ライフサイエンスコーパス: lysophosphatidic acid

1 ds, the acylation of G3P to form 1-acyl G3P (lysophosphatidic acid).

2 incorporation of CPA at the sn-2 position of lysophosphatidic acid.

3 sponses to the endogenous inflammatory lipid lysophosphatidic acid.

4 g cells and in starved cells stimulated with lysophosphatidic acid.

5 llagen induced by TGF-beta1, endothelin, and lysophosphatidic acid.

6 or stimulated to migrate on collagen I with lysophosphatidic acid.

7 constituted basement membrane in response to lysophosphatidic acid.

8 or the biomarkers, heat shock protein 10 and lysophosphatidic acid.

9 ovarian cancer cells after stimulation with lysophosphatidic acid.

10 tors of the extracellular signaling molecule lysophosphatidic acid.

11 Rac1 upon stimulation of HEK-293 cells with lysophosphatidic acid.

12 y extracellular cues including TGF-beta2 and lysophosphatidic acid.

13 ATX) transforms lysophosphatidylcholine into lysophosphatidic acid.

14 esponse to stimulation with the GPCR agonist lysophosphatidic acid.

15 ro-2-(3-phenylproplyamino) benzoic acid, and lysophosphatidic acids.

16 eptors to assess, we found that oxytocin and lysophosphatidic acid 1 receptors are translated and act

17 (GPATs) acylate the sn-1 position to produce lysophosphatidic acid (1-acyl-LPA).

18 plsC316, and plsC3498) that are annotated as lysophosphatidic acid (1-acyl-sn-glycerol-3-phosphate) a

19 The G protein-coupled lysophosphatidic acid 2 (LPA(2)) receptor elicits prosur

20 cin as well as vasoconstriction triggered by lysophosphatidic acid, a bioactive lipid generated by pl

21 dom migration and following stimulation with lysophosphatidic acid, a known activator of cell motilit

22 Stimulation of chromaffin cells with lysophosphatidic acid, a nonsecretory stimulus that stro

23 Lysophosphatidic acid, a physiological activator of YAP

24 position could be restored by treatment with lysophosphatidic acid, a Rho stimulator.

25 lysophosphatidic acid, a signaling lipid abundant in blo

26 Serum levels of lysophosphatidic acid, a well-characterized modulator of

27 with the mitogens epidermal growth factor or lysophosphatidic acid activates the extracellular signal

28 by the mutation, suggesting that Loa1p is a lysophosphatidic acid acyltransferase (LPA AT) with a pr

29 se D (PLD), diacylglycerol kinase (DGK), and lysophosphatidic acid acyltransferase (LPAAT).

30 Lysophosphatidic acid acyltransferase (LPAT) catalyzes a

31 0-specific chloroplast isoform of the enzyme lysophosphatidic acid acyltransferase (LPAT) to the endo

32 In Arabidopsis, lysophosphatidic acid acyltransferase (LPCAT) cycles FA

33 Coexpression of a Sterculia foetida lysophosphatidic acid acyltransferase (SfLPAT) increases

34 Identification of an intrinsic lysophosphatidic acid acyltransferase activity in the li

35 However, the predicted apicoplast-targeted lysophosphatidic acid acyltransferase gene was refractor

36 pat1, which encodes the chloroplast acyl-ACP:lysophosphatidic acid acyltransferase.

37 se, glycerol 3-phosphate acyltransferase and lysophosphatidic acid acyltransferase.

38 -gene approaches, as a hypomorphic allele of lysophosphatidic acid acyltransferase1 (lpat1), lpat1-3.

39 These include lysophosphatidic acid acyltransferases (LPAT) and diacyl

40 anel of asthma-relevant GPCR ligands such as lysophosphatidic acid, adenosine triphosphate, and aller

41 The inhibitory effects were bypassed by lysophosphatidic acid, an activator of RhoA GTPase.

42 s of AGPAT1 and AGPAT2 are quite similar for lysophosphatidic acid and acyl-CoA.

43 ubating cells with the two products of PLA2 (lysophosphatidic acid and arachidonic acid) mimicked tre

44 olize other inflammatory modulators, notably lysophosphatidic acid and cyclic GMP-AMP (cGAMP).

45 lasma fatty acids increased, whereas hepatic lysophosphatidic acid and diacylglycerol levels were sim

46 The dynamics of lysophosphatidic acid and eicosanoids display similar pa

47 lipase that catalyzes phosphatidic acid into lysophosphatidic acid and free fatty acid (both implicat

48 ein-coupled receptor signalling triggered by lysophosphatidic acid and had a function in oncogenic tr

49 MBOAT2 also prefers oleoyl-CoA, using lysophosphatidic acid and lysophosphatidylethanolamine a

50 Liver lysophosphatidic acid and PA levels were increased appro

51 that overexpression of AGPAT6 increased both lysophosphatidic acid and phosphatidic acid levels in ce

52 ates YAP nuclear translocation downstream of lysophosphatidic acid and serum as a result of constitut

53 Thrombin and the lysophospholipids lysophosphatidic acid and sphingosine 1-phosphate (S1P)

54 lipids phosphatidylinositol 4,5-biphosphate, lysophosphatidic acid, and cholesterol, bind to TRPV1 wi

55 Wounding, lysophosphatidic acid, and heparin-binding EGF-like grow

56 We found that LplT cannot transport lysophosphatidic acid, and its substrate binding was not

57 Certain lipids (lysophosphatidylcholine, lysophosphatidic acid, and prostaglandin E2) recapitulat

58 Thrombin, lysophosphatidic acid, and S1P increase COX-2 protein ex

59 ment with serum, epidermal growth factor, or lysophosphatidic acid, and this soluble form of CR-1 exh

60 by ionophores, sphingosine 1-phosphate, and lysophosphatidic acid but not by fMLP or thapsigargin, w

61 imod phosphate, sphingosine 1-phosphate, and lysophosphatidic acid but not by phosphate-free fingolim

62 catalyzes acylation of the sn-2 position on lysophosphatidic acid by an acyl CoA substrate to produc

63 Lysophosphatidic acids C16:0 and C18:1 failed to increas

64 We hypothesized that ATX-lysophosphatidic acid could promote inflammation/mineral

65 position from PC and likely a channeling of lysophosphatidic acid, derived from PC, into the Kennedy

66 Pancreatic cancer cells break lysophosphatidic acid down as they respond to it, settin

67 ously shown that carotid body stimulation by lysophosphatidic acid elicits a reflex stimulation of va

68 N-WASP-depleted cells do not recognize lysophosphatidic acid gradients, leading to altered RhoA

69 sition consisting of phosphoglycerol (GroP), lysophosphatidic acid (GroP bearing C12:0, C16:0, or C16

70 Both kynurenic acid and 2-acyl lysophosphatidic acid have been postulated to be the end

71 epidermal growth factor receptor ligands and lysophosphatidic acid, have been identified.

72 pholipase D autotaxin (ATX) and its product, lysophosphatidic acid, have diverse functions in develop

73 Recent observations on the importance of lysophosphatidic acid in fibrosis suggest that this may

74 new study identifies an unexpected role for lysophosphatidic acid in modulating the strength of both

75 Recently, we demonstrated a vital role for lysophosphatidic acid in stimulating the primary autonom

76 s, we have also investigated the role of ATX-lysophosphatidic acid in the mineralization of isolated

77 In a signaling pathway screen, lysophosphatidic acid increased phosphorylation of AKT,

78 Lysophosphatidic acid induced chemokinesis in T cells.

79 an activator of G-protein coupled receptors (lysophosphatidic acid) induced rapid ATP release, result

80 ne abolished the ability of MEKK3 to mediate lysophosphatidic acid-induced optimal IKKbeta/NF-kappaB

81 PM-recruited GRK2ct-KERE inhibits lysophosphatidic acid-induced phosphorylation of Akt, wh

82 Lysophosphatidic acid-induced RhoA activity was reduced

83 WASP and the endocytic adapter SNX18 promote lysophosphatidic acid-induced RhoA-mediated contractilit

84 ed thromboxane A2 release is responsible for lysophosphatidic acid-induced vascular smooth muscle con

85 Lysophosphatidic acid is a class of bioactive phospholip

86 lly), suggesting that binding and removal of lysophosphatidic acid is a potential mechanism for the i

87 Lysophosphatidic acid is an important lipid ligand regul

88 ular cAMP response to serum factors, such as lysophosphatidic acid, is a potential cause for this phe

89 lasmalogenase was competitively inhibited by lysophosphatidic acid (K(i) approximately 20 mum).

90 also report that lysophosphatidylcholine and lysophosphatidic acid levels are elevated in mutant Dros

91 persons with idiopathic pulmonary fibrosis, lysophosphatidic acid levels in bronchoalveolar lavage f

92 We show that lysophosphatidic acid levels increase in bronchoalveolar

93 Activation of the type 1 lysophosphatidic acid (LPA(1)) receptor is a crucial fac

94 ross all tumour stages, is the lipid agonist lysophosphatidic acid (LPA) acting through the LPA recep

95 ive Galpha(13), p115RhoGEF, or RhoA mimicked lysophosphatidic acid (LPA) action, stimulating the inte

96 nderlying mechanisms by which lipid mediator lysophosphatidic acid (LPA) acts as a growth factor in s

97 (q) protein-coupled receptor in oocytes with lysophosphatidic acid (LPA) also stimulated the B and C

98 S2 mediates phosphatidic acid synthesis from lysophosphatidic acid (LPA) and acyl-coenzyme A.

99 sophosphatidylcholine (LPC) to the bioactive lysophosphatidic acid (LPA) and choline.

100 Autotaxin produces the bioactive lipid lysophosphatidic acid (LPA) and is a drug target of cons

101 We evaluated the effect of lysophosphatidic acid (LPA) and its analog, Radioprotein

102 The bioactive phospholipid lysophosphatidic acid (LPA) and its receptors LPA(1-3) a

103 terminate the signaling actions of bioactive lysophosphatidic acid (LPA) and sphingosine 1 phosphate,

104 Serum-borne lysophosphatidic acid (LPA) and sphingosine 1-phosphopha

105 Lysophosphatidic acid (LPA) and sphingosine-1-phosphate

106 (ATX), which generates two bioactive lipids, lysophosphatidic acid (LPA) and sphingosine-1-phosphate

107 taII, PKCdelta, PKCepsilon, and PKCzeta with lysophosphatidic acid (LPA) and their inhibition with bi

108 nces responsiveness of retinal neovessels to lysophosphatidic acid (LPA) and to elucidate the underly

109 We recently identified lysophosphatidic acid (LPA) as a potent antiapoptotic ag

110 also bind the more hydrophilic phospholipid, lysophosphatidic acid (LPA) but with a higher affinity t

111 ripotent platelet growth factor and mediator lysophosphatidic acid (LPA) controls key regenerative re

112 of endothelial cell agonists, we found that lysophosphatidic acid (LPA) dramatically down-regulated

113 phospholipase A2 with resultant synthesis of lysophosphatidic acid (LPA) driving chemotaxis through L

114 Lysophosphatidic acid (LPA) enhances cell migration and

115 activity that generates the bioactive lipid lysophosphatidic acid (LPA) from lysophosphatidylcholine

116 Lysophosphatidic acid (LPA) functions through activation

117 e tracking methodology, we determined that a lysophosphatidic acid (LPA) gradient induces a spatiotem

118 Lysophosphatidic acid (LPA) has been recognized recently

119 Lysophosphatidic acid (LPA) has wide-ranging effects on

120 Elevated levels of lysophosphatidic acid (LPA) have been linked to aberrant

121 P2) is the main source of the lipid mediator lysophosphatidic acid (LPA) in biological fluids.

122 me playing a major role in the production of lysophosphatidic acid (LPA) in blood through hydrolysis

123 D activity controls physiological levels of lysophosphatidic acid (LPA) in blood.

124 we report a key role for the lipid mediator lysophosphatidic acid (LPA) in decidualization, acting t

125 and release and IL-13-dependent signaling by lysophosphatidic acid (LPA) in primary cultures of human

126 We recently implicated lysophosphatidic acid (LPA) in the pathogenesis of pulmo

127 Evidence suggests a proinflammatory role of lysophosphatidic acid (LPA) in various pathologic abnorm

128 Additionally, oral administration of lysophosphatidic acid (LPA) increased NHE3 activity and

129 In this study, we show that lysophosphatidic acid (LPA) induces alphavbeta6-mediated

130 at the activation of Fas or stimulation with lysophosphatidic acid (LPA) induces cytoskeletal reorgan

131 at through the LPA receptor 1 (LPAR1), serum lysophosphatidic acid (LPA) inhibits Rab11a-Rabin8 inter

132 Lysophosphatidic acid (LPA) is a bioactive lipid capable

133 Lysophosphatidic acid (LPA) is a bioactive lipid that se

134 Lysophosphatidic acid (LPA) is a bioactive phospholipid

135 Lysophosphatidic acid (LPA) is a bioactive phospholipid

136 Lysophosphatidic acid (LPA) is a blood-derived bioactive

137 Lysophosphatidic acid (LPA) is a common product of glyce

138 Lysophosphatidic acid (LPA) is a growth factor-like medi

139 Lysophosphatidic acid (LPA) is a highly potent endogenou

140 Lysophosphatidic acid (LPA) is a ligand for LPA(1-3) of

141 Lysophosphatidic acid (LPA) is a ligand for three endoth

142 Lysophosphatidic acid (LPA) is a ligand of multiple G pr

143 Lysophosphatidic acid (LPA) is a lipid mediator that fun

144 Lysophosphatidic acid (LPA) is a major lysophospholipid

145 Lysophosphatidic acid (LPA) is a membrane-derived lysoph

146 Lysophosphatidic acid (LPA) is a natural bioactive lipid

147 Lysophosphatidic acid (LPA) is a phospholipid that acts

148 Emerging evidence suggests that lysophosphatidic acid (LPA) is a physiological regulator

149 Lysophosphatidic acid (LPA) is a pleiotropic lipid molec

150 Lysophosphatidic acid (LPA) is a pleiotropic lipid that

151 Lysophosphatidic acid (LPA) is a potent inducer of colon

152 The lipid mediator lysophosphatidic acid (LPA) is a potent regulator of vas

153 Lysophosphatidic acid (LPA) is a serum component that ca

154 Lysophosphatidic acid (LPA) is an endogenous cell signal

155 Lysophosphatidic acid (LPA) is an extracellular lipid me

156 Lysophosphatidic acid (LPA) is an important bioactive li

157 Lysophosphatidic acid (LPA) is an important mediator of

158 he G protein-coupled receptor (GPCR) agonist lysophosphatidic acid (LPA) lead to synergistic cyclo-ox

159 a)] is important in regulating extracellular lysophosphatidic acid (LPA) levels around human epitheli

160 Lysophosphatidic acid (LPA) modulates vascular cell func

161 We investigated the effect of lysophosphatidic acid (LPA) on Na(+)/H(+) exchanger acti

162 nal transduction modifiers that modulate the lysophosphatidic acid (LPA) pathway have potential as an

163 The small bioactive lipid lysophosphatidic acid (LPA) plays critical roles in both

164 pase D largely responsible for extracellular lysophosphatidic acid (LPA) production, and was among th

165 Lysophosphatidic acid (LPA) promotes cell survival throu

166 cal step in the development of fibrosis, and lysophosphatidic acid (LPA) promotes fibrosis by regulat

167 sphorylation is induced by activation of the lysophosphatidic acid (LPA) receptor (LPAR) via SRC-depe

168 Previously, we showed that lysophosphatidic acid (LPA) receptor 1 regulates prolife

169 internalization of N-cadherin downstream of lysophosphatidic acid (LPA) receptor 2.

170 Activation of Rho kinase (ROCK) via the lysophosphatidic acid (LPA) receptor elicits clathrin-de

171 The lysophosphatidic acid (LPA) receptor LPA1/Edg2 is the fi

172 tors (GPCRs), complexes with and potentiates lysophosphatidic acid (LPA) receptor signaling to the do

173 The endogenous phospholipid lysophosphatidic acid (LPA) regulates fundamental cellul

174 his study we report that the bioactive lipid lysophosphatidic acid (LPA) regulates hepatocyte glucose

175 We describe novel findings that lysophosphatidic acid (LPA) regulates PLC-beta1 and PLC-

176 There has been much recent interest in lysophosphatidic acid (LPA) signaling through one of its

177 The lipid mediator lysophosphatidic acid (LPA) signals via six distinct G p

178 Lysophosphatidic acid (LPA) stimulates cells by activati

179 Lysophosphatidic acid (LPA) stimulates the formation of

180 ble for the transient activation of YAP upon lysophosphatidic acid (LPA) stimulation and the inhibiti

181 3-P acyltransferase-mediated (GPAT-mediated) lysophosphatidic acid (LPA) synthesis.

182 n of either lysophosphatidylcholine (LPC) or lysophosphatidic acid (LPA) to cells restored their oxid

183 nversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA), a bioactive lipid and a clo

184 Lysophosphatidic acid (LPA), a bioactive lipid mediator

185 Lysophosphatidic acid (LPA), a bioactive phospholipid, i

186 In this study, we demonstrate that lysophosphatidic acid (LPA), a growth factor-like mediat

187 Lysophosphatidic acid (LPA), a growth factor-like phosph

188 Lysophosphatidic acid (LPA), a lipid by-product of autot

189 In the current study, we demonstrated that lysophosphatidic acid (LPA), a lipid mediator present in

190 Lysophosphatidic acid (LPA), a major tumor-promoting fac

191 Lysophosphatidic acid (LPA), a naturally produced phosph

192 pholipase D that catalyzes the production of lysophosphatidic acid (LPA), a pleiotropic growth-factor

193 a secreted lysophospholipase D that produces lysophosphatidic acid (LPA), a pleiotropic lipid mediato

194 Lysophosphatidic acid (LPA), a potent bioactive lipid fo

195 Recent findings indicate that lysophosphatidic acid (LPA), a potent neuronal activator

196 and tissue stiffening, while the addition of lysophosphatidic acid (LPA), a rhoA activator, stimulate

197 Here, we show that lysophosphatidic acid (LPA), a signaling molecule derive

198 We show that lysophosphatidic acid (LPA), a ubiquitous phospholipid t

199 Lysophosphatidic acid (LPA), an endogenous lipid widely

200 Importantly, an injury signal initiated by lysophosphatidic acid (LPA), an upstream regulator of Ya

201 ctivated T cells 2 (NFAT1), autotaxin (ATX), lysophosphatidic acid (LPA), and beta-catenin that contr

202 vels of autotaxin and its enzymatic product, lysophosphatidic acid (LPA), are elevated during HCV inf

203 pholipase, autotaxin (ATX), and its product, lysophosphatidic acid (LPA), as potential mediators of c

204 protein and a major source for extracellular lysophosphatidic acid (LPA), in regulation of IOP in a r

205 ydrolyzes lysophosphatidylcholine (LPC) into lysophosphatidic acid (LPA), initiating signaling cascad

206 enced cell migration via the signaling lipid lysophosphatidic acid (LPA), linking it with GPAM to cel

207 or lipin to increase the cellular content of lysophosphatidic acid (LPA), phosphatidic acid (PA), or

208 holipase D that generates the lipid mediator lysophosphatidic acid (LPA), playing a key role in diver

209 sses the hypothesis that the bioactive lipid lysophosphatidic acid (LPA), prevalent in the EOC microe

210 ng the multiple cellular effects mediated by lysophosphatidic acid (LPA), the effect on cell prolifer

211 und that a wide variety of agonists, such as lysophosphatidic acid (LPA), uridine triphosphate, growt

212 ed G-3-P to increased FGF23 via increases in lysophosphatidic acid (LPA), which activates the LPA rec

213 ing relied on lost axonal sensitivity toward lysophosphatidic acid (LPA), which failed to repel PRG-2

214 This growth in knowledge is epitomized by lysophosphatidic acid (LPA), which functions through int

215 ein-coupled receptor ligands such as ATP and lysophosphatidic acid (LPA), which in turn transactivate

216 The proinflammatory lysophospholipid, lysophosphatidic acid (LPA), which is elevated in multip

217 Treatment of osteoclasts with lysophosphatidic acid (LPA), which phosphorylates TRIP6

218 and demonstrate specific expression of this lysophosphatidic acid (LPA)-generating enzyme in embryon

219 central intermediate signaling component in lysophosphatidic acid (LPA)-induced activation of the nu

220 a focal adhesion molecule known to regulate lysophosphatidic acid (LPA)-induced cell migration throu

221 Lysophosphatidic acid (LPA)-induced ERK phosphorylation

222 cerol and PKC activator), hypertonic stress, lysophosphatidic acid (LPA)-induced G protein-coupled re

223 This is required for p27(KIP1) to enhance lysophosphatidic acid (LPA)-induced ovarian cancer cell

224 ay consisting of G(i)-Ras-NF-kappaB mediates lysophosphatidic acid (LPA)-induced urokinase plasminoge

225 artially blocks RhoA activation, it inhibits lysophosphatidic acid (LPA)-stimulated migration as effi

226 ms, destabilization/regression was driven by lysophosphatidic acid (LPA).

227 zed to generate the lipid signaling molecule lysophosphatidic acid (LPA).

228 tic diseases by producing the lipid mediator lysophosphatidic acid (LPA).

229 is one of six known receptors (LPA(1-6)) for lysophosphatidic acid (LPA).

230 adipose triglyceride lipase and acylation of lysophosphatidic acid (LPA).

231 the conversion of lysophosphatidylcholine to lysophosphatidic acid (LPA).

232 that generates the bioactive lipid mediator lysophosphatidic acid (LPA).

233 onsible for synthesis of the bioactive lipid lysophosphatidic acid (LPA).

234 ed form of lysophospholipase D that produces lysophosphatidic acid (LPA).

235 g the production of oncogenic lipids such as lysophosphatidic acid (LPA).

236 1 pathway is also activated, for example, by lysophosphatidic acid (LPA).

237 (UDP), platelet activating factor (PAF), or lysophosphatidic acid (LPA).

238 PDGF interacts extensively with lysophosphatidic acid (LPA).

239 e cell surface in response to treatment with lysophosphatidic acid (LPA).

240 Autotaxin (ATX) generates the lipid mediator lysophosphatidic acid (LPA).

241 e that hydrolyzes lysophosphatidylcholine to lysophosphatidic acid (LPA).

242 ion of G-protein-coupled receptors [e.g., by lysophosphatidic acid (LPA)]--are molecularly connected

243 Isolated photoreceptors were treated with lysophosphatidic acid (LPA; a RhoA activator) or Y27632

244 G protein-coupled receptor agonists, notably lysophosphatidic acid (LPA; acting through the LPA1 rece

245 ostaglandin D2 (PGD2) as well as some of the lysophosphatidic acids (LPA) in the small intestine were

246 in 4 of 20 patients with increased levels of lysophosphatidic acid [LPA(16:0)], where it correlated w

247 ic acid (PA) (long-chain fatty acyl-CoAs and lysophosphatidic acid [LPA]) were not decreased, we did

248 genic lysophosphatidylcholine (LPC 18:1) and lysophosphatidic acids (LPAs) in the intestine and plasm

249 or reversed damage due to arachidonic acid, lysophosphatidic acid, lysophosphatidylcholine, diacylgl

250 lating activity toward glycerol 3-phosphate, lysophosphatidic acid, lysophosphatidylinositol, and dia

251 ate that adenosine inhibits endothelin-1 and lysophosphatidic acid-mediated HSC contraction.

252 critical intermediate signaling molecule in lysophosphatidic acid-mediated nuclear factor-kappaB (NF

253 onounced increase in phosphatidylcholine and lysophosphatidic acid metabolites, which coincided with

254 glucose-derived glycerol-3-phosphate to form lysophosphatidic acid, mono- and diacylglycerols, and ot

255 gulation, being necessary for stimulation by lysophosphatidic acid of activity and increased mobility

256 Lysophosphatidic acid, one of the known stimuli transduc

257 ic acid from oleoyl-CoA to glycerophosphate, lysophosphatidic acid, or diacylglycerol, suggesting tha

258 mature utricles, exogenous stimulation with lysophosphatidic acid overcame this maturational block a

259 latory gene modules driving HCC risk and the lysophosphatidic acid pathway as a central chemopreventi

260 tions downregulated the LPA-degrading enzyme lysophosphatidic acid phosphatase type 6 (ACP6), leading

261 s essential for dephosphorylating substrates lysophosphatidic acid, phosphatidic acid, or sphingosine

262 2 modulated the levels of phosphatidic acid, lysophosphatidic acid, phosphatidylinositol species, as

263 ng injury, but is not required for pulmonary lysophosphatidic acid production or fibrosis.

264 00/100)/IGFII mice, ATX is overexpressed and lysophosphatidic acid promotes a strong deposition of hy

265 ATX-lysophosphatidic acid promotes inflammation and minerali

266 We showed that ATX-lysophosphatidic acid promotes the mineralization of the

267 This included inhibitory effects on lysophosphatidic acid, purinergic (ATP), bradykinin, and

268 cells, at least in part, by associating with lysophosphatidic acid receptor 1 (LPAR1), leading to enh

269 ection of unidirectional flow; inhibition of lysophosphatidic acid receptor 1 restored the flow-depen

270 (-7), beta = 0.16), which is downstream from lysophosphatidic acid receptor 1.

271 intercellular gaps, which were abolished by lysophosphatidic acid receptor 1/2 inhibition.

272 emonstrate that this activity is mediated by lysophosphatidic acid receptor 3 (Lpar3).

273 nduced activation of pro-apoptotic pathways (lysophosphatidic acid receptor and caspase-domain signal

274 Lysophosphatidic acid receptor antagonists are currently

275 riptionally down-regulates expression of the lysophosphatidic acid receptor EDG2 and this down-regula

276 actility and force generation by controlling lysophosphatidic acid receptor recycling and preventing

277 n 6 modulates NADPH oxidase 2 activation via lysophosphatidic acid receptor signaling in the pulmonar

278 The lysophosphatidic acid receptor type 1 (LPA1) is 1 of 6 k

279 GPR92 was confirmed to be a lysophosphatidic acid receptor with weaker responses to

280 ctivation is impaired downstream of both the lysophosphatidic acid receptor, a G-protein-coupled rece

281 gnaling molecule and activates the family of lysophosphatidic acid receptors (LPA(1-6)).

282 makes P-REX1 activation by G(q)/G(i)-coupled lysophosphatidic acid receptors more effective.

283 e retraction evoked by Galpha12/13-dependent lysophosphatidic acid receptors was augmented in R7BP-ex

284 secretagogue stimulation in the presence of lysophosphatidic acid resulted in reduced evoked secreto

285 This study characterizes the autotaxin-lysophosphatidic acid signaling axis as a modulator of O

286 t the identification of an integral membrane lysophosphatidic acid-specific acyltransferase, LPAAT3,

287 in this issue, Schmidt and Brown report that lysophosphatidic acid-specific acyltransferase, LPAAT3,

288 ed to be activated by lipid ligands, such as lysophosphatidic acid, sphingosine 1-phosphate (S1P), an

289 nous G protein-coupled receptors (GPCRs) for lysophosphatidic acid, sphingosine 1-phosphate, and thro

290 Serum, lysophosphatidic acid, sphingosine-1-phophate (S1P), and

291 acious for RhoA activation include thrombin, lysophosphatidic acid, sphingosine-1-phosphate, and thro

292 Following serum or lysophosphatidic acid stimulation, active RhoA binds and

293 tor (Y27632), Cytochalasin D, Dasatinib, and Lysophosphatidic acid to modulate YAP localization.

294 Jun N-terminal kinase blocked the ability of lysophosphatidic acid to sequester the beta(2)-adrenergi

295 light chains (MLC20) were phosphorylated by lysophosphatidic acid to the same extent in Palladin nul

296 After lysophosphatidic acid treatment, 85% of the mature suppo

297 0, endothelin, 5-HT, chloroquine, histamine, lysophosphatidic acid, trypsin, SLIGRL, beta-alanine, BA

298 trimeric G proteins to downstream effectors, lysophosphatidic acid was shown to regulate the function

299 hosphate phosphatase (LPP3) that inactivates lysophosphatidic acid, was implicated in coronary artery

300 hile preventing exit from pluripotency using lysophosphatidic acid, we 'trap' and maintain cells in a