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1 g 2C (JMJD2C), a recently identified histone lysine demethylase.
2 ex 2, and its erasers, Jumonji-class histone lysine demethylases.
3 nvolving the KDM4A, KDM4B, and KDM4C histone lysine demethylases.
4 KG-dependent enzyme of the Jumonji family of lysine demethylases.
5 bitors of the KDM4 (JMJD2) family of histone lysine demethylases.
6 entially inhibits the subfamily of trimethyl lysine demethylases.
7 Gfi1 are exquisitely dependent on the enzyme lysine demethylase 1 (Kdm1a/Lsd1).
8      The histone modification eraser enzymes lysine demethylase 1 (LSD1) and histone deacetylase 1 (H
9 f a cyclopropylamine containing inhibitor of Lysine Demethylase 1 (LSD1), GSK2879552.
10                                GSK2879552, a lysine demethylase 1 inhibitor currently in clinical tri
11 iC (JmjC) and ARID domain-containing histone lysine demethylase 1a (JARID1a) formed a complex with CL
12                            AOF1, now renamed lysine demethylase 1B (KDM1B) following a new nomenclatu
13 -2HG competitively inhibited the activity of lysine demethylase 2B (KDM2B), an alpha-ketoglutarate-de
14                         We demonstrated that lysine demethylase 3A (KDM3A) binds to PGC-1alpha and de
15                                  The histone lysine demethylase 3A (KDM3A) demethylates H3K9me1 and H
16                                Using histone lysine demethylase 4 (KDM4) as a proof-of-concept, we sh
17                 We demonstrated that histone lysine demethylase 4 (KDM4) can restrict HBV, and pharma
18                             For example, the lysine demethylase 4A/Jumonji domain-containing 2A (KDM4
19               Here, we show that the histone lysine demethylase 4B (KDM4B) is a therapeutic vulnerabi
20                                     In mice, lysine demethylase 4B is expressed during brain developm
21                                              Lysine demethylase 4C (KDM4C), an H3K9me3 demethylase, l
22  significantly decreased ARID3A, ARID3B, and lysine demethylase 4C (KDM4C).
23                       Here, we show that the lysine demethylase 5 (KDM5) family of epigenetic regulat
24                             Mutations in the lysine demethylase 5 (KDM5) family of transcriptional re
25                           Here, we show that lysine demethylase 5 (KDM5) is essential for prothoracic
26 eraction between BRWD3 and the H3K4-specific lysine demethylase 5 (KDM5/Lid), an enzyme that removes
27 rmined the regulation of MPC-1 expression by Lysine demethylase 5A (KDM5A) and critical impact of thi
28 ation of one of the JmjC-containing enzymes, lysine demethylase 5A (KDM5A), mimics hypoxia-induced ce
29 s RNA sequencing, we show that the ASD gene, lysine demethylase 5A (KDM5A), regulates the development
30 6 ADHD cases and 5002 controls), we identify lysine demethylase 5B (KDM5B) as a high-confidence risk
31 ne 170 (R170me2s), a modification removed by lysine demethylase 5C (KDM5C).
32                                              Lysine demethylase 6A (KDM6A) and 6B (KDM6B) were upregu
33                       Elevated expression of lysine demethylase 6A (KDM6A) and lysine demethylase 6B
34  histone H3 at lysine 27 (H3K27) demethylase lysine demethylase 6A (KDM6A) is a tumor suppressor in m
35                                              Lysine demethylase 6A (KDM6A), also known as UTX, belong
36               We identified the induction of lysine demethylase 6B (KDM6B) as the primary epigenetic
37 ression of lysine demethylase 6A (KDM6A) and lysine demethylase 6B (KDM6B) has been reported in prost
38       In this study, we demonstrate that the lysine demethylase 6b (Kdm6b) is essential for the prope
39                                              Lysine demethylase 6B (KDM6B) was identified as a key re
40                We discovered upregulation of lysine demethylase 6B (KDM6B), a demethylase for H3K27me
41 eased expression of the epigenetic regulator lysine demethylase 6B (KDM6B).
42 SPCs revealed that Evi1 directly upregulated lysine demethylase 6b (Kdm6b).
43                         Here, we report that lysine demethylases 7A (KDM7A) and 6A (UTX) play crucial
44 SL produces fumarate, which in turn inhibits lysine demethylase 8-mediated Beclin1 demethylation, res
45 hylation in mouse ESCs, independently of its lysine demethylase activity.
46 n, some of which appear to be independent of lysine demethylase activity.
47    Here, we demonstrate that LSD1, a histone lysine demethylase, also participates in the trans-repre
48 tivated as CGNs mature is facilitated by the lysine demethylase and ASD-risk gene, Kdm6b.
49 ase 1 (LSD1) is the first discovered histone lysine demethylase and, with the help of its cofactor Co
50  generate 2-hydroxyglutarate, which inhibits lysine demethylases and increases heterochromatin.
51  a histone protease, as an N(epsilon)-methyl lysine demethylase, and as an arginine residue hydroxyla
52 atin-remodeling factors, histone deacetylase/lysine demethylase, and corepressors.
53 ygenase family, including prolylhydroxylase, lysine demethylase, and DNA demethylase, have emerged as
54                   Although LSD1 is a histone lysine demethylase, and histone H3K4 was demethylated at
55 tural topology is similar to known oxidases, lysine demethylases, and monooxygenases, but its active
56 us, we suggest that, during gene repression, lysine demethylases can directly interact and function i
57  KDM2A/FBXL11 is a Jumonji-domain containing lysine demethylase catalyzing the removal of mono- and d
58 , we identified de novo variants in KDM2A, a lysine demethylase crucial for embryonic development, in
59  report in this study, KDM8/JMJD5, a histone lysine demethylase/dioxygnase, exhibits a novel property
60 JMJD2) and KDM5 (JARID1) families of histone lysine demethylases (e.g., 1), further optimization led
61  islands directly recruit the H3K36-specific lysine demethylase enzyme KDM2A.
62 ET domain-containing protein 1 (NSD1), and a lysine demethylase, F-box and leucine-rich repeat protei
63                                      Histone lysine demethylases facilitate the activity of oncogenic
64 r of the Jumonji C domain-containing histone lysine demethylase family, specifically targets lower me
65                   Enhanced expression of the lysine demethylase FBXL11, which catalyzes the demethyla
66               Other interactors, such as the lysine demethylase Fbxl11/KDM2A, recognize nucleosomes m
67               Initial studies of the histone lysine demethylases focused on their in vitro enzymatic
68 transcriptomic analysis reveal that Kdm5b, a lysine demethylase gene carrying "bivalent" chromatin do
69 nactivating somatic mutations in the histone lysine demethylase gene UTX, pointing to histone H3 lysi
70                           The KDM5 family of lysine demethylases has developmental and homeostatic fu
71 stone lysine methyltransferases, and histone lysine demethylases, have a role in diverse cancers, spe
72 ydroxylase FIH and histone N(epsilon)-methyl lysine demethylases, identifies branch points in 2OG-dep
73     Since the discovery of the first histone lysine demethylase in 2004, two protein families with nu
74 describe a unique role for the KDM4C histone lysine demethylase in KDM4C-amplified basal breast cance
75 nistic understanding of the roles of histone lysine demethylases in eukaryotic transcription, genome
76 ecent insights into the roles of the histone lysine demethylases in multiple aspects of development a
77  the ligand-dependent recruitment of histone lysine demethylases, including lysine-specific demethyla
78                                      Histone lysine demethylase inhibition (GSK-J1, 2,4-PDCA) decreas
79 e 1 (CES1) confers resistance to the histone lysine demethylase inhibitor GSK-J4 by direct enzymatic
80               Disruption of KDM6A, a histone lysine demethylase, is one of the most common somatic al
81 LSDs or KDM1s) and JmjC families of N-methyl-lysine demethylases (JmjC KDMs, KDM2-7), focusing on the
82            We identify the conserved histone lysine demethylases jmjd-1.2/PHF8 and jmjd-3.1/JMJD3 as
83 m involving OCA-B recruitment of the histone lysine demethylase Jmjd1a to targets such as Il2, Ifng,
84  Upon binding DNA, Oct4 recruits the histone lysine demethylase Jmjd1c.
85 by the lysine methyltransferase PRDM9 or the lysine demethylase JMJD2E.
86 aches, we were able to simultaneously delete Lysine Demethylase (KDM) 5A, 5B and 5C efficiently in vi
87                    Jumonji domain-containing lysine demethylase (KDM) enzymes are encoded by genes of
88 in SCLC consisting of the targetable Jumonji lysine demethylase (KDM) family.
89 a relevant proportion affecting genes of the lysine demethylase (KDM) family.
90 es, a series of potent JmjC histone N-methyl lysine demethylase (KDM) inhibitors which bind to Fe(II)
91 G) and succinate metabolism, including TET2, lysine demethylase (KDM) KDM6A, BRCA1-associated BAP1, a
92 Recently, we identified hepatic demethylases lysine demethylase (KDM)5B and KDM5C as important epigen
93 state cancer, two different types of histone lysine demethylases (KDM), LSD1/KDM1 and JMJD2/KDM4, are
94 g) domain 1 (AOF1), a protein related to the lysine demethylase KDM1 (also known as LSD1), functions
95                     Recently, we showed that lysine demethylase KDM1A is overexpressed in GBM.
96 onitors binding of inhibitors to the histone lysine demethylase KDM1A.
97 ed with epigenetic modifications mediated by lysine demethylases KDM1A and KDM5A, further exacerbated
98 MSN-specific expressional changes of histone lysine demethylases Kdm1a, Kdm6a, and Kdm5c in NAc after
99 nic cellular model, here we identify histone lysine demethylase KDM2A as a molecular vulnerability se
100 71) determine a crystal structure of histone lysine demethylase KDM2A that specifically targets lower
101 lar analysis of chromatin recognition by the lysine demethylase KDM2A.
102 or that is highly potent towards the histone lysine demethylases KDM2A/7A.
103 onditions by directly repressing the histone lysine demethylase, Kdm2a, whose expression increases in
104                                          The lysine demethylase Kdm3a (Jhdm2a, Jmjd1a) is required fo
105                      Here we identified that lysine demethylase KDM3A as a critical regulator of ovar
106 ion in the 15-LOX-1 promoter via the histone lysine demethylase KDM3A was an early and specific histo
107 lance is controlled by the crosstalk between lysine demethylase KDM3B and methyltransferase G9a/EHMT2
108 changes in epigenetic regulators such as the lysine demethylase KDM4.
109         Here, we demonstrate that H3K9/36me3 lysine demethylase KDM4A/JMJD2A overexpression leads to
110 rexpressed Jumonji domain-containing histone lysine demethylases KDM4A/4C.
111  The KDM4/JMJD2 Jumonji C-containing histone lysine demethylases (KDM4A-KDM4D), which selectively rem
112 hat oncometabolite-induced inhibition of the lysine demethylase KDM4B results in aberrant hypermethyl
113  on this promoter is to displace the histone lysine demethylase KDM5A, thereby favoring trimethylatio
114 tive removal of broad H3K4me3 domains by the lysine demethylases KDM5A and KDM5B is required for norm
115                                      Histone lysine demethylase KDM5B (PLU-1) catalyzes the demethyla
116                                  The histone lysine demethylase KDM5B is implicated in recessive inte
117 nsferases Ash1l, Smyd2, and Ezh2 and histone lysine demethylases Kdm5b and Kdm6b in J774 macrophages
118                More mutations in the histone lysine demethylase KDM6A were present in non-invasive tu
119 emonstrated enhanced binding of the H3K27me3 lysine demethylase KDM6A, which significantly correlated
120                                The Jumonji C lysine demethylases (KDMs) are 2-oxoglutarate- and Fe(II
121                                      Histone lysine demethylases (KDMs) are epigenetic enzymes that c
122                             Jumonji C (JmjC) lysine demethylases (KDMs) are Fe(II)-dependent hydroxyl
123                                      Histone lysine demethylases (KDMs) are involved in the dynamic r
124                                      Histone lysine demethylases (KDMs) are of critical importance in
125 -seq, and docking analyses implicate histone lysine demethylases (KDMs) as its targets.
126                                          The lysine demethylases (KDMs) catalyze the demethylation of
127                                              Lysine demethylases (KDMs) catalyze the oxidative remova
128 pecific lysine methyltransferases (KMTs) and lysine demethylases (KDMs) have been implicated in the d
129 and the lysine methyltransferases (KMTs) and lysine demethylases (KDMs) that regulate them.
130                    Twenty years ago, histone lysine demethylases (KDMs) were discovered.
131  detransferases and successfully apply it to lysine demethylases (KDMs) which catalyze the removal of
132 asing interest in targeting histone N-methyl-lysine demethylases (KDMs) with small molecules both for
133 ylation-lysine methyltransferases (KMTs) and lysine demethylases (KDMs), respectively-are frequently
134 ive sites of selected iron-dependent histone lysine demethylases (KDMs), resulting in pan inhibition
135 e TYW5 but displays limited homology to JmjC lysine demethylases (KDMs).
136 ly, which includes histone N(epsilon)-methyl lysine-demethylases (KDMs) and hydroxylases catalysing f
137 h histone arginine methylases like PRMT5 and lysine demethylases like JARID1B/KDM5B.
138                                          The lysine demethylase LSD1 (also called KDM1A) plays import
139 to pharmacological inhibition of the histone lysine demethylase LSD1 and genetic ablation of the PRC2
140         Thus, our data revealed that histone lysine demethylase LSD1 may negatively regulate TAL1-med
141 ltiple clinically relevant inhibitors of the lysine demethylase LSD1 were tested to determine which i
142 ing corepressor that recruits the repressive lysine demethylase LSD1/KDM1A to Notch target genes.
143   We establish a requirement for the histone lysine demethylase, LSD1, in directing specific interchr
144             Here, we report that the histone lysine demethylase, LSD1--a component of the CoREST-CtBP
145         Based on the prediction that histone lysine demethylases may contain the JmjC domain, we exam
146 d and erase the methylated histone residues, lysine demethylases must specifically recognize the hist
147 hough, histone lysine methyltransferases and lysine demethylases orchestrate these events, their role
148                                              Lysine demethylases play an important role in epigenetic
149 ase 1 (LSD1) as the first identified histone/lysine demethylase regulates gene expression and protein
150                    Here we show that LSD1, a lysine demethylase, regulates histone H3 lysine 4 di-met
151 M2A/B, or any related JumonjiC (JmjC) domain lysine demethylase, remain unclear.
152  is a member of the JARID1 family of histone lysine demethylases responsible for the demethylation of
153 ing repressor complexes that include histone lysine demethylases, such as KDM1 in animals and KDM1C i
154             Inhibition of KDM2A, the primary lysine demethylase that is selective for H3K36, reversed
155  change with the recent discovery of histone lysine demethylases that reversibly remove methyl marks?
156 methylation, as catalysed by two families of lysine demethylases (the flavin-dependent KDM1 enzymes a
157  we show that Oct1 recruits the Jmjd1a/KDM3A lysine demethylase to catalyze the removal of the inhibi
158                            PHF8 is a histone lysine demethylase ubiquitously expressed in nuclei.
159 r Oct1 overlapped with those for the histone lysine demethylase Utx, and an interaction between Oct1
160                     We hypothesized that the lysine demethylase UTY (ubiquitously transcribed tetratr
161 d 2-oxoglutarate-dependent N(epsilon)-methyl lysine demethylase, which acts on histone substrates.

 
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