ライフサイエンスコーパス: macromolecular complex

1 uced posttranslational modifications of RyR2 macromolecular complex.

2 ) with key functions in assembling the nodal macromolecular complex.

3 achine is either a single macromolecule or a macromolecular complex.

4 ompetition for PP1 molecules within the same macromolecular complex.

5 activity of multiple proteins, possibly as a macromolecular complex.

6 nnel proteins (Kir2.1 and Na(V)1.5) within a macromolecular complex.

7 domain protein SAP97 is a component of this macromolecular complex.

8 iple target sites in a pre-formed polymer or macromolecular complex.

9 g the integrity of the CFTR-PDE3A-containing macromolecular complex.

10 can be ascribed to subtle changes in the Nav macromolecular complex.

11 hat HCN4 associates with Cav3 to form a HCN4 macromolecular complex.

12 and AQP4 exist in astrocytic membranes as a macromolecular complex.

13 remodeling enzymatic activities in a single macromolecular complex.

14 of active helicase factors forming a single, macromolecular complex.

15 ably coordinates the proper assembly of this macromolecular complex.

16 at most native ion channels are assembled in macromolecular complexes.

17 omic resolution structures of highly ordered macromolecular complexes.

18 rtant for the generation of atomic models of macromolecular complexes.

19 mechanical properties not seen with cellular macromolecular complexes.

20 ity on the level of biological assemblies or macromolecular complexes.

21 ctural rearrangements during the assembly of macromolecular complexes.

22 0 to Hsp90 to facilitate their assembly into macromolecular complexes.

23 d by limited structural information on these macromolecular complexes.

24 mutant PrP(C) upon Kv4.2-based cell surface macromolecular complexes.

25 uning and versatile assembly of higher order macromolecular complexes.

26 rom their vicinity leads to self-assembly of macromolecular complexes.

27 unctionalities known today only from natural macromolecular complexes.

28 Mia40 for further folding and assembly into macromolecular complexes.

29 e used to locate other flexible molecules in macromolecular complexes.

30 ules for both the assembly and modulation of macromolecular complexes.

31 tivities in a number of functional states or macromolecular complexes.

32 h for exploring the structure of pleomorphic macromolecular complexes.

33 Proteins perform most cellular functions in macromolecular complexes.

34 d here is applicable to other coarse-grained macromolecular complexes.

35 uctures of many important macromolecules and macromolecular complexes.

36 uding protein turnover and the remodeling of macromolecular complexes.

37 olenoid, implying a role as a facilitator of macromolecular complexes.

38 es on synthesis of two of the cell's largest macromolecular complexes.

39 n removing damaged or surplus organelles and macromolecular complexes.

40 should be broadly applicable to the study of macromolecular complexes.

41 ns depend on the assembly and disassembly of macromolecular complexes.

42 arco/endoplasmic reticulum calcium ATPase-2a macromolecular complexes.

43 il aggregates to "cap" and stabilize soluble macromolecular complexes.

44 r the structural determination of biological macromolecular complexes.

45 e of local cAMP production in the context of macromolecular complexes.

46 ulation of protein functions and assembly of macromolecular complexes.

47 olution structures of biochemically isolated macromolecular complexes.

48 ined with SDS-PAGE yielded NOX4 to reside in macromolecular complexes.

49 m contains structural information of all its macromolecular complexes.

50 res and associated conformational changes of macromolecular complexes.

51 is not required to form scribble-syntrophin macromolecular complexes.

52 rnary structure and in the assembly of large macromolecular complexes.

53 protein domains of unknown function in large macromolecular complexes?

54 ns (Q54IX5) and having homology to mammalian macromolecular complex adaptor proteins was identified.

55 oduce ChIMP as a versatile tool to probe the macromolecular complex and function of Ca(2+)-activated

56 identify new members of the cardiac Ca(v)1.2 macromolecular complex and identify a mechanism by which

57 icellular eukaryotes-pinpointing subunits of macromolecular complexes and components functioning in c

58 electron tomogram images with non-deformable macromolecular complexes and deformable ultrastructures

59 ron tomogram images including non-deformable macromolecular complexes and deformable ultrastructures.

60 large/zona occludens) protein that assembles macromolecular complexes and determines the localization

61 our understanding of the formation of large macromolecular complexes and how their components intera

62 tively stable linkages between components of macromolecular complexes and in some cases to bridge to

63 Eukaryotic cells are densely packed with macromolecular complexes and intertwining organelles, co

64 free energy required to assemble these large macromolecular complexes and maintain them under physiol

65 Mesoscale macromolecular complexes and organelles, tens to hundred

66 ion for in situ three-dimensional imaging of macromolecular complexes and organelles.

67 tion and a spatially organized complement of macromolecular complexes and organelles.

68 ar substrates, including protein aggregates, macromolecular complexes and polymers.

69 can provide better estimates of the size of macromolecular complexes and report on sample homogeneit

70 nges within biomolecules to the formation of macromolecular complexes and the associations between th

71 eptor 2, cardiac (RyR2)/Ca2+ release channel macromolecular complexes and the sarcoplasmic/endoplasmi

72 a powerful tool for analyzing structures of macromolecular complexes and their spatial organizations

73 he labeled data which covers a wide range of macromolecular complexes and ultrastructure.

74 e the shape and size of the macromolecule or macromolecular complex, and are therefore complementary

75 Co-immunoprecipitation showed formation of a macromolecular complex, and live immunolabeling demonstr

76 of the size-distribution of macromolecules, macromolecular complexes, and nanoparticles.

77 tegration of three mitoribosomal proteins in macromolecular complexes, and provide evidence suggestin

78 for measuring the masses of large molecules, macromolecular complexes, and synthetic polymers that ar

79 urprising degree of functional plasticity of macromolecular complexes, and the existence of numerous

80 osal to obtain structures of macromolecules, macromolecular complexes, and virus particles, without t

81 s of amyloid and membrane proteins and large macromolecular complexes are an important new approach t

82 ility in the way that homologous prokaryotic macromolecular complexes are assembled than has generall

83 These two macromolecular complexes are connected by a direct inter

84 ast Saccharomyces cerevisiae, organelles and macromolecular complexes are delivered from the mother t

85 Spatially organized macromolecular complexes are essential for cell and tiss

86 Macromolecular complexes are essential to conserved biol

87 Domains in macromolecular complexes are often considered structural

88 Macromolecular complexes are responsible for many key bi

89 Molecular machines or macromolecular complexes are supramolecular assemblies o

90 cognize that numerous proteins assemble into macromolecular complexes as part of normal physiology, s

91 Furthermore, recruitment of SMN into large macromolecular complexes as well as increased associatio

92 death, translation and protein folding, and macromolecular complex assembly.

93 y and that the corresponding proteins form a macromolecular complex at the cytoplasmic membrane, whic

94 Formation of multiple-protein macromolecular complexes at specialized subcellular micr

95 ner through the formation of CFTR-containing macromolecular complexes at the plasma membrane.

96 ponents of wt-CFTR- or rPhe508del-containing macromolecular complexes at the surface of human bronchi

97 e estimation of NMR chemical-shifts of large macromolecular complexes based on the previously publish

98 We discover a macromolecular complex between the scaffolding protein G

99 interactome have identified several hundred macromolecular complexes, but direct binary protein-prot

100 polyubiquitinated proteins from membranes or macromolecular complexes, but how they perform these fun

101 Cb proteins are cotransported as one or more macromolecular complexes, but the basis for this cotrans

102 Visualizing macromolecular complexes by single-particle electron mic

103 the stability, homogeneity and solubility of macromolecular complexes by sparse-matrix screening of t

104 of EM structural data of macromolecules and macromolecular complexes by the wider scientific communi

105 red by formation of a stable, tRNA-dependent macromolecular complex called the Asn-transamidosome.

106 causative agent of malaria, is powered by a macromolecular complex called the glideosome that lies b

107 on of DNA in the cytosol by AIM2 assembles a macromolecular complex called the inflammasome, which un

108 hogenesis of Plasmodium falciparum rely on a macromolecular complex, called the glideosome.

109 precise structural ensembles of proteins and macromolecular complexes can be obtained with metainfere

110 Many new macromolecular complexes can benefit significantly from

111 ate signal-dependent RNA processing and that macromolecular complexes can compartmentalize c-di-GMP s

112 one H3 on lysine 4 (H3K4) implemented by the macromolecular complex COMPASS and its related complexes

113 As a macromolecular complex composed of both RNAs and protein

114 ochondrion, by increasing interaction with a macromolecular complex composed of the VDAC1 (voltage-de

115 Ribosomes exist as a heterogenous pool of macromolecular complexes composed of ribosomal RNA molec

116 o new databases of protein-protein and other macromolecular complexes, ComPPI and the Complex Portal.

117 In eukaryotes, this process requires a macromolecular complex comprising over 200 proteins and

118 The cardiac I(Ks) potassium channel is a macromolecular complex consisting of alpha-(KCNQ1) and b

119 Ribosomes are large and highly charged macromolecular complexes consisting of RNA and proteins.

120 identified novel layers of interplay within macromolecular complexes containing diverse channel type

121 high levels, bound to detergent-solubilized macromolecular complexes containing neuronal voltage-gat

122 h eukaryotic cellulose synthases function in macromolecular complexes containing several different en

123 The kinetic stability of non-covalent macromolecular complexes controls many biological phenom

124 s between CFTR and other transporters within macromolecular complexes coordinated at the apical membr

125 mple of such protein assemblies, the BRCA1-A macromolecular complex, couples ubiquitin recognition an

126 o proteins that form, with CASQ2 and RyR2, a macromolecular complex devoted to control of calcium rel

127 microscopy and allows the probing of single macromolecular complexes directly from cell or tissue ex

128 lter protein-protein interactions modulating macromolecular complexes enriched in disease risk candid

129 roach for analyzing assembly and function of macromolecular complexes, especially those too large for

130 To stabilize macromolecular complexes for native MS, charge reducing

131 a framework to generate crowded mixtures of macromolecular complexes for realistically simulating cr

132 produce specimens of His-tagged proteins or macromolecular complexes for single-particle electron mi

133 previously described to isolate proteins and macromolecular complexes for single-particle EM, we were

134 polyubiquitinated proteins from membranes or macromolecular complexes for subsequent degradation by t

135 companying protocol entitled 'Preparation of macromolecular complexes for visualization using cryo-el

136 ying the dynamic regulation of submembranous macromolecular complex formation between group I mGluRs

137 ing kinetic coupling, collision coupling, or macromolecular complex formation has remained unknown.

138 ilencing by unpaired DNA (MSUD) and observed macromolecular complex formation involving only SAD-1 pr

139 Our findings illustrate that the asymmetric macromolecular complex formation of chemoattractant rece

140 In vitro, a macromolecular complex formed by TRPC1/TRPC3/TRPC6 exist

141 e multifunctional protein nephrin within the macromolecular complex forming the glomerular slit diaph

142 Averaging of macromolecular complexes found within tomograms is known

143 e or multi-modular protein, and assembling a macromolecular complex from its subunits.

144 We have implemented this screen on several macromolecular complexes from a variety of organisms, re

145 Escape of large macromolecular complexes from the endoplasmic reticulum

146 This macromolecular complex functioned to amplify inside-out

147 interactions between cellular organelles and macromolecular complexes has been the result of imaging

148 M) to generate high-resolution structures of macromolecular complexes has changed the landscape of st

149 est that alpha-actinins may link ASIC1a to a macromolecular complex in the postsynaptic membrane wher

150 It contains detailed information of all macromolecular complexes in a sample cell.

151 and lymphoid enhancer-binding factor-1 form macromolecular complexes in cells, (b) ERRalpha transcri

152 is an important tool to study structures of macromolecular complexes in close to native states.

153 to investigate complete and fully functional macromolecular complexes in different functional states,

154 d receptors (GPCRs) are organized as dynamic macromolecular complexes in human cells.

155 esults, H1 existed in large (400 to >650kDa) macromolecular complexes in human T cell nucleolar extra

156 yo-electron tomography allows the imaging of macromolecular complexes in near living conditions.

157 st reliably map the interactomes of cellular macromolecular complexes in order to fully explore and u

158 luable tool for the structural dissection of macromolecular complexes in situ.

159 ionary method for resolving the structure of macromolecular complexes in situ.

160 technique allows structure determination of macromolecular complexes in situ.

161 e structural characterizations of biological macromolecular complexes in solution.

162 This system is applicable to studying macromolecular complexes in the context of cell signalin

163 D) is the dominant method for probing intact macromolecular complexes in the gas phase by means of ma

164 r native state and determining structures of macromolecular complexes in their cellular context.

165 To improve the stability of macromolecular complexes in vitro, we present a generic

166 bly factors facilitate the formation of many macromolecular complexes in vivo.

167 Ion channels in excitable cells function in macromolecular complexes in which auxiliary proteins mod

168 spatial distributions of previously unknown macromolecular complexes in whole cell tomograms.

169 ributed to their association with protective macromolecular complexes, including extracellular vesicl

170 ence of cellular lysis, of other cytoplasmic macromolecular complexes, including infectious agents an

171 hy (ECT) provides three-dimensional views of macromolecular complexes inside cells in a native frozen

172 The human SMN protein is part of a large macromolecular complex involved in the biogenesis of sma

173 ng the nuclear transport channel to multiple macromolecular complexes involved in the regulation of g

174 ivation induces internalization of a cardiac macromolecular complex involving VDCC and beta-arrestin

175 e further observed that the CXCR2-containing macromolecular complex is critical for the CXCR2-mediate

176 The LMO2/LDB1 macromolecular complex is critical in hematopoietic stem

177 f the structure and mechanism of these large macromolecular complexes is an active and ongoing resear

178 The cardiac RyR2 macromolecular complexes isolated from murine and human

179 ber of experimentally resolved structures of macromolecular complexes, it becomes clear that the inte

180 serves functional attributes of proteins and macromolecular complexes, it is considered a chemical ch

181 In light of the complexity of macromolecular complexes, it is essential to use compute

182 ds another dimension by which this essential macromolecular complex may be regulated in health and di

183 f-organization and that introduction of such macromolecular complexes may advance nanoengineering of

184 Macromolecular complexes may disassociate or adopt nonra

185 LRRC52, through stabilization of a macromolecular complex, may help retain some other compo

186 Specific genomic functions are dictated by macromolecular complexes (MCs) containing multiple prote

187 ing E2-BSA-FITC (fluorescein isothiocyanate) macromolecular complex, membrane E2 binding sites were o

188 cretory molecules, enzymes, receptors, large macromolecular complexes, membrane vesicles, and exosome

189 y for small-angle scattering data of various macromolecular complexes; MoonProt, a database of 'moonl

190 l-cell contact sites and assemble into large macromolecular complexes named adherens junctions (AJs).

191 er 1 (KCNB1, Kv2.1) and integrin-alpha5 form macromolecular complexes-named integrin-alpha5-KCNB1 com

192 unctional node and that perturbation of this macromolecular complex not only is responsible for the w

193 this membrane, PTEX is arranged in a stable macromolecular complex of >1230 kDa that includes an app

194 hologue to DYF-13, PIFTC3, participates in a macromolecular complex of approximately 660 kDa.

195 data to produce a systems-level view of the macromolecular complex of chromatin.

196 We assembled a macromolecular complex of CXCR2.NHERF1.PLC-beta2 in vitr

197 on of the PDZ motif-mediated assembly of the macromolecular complex of LPA2 disorganizes the gradient

198 n together, we suggest that 4.1R organizes a macromolecular complex of skeletal and transmembrane pro

199 of RyR2s in the middle of the sarcomere are macromolecular complexes of approximately 20 RyR2s with

200 h Galpha and Gbeta are associated with large macromolecular complexes of approximately 700 kDa in the

201 it is possible to obtain reconstructions of macromolecular complexes of different sizes to better th

202 minal domain to allow the formation of large macromolecular complexes of functionally related transcr

203 are critically dependent on the formation of macromolecular complexes of Kv4 channels with a family o

204 These localized PDZ motif-mediated macromolecular complexes of LPA2 trigger a Ca(2+) puff g

205 Proteins are manufactured by ribosomes-macromolecular complexes of protein and RNA molecules th

206 ssential and participates in the assembly of macromolecular complexes of RNA and protein in all cells

207 y regulating cAMP in microdomains containing macromolecular complexes of SR calcium ATPase type 2a-ph

208 SK channels are stable macromolecular complexes of the ion pore-forming subunit

209 and pi-basicity of metal-organic trimetallic macromolecular complexes of the type [M(mu-L)]3, where M

210 insight into the mechanisms, structures, and macromolecular complexes of these enzymes has grown expo

211 These results indicate that Myc populates macromolecular complexes of widely heterogenous size and

212 eral of the Coq proteins are associated in a macromolecular complex on the matrix face of the inner m

213 inase (PKA) holoenzyme typically nucleates a macromolecular complex or a "PKA signalosome." Using the

214 method to study the detailed architecture of macromolecular complexes or cellular structures.

215 can now be obtained, not only for megadalton macromolecular complexes or highly symmetrical assemblie

216 -1, and demonstrate that disruption of these macromolecular complexes or knockdown of TRIP6 or NHERF2

217 Proteins within most macromolecular complexes or organelles continuously turn

218 Macromolecular complexes play crucial roles in transcrip

219 Conformational changes of macromolecular complexes play key mechanistic roles in m

220 and demonstrate that detailed dissection of macromolecular complexes provides fuller understanding o

221 4 as a critical component of the Nav channel macromolecular complex, providing evidence for a novel G

222 on the state of cytoplasmic and intraluminal macromolecular complexes regulating cardiac RyR2 functio

223 Additional antigenic components of VGKC macromolecular complexes remain to be defined.

224 gh the proposed requirement for a TRPV4-AQP4 macromolecular complex remains to be resolved.

225 mediate protein folding, translocation, and macromolecular complex remodeling reactions.

226 RyR2 macromolecular complex remodeling, characterized by depl

227 Basal bodies (BBs) are macromolecular complexes required for the formation and

228 T6SS components are proposed to be part of a macromolecular complex resembling the bacteriophage tail

229 The macromolecular complex responsible for processing both c

230 spectrometry (IM-MS), we find that all four macromolecular complexes retain their native-like topolo

231 plications are illustrated for several large macromolecular complexes: ribosome, virus capsids, chemo

232 the nanostructure formation of a biological macromolecular complex: RNA interference microsponges.

233 In yeast, the macromolecular complex Set1/COMPASS is capable of methyl

234 ein containing a CARD (ASC) formed cytosolic macromolecular complexes (so-called pyroptosomes) that w

235 as well as a substantial boost in successful macromolecular complex structure determination by both X

236 etero-hexameric ring that is part of several macromolecular complexes such as INO80, SWR1, and R2TP.

237 -network tend to include components of large macromolecular complexes such as ribosomes and photosynt

238 Low copy number proteins within macromolecular complexes, such as viruses, can be critic

239 proteins are synthesized by the ribosome, a macromolecular complex that accomplishes the life-sustai

240 gamma-secretase is a macromolecular complex that catalyzes intramembranous hy

241 The kinetochore is a macromolecular complex that controls chromosome segregat

242 The cytomatrix at the active zone (CAZ) is a macromolecular complex that facilitates the supply of re

243 The RNA degradosome is a multiprotein macromolecular complex that is involved in the degradati

244 In these mutants, the macromolecular complex that links metabotropic glutamate

245 stem (MAPS), which enables the creation of a macromolecular complex that mimics the properties of WCV

246 Radial spokes are conserved macromolecular complexes that are essential for ciliary

247 ss out interesting patterns present in large macromolecular complexes that are typically solved by lo

248 Recent advances have identified macromolecular complexes that assemble at the DNA lesion

249 i that promote the assembly of kinetochores, macromolecular complexes that bind spindle microtubules

250 e dynamics of assembly and turnover of other macromolecular complexes that can be isolated from cells

251 s operate in intact tissues as part of large macromolecular complexes that can include cytoskeletal p

252 Chemoreceptor arrays are macromolecular complexes that form extended assemblies p

253 on the promoters of mRNA genes to form large macromolecular complexes that initiate transcription in

254 Kinetochores are the macromolecular complexes that interact with microtubules

255 gments the formation of MRP4-CFTR-containing macromolecular complexes that is mediated via scaffoldin

256 Inflammasomes are macromolecular complexes that mediate inflammatory and c

257 in controlling the assembly and activity of macromolecular complexes that monitor chromosome duplica

258 ement of such breathing in the mechanisms of macromolecular complexes that operate at these loci is n

259 -linked ubiquitin chains as part of distinct macromolecular complexes that participate in either inte

260 ges iNOS with CFTR, forming CFTR-NHERF2-iNOS macromolecular complexes that potentiate CFTR channel fu

261 ation and function, we know little about the macromolecular complexes that regulate electrical synaps

262 The NPC is a large macromolecular complex, the size and complexity of which

263 stoichiometric differences among members of macromolecular complexes, the interactome, and signaling

264 ector phospholipase C (PLC)-beta2, forming a macromolecular complex, through a PDZ-based interaction.

265 We hypothesized that XB130 and Tks5 form a macromolecular complex to mediate signal transduction ca

266 esting that they work in tandem as part of a macromolecular complex to regulate KOR/MOR formation.

267 that p97 extracts proteins from membranes or macromolecular complexes to enable their proteasomal deg

268 tin structure confines the movement of large macromolecular complexes to interchromatin corrals.

269 d serve as a scaffold for the recruitment of macromolecular complexes to modify chromatin accessibili

270 structure neighboring results and shows, for macromolecular complexes tracked in MMDB, lists of simil

271 gh-throughput structural characterization of macromolecular complexes under physiological conditions.

272 Nanostructures formed from biological macromolecular complexes utilizing the self-assembly pro

273 ystal structure of this large membrane-bound macromolecular complex via in silico modeling.

274 2-R2474S+/- mice were oxidized, and the RyR2 macromolecular complex was depleted of calstabin2.

275 The RyR1 macromolecular complex was oxidized, S-nitrosylated, Ser

276 bunit of ryanodine receptor subtype 2 (RyR2) macromolecular complex, which is an intracellular calciu

277 ent of the cardiac ryanodine receptor (RyR2) macromolecular complex, which modulates Ca(2+) release f

278 Proteins of the secretin family form large macromolecular complexes, which assemble in the outer me

279 res organization of signaling molecules into macromolecular complexes, whose components are in intima

280 ests that targeting CFTR and CFTR-containing macromolecular complexes will ameliorate diarrheal sympt

281 f Salmonella-infected macrophages revealed a macromolecular complex with an outer ring of apoptosis-a

282 is novel method of pERK1/2 accumulation to a macromolecular complex with dual specific phosphatase ac

283 , the NuRD components HDAC1/2 associate in a macromolecular complex with Foxp proteins, and loss of e

284 to accurately predict how to capture a given macromolecular complex with its physiological binding pa

285 Prx exists in a macromolecular complex with proteins involved in membran

286 ic approach, we found that DOCK8 exists in a macromolecular complex with the Wiskott-Aldrich syndrome

287 Voltage-gated K(+) channels function in macromolecular complexes with accessory subunits to regu

288 as source for purifying thermostable native macromolecular complexes with an emphasis on the nuclear

289 r results suggest that endogenous NOX4 forms macromolecular complexes with calnexin, which are needed

290 ne the stoichiometry, affinity, and shape of macromolecular complexes with dissociation equilibrium c

291 ral under physiological conditions reside in macromolecular complexes with other sticky proteins due

292 o the R7 subfamily of RGS proteins that form macromolecular complexes with R7-binding protein (R7BP).

293 y involved as a consequence of forming large macromolecular complexes with the DNA-binding subunits o

294 established that R7 RGS proteins function as macromolecular complexes with two subunits: type 5 G pro

295 physically and functionally associated in a macromolecular complex within lipid rafts at the apical

296 vious version enabling the analysis of large macromolecular complexes within a user-friendly interfac

297 ed clarity, the organizational principles of macromolecular complexes within cells, thus leading to d

298 Se7942 Rubisco and CcmM35 formed macromolecular complexes within the chloroplast stroma,

299 d to determine the structure of proteins and macromolecular complexes without the need for crystals.

300 ein interactions (PPIs) regulate assembly of macromolecular complexes, yet remain challenging to stud