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1 or 4), Yes1 (YES proto-oncogene 1), and Lox (lysyl oxidase).
2 activation of PI3K/AKT, GSK3beta, Snail, and lysyl oxidase.
3 es proteolytic activation of the zymogen for lysyl oxidase.
4 ases, procollagen C-proteinase enhancer, and lysyl oxidase.
5 echanism of the tumor suppressor activity of lysyl oxidase.
6 amine oxidases, and lysine tyrosylquinone in lysyl oxidase.
7 collagens and collagen cross-linking enzyme lysyl oxidase.
8 y in the collagen cross-linking cupro-enzyme lysyl oxidase.
9 ysyl oxidase and mature approximately 30-kDa lysyl oxidase.
10 f mechanism-based inactivators selective for lysyl oxidase.
11 ur or selenium lactones that fully inhibited lysyl oxidase.
12 increased aortic levels of tropoelastin and lysyl oxidase.
13 a property driven by the oxidative action of lysyl oxidase.
14 s interaction also increases the activity of lysyl oxidase.
15 ced angiogenesis via activation of Cu enzyme lysyl oxidase.
16 and a member of an emerging family of human lysyl oxidases.
17 trix (ECM) components and high expression of lysyl oxidases.
18 etylation and deacetylimination catalyzed by lysyl oxidases.
20 growth factor (PDGF)-BB, angiopoietin-1, and lysyl oxidase-2 and the cerebrovascular-selective protei
21 cted an interaction between fibromodulin and lysyl oxidase (a major collagen cross-linking enzyme) an
23 ctly assess the roles of BMP-1 and mTLL-1 in lysyl oxidase activation by connective tissue cells, fib
27 e extracellular matrix enzymes revealed that lysyl oxidase activity is required for cross-linking of
28 ribes a more sensitive fluorescent assay for lysyl oxidase activity that utilizes 1,5-diaminopentane
30 p.Ser348Arg resulted in significantly lower lysyl oxidase activity when compared with the wild-type
31 creases in extracellular matrix rigidity and lysyl oxidase activity, which can be prevented by inhibi
32 l aldehyde-derived cross-links introduced by lysyl oxidase activity, which, in turn, only weakly infl
34 hypoxia-inducible factor-1alpha, syndecan-1, lysyl oxidase, adamalysin metalloproteinase-17, tissue i
36 (b) lysyl topa quinone of the copper protein lysyl oxidase, an enzyme required for proper cross-linki
37 protein (MMP-2) and unchanged expression of lysyl oxidase and a second metalloproteinase, MMP-9, in
38 roduced predominantly unprocessed 50-kDa pro-lysyl oxidase and had lysyl oxidase enzyme activity dimi
39 ion and purification of recombinant forms of lysyl oxidase and lysyl oxidase-like proteins have been
40 enzyme activity and for accumulation of pro-lysyl oxidase and mature approximately 30-kDa lysyl oxid
41 null for Bmp1 or Tll1 all produced both pro-lysyl oxidase and processed lysyl oxidase at similar lev
43 and VI and the collagen crosslinking enzyme lysyl oxidase and up-regulates in vitro expression of th
44 out the cement proteome, as well as multiple lysyl oxidases and peroxidases, establish homology with
47 creases in the pro-synthetic elastin enzyme, lysyl oxidase, and increases in the elastin-degrading en
48 alpha-amylase, concanavalin, Pichia pastoris lysyl oxidase, and Klebsiella pneumoniae acetolactate sy
50 as those encoding hypoxia-inducible gene-2, lysyl oxidase, and vascular endothelial growth factor, a
52 tatus does not influence the accumulation of lysyl oxidase as protein or lysyl oxidase steady state m
53 lasts, whereas in vitro studies identify pro-lysyl oxidase as the first known substrate for mTLL-2.
54 roduced both pro-lysyl oxidase and processed lysyl oxidase at similar levels, indicating apparently n
55 all four proteinases productively cleave pro-lysyl oxidase at the correct physiological site but that
57 ority of processing leading to activation of lysyl oxidase by murine embryonic fibroblasts, whereas i
61 e, a known inhibitor of the copper-dependent lysyl oxidases, causes notochord distortion in the zebra
63 some differentially expressed genes such as lysyl oxidase, copper transporter ATP7A, EphB6, RUNX2 an
64 in-4), collagens (types I, III, and IV), and lysyl oxidase crosslinking enzymes (LOX, LOXL1, LOXL2) w
69 Similarly, d-penicillamine, which inhibits lysyl oxidase enzymatic activity by depleting intracereb
70 hree enzymes, respectively, were assayed for lysyl oxidase enzyme activity and for accumulation of pr
71 unprocessed 50-kDa pro-lysyl oxidase and had lysyl oxidase enzyme activity diminished by 70% compared
74 inopropionitrile, the selective inhibitor of lysyl oxidase enzyme activity, was remarkably unable to
76 hydroxylysine would enhance the activity of lysyl oxidase enzyme to form collagen cross-links, incre
77 at the lysyl oxidase propeptide, and not the lysyl oxidase enzyme, inhibits ras-dependent transformat
80 ase reverts ras-mediated transformation, and lysyl oxidase expression is down-regulated in human canc
81 utocrine growth factor pathways maintain low lysyl oxidase expression levels in c-H-ras-transformed f
86 We also established that LOXL2 is the main lysyl oxidase family member present in the glomerular ex
88 d more recently periostin and members of the lysyl oxidase family of enzymes have been documented in
89 ysyl oxidase-like 2 (LOXL2), a member of the lysyl oxidase family, as a Snail1 regulator and EMT indu
92 extracellular proteolytic processing of pro-lysyl oxidase, functions to inhibit ras-dependent cell t
95 ic antisense lysyl oxidase demonstrated that lysyl oxidase gene expression mediated phenotypic revers
105 does inhibit the expression and activity of lysyl oxidase in osteoblasts, thereby contributing to pe
106 growth factor signaling pathways and induces lysyl oxidase in ras-transformed NIH3T3 cells (RS485 cel
109 e deficiency of LOX in mice or inhibition of lysyl oxidases in turkeys and rats causes aortic dissect
116 found that the collagen cross-linking enzyme lysyl oxidase is expressed in all vascular cells and tha
117 viously shown that proteolytic activation of lysyl oxidase is much reduced in cultures of FN-null mou
122 ll-known irreversible inhibitor of mammalian lysyl oxidases, is also a potent inhibitor of rDmLOXL-1.
123 e inhibitor of the enzymatic activity of all lysyl oxidases, is unable to abolish the LOXL2-induced i
124 Lysyl oxidase-like 1 proved to be the major lysyl oxidase isoform in the normal lamina cribrosa in a
128 lly manipulating stromal matrix with an anti-lysyl oxidase like-2 (anti-LOXL2) antibody in syngeneic
132 ression of LOX and other LOX family members [lysyl oxidase-like (LOXL), LOXL2, LOXL3, and LOXL4] was
134 as reported that mice with null mutations in lysyl oxidase-like 1 (LOXL1) develop pelvic organ prolap
135 Here we show that mice lacking the protein lysyl oxidase-like 1 (LOXL1) do not deposit normal elast
136 genetic predisposition due to variations in lysyl oxidase-like 1 (LOXL1) function, leading to altere
137 Two single nucleotide polymorphisms in the lysyl oxidase-like 1 (LOXL1) gene (rs1048661 and rs38259
139 ation between common genetic variants in the lysyl oxidase-like 1 (LOXL1) gene with pseudoexfoliation
140 Strong genetic risk is conferred by the lysyl oxidase-like 1 (LOXL1) gene, but additional comodu
141 ey of the expression of lysyl oxidase (LOX), lysyl oxidase-like 1 (LOXL1), and lysyl oxidase-like 2 (
143 trong familial association and recently, the lysyl oxidase-like 1 gene has been strongly associated w
144 However, the exact relationship between lysyl oxidase-like 1 polymorphisms and the development o
145 is an important risk factor for glaucoma and lysyl oxidase-like 1 polymorphisms are strongly associat
151 essed the steady-state enzymatic activity of lysyl oxidase-like 2 (LOXL2) against the substrates 1,5-
152 derived 3D matrix system and identified anti-lysyl oxidase-like 2 (LOXL2) antibodies that alter the n
154 ase (LOX), lysyl oxidase-like 1 (LOXL1), and lysyl oxidase-like 2 (LOXL2) has yet to be performed.
158 oxyphenolics required the presence of active lysyl oxidase-like 2 (LOXL2), thereby limiting effects t
159 show that an enzyme that crosslinks collagen-Lysyl oxidase-like 2 (Loxl2)-is essential for interstiti
161 oss-linking domains in elastin and decreased lysyl oxidase-like 2 expression leads to decreased amoun
162 The inclusion of exon 23 in elastin mRNA and lysyl oxidase-like 2 mRNA levels was significantly reduc
163 , crosslinking genes/enzymes (lysyl oxidase, lysyl oxidase-like 2-4, tissue transglutaminase-2), and
164 to be due to disruption of regulatory genes (lysyl oxidase-like and clusterin) that are involved in b
165 ic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and more divergent p
166 te hypermethylated genes, including LOXL1, a lysyl oxidase-like gene, in human bladder cancer cells.
167 rrent study suggests for the first time that lysyl oxidase-like genes can act as tumor suppressor gen
169 sors histone deacetylases 1 and 2 as well as lysyl oxidase-like protein 3 with Snail1 was impaired wh
171 on of recombinant forms of lysyl oxidase and lysyl oxidase-like proteins have been reported in the li
174 identified a new role for the matrix enzyme lysyl oxidase-like-2 (LOXL2) in the creation and mainten
177 Among all lysyl oxidase family members, lysyl oxidase-like-2 (LOXL2) was identified as the isofo
181 ly, the enzymes lysyl hydroxylase 2 (LH2) or lysyl oxidase (LOX) and LOX-like 2 (LOXL2) were signific
185 l oxidase family is made up of five members: lysyl oxidase (LOX) and lysyl oxidase-like 1-4 (LOXL1-LO
186 copper-binding and catalytic domains of both lysyl oxidase (LOX) and the lysyl oxidase-like (LOXL) pr
187 we identify hypoxia-induced ECM re-modeler, lysyl oxidase (LOX) as a key inducer of chemoresistance
188 analysis of the hypoxic secretome identified lysyl oxidase (LOX) as significantly associated with bon
190 pression of the collagen crosslinking enzyme lysyl oxidase (LOX) compared with PyMT(fl/fl) mammary ca
191 levation of the extracellular matrix protein lysyl oxidase (LOX) correlates with metastatic disease a
192 of the extracellular matrix modifying enzyme lysyl oxidase (LOX) correlates with metastatic dissemina
194 helial-mesenchymal transition marker levels, lysyl oxidase (LOX) expression, and metastatic capacity.
195 We identified previously an up-regulation in lysyl oxidase (LOX) expression,an extracellular matrix r
200 through induction of multiple members of the lysyl oxidase (LOX) family, including LOX, LOX-like 2, a
202 ved human MSCs promote de novo production of lysyl oxidase (LOX) from human breast carcinoma cells, w
203 AD, we identified a missense mutation in the lysyl oxidase (LOX) gene (c.893T > G encoding p.Met298Ar
206 such pathologies, and recently, the protein lysyl oxidase (LOX) has been implicated in proliferation
207 The extracellular, matrix-modifying enzyme lysyl oxidase (LOX) has recently been linked to colorect
210 y, hypoxic signaling increased expression of lysyl oxidase (LOX) in mesothelial and ovarian cancer ce
211 d mast cell protease expression, and induced lysyl oxidase (LOX) in the aortic wall, improved systemi
212 ession and localization of LOXL1, LOXL2, and lysyl oxidase (LOX) in tissues of PEX syndrome/glaucoma
221 of the extracellular matrix-modifying enzyme lysyl oxidase (LOX) is essential for stimulating endothe
229 roarray studies have shown the expression of lysyl oxidase (LOX) to be elevated in hypoxic human tumo
230 We studied the functional contribution of lysyl oxidase (LOX) to collagen stabilization and hepati
232 d is then cleaved to a 30-kDa mature enzyme (lysyl oxidase (LOX)) and an 18-kDa propeptide (lysyl oxi
234 ypothesized that HG-induced up-regulation of lysyl oxidase (LOX), a collagen-cross-linking enzyme, in
235 d whether altered expression and activity of lysyl oxidase (LOX), a cross-linking enzyme, may comprom
237 the dramatic reduction in the expression of lysyl oxidase (LOX), a metastasis-promoting, matrix-remo
239 Previously, fibulin-4 was shown to bind lysyl oxidase (LOX), an elastin/collagen cross-linking e
240 A key regulator of collagen homeostasis is lysyl oxidase (LOX), an enzyme responsible for cross-lin
242 ng inhibited by a known suicide inhibitor of lysyl oxidase (LOX), beta-aminopropionitrile, which we f
243 0b; miR-200b directly inhibits expression of lysyl oxidase (LOX), leading to decreased invasion.
245 a comprehensive survey of the expression of lysyl oxidase (LOX), lysyl oxidase-like 1 (LOXL1), and l
246 A series of studies examined the effects of lysyl oxidase (LOX), the enzyme responsible for the form
247 GFbeta1 stimulation increased collagen I and lysyl oxidase (LOX), the enzyme that cross-links soluble
248 cognized targets of the extracellular enzyme lysyl oxidase (LOX), the level of which is increased in
249 supplies Cu to the secretory enzymes such as lysyl oxidase (LOX), while Atox1 in the nucleus function
253 ated that Atox1, ATP7A, and the proenzyme of lysyl oxidase (LOX; copper-loaded via ATP7A) are all in
256 ch in cysteine), crosslinking genes/enzymes (lysyl oxidase, lysyl oxidase-like 2-4, tissue transgluta
258 accompanying intermolecular cross-linking by lysyl oxidase-mediated bonds, is vital to the structural
259 electively affects the extent and pattern of lysyl oxidase-mediated collagen cross-linking by sterica
260 ing as a potential contributor, we inhibited lysyl oxidase-mediated collagen cross-linking, which sig
261 trix compliance in vitro and by manipulating lysyl oxidase-mediated collagen crosslinking in vivo.
267 -terminal catalytic domains that provide for lysyl oxidase or lysyl oxidase-like enzyme activity; and
268 ltures with inhibitors of TGFbeta signaling, lysyl oxidase, or integrin beta1-mediated mechanosignali
269 s of transforming growth factor (TGF)-beta1, lysyl oxidase, periostin, and osteopontin are elevated.
270 relationship exists between fibromodulin and lysyl oxidase, potentially imparting a specific collagen
271 ativum amine oxidase (PSAO), Pichia pastoris lysyl oxidase (PPLO), bovine plasma amine oxidase (BPAO)
274 propeptide region (LOX-PP) derived from pro-lysyl oxidase (Pro-LOX) and not on lysyl oxidase enzyme
275 t study is the first to directly compare pro-lysyl oxidase processing by these four related proteinas
279 LOX has complex roles in cancer in which the lysyl oxidase propeptide (LOX-PP) domain of secreted pro
282 Here we report, for the first time, that the lysyl oxidase propeptide, and not the lysyl oxidase enzy
283 cally increases intranuclear localization of lysyl oxidase propeptide, which interferes with NF-kappa
287 studies demonstrate that the mature form of lysyl oxidase retains many of its functions in the absen
289 ed on the possibility that copper efflux and lysyl oxidase secretion from cells may share a common pa
290 lloproteinases, IL-8, PDGFs, caveolin 1, and lysyl oxidase), several of which were associated with po
291 accumulation of lysyl oxidase as protein or lysyl oxidase steady state messenger RNA concentrations,
293 method exists that employs nonpeptidyl amine lysyl oxidase substrates and measures hydrogen peroxide
294 on is unlikely to affect the efficacy of the lysyl oxidase, suggesting that the defect is in the mole
295 ollagen domain and also forms a complex with lysyl oxidase, targeting the enzyme toward specific cros
296 n mineralization, and Loxl4, which encodes a lysyl oxidase that catalyzes collagen crosslinking.
297 er280Arg), was identified in LOX, encoding a lysyl oxidase, that segregated with disease in the famil
298 alyses revealed that the mRNA expression for lysyl oxidase, the determining enzyme required for colla
299 ort that an FGF-2 autocrine pathway inhibits lysyl oxidase transcription in the tumorigenic-transform
300 rk (TGN) is necessary for proper activity of lysyl oxidase, which is the predominant cuproenzyme whos
301 nt loss of col8a1a function or inhibition of Lysyl oxidases with drugs during embryogenesis was suffi
302 o be competitive, irreversible inhibitors of lysyl oxidase, with KI values of 21 +/- 3 microM, 8.3 +/