ライフサイエンスコーパス: macromolecular

1 valuation criteria for the reconstruction of macromolecular 3D structure in the field of cryoelectron

2 ms tissues into elastic hydrogels to enhance macromolecular accessibility and mechanical stability si

3 N22 is an effective and curative multivalent macromolecular agent in multiple solid tumor mouse model

4 RP-HPLC indicated that salt enhanced the macromolecular aggregation of gluten proteins.

5 esults provide a framework for understanding macromolecular aggregation on lipid membranes in a broad

6 tography, gas-phase electrophoretic mobility macromolecular analysis, EM, X-ray crystallography, and

7 The development of macromolecular and cellular therapies has largely been d

8 line covalent organic frameworks (COFs) from macromolecular and even infinite building units is large

9 his synergy could lead to the development of macromolecular and polymer therapeutics with structural

10 Macromolecular and rheological characterisation confirm

11 eins are part of an evolutionarily conserved macromolecular apparatus that maintains genomic integrit

12 an be broadly incorporated into a variety of macromolecular architectures using traditional living po

13 ion is selectively directed toward different macromolecular architectures, allowing for formation of

14 important implications for building advanced macromolecular architectures.

15 of the lipids on the functioning of complex macromolecular assemblies at the membrane interface.

16 Determining the structure and composition of macromolecular assemblies is a major challenge in biolog

17 hese new studies are beginning to reveal how macromolecular assemblies of dedicated clock proteins fo

18 gins, the proteins that define them, and the macromolecular assemblies that drive DNA unwinding and n

19 Sarcomeres are extremely highly ordered macromolecular assemblies where structural organization

20 Focal adhesions (FA) are large macromolecular assemblies which help transmit mechanical

21 ellular processes are largely carried out by macromolecular assemblies, most of which are dynamic, ha

22 the compositions of NCBP1-, 2- and 3-related macromolecular assemblies, we have applied an affinity c

23 As such, these macromolecular assemblies-as well as the dynamics of the

24 in the regulation and assembly of circadian macromolecular assemblies.

25 on-based characterization of biopolymers and macromolecular assemblies.

26 Our approach opens a new window into macromolecular assembly dynamics.

27 onally challenging for any complex and large macromolecular assembly like the thin filament.

28 specifically proteins, provide an intrinsic macromolecular backbone for the construction of anisotro

29 tform could address critical questions about macromolecular behavior in live cells.

30 g a toy model with properties reminiscent of macromolecular behavior.

31 ary structure, intrinsic disorder, metal and macromolecular binding, post-translational modifications

32 vant synthetic and characterization methods, macromolecular biodegradation pathways, and polyphosphaz

33 n and therapies, since the lipid content and macromolecular cargo of EVs can provide key phenotypic a

34 wing intracellular delivery of molecular and macromolecular cargo.

35 PP1 regulatory subunit type 3A]) in the RyR2 macromolecular channel complex that has been previously

36 y, observed variations in polymer amount and macromolecular characteristics were linked to several ge

37 n a concept that combines supramolecular and macromolecular chemistry and differs from the convention

38 a purple photosynthetic bacterium, producing macromolecular chimeras that display mechanisms of polyc

39 We discovered massive macromolecular clusters on the luminal face of EV membra

40 causative agent of malaria, is powered by a macromolecular complex called the glideosome that lies b

41 on of DNA in the cytosol by AIM2 assembles a macromolecular complex called the inflammasome, which un

42 As a macromolecular complex composed of both RNAs and protein

43 The LMO2/LDB1 macromolecular complex is critical in hematopoietic stem

44 gamma-secretase is a macromolecular complex that catalyzes intramembranous hy

45 hogenesis of Plasmodium falciparum rely on a macromolecular complex, called the glideosome.

46 can be ascribed to subtle changes in the Nav macromolecular complex.

47 remodeling enzymatic activities in a single macromolecular complex.

48 of active helicase factors forming a single, macromolecular complex.

49 Specific genomic functions are dictated by macromolecular complexes (MCs) containing multiple prote

50 electron tomogram images with non-deformable macromolecular complexes and deformable ultrastructures

51 ron tomogram images including non-deformable macromolecular complexes and deformable ultrastructures.

52 Mesoscale macromolecular complexes and organelles, tens to hundred

53 ar substrates, including protein aggregates, macromolecular complexes and polymers.

54 he labeled data which covers a wide range of macromolecular complexes and ultrastructure.

55 ponents of wt-CFTR- or rPhe508del-containing macromolecular complexes at the surface of human bronchi

56 e estimation of NMR chemical-shifts of large macromolecular complexes based on the previously publish

57 To stabilize macromolecular complexes for native MS, charge reducing

58 polyubiquitinated proteins from membranes or macromolecular complexes for subsequent degradation by t

59 Escape of large macromolecular complexes from the endoplasmic reticulum

60 interactions between cellular organelles and macromolecular complexes has been the result of imaging

61 M) to generate high-resolution structures of macromolecular complexes has changed the landscape of st

62 It contains detailed information of all macromolecular complexes in a sample cell.

63 d receptors (GPCRs) are organized as dynamic macromolecular complexes in human cells.

64 r native state and determining structures of macromolecular complexes in their cellular context.

65 Ion channels in excitable cells function in macromolecular complexes in which auxiliary proteins mod

66 Proteins are manufactured by ribosomes-macromolecular complexes of protein and RNA molecules th

67 Basal bodies (BBs) are macromolecular complexes required for the formation and

68 etero-hexameric ring that is part of several macromolecular complexes such as INO80, SWR1, and R2TP.

69 Recent advances have identified macromolecular complexes that assemble at the DNA lesion

70 on the promoters of mRNA genes to form large macromolecular complexes that initiate transcription in

71 Voltage-gated K(+) channels function in macromolecular complexes with accessory subunits to regu

72 tegration of three mitoribosomal proteins in macromolecular complexes, and provide evidence suggestin

73 for measuring the masses of large molecules, macromolecular complexes, and synthetic polymers that ar

74 osal to obtain structures of macromolecules, macromolecular complexes, and virus particles, without t

75 ributed to their association with protective macromolecular complexes, including extracellular vesicl

76 serves functional attributes of proteins and macromolecular complexes, it is considered a chemical ch

77 er 1 (KCNB1, Kv2.1) and integrin-alpha5 form macromolecular complexes-named integrin-alpha5-KCNB1 com

78 arco/endoplasmic reticulum calcium ATPase-2a macromolecular complexes.

79 olution structures of biochemically isolated macromolecular complexes.

80 protein domains of unknown function in large macromolecular complexes?

81 organelles, comprising dozens to hundreds of macromolecular components, form heterogeneous phases in

82 These results show that the complex macromolecular composition of the extracellular fluid st

83 4-MALS-dRI indicated high variability in the macromolecular compositions of classical lager beers.

84 By altering the macromolecular concentration surrounding cells in the mi

85 Twenty unique features characterizing macromolecular conformation information of vWF multimers

86 Transition paths of macromolecular conformational changes such as protein fo

87 Thus, the accurate description of macromolecular conformational transitions is crucial for

88 from a soft and liquid-environment dependent macromolecular construction into a solid structure, foll

89 y of Au catalysis in providing access to new macromolecular constructs.

90 imaging method which is sensitive to tissue macromolecular content and may therefore have an importa

91 al vein endothelial cells, responded to high-macromolecular-content solutions by elongating and align

92 nvironment due to the mechanism of nanoscale macromolecular cooperativity.

93 c acid conformations by acting as a flexible macromolecular counterion that locally screens repulsive

94 imary sequence that trigger the formation of macromolecular cross-beta aggregates can be measured onl

95 squeezing on Escherichia coli, we show that macromolecular crowders play a dominant role in the comp

96 DNA binding proteins, supercoiling, macromolecular crowders, and transient DNA attachments t

97 Although it was previously demonstrated that macromolecular crowding affects association of RNAP to D

98 Physicochemical properties such as pH and macromolecular crowding are essential to all molecular p

99 Here, we demonstrate that macromolecular crowding enhances the rate of late initia

100 o the ever-growing interest in understanding macromolecular crowding in living cells and their effect

101 Importantly, macromolecular crowding is able to partially rescue G4Q

102 in mislocalization, and demonstrates how the macromolecular crowding of RPBs at the ribosome exit sit

103 However, little is known about the effect of macromolecular crowding on the interactions of IDPs with

104 s works have reported significant effects of macromolecular crowding on the structure and behavior of

105 to a dead-end aggregate, rather than through macromolecular crowding or diffusion-limitations.

106 indicating that an age-dependent increase in macromolecular crowding resulting from water loss may be

107 Using a macromolecular crowding sensor optimized for long-term F

108 hat the random network architecture resisted macromolecular crowding with polyethylene glycol and blo

109 iers, the mobility of which is challenged by macromolecular crowding.

110 Macromolecular Crystallography is a powerful and valuabl

111 computed from MD trajectories using standard macromolecular crystallography methods.

112 MD water models for force-field development, macromolecular crystallography, and medicinal chemistry

113 n years of technology advancements, first in macromolecular crystallography, and recently in Cryo-ele

114 al structure determination methods including macromolecular crystallography, cryo-electron microscopy

115 Crystallization is the bottleneck in macromolecular crystallography; even when a protein crys

116 pathways regulate proteostasis and mitigate macromolecular damage to promote long-term cellular heal

117 prevented indomethacin-induced mitochondrial macromolecular damage, caspase activation, mucosal infla

118 ogy; (iv) RNA-mediated interactions; and (v) macromolecular demixing and heterogeneity, which may gen

119 s can coexist if they differ sufficiently in macromolecular density, and we show that the associated

120 d DNA-protein binding affinity, dependent on macromolecular density.

121 provides unique avenues and perspectives in macromolecular design for both nanoscience and biomedici

122 Macromolecular design in conjunction with rational monom

123 oxypropyl) methacrylamide (HPMA) to obtain 5 macromolecular Dex prodrugs.

124 However, the origin of macromolecular diffuse scattering has been poorly unders

125 ced skin structural changes result in faster macromolecular diffusion for enhanced permeability.

126 dic multi-functional organelle with roles in macromolecular digestion, nutrient sensing, and signalin

127 med to achieve a better understanding of the macromolecular displacement in the H-cell microchannels.

128 ers: original gravity, viscosity, indices of macromolecular distribution, total nitrogen (p < 0.001),

129 gnificantly in palate fullness intensity and macromolecular distribution.

130 To explore this proposition, macromolecular disulfide substrates were elongated withi

131 can probe otherwise inaccessible aspects of macromolecular dynamics and interactions that underly bi

132 ng a new tool to support the future study of macromolecular dynamics, fluctuation and chemical activi

133 ow that transient thermal transport reflects macromolecular energy landscape architecture through the

134 sociated chromatin organization in a crowded macromolecular environment by systematically varying the

135 h a genome-scale model of its metabolism and macromolecular expression (ME-model).

136 ons of strain-specific models, metabolic and macromolecular expression models, and simulation of stre

137 The molecular and macromolecular features of cellulose and the physicochem

138 The macromolecular features that enable condensates and the

139 tration using transepithelial resistance and macromolecular flux and assessed tight junctional gene e

140 offsets (2-50 kHz) were used to measure the macromolecular fraction (MMF) and macromolecular T2 (T2(

141 tions were found between palate fullness and macromolecular fractions and beer composition parameters

142 ct that knowledge of structure can elucidate macromolecular functions in living organisms.

143 therapeutic efficacy and reduced toxicities, macromolecular GC prodrugs have been developed with prom

144 s an effective method for controlling living macromolecular HCR oligomerization in a manner analogous

145 sosomes promote cellular homeostasis through macromolecular hydrolysis within their lumen and metabol

146 a variant perturbing a site involved in key macromolecular interactions and/or cellular signaling?',

147 nd demonstrated the significance of specific macromolecular interactions that are formed early in the

148 , solid-state nuclear magnetic resonance for macromolecular interactions within biofilms, and super-r

149 ld see broad application to a range of tight macromolecular interactions.

150 prehensive database of structurally resolved macromolecular interactions.

151 illustrate how the use of mutually exclusive macromolecular interfaces enables modulation of both the

152 From these, we introduce a strategy to form macromolecular intermediate phases using long chain poly

153 vironment interactions, by means of abnormal macromolecular intestinal adsorption, is one of the poss

154 t heating but suffices to lock the permanent macromolecular ion dipoles, producing novel separations

155 ubules segregate chromosomes by attaching to macromolecular kinetochores.

156 ndency to decrease with increasing number of macromolecular layers.

157 demonstrate the sequence recognition at the macromolecular level by conjugating the cytochrome c pro

158 he aza-glycine backbone and culminate at the macromolecular level of the triple helix lead to increas

159 d metal catalysts by positioning itself as a macromolecular ligand, which conditions the nature of th

160 structural information concerning this large macromolecular machine has been difficult to obtain.

161 al flagellar motor, a cell-envelope-embedded macromolecular machine that functions as a cellular prop

162 Here, we examine how, as a macromolecular machine, the ribosome modulates the intri

163 nmentally regulated self-assembly of a major macromolecular machine.

164 orce microscopy (AFM) to understand how this macromolecular machinery orchestrates DNA repair.

165 l and functional regions of more challenging macromolecular machines and systems, for example ribosom

166 How complex, multi-component macromolecular machines evolved remains poorly understoo

167 How do the large communities of macromolecular machines interact with each other?

168 The macromolecular machines of life use allosteric control t

169 The self-assembly of cellular macromolecular machines such as the bacterial flagellar

170 MTCs) are large (250 to >750 kDa), conserved macromolecular machines that are essential for soluble N

171 erse cellular activities (AAA+ proteins) are macromolecular machines that convert the chemical energy

172 ike proteins are large, densely glycosylated macromolecular machines that mediate receptor binding an

173 t in the cell necessitate a diverse array of macromolecular machines to maintain homeostasis, allow f

174 ts of transcripts for building complementary macromolecular machines within the organelle.

175 distribution on the functional properties of macromolecular materials underscores the need for reprod

176 mpact the conformational energy landscape of macromolecular membrane complexes whose functioning invo

177 Bs and BBCPs into new morphologies driven by macromolecular metamorphosis.

178 against high vacuum, and is shaped such that macromolecular migration in centrifugal fields exceeding

179 The Rosetta software for macromolecular modeling, docking and design is extensive

180 ta is one of the largest software suites for macromolecular modeling, with 3.1 million lines of code

181 lar paroxysms, a near-instantaneous burst of macromolecular motion that occurs during UV induced cell

182 r chains, as well as extracting the dominant macromolecular motions associated with sub-monomer behav

183 cs occurring amidst the dominant large-scale macromolecular motions of the biopolymer von Willebrand

184 ng in very large aggregates and depletion of macromolecular mucin and occurring at concentrations rel

185 al for biologically inspired self-assembling macromolecular nanomaterials.

186 kinetically controllable self-assembling 2D macromolecular nanomaterials.

187 The brain's extracellular matrix (ECM) is a macromolecular network composed of glycosaminoglycans, p

188 Within these coats are receptors for macromolecular nutrients such as transferrin(2,3).

189 e phase and coassembles with CHMP7 to form a macromolecular O-ring seal at the confluence between mem

190 (cryo-EM) enables structure determination of macromolecular objects and their assemblies.

191 in real time is necessary to understand how macromolecular organization of the membrane is altered b

192 of thioflavin T, which in turn reflects the macromolecular packing density inside droplets.

193 mputational studies, we envisioned that this macromolecular platform provides unique avenues and pers

194 ng in order to provide the bioenergetics and macromolecular precursors needed to sustain a malignant

195 lves the obligatory subversion of the host's macromolecular processes for efficient viral progeny pro

196 for crystal engineering, drug design and bio-macromolecular processes.

197 Here, we design and synthesize a macromolecular prodrug (P407-CM-T) in which the local an

198 The macromolecular prodrug has no anesthetic effect itself u

199 Synthesis of a macromolecular prodrug of talazoparib (TLZ) was achieved

200 t activation mechanisms may help to identify macromolecular prodrugs with the most potent therapeutic

201 ometry (MS) is a powerful means for studying macromolecular protein assemblies, including accessing a

202 provided significant insights into LMO2/LDB1 macromolecular protein complex assembly and stability, w

203 To ensure the faithful inheritance of DNA, a macromolecular protein complex called the kinetochore su

204 Kinetochores are macromolecular protein complexes at centromeres that ens

205 uggest a model for autophagic degradation of macromolecular protein complexes by the action of intrin

206 may be threatened during ER escape of large macromolecular protein complexes, the action of RTN coun

207 ed with compromised biophysical integrity of macromolecular protein pools in nodal regions of the unc

208 attenuation of the biophysical integrity of macromolecular protein pools in this circuit.

209 compromised because of the limited access of macromolecular proteins to the peptide substrate, leadin

210 arriers relative to non-carriers had a lower macromolecular proton fraction (MPF) in the left thalamu

211 erizing temperature sensitivity, focusing on macromolecular rate theory (MMRT); (b) provide strategie

212 This is explained by macromolecular rate theory: A negative activation heat c

213 In this novel concept, macromolecular recognition by the B cell receptor leadin

214 h nanoscale water channels threading between macromolecular regions within a dynamically organized st

215 et-forming proteins dictates whether and how macromolecular regulators promote or suppress LLPS.

216 encode core components of stress tolerance, macromolecular repair, and maintenance of homeostasis.

217 al-clearable near-infrared (NIR) fluorescent macromolecular reporters are synthesized to specifically

218 analyses of complete donor islets with up to macromolecular resolution.

219 ts associated with growth in the nucleus and macromolecular RNA-protein complexes contributes to the

220 rated with the synthesis of a chain-centered macromolecular rotaxane.

221 ituted systems PopZ can self-assemble into a macromolecular scaffold that directly binds to at least

222 .SIGNIFICANCE STATEMENT Synaptic ribbons are macromolecular scaffolds that tether synaptic vesicles c

223 croscopy with image deconvolution to acquire macromolecular-scale detail of dynamic actomyosin networ

224 find each of these designs allows unimpeded macromolecular sedimentation and can provide high-qualit

225 ble to other bacterial microcompartments and macromolecular self-assembling systems, advance our know

226 ces, small-molecule chemical descriptors, 3D macromolecular shapes, and sequence motifs.

227 llular organisms, caspases are activated via macromolecular signaling complexes that bring inactive p

228 plicit consideration of solvent molecules in macromolecular simulations.

229 ing, peptide structure, and the formation of macromolecular-sized pores in membranes.

230 Here, we introduce DNA punch cards, a macromolecular storage mechanism in which data is writte

231 ate the functional form of the birefringence-macromolecular strain relationship based on Peterlin's t

232 This macromolecular strategy for integrating tumour acidosis

233 Efficient means of working with 3D macromolecular structural data for archiving, analyses,

234 3D macromolecular structural data is growing ever more comp

235 ht, efficient, and extensible handling of 3D macromolecular structural data.

236 The sharing of macromolecular structural information online by scientis

237 s capable to provide simultaneous imaging of macromolecular structure and its charge distribution whi

238 ified a fundamental relationship between the macromolecular structure and mechanical behavior of cell

239 Correct reconstruction of macromolecular structure by cryo-electron microscopy (cr

240 nd PYD domains-containing protein 3) forms a macromolecular structure called the NLRP3 inflammasome.

241 ors in the Americas and Oceania and makes 3D macromolecular structure data available at no charge and

242 help users to more easily find and interpret macromolecular structure data in order to solve scientif

243 tackle challenges with increasingly complex macromolecular structure data.

244 , validation, archiving and dissemination of macromolecular structure data.

245 An important task of macromolecular structure determination by cryo-electron

246 structural cell biology-the study of the 3-D macromolecular structure of cells.

247 Amyloid-beta (Abeta) is a macromolecular structure of great interest because its m

248 nces of oligomerization and insight into the macromolecular structure of oligomeric BAX.

249 Constructing a macromolecular structure of this scale generally require

250 elationship between intracellular motion and macromolecular structure remains a challenge in biology.

251 The kinetochore is a macromolecular structure that assembles on the centromer

252 We now know that the GBM is a complex macromolecular structure that undergoes key transitions

253 Julia programming language for dealing with macromolecular structures and the Protein Data Bank.

254 diverse research communities in their use of macromolecular structures by enriching the PDB data and

255 osensing mechanisms and outline how specific macromolecular structures can inform bacteria about surf

256 evaluate the 3D resolution for reconstructed macromolecular structures from Single Particle Analysis

257 ent of protein crystallography, atomic-level macromolecular structures have provided a basis to under

258 ever, systematic recognition and recovery of macromolecular structures in cryo-ET data remain challen

259 Radiation damage limits the accuracy of macromolecular structures in X-ray crystallography.

260 ynamic synthesis and proper self-assembly of macromolecular structures inside liposomes, the cytoskel

261 fast software to read, write and manipulate macromolecular structures is a prerequisite for producti

262 ron cryo-tomography to determine the in situ macromolecular structures of three Gammaproteobacteria m

263 cell cycle and cell polarity through forming macromolecular structures that behave like condensates.

264 Type IV pili (Tfp) are highly conserved macromolecular structures that fulfill diverse cellular

265 With a constantly increasing complexity of macromolecular structures, advanced polymer analysis fac

266 uncovering the actions of single molecules, macromolecular structures, and integrated machines that

267 ials due to their highly contorted and rigid macromolecular structures, which prevent space-efficient

268 ion of subtle variations among reconstructed macromolecular structures.

269 polymers for the preparation of well-defined macromolecular structures.

270 fic file formats to convey information about macromolecular structures.

271 of how the reaction mechanism influences the macromolecular structures.

272 improve cross data source recovery of novel macromolecular structures.

273 toxins have different effects on growth and macromolecular syntheses, and they phosphorylate distinc

274 a novel genome-scale model of metabolism and macromolecular synthesis (ME-model) to gain new insights

275 Measuring nascent macromolecular synthesis in vivo is key to understanding

276 alpha/beta-dependent manner, to VEEV-induced macromolecular synthesis inhibition.IMPORTANCE Most prev

277 Efficient macromolecular synthesis was achieved under illumination

278 materials, Nature has evolutionarily refined macromolecular synthesis with perfect atomic resolution

279 xphos), and those that consume it, including macromolecular synthesis, the maintenance of ionic gradi

280 ddiction to anaplerotic use of glutamine for macromolecular synthesis.

281 eet the challenges of high energy demand and macromolecular synthesis.

282 e reconstituted and understood via a minimal macromolecular system.

283 kely applicable to many charged colloidal or macromolecular systems in which the structural conformat

284 footprinting to extend our understanding of macromolecular systems, particularly for systems challen

285 nthesize glycerol to maintain flexibility of macromolecular systems.

286 easure the macromolecular fraction (MMF) and macromolecular T2 (T2(MM)).

287 predicting how a small molecule might bind a macromolecular target.

288 ze the transfer of ADP-ribose from NAD(+) to macromolecular targets (namely, proteins, but also DNA a

289 Molecules that covalently bind macromolecular targets have found widespread application

290 er or polymers of ADP-ribose nucleotide onto macromolecular targets such as proteins and DNA.

291 rd tissue, from the secretion of its organic macromolecular template to the formation of the fully fu

292 Here we present a methodology where macromolecular templates are used to confine an on-surfa

293 as a workable, on-demand strategy to create macromolecular therapeutic vaccine assemblies.

294 fer of fluorescently-labeled metabolites and macromolecular tracers.

295 proteins called Nups that mediates selective macromolecular transport between the nucleus and cytopla

296 ced viscosity increase and slowdown in ionic/macromolecular transport properties within the cells aff

297 ratio, we calculated the volume of simulated macromolecular under our multi-ball method and tradition

298 Alternatives using macromolecular, viral, or cell-based therapies show earl

299 customization and sharing of interactive 3D macromolecular visualizations for digital media without

300 cation, previously used to improve maps from macromolecular X-ray crystallography.