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1 rates are thought to be sphingomyelin and/or lysophosphatidylcholine.
2 nerates extracellular LPA from the precursor lysophosphatidylcholine.
3 was increased in lungs of mice that received lysophosphatidylcholine.
4 formation of early fusion intermediates with lysophosphatidylcholine.
5 hatidylethanolamine, phosphatidylserine, and lysophosphatidylcholine.
6 hingomyelin, platelet-activating factor, and lysophosphatidylcholine.
7 mulate within phospholipid fractions such as lysophosphatidylcholine.
8 te lower levels of the "come-get-me" signal, lysophosphatidylcholine.
9 on the production of its catalytic product, lysophosphatidylcholine.
10 ighly selective generation of 2-arachidonoyl lysophosphatidylcholine.
11 ing in the production of a neutral lipid and lysophosphatidylcholine.
12 at McaP cleaves both phosphatidylcholine and lysophosphatidylcholine.
13 ing in the production of a neutral lipid and lysophosphatidylcholine.
14 poptosis by treatment with phosphocholine or lysophosphatidylcholine.
15 arachidonic acid, lysophosphatidic acid, and lysophosphatidylcholine.
16 ccurring l-enantiomer of the ether analog of lysophosphatidylcholine.
17 (ATX), a secreted lysophospholipase D, from lysophosphatidylcholine.
18 xidized phospholipids with a high content in lysophosphatidylcholine.
19 for preparation of spectroscopically labeled lysophosphatidylcholines.
20 ofiling and regression analysis, we detected lysophosphatidylcholine 14:0, tryptophan, as well as pim
23 , diacyl phosphatidylcholines 36:4 and 38:4, lysophosphatidylcholine 17:0, and hydroxy-sphingomyelin
24 ntified plasma lysophosphatidylcholine 16:0, lysophosphatidylcholine 17:0, and lysophosphatidylcholin
25 line 16:0, lysophosphatidylcholine 17:0, and lysophosphatidylcholine 18:0 as significant metabolites
26 high in pancreatic cancer, while increasing lysophosphatidylcholine (18:2), uric acid, citrulline, a
27 d stereospecific oxidation of 2-arachidonoyl-lysophosphatidylcholine (2-AA-LPC) and 2-arachidonoyl-ly
28 stimulated the production of 2-arachidonoyl-lysophosphatidylcholine (2-AA-LPC) from 1-palmitoyl-2-[(
31 d on 1) the temporal inhibition of fusion by lysophosphatidylcholine, 2) rapid dissociation of the HA
34 d coronary sinus for measurement of Lp-PLA2, lysophosphatidylcholine (a product of Lp-PLA2), and C-re
36 mmatory consequences have been described for lysophosphatidylcholine, a lipid product of cellular inj
37 ogical role of this system is to internalize lysophosphatidylcholine, a signalling lipid involved in
38 rophages upon exposure to apoptotic cells or lysophosphatidylcholine, a specific phospholipid that is
40 l insulin secretion and a role in generating lysophosphatidylcholine acceptors for arachidonic acid i
41 h LTL after adjustment for multiple testing: lysophosphatidylcholine acyl C17:0 (lysoPC a C17:0, p-va
42 ipid reacylation by a novel Golgi-associated lysophosphatidylcholine acyltransferase (LPAT) induces t
43 es to LPS, was found to selectively activate lysophosphatidylcholine acyltransferase (LPCAT) (P < 0.0
45 PC) and sphingomyelin levels due to elevated lysophosphatidylcholine acyltransferase (LPCAT) and sphi
46 catalyzed by the reverse action of acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT) can tran
49 ), lysophospholipid acyltransferase (LPEAT), lysophosphatidylcholine acyltransferase (LPCAT), and lys
51 enzyme in the Lands' cycle is fatty acyl-CoA:lysophosphatidylcholine acyltransferase (LPCAT), which u
53 mouse enzyme with characteristics of a lung lysophosphatidylcholine acyltransferase (LPCAT1) that we
54 ing mammalian target of rapamycin (mTOR) and lysophosphatidylcholine acyltransferase (LPCAT1)-mediate
56 show, for the first time, that the inducible lysophosphatidylcholine acyltransferase 2 (LPCAT2) plays
58 show that the phospholipid remodeling enzyme lysophosphatidylcholine acyltransferase 3 (Lpcat3) is a
60 es and proteins involved in LPC degradation (lysophosphatidylcholine acyltransferase [Lpcat] 1-4), ba
61 ophospholipids, and overexpression increased lysophosphatidylcholine acyltransferase activity 7-fold.
62 ivum) leaf protoplasts indicated that 30% of lysophosphatidylcholine acyltransferase activity colocal
63 n of the remodeling enzyme, LPCAT1 (acyl-CoA:lysophosphatidylcholine acyltransferase) in epithelia de
64 hift, leading to premature truncation of the lysophosphatidylcholine acyltransferase-1 (LPCAT1) prote
67 formation of phosphatidylcholine, including LYSOPHOSPHATIDYLCHOLINE ACYLTRANSFERASE2, and REDUCED OL
68 mouse genetic models have demonstrated that lysophosphatidylcholine acyltransferases (LPCATs), which
69 , we demonstrate that two genes encoding the lysophosphatidylcholine acyltransferases LPCAT1 and LPCA
71 es of glycerophosphoinositol, sphingomyelin, lysophosphatidylcholine and cholesterol sulfate were hig
73 duced lipid mixing was reversibly blocked by lysophosphatidylcholine and low temperature, 4 degrees C
78 high levels of amino acids but low levels of lysophosphatidylcholine and lysophosphatidylethanolamine
79 ed by agents that thin the membrane (L-alpha-lysophosphatidylcholine and octyl-beta-D-glucopyranoside
80 ities of the two pro-inflammatory mediators, lysophosphatidylcholine and oxidized nonesterified fatty
81 nd to phosphatidyl lipids, but did recognize lysophosphatidylcholine and the phosphorylcholine head g
82 ells in the presence of the fusion inhibitor lysophosphatidylcholine and then removed the inhibitor t
83 fer from water to self-assembled micelles of lysophosphatidylcholines and diacyl phosphatidylcholines
84 tigotes occurred to phosphatidylcholines and lysophosphatidylcholines and results indicate that the K
85 the plasma membrane, resulting in a peak of lysophosphatidylcholine, and (2) a subsequent, transient
86 nhibition in the adenosine, PG/lipoxygenase, lysophosphatidylcholine, and sphingosine-1-phosphate pat
87 lar, lysolipids, including lysocardiolipins, lysophosphatidylcholines, and lysophosphatidylinositol,
89 support a novel transport mechanism by which lysophosphatidylcholines are "flipped" within the transp
90 yso-PE and lysophosphatidylglycerol, but not lysophosphatidylcholine, are taken up by LplT for reacyl
91 ments a V. cholerae VolA mutant in growth on lysophosphatidylcholine as the sole carbon source and in
92 lated splenic macrophages identifies several lysophosphatidylcholines as the resistance-inducing mole
93 vity and the signaling pathway through which lysophosphatidylcholine augments endothelial nitric-oxid
94 ythmogenic toxins (eg, ouabain, high Ca(2+), lysophosphatidylcholine, beta-adrenergic agonist, acylca
95 phatidylcholine, lysophosphatidylserine, and lysophosphatidylcholine but lacked appreciable acylating
97 human eosinophils degranulate in response to lysophosphatidylcholine, but not phosphatidylcholine, ly
100 malogen, C34:2 PC plasmalogen, C36:2 PC) and lysophosphatidylcholines (C18:2, C20:5, C18:1), and 3 ph
102 l activation in human ALD (10 autopsies) and lysophosphatidylcholine (C24:0) injection into the parie
104 reperfusion caused a significant increase in lysophosphatidylcholine concentration compared with cont
105 urocortin, the ischemia-induced increase in lysophosphatidylcholine concentration was significantly
109 n reactions of a docosahexaenoate ester of 2-lysophosphatidylcholine (DHA-PC) was also demonstrated.
110 to arachidonic acid, lysophosphatidic acid, lysophosphatidylcholine, diacylglycerol, monoacylglycero
111 class phosphatidylcholine expanded 17-fold, lysophosphatidylcholine expanded 54-fold, and the surfac
112 We also elicited SMase activity by adding lysophosphatidylcholine externally or by generating it w
113 d out on a large scale afforded feruloylated lysophosphatidylcholine (FLPC) in high isolated yield of
115 potently releases arachidonic acid (AA) and lysophosphatidylcholine from mammalian cell membranes.
116 +/- 0.1 to 2.1 +/- 0.3 nmol/mg of protein), lysophosphatidylcholine (from 0.3 +/- 0.1 to 0.6 +/- 0.1
118 salt-independent hydrolytic activity against lysophosphatidylcholine, having 6.5- and 2-fold higher k
119 -9-hydroxy-13-oxotridec-11-enoate ester of 2-lysophosphatidylcholine (HOT-PC) was devised to facilita
120 Furthermore, the EC(50) of 2-12(S)-HETE-lysophosphatidylcholine in activating THP-1 cells was 2.
121 tributed to the lower levels of ceramide and lysophosphatidylcholine in CEL-expressing cells than in
122 TAG and the accumulation of small amounts of lysophosphatidylcholine in developing seeds revealed by
124 alpha-chloro fatty aldehydes and unsaturated lysophosphatidylcholine in human atherosclerotic lesions
125 xins cleave the substrates sphingomyelin and lysophosphatidylcholine in mammalian tissues, releasing
126 is because of its hydrolysis of ceramide and lysophosphatidylcholine in promoting cholesterol esterif
127 hallenge altered the concentration of plasma lysophosphatidylcholines in an oil treatment-dependent m
128 r was associated with lower cord-blood total lysophosphatidylcholines in index and control children.
130 hepatocytes and Huh7 cells with palmitate or lysophosphatidylcholine increased their release of EVs,
131 isruption of paranodal myelin (by stretch or lysophosphatidylcholine) increased the stimulation-induc
133 infectivity) and the fusion-inhibitory agent lysophosphatidylcholine inhibit the formation of the >15
135 of lysophospholipids and PUFAs are such that lysophosphatidylcholine is able to modulate TRPM8 in the
137 associated with high GCR, while high plasma lysophosphatidylcholine levels are associated with low G
139 hroughput screen of ATX inhibition using the lysophosphatidylcholine-like substrate fluorogenic subst
140 n the cecum, as well as elevated atherogenic lysophosphatidylcholine (LPC 18:1) and lysophosphatidic
141 /-) HDL had a 4-fold increase in PC, whereas lysophosphatidylcholine (LPC) (125-fold), sphingomyelin
142 dministration of DHA to normal adult mice as lysophosphatidylcholine (LPC) (40 mg DHA/kg) for 30 days
143 oleic acid) as well as the lysophospholipids lysophosphatidylcholine (LPC) 18:1 and LPC 16:0 were sig
144 revealed a crucial role of lysophospholipids lysophosphatidylcholine (LPC) 18:1, LPC 16:0, and 9,10-E
145 A housekeeping role for iPLA2 in generating lysophosphatidylcholine (LPC) acceptors for arachidonic
147 s in serum palmitoyl-, stearoyl-, and oleoyl-lysophosphatidylcholine (LPC) and marked increases in ta
148 exposure in mice resulted in decreased serum lysophosphatidylcholine (LPC) and sphingomyelin levels d
150 n assay, we found that phospholipids such as lysophosphatidylcholine (LPC) can stimulate the sulfatid
152 dose-dependent manner, while treatment with lysophosphatidylcholine (LPC) enhanced the expression of
154 d the presence of monoacylglycerol (MAG) and lysophosphatidylcholine (LPC) hydrolytic activities, ind
155 actions of the cell membrane and serum lipid lysophosphatidylcholine (LPC) in atherosclerosis and sys
156 exhibited excellent remyelinating effects on lysophosphatidylcholine (LPC) induced demyelination in a
157 f asymmetrically incorporating single-tailed lysophosphatidylcholine (LPC) into a membrane bilayer us
158 mbrane merger was prevented by incorporating lysophosphatidylcholine (LPC) into cell membranes at the
159 secreted lysophospholipase D that hydrolyzes lysophosphatidylcholine (LPC) into lysophosphatidic acid
160 G2A, a G protein-coupled receptor for which lysophosphatidylcholine (LPC) is a high affinity ligand,
162 riments show that the soluble lipid mediator lysophosphatidylcholine (LPC) is released by p25 overexp
163 application of micromolar concentrations of lysophosphatidylcholine (LPC) led to an increase of the
164 a housekeeping enzyme that regulates cell 2-lysophosphatidylcholine (LPC) levels and arachidonate in
167 a housekeeping enzyme that regulates cell 2-lysophosphatidylcholine (LPC) levels, rates of arachidon
169 activity (PLA2) of Prdx6; addition of either lysophosphatidylcholine (LPC) or lysophosphatidic acid (
171 on TSC2 loss, causing enhanced production of lysophosphatidylcholine (LPC) species by TSC2-deficient
173 sophosphatidylglycerol (LPG) or zwitterionic lysophosphatidylcholine (LPC) stimulate aggregation, LPG
174 Mfsd2a is a newly described sodium-dependent lysophosphatidylcholine (LPC) symporter expressed at the
175 ectoenzyme that catalyzes the conversion of lysophosphatidylcholine (LPC) to lysophosphatidic acid (
176 ce chemotaxis through its ability to convert lysophosphatidylcholine (LPC) to lysophosphatidic acid (
177 ted enzyme responsible for the hydrolysis of lysophosphatidylcholine (LPC) to the bioactive lysophosp
178 he circulation is through a sodium-dependent lysophosphatidylcholine (LPC) transporter (MFSD2A), expr
179 udy, we discovered that the sodium-dependent lysophosphatidylcholine (LPC) transporter major facilita
182 ple tumor types, autotaxin produces LPA from lysophosphatidylcholine (LPC) via lysophospholipase D ac
185 choline acyltransferase Gpc1, which produces lysophosphatidylcholine (LPC), and LPC can be converted
186 her Lp-PLA2 and its major enzymatic product, lysophosphatidylcholine (LPC), are involved in blood-ret
187 es as opposed to vesicles containing L-alpha-lysophosphatidylcholine (LPC), as observed using atomic
188 tion was blocked by the hemifusion inhibitor lysophosphatidylcholine (LPC), but not if a complementar
189 We report here that increased production of lysophosphatidylcholine (LPC), catalyzed by the activati
190 large amounts of AA and the lysophospholipid lysophosphatidylcholine (LPC), from membrane preparation
191 ts of Them1's enzymatic reaction, as well as lysophosphatidylcholine (LPC), lipids shown to activate
192 adherent HA-cell at different time points by lysophosphatidylcholine (LPC), so that only the cell pai
194 idermal keratinocytes and we have shown that lysophosphatidylcholine (LPC), the main lysophospholipid
196 the selective accumulation of 2-arachidonoyl lysophosphatidylcholine (LPC), which was not metabolized
197 v administration, although more radiolabeled lysophosphatidylcholine (LPC)-DHA enters the brain than
199 t carotid arteries to compare the effects on lysophosphatidylcholine (LPC)-induced endothelial dysfun
200 acute focal neuroinflammation in the brain, lysophosphatidylcholine (LPC)-induced focal demyelinatio
210 tidylserines, lysophosphatidylethanolamines, lysophosphatidylcholines (LPCs), sphingolipids, and chol
212 positively curved lipids (ganglioside, GM1; lysophosphatidylcholine, LPCs) and negatively curved lip
213 the production of arachidonic acid (AA) and lysophosphatidylcholine (Lyso-PC) by activating multiple
214 plasma membrane, liberating fatty acids and lysophosphatidylcholine (lyso-PC), whereas cPLA(2) acted
216 y phosphatidylcholine (PC) remodeling, and a lysophosphatidylcholine (lysoPC) acyltransferase is thou
217 We report the characterization of three lysophosphatidylcholine (lysoPC) acyltransferases (LPCAT
218 line acyltransferase (LPCAT), which utilizes lysophosphatidylcholine (LysoPC) and fatty acyl-CoA to p
219 olyunsaturated fatty acids (PUFA) as well as lysophosphatidylcholine (LysoPC) and lysophosphatidyleth
220 implicated PA, phosphatidylcholine (PC) and lysophosphatidylcholine (LysoPC) as potential SOBER1 sub
221 significantly elevated erythrocyte membrane lysophosphatidylcholine (LysoPC) content and circulating
222 Here, we show that the host-derived lipid lysophosphatidylcholine (LysoPC) controls P. falciparum
223 nd colleagues describes a host-derived lipid lysophosphatidylcholine (LysoPC) that regulates sexual c
226 hen endothelial cells (ECs) are incubated in lysophosphatidylcholine (lysoPC), rapid translocation of
227 Progressively lower levels of long-chain lysophosphatidylcholines (lysoPC a C18:2, lysoPC a C20:3
230 and triacylglycerides, sphingomyelins (SMs), lysophosphatidylcholines (LysoPCs), and esterified stero
232 r lysophospholipids as substrates, including lysophosphatidylcholine, lysophosphatidylethanolamine, a
233 dding yeast P4-ATPases Dnf1 and Dnf2 include lysophosphatidylcholine, lysophosphatidylethanolamine, d
234 or a variety of lysophospholipids, including lysophosphatidylcholine, lysophosphatidylethanolamine, l
236 olamine, lysophosphatidylglycerol, 1-O-alkyl-lysophosphatidylcholine, lysophosphatidylserine, and lys
237 duct shows lysophospholipase activity toward lysophosphatidylcholine, lysophosphatidylserine, and lys
239 ent in wild-type mice), a 4-fold increase in lysophosphatidylcholine mass in ischemic zones (4.9 nmol
240 e production of a novel group of unsaturated lysophosphatidylcholine molecular species and chlorinate
241 lasmalogen cooxidation products, unsaturated lysophosphatidylcholine molecular species containing lin
243 ery endothelial cells to plasmalogen-derived lysophosphatidylcholine molecular species produced marke
244 rated that a novel population of unsaturated lysophosphatidylcholine molecular species was produced b
246 l activated oleosin phosphorylation, whereas lysophosphatidylcholine, oleic acid, and Ca(2+) inhibite
247 y, this process was dependent on exposure of lysophosphatidylcholine on activated cell membranes, whi
248 Recent data support an indirect effect of lysophosphatidylcholine on G2A rather than direct ligand
251 brane curvature-promoting phospholipids like lysophosphatidylcholine or oleic acid profoundly alter p
252 herosclerotic plaque, including CD40 ligand, lysophosphatidylcholine, or cholesterol crystals, could
254 elin, lysophingomyelin, phosphatidylcholine, lysophosphatidylcholine, or phosphatidic acid among the
255 reas in vivo remyelination is accelerated in lysophosphatidylcholine- or cuprizone-induced demyelinat
256 The mode of interactions between palmitoyl lysophosphatidylcholine (palmitoyl lyso-PC) or other lys
258 viously published, a significant decrease in lysophosphatidylcholines, phosphatidylcholines and chole
259 S approach showed significant differences in lysophosphatidylcholines, phosphatidylcholines, acylcarn
260 o PEs and suggesting crosstalk between these lysophosphatidylcholines, phosphatidylcholines, and coag
261 ividual species of cholesterol esters (CEs), lysophosphatidylcholines, phosphatidylcholines, phosphat
262 ipid compartment in the plasma membrane with lysophosphatidylcholine, previously shown to decrease ch
263 eukin 6 (IL-6) and lipid (neutral lipids and lysophosphatidylcholines) priming activity (P <.05).
265 n abundance was observed for acylcarnitines, lysophosphatidylcholines, quaternary amines, and cholest
266 f this model, the inverted cone-shaped lipid lysophosphatidylcholine rescues secretion from SNARE mut
269 Treatment with increasing concentrations of lysophosphatidylcholine resulted in a dose-dependent red
270 ta demonstrate that, whereas maintaining the lysophosphatidylcholine route of DHA supply to the retin
272 ilis QST713 as well as digitonin, CHAPS, and lysophosphatidylcholine solubilize membranes without sub
273 common endogenous compound classes (e.g., 51 lysophosphatidylcholines spectra) and were then used to
274 complexes formed with diverse lipids such as lysophosphatidylcholine, sulfatide, or mannosyl-phosopho
275 ses phosphatidylcholine as substrate to form lysophosphatidylcholine that has the potential to disrup
276 A2 activity, with the subsequent release of lysophosphatidylcholine that influences macrophage chole
277 se-induced adaptation, we identified various lysophosphatidylcholines that might function as surrogat
280 ge of arachidonate and linoleate esters of 2-lysophosphatidylcholine, the two most abundant polyunsat
281 endent proton fluxes that were stimulated by lysophosphatidylcholine, thus giving rise to a net efflu
282 that facilitates the conversion of palmitoyl-lysophosphatidylcholine to dipalmitoylphosphatidylcholin
283 pholipase D that catalyzes the conversion of lysophosphatidylcholine to lysophosphatidic acid (LPA).
284 n (ATX) is a secreted enzyme that hydrolyzes lysophosphatidylcholine to lysophosphatidic acid (LPA).
285 Inhibition was largely overcome by adding lysophosphatidylcholine to the medium at concentrations
286 recently characterized as a sodium-dependent lysophosphatidylcholine transporter expressed at the blo
289 ssors, with simultaneous lower diglycerides, lysophosphatidylcholines, triglycerides, and alanine bef
292 thesis of CysLTs in response to sPLA(2)-X or lysophosphatidylcholine was inhibited by p38 or JNK inhi
294 -sn-glycero-3-phosphocholine, and of various lysophosphatidylcholines were also significantly elevate
297 and of 18:1 in phosphatidylethanolamine and lysophosphatidylcholine, whereas concomitant decreases w
298 metabolites, gamma-glutamyl dipeptides, and lysophosphatidylcholines, which are considered to be inv
299 ns were semi-synthesized by acylation of C20-lysophosphatidylcholine with unsaturated C20 fatty acids
300 ion that adding the positive curvature agent lysophosphatidylcholine would synergistically lower line