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1  in B cell LAMP-2C expression did not impact macroautophagy.
2 apoptotic pathway requires the inhibition of macroautophagy.
3 iseases are associated with dysregulation of macroautophagy.
4 ly to its role in the degradative process of macroautophagy.
5 onserved and essential mediator of canonical macroautophagy.
6 cation compartment formation; and micro- and macroautophagy.
7  and intracellular components sequestered by macroautophagy.
8 tants were defective in ER-Golgi traffic and macroautophagy.
9 tion of the phagophore and in the process of macroautophagy.
10 mune response, chemotaxis, and regulation of macroautophagy.
11  shortage or organelle damage, cells undergo macroautophagy.
12                     Their clearance requires macroautophagy.
13 lglycerol, and their metabolizing enzymes in macroautophagy.
14 naive T cells, two physiological inducers of macroautophagy.
15 nly proteasome-mediated proteolysis but also macroautophagy.
16 the ER-Golgi fusion machinery are needed for macroautophagy.
17 n functionally links ER stress responses and macroautophagy.
18 reby mitochondria are turned over is through macroautophagy.
19 ylation of lysosomal GFAP, with no change in macroautophagy.
20 e proteins via mechanisms acting upstream of macroautophagy.
21 e, and 3) reveal that vaults arrive early in macroautophagy.
22 asome, tauDeltaC is cleared predominantly by macroautophagy.
23 ivation of AMPK, which activates prosurvival macroautophagy.
24 at trigger cytoprotective detoxification via macroautophagy.
25 agments by selective autophagy, particularly macroautophagy.
26 umulation, neuroinflammation, and changes in macroautophagy.
27 ic contents to lysosomes for degradation via macroautophagy.
28 of Rapamycin (mTOR)-dependent suppression of macroautophagy.
29 of Ca(v)3.1 accompanied by the activation of macroautophagy.
30 of lysosomal biogenesis and up-regulation of macroautophagy.
31 ing catabolic pathways, particularly that of macroautophagy.
32 ion, the cell activates one or more forms of macroautophagy.
33 e show that the N-end rule pathway modulates macroautophagy.
34 complex, which is required for initiation of macroautophagy.
35 l lysosomes from autolysosomes formed during macroautophagy.
36 tion of the proteasome (bortezomib), but not macroautophagy (3-methyladenine), markedly increased PNP
37                                         When macroautophagy, a catabolic process that rids the cells
38        ER stress is also a strong inducer of macroautophagy, a cell-protective mechanism of self-degr
39 east partially attributable to regulation of macroautophagy, a highly conserved protein catabolism pa
40                                              Macroautophagy, a homeostatic process that shuttles cyto
41 us for this purpose, we assessed the role of macroautophagy, a process in which cytosolic proteins ar
42                 NSAIDs are known to modulate macroautophagy, a process indispensable for intestinal h
43 has shown that WNV growth was independent of macroautophagy activation, but the role of the evolution
44  long been recognised for its involvement in macroautophagy activation, the underlying mechanisms and
45 n of intraneuronal aggregates containing the macroautophagy adapter proteins p62 and NBR1 in the neur
46                             Up-regulation of macroautophagy alone is not sufficient to induce connexi
47 o regulate the cellular catabolic process of macroautophagy, although the precise mechanism whereby t
48                      We investigated whether macroautophagy, an evolutionarily conserved cellular mec
49 ave pronounced effects on the fusion step of macroautophagy and affect the overall activity of this i
50 dysfunction was accompanied by impairment of macroautophagy and chaperone-mediated autophagy, increas
51 ss is mediated by distinct functions of both macroautophagy and CMA, indicating that impaired functio
52  degradation in mediating cross-talk between macroautophagy and CMA.
53 , we report a functional interaction between macroautophagy and Corticotropin Releasing Hormone (Crh)
54 found that ubiquilin is degraded during both macroautophagy and during chaperone-mediated autophagy (
55 cle fibers show a high level of constitutive macroautophagy and express MHC class II molecules upon i
56 dy were to determine whether NSAIDs impaired macroautophagy and how this affects macroautophagy-regul
57          Whether NSAIDs stimulate or repress macroautophagy and how this correlates with the clinical
58        Sec22 is also reported to function in macroautophagy and in formation of endoplasmic reticulum
59   This review discusses emerging concepts in macroautophagy and macroautophagy-independent processes
60 anism through which TNF-alpha regulates both macroautophagy and MHC class II expression and suggest t
61 P-2B regulates lysosome maturation to impact macroautophagy and phagocytosis.
62                                              Macroautophagy and selective autophagy (e.g., mitophagy,
63 que roles for GABARAP and LC3 subfamilies in macroautophagy and selective autophagy and demonstrates
64 ce of these phosphatases, starvation-induced macroautophagy and the cytoplasm-to-vacuole targeting pa
65 macroautophagic machinery, the regulation of macroautophagy and the process of cargo recognition in s
66  of plasma membrane connexin 43 targeted for macroautophagy and the sequence of events that trigger t
67 Ypt1 and its mammalian homolog Rab1 regulate macroautophagy and two other trafficking events: endopla
68 al tau levels, coincident with activation of macroautophagy and ubiquitin-proteosome pathways.
69 endritic pruning, elevated mTORC1 signaling, macroautophagy, and autism spectrum disorder.
70     Influenza infection triggered productive macroautophagy, and autophagy-dependent presentation was
71 cles, organelle degradation by mitophagy and macroautophagy, and in some cases transfer to glial cell
72 gosome formation is the most complex part of macroautophagy, and it is a dynamic event that likely in
73 3, a component of the molecular machinery of macroautophagy, and maintains phagocytosed antigens for
74 e proton pump, whereas Atg genes involved in macroautophagy are dispensable for crinophagy.
75 ly, a reduction in LC3 flux and dampening of macroautophagy are observed in dendritic cells from Anxa
76 oteolysis and autophagosome clearance during macroautophagy are prevented as a result of a selective
77               These findings have identified macroautophagy as a previously unappreciated route for d
78 xpectedly, these increases did not depend on macroautophagy, as similar increases in vacuole size wer
79 tingtin transgene expression, the absence of macroautophagy (ATG5 or ATG7 expression), an increase in
80                                              Macroautophagy (autophagy hereafter) degrades and recycl
81 role in the initiation of starvation-induced macroautophagy (autophagy) and is activated by the guani
82                                              Macroautophagy (autophagy) is a critical cellular stress
83                                              Macroautophagy (autophagy) is a lysosome-dependent degra
84                                              Macroautophagy (autophagy) is a process wherein bulk cyt
85                                              Macroautophagy (autophagy) is a regulated catabolic path
86                                              Macroautophagy (autophagy) targets cytoplasmic cargoes t
87                                              Macroautophagy (autophagy), associated with bulk cytopla
88 ing of damaged mitochondria to lysosomes via macroautophagy (autophagy).
89 denocarcinoma cell models, MAGEA6 suppresses macroautophagy (autophagy).
90                                              Macroautophagy ("autophagy" hereinafter) is a process by
91                                              Macroautophagy ("autophagy") is the main lysosomal catab
92                                              Macroautophagy/autophagy is a key catabolic recycling pa
93 for mutants defective in a type of selective macroautophagy/autophagy.
94 a mechanism different from that of a loss of macroautophagy, because death occurred in the absence of
95 sing pharmacological and genetic blockage of macroautophagy both in vitro and in vivo, we found that
96 gophore is a key event in the early phase of macroautophagy, but can also occur on single-membrane st
97 t PP2C phosphatases, Ptc2 and Ptc3, regulate macroautophagy by dephosphorylating Atg13 and Atg1.
98                  We show that suppression of macroautophagy by multiple means promotes the degradatio
99 ind that alpha-syn aggregates impair overall macroautophagy by reducing autophagosome clearance, whic
100  suggest that PP2C-type phosphatases promote macroautophagy by regulating the Atg1 complex.
101                                              Macroautophagy can regulate cell signalling and tumorige
102 s; however, either insufficient or excessive macroautophagy can seriously compromise cell physiology,
103          hsc-70 is pivotal to the process of macroautophagy, chaperone-mediated autophagy, and endoso
104 efficient removal of damaged mitochondria by macroautophagy contributes to Parkinson's disease (PD).
105 phosphorylation sites partially bypasses the macroautophagy defect in ptc2Delta ptc3Delta strains.
106  was accelerated in transgenic mice in which macroautophagy deficiency was restricted to dopaminergic
107 cally deleted in T cells, we have found that macroautophagy-deficient effector Th cells have defectiv
108  when an exogenous energy source is added to macroautophagy-deficient T cells.
109         When triggered by mTOR inactivation, macroautophagy degrades long-lived proteins and organell
110 mary dendritic cells, revealed no detectable macroautophagy-dependent component.
111  DCs operated in a redundant manner, whereas macroautophagy-dependent endogenous loading was essentia
112 ent proteolysis, autophagy and regulation of macroautophagy, DNA repair and replication, as well as o
113 encing Beclin-1, Atg7, or p62 indicated that macroautophagy does not protect cells undergoing necrosi
114                       However, repression of macroautophagy during mitosis remains controversial and
115  inhibited mTORC1 as the master regulator of macroautophagy during mitosis, uncoupling autophagy regu
116 from nutrient status to ensure repression of macroautophagy during mitosis.
117 tes delayed chaperone-mediated autophagy and macroautophagy dysfunction observed in the hSYN(A53T) mi
118 teract cardiac aging through improvements in macroautophagy (eg, calorie restriction and calorie rest
119                                              Macroautophagy facilitates degradation of cellular const
120  MHC class II-restricted thymocytes required macroautophagy for a mitochondrial version of a neo-anti
121 -driven tumors have been reported to rely on macroautophagy for growth and survival, suggesting a pot
122 confirm that KRAS-driven tumor lines require macroautophagy for growth.
123 TNF-alpha facilitates antigen processing via macroautophagy for more efficient MHC class II loading.
124                Through this basic mechanism, macroautophagy has a critical role in cellular homeostas
125                            Here we show that macroautophagy has a dominant role in the death of fibro
126 G12, an ubiquitin-like modifier required for macroautophagy, has a single known conjugation target, a
127                                              Macroautophagy (hereafter autophagy) functions in the no
128                                              Macroautophagy (hereafter autophagy) is a bulk degradati
129                                              Macroautophagy (hereafter autophagy) is a catabolic cell
130                                              Macroautophagy (hereafter autophagy) is a degradative ce
131                                              Macroautophagy (hereafter autophagy) is a key pathway in
132                                              Macroautophagy (hereafter autophagy) is a ubiquitous pro
133                                              Macroautophagy (hereafter autophagy) is a well-conserved
134                                              Macroautophagy (hereafter autophagy) is an evolutionaril
135 ngulf cellular components for degradation by macroautophagy (hereafter called autophagy).
136                   Endoplasmic reticulum (ER) macroautophagy (hereafter called ER-phagy) uses autophag
137                                              Macroautophagy (hereafter referred to as autophagy) is a
138                                              Macroautophagy (hereafter referred to as autophagy) is a
139                                              Macroautophagy (hereafter referred to as autophagy) is a
140                                              Macroautophagy (hereafter referred to as autophagy) is a
141                                              Macroautophagy (hereafter referred to as autophagy) is e
142 compartments that were positive for both the macroautophagy (hereafter referred to as autophagy) mark
143                          Here we report that macroautophagy (hereafter referred to as autophagy), a c
144                                              Macroautophagy (hereafter referred to simply as autophag
145 isolation, immobilization and degradation by macroautophagy (hereafter, mitophagy).
146 nse mechanism is the degradative activity of macroautophagy (herein autophagy), mediated by the coord
147                                              Macroautophagy (herein referred to as autophagy) is an e
148                                              Macroautophagy (herein referred to as autophagy) is an e
149                                              Macroautophagy (herein referred to as autophagy) is an e
150 unknown, but many studies suggest a role for macroautophagy (herein termed autophagy), a process by w
151 blish an essential link between mitochondria macroautophagy impairments and DA neuron degeneration in
152 nase activity resulted in the stimulation of macroautophagy in a non-canonical fashion, independent o
153 , we found that vacuolar hydrolysis inhibits macroautophagy in a target of rapamycin complex 1-depend
154                  PROPPINs play a key role in macroautophagy in addition to other functions.
155   Recent work demonstrated the importance of macroautophagy in dendritic cell (DC) maturation and inn
156 g the regulation and molecular mechanisms of macroautophagy in different organisms; however, many que
157 ycan in inducing Peg3, a master regulator of macroautophagy in endothelial cells.
158 is study reveals a novel regulatory role for macroautophagy in GJ function that is directly dependent
159                                              Macroautophagy in Leishmania, which is important for the
160 -type alpha-synuclein overexpression impairs macroautophagy in mammalian cells and in transgenic mice
161  that alpha-synuclein overexpression impairs macroautophagy in mammalian cells and in transgenic mice
162                                 The study of macroautophagy in mammalian cells has described inductio
163 d the effects of alpha-synuclein deletion on macroautophagy in mouse brains.
164 (RUFY4) as a positive molecular regulator of macroautophagy in primary dendritic cells (DCs).
165                  To test the requirement for macroautophagy in restriction, we examined the ability o
166  (ATG7) by genome editing completely blocked macroautophagy in several tumor lines with oncogenic mut
167                              Ethanol-induced macroautophagy in the livers of mice and cultured cells
168            Here, we characterize the role of macroautophagy in thymic epithelial cells (TECs) for neg
169 e show that NSAID treatment of IECs inhibits macroautophagy in vitro and in vivo.
170                                              Macroautophagy (in this paper referred to as autophagy)
171 r organelles involved in different stages of macroautophagy, including disorganized protein aggregati
172          FGF19 treatment or feeding inhibits macroautophagy, including lipophagy, but these effects a
173 e of specific lipids in the various steps of macroautophagy, including the signaling processes underl
174 port that metabolic stress markedly enhances macroautophagy-independent lysosomal degradation of nasc
175 sses emerging concepts in macroautophagy and macroautophagy-independent processes of cargo delivery t
176                                              Macroautophagy induced by ethanol seemed to be selective
177 ng to its ligand, p62 acts as a modulator of macroautophagy, inducing autophagosome biogenesis.
178 rylated, triggering Atg1 kinase activity and macroautophagy induction.
179 n, depletion of mutant p53 expression due to macroautophagy inhibition sensitizes the death of dorman
180  antigen (HLA)-DR levels and was reversed by macroautophagy inhibition, suggesting that TNF-alpha fac
181 macological tool to evaluate the response to macroautophagy inhibition.
182  mutation status can predict the efficacy to macroautophagy inhibition.
183                                 In contrast, macroautophagy inhibitors did not increase HIF-1 activit
184 including the signaling processes underlying macroautophagy initiation, autophagosome biogenesis and
185 to other intracellular trafficking pathways, macroautophagy involves a complex sequence of membrane r
186   The most studied type of autophagy, called macroautophagy, involves membrane mobilisation, cargo en
187                                              Macroautophagy is a bulk clearance mechanism in which th
188                                              Macroautophagy is a catabolic pathway used for the turno
189                                              Macroautophagy is a cellular degradation process respons
190                                              Macroautophagy is a fundamental and evolutionarily conse
191                                              Macroautophagy is a highly conserved mechanism of lysoso
192                                              Macroautophagy is a key stress-response pathway that can
193                                              Macroautophagy is a lysosomal degradative pathway essent
194                                              Macroautophagy is a major catabolic pathway that impacts
195                Here we present evidence that macroautophagy is a significant pathway for lipid turnov
196                   These results suggest that macroautophagy is an actively regulated process in T cel
197                                              Macroautophagy is an essential cellular pathway mediatin
198                                              Macroautophagy is an evolutionarily conserved cellular p
199                                              Macroautophagy is an evolutionarily conserved dynamic pa
200                                              Macroautophagy is an intracellular mechanism that plays
201 d with the absence of significant defects in macroautophagy is consistent with lysosomal membrane per
202 lasticity, and neurodegeneration occurs when macroautophagy is deficient.
203  for survival in glucose starvation, whereas macroautophagy is dispensable.
204                                        Since macroautophagy is essential for gastrointestinal health,
205                                              Macroautophagy is essential to cell survival during star
206                           We have found that macroautophagy is induced after effector T cell activati
207 cruited to the phagophore assembly site when macroautophagy is induced.
208                                              Macroautophagy is initiated primarily by a complex conta
209                                     Although macroautophagy is known to be an essential degradative p
210                                              Macroautophagy is known to play an essential role in the
211 n LC3B levels, indicating that LC3B-mediated macroautophagy is necessary for RCC progression.
212 wn to be autophagic substrates, induction of macroautophagy is not required for insoluble protein for
213                                              Macroautophagy is orchestrated by the Atg1-Atg13 complex
214                                 Furthermore, macroautophagy is perturbed after YW3-56 treatment in ca
215 ltapsi(m) and (ii) mTORC1-controlled general macroautophagy is required for mitophagy.
216      Furthermore, lysosomal activity but not macroautophagy is responsible for ALIS clearance.
217                                Activation of macroautophagy is suggested to facilitate degradation of
218                 The general principle behind macroautophagy is that cytoplasmic contents can be seque
219          A major function of proteasomes and macroautophagy is to eliminate misfolded potentially tox
220 ting degradation of cytoplasmic materials by macroautophagy, is formed in close proximity to the endo
221  mouse model where Atg7, a critical gene for macroautophagy, is specifically deleted in T cells, we h
222 tem function and only modest inefficiency in macroautophagy late in disease.
223  23 kDa) deficiency blocks the activation of macroautophagy, leading to an increased abundance of BAX
224                                      Loss of macroautophagy led to overactivation of the c-Jun N-term
225 tions to crucial components of the canonical macroautophagy machinery and can occur in the absence of
226 creen exposed MTOR signalling and the entire macroautophagy machinery as key regulators of SQSTM1 and
227  signal for the selective recognition by the macroautophagy machinery.
228 review, we summarize current knowledge about macroautophagy mainly in yeast, including the mechanism
229        However, the precise mechanism behind macroautophagy malfunction in HD is poorly understood.
230 mitochondria abnormalities, characterized by macroautophagy marker-positive cytoplasmic inclusions co
231             Here, we show that initiation of macroautophagy, measured by the translocation of the ULK
232 and MHC class II expression and suggest that macroautophagy-mediated antigen presentation contributes
233                                              Macroautophagy mediates the degradation of long-lived pr
234                                              Macroautophagy mediates the selective degradation of pro
235                         Reagents that modify macroautophagy might be developed as therapeutics for pa
236 testinal health, NSAID-induced inhibition of macroautophagy might contribute to the severity of intes
237 roteasome system, unfolded protein response, macroautophagy, mitophagy, and telomere maintenance) res
238 thermore, treatments that enhance or inhibit macroautophagy modulated the level of presentation from
239           It is nevertheless unknown whether macroautophagy modulates presynaptic function.
240 in metazoan cells, it has been proposed that macroautophagy must be inhibited to maintain genome inte
241                             A basal level of macroautophagy occurs constitutively, but this process c
242 roaches, we confirmed the implication of the macroautophagy on PLK2-mediated alpha-syn turnover, and
243 pecifically in a process called nonselective macroautophagy, or target specific protein aggregates de
244                 We examined flux through the macroautophagy pathway as a determinant of the discrepan
245 signaling aggregates, 2) offer images of the macroautophagy pathway in a near-native state, and 3) re
246                     Reduced flux through the macroautophagy pathway was found to be coincident with t
247 teins (ATG8s) are active in all steps of the macroautophagy pathway, and their lipidation is essentia
248   Phagophore maturation is a key step in the macroautophagy pathway, which is critical in many import
249 tumor suppressor Tid56, is a key mediator of macroautophagy pathway.
250 uctures for elimination independently of the macroautophagy pathway.
251                                   Increasing macroautophagy pharmacologically reduced hepatotoxicity
252                                              Macroautophagy protects against ethanol-induced toxicity
253                                              Macroautophagy provides eukaryotes with an adaptive resp
254      Thus, upon AICD induction regulation of macroautophagy, rather than selective mitophagy, ensures
255                                              Macroautophagy (referred to here as autophagy) degrades
256                                              Macroautophagy (referred to here as autophagy) is induce
257                                              Macroautophagy (referred to hereafter as autophagy) is a
258                                              Macroautophagy (referred to hereafter as autophagy) is a
259 impaired macroautophagy and how this affects macroautophagy-regulated intestinal epithelial cell (IEC
260 ning some of the most fundamental aspects of macroautophagy remain unresolved.
261 al processes, the molecular understanding of macroautophagy remains far from complete.
262                                              Macroautophagy requires membrane trafficking and remodel
263                           Here, we show that macroautophagy requires the Alzheimer's disease (AD)-rel
264                                              Macroautophagy responds to a variety of intra- and extra
265                   Interruption of connexins' macroautophagy resulted in their retention at the plasma
266                                      Loss of macroautophagy sensitized cells to apoptotic and necroti
267                      Selective autophagy and macroautophagy sequester specific organelles/substrates
268                                              Macroautophagy serves cellular housekeeping and metaboli
269                                              Macroautophagy serves in intracellular quality control a
270 view the effect of ROS on selective forms of macroautophagy, specifically on cargo recognition by aut
271 hanisms and the wider impact of ROS-mediated macroautophagy stimulation remain incompletely understoo
272  autophagy and clearance of a well-described macroautophagy substrate, demonstrating the critical rol
273                    Our findings suggest that macroautophagy supports central CD4(+) T cell tolerance
274 on of lysosomes available for degradation of macroautophagy-targeted cargo.
275 herefore, both elevated NY-ESO-1 release and macroautophagy targeting could improve melanoma cell rec
276                                     However, macroautophagy targeting of NY-ESO-1 enhanced MHC class
277                                              Macroautophagy that follows mTOR inhibition in presynapt
278                                        After macroautophagy, the antigen is processed through a prote
279                                              Macroautophagy, the degradation of cytoplasmic content b
280                               Alterations in macroautophagy, the main process responsible for bulk au
281 events through which LRRK2 acts to influence macroautophagy, the mammalian target of rapamycin (mTOR)
282 leton scaffolds also have essential roles in macroautophagy, the process by which cellular waste is i
283                                              Macroautophagy--the process by which cytosolic material
284 eased hepatocyte apoptosis and liver injury; macroautophagy therefore protected cells from the toxic
285 n pathway, possibly linking dysregulation of macroautophagy to a female-dominated COPD disease phenot
286                        B lymphocytes exploit macroautophagy to capture cytoplasmic and nuclear protei
287 this work, we focused on the contribution of macroautophagy to connexin degradation.
288 contributions of abnormal ROS signalling and macroautophagy to the development and progression of neu
289                          The contribution of macroautophagy to the MHC class II-restricted response m
290 lay important roles in autophagosome-forming macroautophagy under various stress conditions.
291 tream of T-cell receptor signalling inhibits macroautophagy upon AICD induction.
292 ted mice, and feeding-mediated inhibition of macroautophagy was attenuated in FXR-knockout mice.
293  in the RALA255-10G rat hepatocyte line when macroautophagy was inhibited by a short hairpin RNA (shR
294          To further validate these findings, macroautophagy was inhibited chemically in ER-stressed w
295  for intestinal homeostasis and dependent on macroautophagy were dysfunctional in the presence of NSA
296  are three different types of autophagy, but macroautophagy, which involves the formation of double m
297 e models is accompanied by the occurrence of macroautophagy, which is suppressed by Myr-Akt.
298                               Suppression of macroautophagy with pharmacologic agents or small interf
299 ulated tumor suppressor acting by inhibiting macroautophagy, with MAP1LC3B (LC3B) as a direct and fun
300 he process of cargo recognition in selective macroautophagy, with the goal of providing insights into

 
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