ライフサイエンスコーパス: lysosomal membrane protein

1 primary deficiencies of LAMP-2, a principal lysosomal membrane protein.

2 ene product, cystinosin, is a novel integral lysosomal membrane protein.

3 rane protein, cystinosin, with features of a lysosomal membrane protein.

4 ne or synaptic vesicle proteins and LAMP1, a lysosomal membrane protein.

5 vitro and in vivo and impairs the sorting of lysosomal membrane proteins.

6 complex-related intracellular trafficking of lysosomal membrane proteins.

7 human chromosome 13 is LAMP1, which encodes lysosomal membrane protein 1.

8 caused by mutations in CLN3, which encodes a lysosomal membrane protein(1-3).

9 Lysosomal membrane protein 2 (LAMP-2) is a target of ant

10 no acids of the N-terminal domain of NPC1, a lysosomal membrane protein, abolish its cholesterol bind

11 TMEM106B encodes a lysosomal membrane protein and was initially identified

12 on between MFSD1 and both GLMP (glycosylated lysosomal membrane protein) and GIMAP5 (GTPase of immuni

13 ulate in lysosomes, alter the trafficking of lysosomal membrane proteins, and inhibit the degradation

14 e that AP-3 defines a novel pathway by which lysosomal membrane proteins are transported from tubular

15 Mutations in the CLN3 gene, which encodes a lysosomal membrane protein, are responsible for the neur

16 Mutations in lysosomal membrane protein ATP13A2 (PARK9) cause familia

17 plex has been implicated in the transport of lysosomal membrane proteins, but its precise site of act

18 It results from a dysfunctional endo-lysosomal membrane protein causing altered pH homeostasi

19 perforin expression and up-regulation of the lysosomal membrane protein CD107a after SIV Gag stimulat

20 sults in increased surface expression of the lysosomal membrane proteins CD63, lamp-1, and lamp-2, bu

21 d normal distribution and trafficking of the lysosomal membrane proteins, CD63 and Lamp-1.

22 Mutations in the lysosomal membrane protein CLN3 cause Juvenile Neuronal

23 ile NCL (vLINCL) is caused by mutations of a lysosomal membrane protein CLN7, the function of which h

24 nts where both selected synaptic vesicle and lysosomal membrane proteins coexist with the adaptor pro

25 by pathogenic mycobacteria inhibit NPC1, the lysosomal membrane protein deficient in the lysosomal st

26 is caused by mutation of a novel, endosomal/lysosomal membrane protein encoded by CLN3.

27 -linked oligosaccharides protect a subset of lysosomal membrane proteins from proteolytic digestion i

28 establishes a powerful platform for studying lysosomal membrane protein function in health and diseas

29 forms a tight complex with the glycosylated lysosomal membrane protein (GLMP) in the lysosomal membr

30 und to the cytosolic tail of a 96-kilodalton lysosomal membrane protein in two different binding assa

31 ove the Asn-linked glycans from fully folded lysosomal membrane proteins in living cells.

32 position, the structural characterization of lysosomal membrane proteins in their native environment

33 colocalization of C. neoformans and the MDM lysosomal membrane protein LAMP-1 was demonstrated, esta

34 cells by processing the sialic acids on the lysosomal membrane protein LAMP-1.

35 ay that measures transient surface levels of lysosomal membrane proteins LAMP-1 (CD107a) and LAMP-2 (

36 e, required for substrate uptake, and of the lysosomal membrane protein (lamp) type 2a, previously id

37 y normal distribution and trafficking of the lysosomal membrane protein, Lamp-2, in contrast to fibro

38 of the CD-MPR to the cytoplasmic tail of the lysosomal membrane protein Lamp1 was sufficient to parti

39 enlarged lysosomes, increased levels of the lysosomal membrane protein LAMP1, and increased levels o

40 Knockdown of the lysosomal membrane proteins LAMP1 and LAMP2 resulted in

41 coproteins and mannose-6-phosphate or to the lysosomal membrane protein, lgp120, distributed to endos

42 ignaling pathways, little is known about how lysosomal membrane protein lifetimes are regulated.

43 ure the half-lives of approximately 30 human lysosomal membrane proteins (LMPs) and identified RNF152

44 onal small molecules that co-opt short-lived lysosomal membrane proteins (LMPs) as effectors to deliv

45 Mutations in the late endosomal/lysosomal membrane protein Niemann-Pick C1 (NPC1) are kn

46 by quantitative proteomics, we identify the lysosomal membrane protein Niemann-Pick type C1 (NPC1) a

47 The CLN3 gene encodes a lysosomal membrane protein of unknown function, and CLN3

48 surface glycoprotein (VSG221) as well as the lysosomal membrane protein p67 was observed in Deltatbns

49 of transmembrane protein 106B (TMEM106B), a lysosomal membrane protein previously implicated as a ge

50 This screen revealed the lysosomal membrane protein SLC46A3, the genetic attenuat

51 nase Calpha, as well as reduced abundance of lysosomal membrane proteins such as LAMP1.

52 Acid beta-glucosidase is a lysosomal membrane protein that cleaves the O-beta-D-glu

53 Niemann-Pick C1 (NPC1) is a lysosomal membrane protein that exports cholesterol deri

54 mpair lysosomal function by interfering with lysosomal membrane proteins, thereby disrupting lipid me

55 precipitation, using the endogenous integral lysosomal membrane protein TMEM192, directly from clinic

56 the nuclear envelope and as a chimera with a lysosomal membrane protein to demonstrate rapid interlys

57 endolysosomes by independently targeting two lysosomal membrane proteins, transient receptor potentia

58 Our data reveal a tightly linked MFSD1/GLMP lysosomal membrane protein transporter complex.

59 fusion, is essential for the trafficking of lysosomal membrane proteins via lysosome-associated memb

60 ginine requires SLC38A9, a poorly understood lysosomal membrane protein with homology to amino acid t

61 yo electron tomography workflow to visualize lysosomal membrane proteins within intact, native lysoso