ライフサイエンスコーパス: macaque

1 mate model of MERS-CoV infection, the rhesus macaque.

2 ns in three fMRI-defined face patches of the macaque.

3 ciency virus (SIV) acquisition in humans and macaques.

4 ific IgG antibody levels compared with young macaques.

5 s determined as a correlate of protection in macaques.

6 cell subset accumulated in the lungs of LTBI macaques.

7 r implant, N = 41) of cabotegravir in rhesus macaques.

8 eloped an assay to monitor CMV in Cynomolgus macaques.

9 SCAT and VAT from INSTI-treated noninfected macaques.

10 xperimental infection in mice and cynomolgus macaques.

11 nga infection during acute disease in rhesus macaques.

12 ing and neurocognitive assessments in rhesus macaques.

13 were collected from EBOV-infected cynomolgus macaques.

14 red for treatment of SARS-CoV-2 infection in macaques.

15 ehavior but they have serious limitations in macaques.

16 rophylactically or therapeutically in rhesus macaques.

17 e protection against SIV infection in rhesus macaques.

18 f type-1 and type-2 T helper cells in rhesus macaques.

19 e robust HIV-1-specific antibodies in rhesus macaques.

20 ns, transmission, and pathogenesis in rhesus macaques.

21 rved in the prostate of ZIKV-infected rhesus macaques.

22 (S) protein and evaluated them in 35 rhesus macaques.

23 nted reactivation of TB in latently infected macaques.

24 gions across humans, chimpanzees, and rhesus macaques.

25 d visual function with diffusion MRI in aged macaques.

26 er of mutations accumulate before puberty in macaques.

27 and scale with single-unit timescales within macaques.

28 n vaccinated and control SARS-CoV-2-infected macaques.

29 llected from EBOV-Makona-infected cynomolgus macaques.

30 rophysiology and two-photon imaging in awake macaques.

31 tional MRI adaptation paradigm in awake male macaques.

32 was also detected in most of the vaccinated macaques.

33 flow studies in 16 male and 22 female rhesus macaques.

34 s (SIV) infection of adult humans and rhesus macaques.

35 ntially more lung inflammation compared with macaques.

36 rotection against viral challenges in rhesus macaques.

37 ircuit (mouse->human: 85% unassigned; mouse->macaque 69% unassigned; macaque->human; 31% unassigned).

38 In surviving macaques (80-89%), we observed induction of genes mappin

39 that intravenous inoculation of SIV-infected macaques, a well-accepted non-human primate model of HIV

40 We report rhesus macaque A3G structures that show different inter-domain

41 ly, crystal structures of full-length rhesus macaque A3G variants were solved which suggested dimeriz

42 cy, following behavioral, computational, and macaque action planning results and comparisons to alter

43 by choice-linked reward associations alone; macaques also maintain a memory of the general, average

44 mmunodeficiency virus (SHIV)-infected rhesus macaques, an earlier and sharper decline in viral load w

45 Immunoperoxidase analysis of macaque and human brain tissue demonstrate a conserved p

46 T and VAT, respectively) from 14 noninfected macaques and 19 PHIV treated or not treated with an INST

47 Acute respiratory distress in macaques and baboons recapitulates the progression of CO

48 g with HIV envelope (Env) vaccines to rhesus macaques and bnAb immunoglobulin knock-in (KI) mice expr

49 loroquine (together with previous reports in macaques and ferrets) thus provide no scientific basis f

50 rom experimental iBCI measurements in rhesus macaques and from a clinical-trial participant with impl

51 ccumulation after puberty is similar between macaques and humans, but that a smaller number of mutati

52 ome abundant across the neocortex of humans, macaques and marmosets but not mice or ferrets.

53 Given the evolutionary separation between macaques and marmosets, our results suggest this frontal

54 cin intranasally and intravenously to rhesus macaques and measure, with mass spectrometry, concentrat

55 sed SIV RNA expression in the lymph nodes of macaques and robust induction of HIV in almost all tissu

56 levels of virus in the blood of nonpregnant macaques and to be transmitted by mosquitoes.

57 ed measures of welfare for laboratory-housed macaques and to determine their relative importance in o

58 bus), Macaca nemestrina (southern pig-tailed macaque), and Mandrillus leucophaeus (the drill).

59 CN2 (rh-LCN2) and autoradiography in baboon, macaque, and human brain sections, that LCN2 crosses the

60 d somatic cell types of the testes in human, macaque, and mice.

61 for protection against SARS-CoV-2 in rhesus macaques, and that cellular immune responses may contrib

62 ce is found in layer 2/3 V1 neurons of awake macaques, anesthetized mice, and acute brain slices.

63 However, only large animal models such as macaques are thought to reproduce the morphological hall

64 The establishment of the rhesus macaque as a model of COVID-19 will increase our underst

65 ordings from multiple sessions with a single macaque as the animal transitioned from consciousness to

66 Here, we used macaques as a model to assess whether different dominanc

67 swabs from the nose and throat of all of the macaques, as well as in bronchoalveolar lavages; in one

68 ARS-CoV-2) infection in young and old rhesus macaques, baboons and old marmosets.

69 ed MAIT cell dynamics and function in rhesus macaque blood and bronchoalveolar lavage (BAL) following

70 nstant, there are separate mechanisms in the macaque brain for processing transient changes in the fa

71 aPFC that lacks a homologous counterpart in macaque brains.

72 ), an ebolavirus, causes clinical disease in macaques but has yet only been associated with rare asym

73 ogy of this EEG signature between humans and macaques but raise questions about the current interpret

74 Among bonnet macaques, but not rhesus or long-tailed macaques, indivi

75 both in vitro and in vivo in SIVmac-infected macaques, by upregulating antioxidant pathways and the i

76 The restriction factors identified in macaques can be harnessed for development of effective c

77 We conclude that macaques can develop bNAbs against the V3-glycan patch t

78 Our results demonstrate that rhesus macaques can learn to use a middle concept for a discret

79 Virus-antibody coevolution in macaques can thus recapitulate developmental features of

80 this molecule to induce signaling via rhesus macaque CD200R, as well as the potential function of a s

81 ar layer, and white matter in chimpanzee and macaque cerebellum slices.

82 Macaques co-administered bNAbs 10-1074 and 3BNC117, or 3

83 induced reactivation of LTBI, recent work in macaques co-infected with Mycobacterium tuberculosis (Mt

84 eated a network of cortical "patches" in the macaque cortex, processing faces, eventually also extrac

85 For the macaque data set, coherence and our new MIF estimator la

86 We show that, in macaques, decisions about whether and when to act are pr

87 However, only macaques developed a consumptive coagulopathy whereas YF

88 ed macaque health in interaction with actual macaque dominance drives close interactions despite huma

89 Cabotegravir plasma levels in macaques dropped below detectable levels within two week

90 ificantly predicted intended approach to the macaques during hypothetical interactions.

91 used an Ab to neutralize IL-10 in cynomolgus macaques during M. tuberculosis infection.

92 n = 187), and F5 (n = 115) as two adult male macaques executed, observed, or withheld (NoGo) reach-to

93 social and health traits were related to the macaques' facial morphology and their observed behaviour

94 As in humans, older macaque fathers transmit more mutations to their offspri

95 ressing common allotypes of human and rhesus macaque FcgammaR2A and FcgammaR3A were established.

96 ng modes and protein contacts indicates that macaque, ferrets and hamster are the most suitable model

97 Extrapolating the macaque findings in humans suggests that such differenti

98 tro with its parent serotype, AAV2, in adult macaques following delivery into the caudate and putamen

99 networks active in adipose tissue of rhesus macaques following FGF21-induced weight loss.

100 Ultimately, this strategy failed to protect macaques from SIV acquisition.

101 e SIV envelope protein and failed to protect macaques from viral infection.

102 Four macaque groups included vaccine only, vaccine-microbicid

103 % unassigned; mouse->macaque 69% unassigned; macaque->human; 31% unassigned).

104 Macaques had clinical signs of viral infection, mild to

105 el of SARS-CoV-2 infection and observed that macaques had high viral loads in the upper and lower res

106 Old macaques had lower titres of SARS-CoV-2-specific IgG ant

107 s of viral reservoirs in SIV-infected rhesus macaques had no demonstrable effect on plasma viremia af

108 MRI showed that ZIKV-infected infant rhesus macaques had persistent enlargement of lateral ventricle

109 s Mtb infection in highly susceptible rhesus macaques has important implications for vaccine delivery

110 Specifically, perceived macaque health in interaction with actual macaque domina

111 contrast, our method allows to extract awake macaques HR from both RGB and IR videos and is particula

112 photoplethysmography allows to extract awake macaques HR from RGB videos.

113 genome sequencing (WGS) data from 853 rhesus macaques identified 85.7 million single-nucleotide varia

114 These studies reveal that rhesus macaque IgG responses during chronic SIV infection gener

115 this reflects limited sequence variation of macaque IgGs as a result of their relatively recent dive

116 interactions between humans and (peri)urban macaques in Asia.

117 Striking differences between female and male macaques in correlations of prevalent rectal bacteria wi

118 ormal neurodevelopment, by studying 203 male macaques in large social groups.

119 stem for estimating 3D pose in freely moving macaques in large unconstrained environments.

120 f SIV-induced TB reactivation in ART-treated macaques in the early phase of treatment.

121 n and preclinical species (e.g. murine, dog, macaque) in both biochemical and cellular assays.

122 The bumps emerge during fetal development in macaques, indicating that they arise from general develo

123 nnet macaques, but not rhesus or long-tailed macaques, individuals who were more well-connected in th

124 Rhesus macaque infants experienced on average 5% reduced hazard

125 el predictions are consistent with data from macaques infected with a mixture of simian immunodeficie

126 liver-thymus (BLT) humanized mice and rhesus macaques infected with HIV and SIV, respectively.

127 g infection had a clinical benefit in rhesus macaques infected with SARS-CoV-2.

128 le to those found in convalescent humans and macaques infected with SARS-CoV-2.

129 Similarly, a small number of macaques infected with SHIVs develop broadly neutralizin

130 4 simian/HIV-infected, ART-suppressed rhesus macaques infused with virus-specific CD4CAR T cells, fol

131 We show that five rhesus macaques initially infected with ZIKV 22 to 28 months pr

132 analysis to provide a multimodal map of the macaque IPS.

133 The rhesus macaque is an important animal model for AIDS and other

134 Rhesus macaque is an Old World monkey that shared a common ance

135 Canine, porcine, and rhesus macaque ISG15, such as human ISG15, stabilize USP18, a p

136 networks to investigate the organization of macaque IT cortex.

137 of RhCMV/SIV vaccines in RhCMV-seronegative macaques lacking anti-vector immunity.

138 ion from a common IGHG gene since humans and macaques last shared a common ancestor.

139 Three defining features of PTB in macaque lungs include the influx of plasmacytoid dendrit

140 n metabolic signatures, in female cynomolgus macaque (Macaca fascicularis) displaying naturally occur

141 esus macaque (Macaca mulatta) and cynomolgus macaque (Macaca fascicularis), all male.

142 ies of IOP dynamics and glaucoma: cynomolgus macaque (Macaca fascicularis), rhesus macaque (Macaca mu

143 persensitivity (DTH) model in the cynomolgus macaque (Macaca fascicularis).

144 cies: vervets (Chlorocebus aethiops), rhesus macaque (Macaca mulatta) and cynomolgus macaque (Macaca

145 The rhesus macaque (Macaca mulatta) is the most widely studied nonh

146 e of the de novo mutation rate in the rhesus macaque (Macaca mulatta) using whole-genome sequence dat

147 molgus macaque (Macaca fascicularis), rhesus macaque (Macaca mulatta), pig (Sus scrofa), and mouse (M

148 Rhesus macaques (Macaca mulatta) are key for modeling human imm

149 Fifty-two rhesus macaques (Macaca mulatta) were immunized with Ad26 vecto

150 tested innovation in a wild group of Barbary macaques (Macaca sylvanus).

151 is related to the largest disparity scale in macaque medial temporal area and to the estimated size o

152 arance of Mtb infection in latently infected macaques.Methods: Sixteen NHPs were infected via inhalat

153 Although the rhesus macaque model does not represent the severe disease obse

154 rom simian immunodeficiency virus (SIV), the macaque model for HIV.

155 ny, but not all, brain regions in the rhesus macaque model is consistent with the possible existence

156 and treatment of CMV viremia in a Cynomolgus macaque model of bone marrow transplantation (BMT) for t

157 We used an infant rhesus macaque model of HIV-1 infection via breastfeeding to id

158 591 as preexposure prophylaxis in the rhesus macaque model of intrarectal challenge with simian/human

159 In a preterm rhesus macaque model of IUI given intra-amniotic LPS, induction

160 t simian-human immunodeficiency virus (SHIV)-macaque model of latency is critical to investigate erad

161 We developed a rhesus macaque model of SARS-CoV-2 infection and observed that

162 igate the efficacy of remdesivir in a rhesus macaque model of SARS-CoV-2 infection(9).

163 irologic efficacy of baricitinib in a rhesus macaque model of SARS-CoV-2 infection.

164 RT on the gut microbiota, we used the rhesus macaque model of SIV infection to characterize and compa

165 10H2), was down-selected for assessment in a macaque model of SUDV infection.

166 We conclude that the TF SHIV-macaque model reflects several hallmarks of HIV and SIV

167 ow that postnatal ZIKV infection in a rhesus macaque model resulted in long-term behavioral, motor, a

168 The utility of the macaque model would be greatly enhanced by the ability t

169 Using our recently developed macaque model, we show that a single subcutaneous admini

170 l ultimately have to be tested in the rhesus macaque model, which is shown here to have MUC16-targete

171 t on the outcome of preclinical studies with macaque models.

172 The organization of projections from the macaque monkey hippocampus, subiculum, presubiculum, and

173 oreactive to calbindin, whereas in primates (macaque monkey, lar gibbon and human) the highest propor

174 cell types between human and the cynomolgus macaque monkey, Macaca fascicularis.

175 tage along the ventral visual pathway of the macaque monkey.

176 cribe resulting medial-frontal EEG on a male macaque monkey.

177 in layer 6 of primary visual cortex in male macaque monkeys (Macaca fascicularis) to achromatic grat

178 In two male rhesus macaque monkeys (Macaca mulatta), we found that lateral

179 tion of corticoreticular connections in five macaque monkeys (one male) using both intracellular and

180 ses of EEG recorded over the frontal lobe of macaque monkeys (one male, one female) performing a sacc

181 y precise eye tracking in three well trained macaque monkeys and found that even fleeting (~8 ms dura

182 mporal responses in the entorhinal cortex of macaque monkeys as they viewed complex images.

183 ctures, we recorded CDh neuronal activity of macaque monkeys before and during unilateral SC inactiva

184 Here, we show that macaque monkeys exhibit perceptual crowding for target o

185 We recorded from single OFC neurons while macaque monkeys made cost-benefit decisions.

186 visuomotor tracking task, in which 2 female macaque monkeys moved their index finger against a resis

187 recorded from single hippocampal neurons in macaque monkeys navigating a virtual maze during a forag

188 he inferior temporal cortex (IT) while naive macaque monkeys passively viewed images of letters, Engl

189 Macaque monkeys performed an eight-alternative 3D orient

190 and female human subjects as well as in male macaque monkeys performing a visual detection task.

191 ighted MRI data before and after male rhesus macaque monkeys received extensive training to learn nov

192 Macaque monkeys were trained for a behavioural task desi

193 Here, we used rER BOLD fMRI in macaque monkeys while viewing real-world images, and fou

194 des in the primary visual cortex of 2 female macaque monkeys, and also recorded electroencephalogram

195 ement of four terminally anesthetized female macaque monkeys, and recorded recurrent IPSPs in respons

196 prefrontal cortex (PFC; area 46) of two male macaque monkeys, recording >500 neurons simultaneously.

197 In humans and macaque monkeys, socially relevant face processing is ac

198 We show that this is the case in humans and macaque monkeys, suggesting that the reflex pathways tha

199 Here, using multi-structure recordings in macaque monkeys, we show that the brainstem transiently

200 ng biplanar videoradiography (XROMM) of four macaque monkeys, we tested the extrinsic muscle shorteni

201 ned electrical stimulation with fMRI in male macaque monkeys.

202 ent cancellation in medial frontal cortex of macaque monkeys.

203 field potentials (LFP) in visual area MT of macaque monkeys.

204 Two cynomogulus macaque monkeys.

205 l structure to humans of either sex and male macaque monkeys.

206 athways during strength training in 2 female macaque monkeys.

207 mples from C57BL/6J mice (n = 28) and rhesus macaques (n = 4) immunized with the same HCV E1E2 antige

208 oductive success of high-ranking male rhesus macaques on Cayo Santiago.

209 Here, we used infant rhesus macaques orally infected with simian/human immunodeficie

210 sembles of neurons in both LIP and FEF while macaques performed a memory-guided saccade task.

211 riatum (VS), and dorsal striatum (DS), while macaques performed a rule-based decision-making task.

212 hin neural activity from area V4 of two male macaques performing a visual attention task.

213 Capuchin monkeys and especially rhesus macaques persisted to trial completion even when it was

214 t neurons in a particular area of the rhesus macaque posterior thalamus encoded the historical value

215 orm a very important role in the function of macaque primary visual cortex, V1, but not enough is und

216 Together, the rhesus macaque recapitulates the moderate disease that has been

217 In study 1, 8 rhesus macaques received 3.9 mg/kg of MK-8591 orally on day 0 a

218 Ten pregnant pigtail macaques received choriodecidual inoculation of either g

219 group exhibited potent protection; 10 of 12 macaques remained uninfected following 15 SIV challenges

220 mples from humans, chimpanzees, bonobos, and macaques representing 33 anatomical regions, as well as

221 A connectome from central macaque retina was generated by serial blockface scannin

222 Using serial electron microscopy in the macaque retina, we reconstructed the neurons and synapse

223 this study, we show that strain 68-1 rhesus macaque (RM) CMV vaccine vectors expressing HBV Ags enge

224 d an HIV cure by depleted Tregs in 14 rhesus macaque (RM) controllers infected with SIVsab, the virus

225 morphine dependent SIVmac251 infected rhesus macaque (RM) model to study the impact of opioids on HIV

226 morphine dependent SIVmac251 infected Rhesus macaque (RM) model to study the impact of opioids on HIV

227 ency virus (SIV)/SHIV-infected infant rhesus macaques (RM) and tracked changes in frequency, traffick

228 nable efficient replication in Indian rhesus macaques (RM).

229 Rhesus macaques (RMs) (n = 13) were infected with simian/human

230 the two surviving, aged AGMs and four rhesus macaques (RMs) infected with SARS-CoV-2.

231 imian immunodeficiency virus-infected rhesus macaques (RMs) undergoing CD8alpha depletion and treated

232 we identified 7 SIV(mac239)-infected rhesus macaques (RMs), defined as PTCs, who started ART 8 weeks

233 of detrusor function is prominent in rhesus macaques, shares many features with the human, and merit

234 ized with gp150 complexed to BMS-529, rhesus macaques showed neutralization against tier 2 pseudoviru

235 Using the rhesus macaque simian immunodeficiency virus SIVmac251 model, w

236 irst impression ratings (n = 227) of Barbary macaques' social and health traits were related to the m

237 In human and macaque some subplate cells undergo regulated cell death

238 ergic innervation of the amygdala among four macaque species using histological and immunohistochemic

239 ocial connections within a socially tolerant macaque species), but also higher costs on account of co

240 vioral diversity has been reported among the macaque species, but little is known about the neural su

241 However, a large number of human and macaque striatal voxels were not matched to any mouse co

242 o be only marginally smaller compared to the macaque, suggesting that these circuit elements are near

243 dentified an attention-related region in the macaque temporal cortex, here called the floor of the su

244 CoV-2 causes a respiratory disease in rhesus macaques that lasts between 8 and 16 days.

245 espiratory tract tissue of vaccinated rhesus macaques that were challenged with SARS-CoV-2 compared w

246 In macaques, the circuit spanning the anterior intraparieta

247 the finding that discrimination reversal in macaques, the classic test of behavioral flexibility, is

248 to viremic simian HIV (SHIV)-infected rhesus macaques, there was a 21% difference in slope of plasma-

249 n the other hand, within the cART suppressed macaques, there was a reduction in cell-associated DNA l

250 In macaques, these face patches are located in similar part

251 We tested our hypothesis on 4 macaques, three decision-making tasks, and two brain are

252 oral and gastrointestinal mucosae of infant macaques through alterations of resident innate immune c

253 and visual system function in adult and aged macaques to better understand how age-related changes in

254 ) methods established for Chinese cynomolgus macaques to generate in vitro MCM embryos.

255 We recorded from two male macaques to investigate how neurons in the middle tempor

256 imian immunodeficiency virus (SIV) in rhesus macaques to investigate the generation and selection of

257 -coinfected (M. tuberculosis/SIV-coinfected) macaques to model M. tuberculosis/HIV coinfection and st

258 We trained three macaques to perform a joystick-controlled pursuit task i

259 To address this question, we trained macaques to perform an auditory-motor task producing sou

260 fection, we randomly assigned newborn rhesus macaques to receive BCG vaccine or remain unvaccinated a

261 ted long-term social status in female rhesus macaques to show that social subordination alters the ge

262 B) and infrared (IR) videos, in anesthetized macaques, to a level comparable to what can be achieved

263 TB risk was not decreased in the coinfected macaques treated with ART for 14-63 days, suggesting tha

264 Our objective was to develop macaque trophoblast stem cells (TSCs) as an in vitro pla

265 Macaque TSC lines were generated by isolating first and

266 y TSC-derived ST reflects a reprogramming of macaque TSCs to an earlier pregnancy phenotype.

267 ith human hepatocytes (hFRG mice) and rhesus macaques using a highly pathogenic African YFV strain.

268 Here, we tested a vaccine regimen in pigtail macaques using an intranasal (i.n.) recombinant Fowl Pox

269 ivity in dorsal-lateral prefrontal cortex of macaques using eight microelectrode arrays (768 electrod

270 l, we studied spiking activity of neurons in macaque V1 and V2 elicited by repeated presentations of

271 nerality of the approach was demonstrated in macaque V1 neurons.

272 eous optical imaging of intrinsic signals in macaque V1, V2, and V4, supplemented by higher-resolutio

273 to create strong stimuli for neurons in the macaque visual cortex.

274 taper MIF and coherence are computed between macaque visual cortical recordings and their correlation

275 Infection in macaques was associated with activation and predicted re

276 In contrast, the response of non-surviving macaques was characterized by hypercytokinemia; a T help

277 s well as in bronchoalveolar lavages; in one macaque, we observed prolonged rectal shedding.

278 Using SIV-infected rhesus macaques, we analyzed multiple brain regions through acu

279 10 groups of rhesus, long-tailed, and bonnet macaques, we collected social behavior, spatial data, an

280 ctional MRI data from humans and from rhesus macaques, we first identified an asymmetrical response o

281 s associated with SARS-CoV-2 pathogenesis in macaques, we performed transcriptomic analyses of bronch

282 penile and vaginal SHIV infection risk among macaques were achieved at clinically relevant plasma bNA

283 Six months after BCG vaccination, macaques were challenged with virulent Mtb.

284 In addition, the depressive-like macaques were characterized by changes in three microbia

285 Twenty-two macaques were exposed to SHIV via the foreskin and ureth

286 Control macaques were infected after a median of 1 challenge (ra

287 Rhesus macaques were primed twice mucosally with replication-co

288 and metabolic signatures of depressive-like macaques were significantly different from those of cont

289 To determine its identity, a group of nine macaques were taught discrimination reversal learning ta

290 ing 4 or 5 days post inoculation, cynomolgus macaques were treated once daily for 12 days with vehicl

291 Cynomolgus macaques were vaccinated twice with the quadrivalent for

292 ons in the putamen (four injections in three macaques) were widely distributed, up to 10 mm antero-po

293 ded protection from SUDV infection in rhesus macaques when administered at 50 mg/kg on days 4 and 6 p

294 These data were confirmed in rhesus macaques where a low dose of TMV-NPNAx5 elicited Abs tha

295 We recorded AIP neuronal activity from two macaques while they observed videos portraying seven man

296 We vaccinated 30 rhesus macaques with Ad26-SIV Env/Gag/Pol and SIV Env gp140 pro

297 tomical sites in chronically infected rhesus macaques with high (>10,000 copies/mL plasma) or low bur

298 dies have shown that rER fMRI is possible in macaques with MION, despite MION's prolonged response fu

299 In total, the synovium of 28 of 30 rhesus macaques with terminal filovirus disease had evidence of

300 In a hamster model(2) and in macaques, YF-S0 prevents infection with SARS-CoV-2.