lysine acetyltransferase complex.

34 We previously reported that the lysine acetyltransferase CREB-binding protein (CBP) is r

35 paralogous transcriptional coactivators and lysine acetyltransferases CREB binding protein (CBP) and

36 ng 21 (TRIM21), which activates CREB binding lysine acetyltransferase (CREBBP) via its E3 ligase acti

37 n events is indicated by the associations of lysine acetyltransferases, deacetylases, and acetyl-lysi

38 ntrast the role of missense mutations in the lysine acetyltransferase domain that are more frequently

39 chain lysine substrate that is acetylated by lysine acetyltransferase enzymes such as Gcn5.

40 le substrates for the cAMP-dependent protein lysine acetyltransferase from Mycobacterium tuberculosis

41 is implicated in neurodegeneration, and the lysine acetyltransferase GCN5 (also known as KAT2A) is i

42 ucleosome remodelers INO80 or ISW1A, and the lysine acetyltransferases Gcn5 and Esa1 each contribute

43 due to conditional disruption of the histone lysine acetyltransferase gene Kat2a.

44 Lysine acetyltransferases have been shown to regulate va

45 that pharmacological inhibition of KAT2B, a lysine acetyltransferase identified by our genetic scree

46 fied Gcn5 as the first transcription-related lysine acetyltransferase in 1996, providing a molecular

47 anism of FadD33 by the mycobacterial protein lysine acetyltransferase in a cAMP-dependent manner.

48 Further, we show that lower quality lysine acetyltransferase inhibitors and nonspecific elec

49 Lysine acetyltransferases interact with steroid receptor

50 comprise the KAT3 family of histone/protein lysine acetyltransferases, interact with over 50 T-lymph

51 and the consequences of loss of SAGA complex lysine acetyltransferase (KAT) activity on histone acety

52 NuA4, the major H4 lysine acetyltransferase (KAT) complex in Saccharomyces

53 ted by each mark individually, including the lysine acetyltransferase (KAT) complex KAT6B.

54 tion between native nucleosomes and the NuA4 lysine acetyltransferase (KAT) complex.

55 , reversible binding of the inhibitor to the lysine acetyltransferase (KAT) domain of p300 is largely

56 Here, we explore an emerging concept that lysine acetyltransferase (KAT) enzymes drive cellular pl

57 The GCN5 lysine acetyltransferase (KAT) functions together with M

58 However, no lysine acetyltransferase (KAT) has been definitively loc

59 nal lysine acetylation and the corresponding lysine acetyltransferase (KAT) in RC nucleosome assembly

60 Development of optimized p300 lysine acetyltransferase (KAT) inhibitors enabled inhibi

61 The CREBBP lysine acetyltransferase (KAT) is frequently mutated in

62 we focused on ADA2B, the only subunit in the lysine acetyltransferase (KAT) module that specifically

63 t ID approach, we identified the coactivator lysine acetyltransferase (KAT) p300 as a key IRF4 partne

64 The p300, CBP, and pCAF lysine acetyltransferase (KAT) proteins have been report

65 ally with a second chaperone, Vps75, and the lysine acetyltransferase (KAT) Rtt109.

66 We define a lysine acetyltransferase (KAT)-TF network in resting and

67 ing clinically targeted, the role of histone lysine acetyltransferases (KAT) in malignancy is less we

68 characterize cellular functions of the human lysine acetyltransferases KAT2A (GCN5) and KAT2B (PCAF),

69 1 can be acetylated at its N terminus by the lysine acetyltransferases KAT2B and KAT3B.

70 ydroxynaphthoquinone-based inhibitors of the lysine acetyltransferase KAT3B (p300), such as plumbagin

71 The lysine acetyltransferase KAT5 is a pivotal enzyme respon

72 those encoding the largest family of histone lysine acetyltransferases (KAT5-KAT8).

73 4 nucleosome-binding domains and activates 3 lysine acetyltransferases (KAT6A, KAT6B, and KAT7), sugg

74 Mis18 complex is to transiently recruit the lysine acetyltransferase KAT7 to centromeres to facilita

75 ion was observed after the inhibition of the lysine acetyltransferase KATB3/p300.

76 n acetylation and deacetylation catalysed by lysine acetyltransferases (KATs) and deacetylases (KDACs

77 r proteins that is catalysed by the 'writer' lysine acetyltransferases (KATs) and mediates interactio

78 Lysine acetyltransferases (KATs) are a family of epigene

79 Lysine acetyltransferases (KATs) are key mediators of ce

80 Histone deacetylases (HDACs) and lysine acetyltransferases (KATs) catalyze dynamic histon

81 Several conserved lysine acetyltransferases (KATs) contributed to hemolysi

82 ctivation of EP300/CREBB paralogous cellular lysine acetyltransferases (KATs) during the early phase

83 The MYST family of lysine acetyltransferases (KATs) function in a wide vari

84 ogical and pathological functions of protein lysine acetyltransferases (KATs) greatly depends on the

85 Inhibition of histone lysine acetyltransferases (KATs) KAT6A and KAT6B has sho

86 Lysine acetyltransferases (KATs) play a critical role in

87 Lysine acetyltransferases (KATs) play a unique role in r

88 P/KAT3A) and its paralogue EP300 (KAT3B) are lysine acetyltransferases (KATs) that are essential for

89 The next challenge is connecting lysine acetyltransferases (KATs) to their cellular targe

90 Lysine acetyltransferases (KATs, also termed histone ace

91 plex with the double PHD finger (DPF) of the lysine acetyltransferase MOZ/MYST3/KAT6A.

92 Compared with other lysine acetyltransferases of known structure, alpha-tubu

93 acetylation, which is regulated by either a lysine acetyltransferase or a lysine deacetylase enzyme.

94 oyl-CoA, function as efficient substrates of lysine acetyltransferase p300 and serve as sensitive rea

95 tilizes bifunctional molecules to direct the lysine acetyltransferase p300/CBP to proteins fused with

96 following acute inhibition of major cellular lysine acetyltransferases P300 and CBP in hematological

97 The lysine acetyltransferases p300 and CREB-binding protein

98 ltransferases G9a, GLP and SETD7 and histone lysine acetyltransferases PCAF and GCN5 do somewhat tole

99 g highlights an expanded landscape of orphan lysine acetyltransferases present in the human genome an

100 KAT5 encodes an essential lysine acetyltransferase, previously called TIP60, which

101 KAT8 is a lysine acetyltransferase primarily catalyzing the acetyl

102 Thus, lysine acetyltransferases represent a potential therapeu

103 acetylation of H3 lysine 56 catalyzed by the lysine acetyltransferase Rtt109.

104 Indeed the mycobacterial Pat (protein lysine acetyltransferase), Rv0998, specifically acetylat

105 regulate the lysine acetylation of a 42 kDa lysine acetyltransferase substrate, suggesting a causal

106 Rtt109 is a lysine acetyltransferase that acetylates histone H3 at l

107 Tip60 is a lysine acetyltransferase that acetylates histones and ot

108 Furthermore, p300 is a lysine acetyltransferase that catalyzes acetylation of h

109 KAT8 is an evolutionarily conserved lysine acetyltransferase that catalyzes histone acetylat

110 AT6A and KAT6B genes are two closely related lysine acetyltransferases that transfer an acetyl group

111 We show that the lysine acetyltransferase Tip60 acetylates eEF1A1, wherea

112 activating phase of the circadian cycle, the lysine acetyltransferase TIP60 acetylates the transcript