ライフサイエンスコーパス: macromolecule

1 e as a mechanical signature for a biological macromolecule.

2 onal changes during the chemical reaction of macromolecules.

3 mena observed for IgG is ubiquitous for most macromolecules.

4 ial biosynthetic intermediates to synthesize macromolecules.

5 ted from PlaMoM, a database for plant mobile macromolecules.

6 bles stronger binding between the binder and macromolecules.

7 uctures and working mechanisms of biological macromolecules.

8 arrier is our limited formats for describing macromolecules.

9 gating the structural dynamics of biological macromolecules.

10 r both energy generation and biosynthesis of macromolecules.

11 amic covalent bonds with small molecules and macromolecules.

12 temperature at the isoelectric point of the macromolecules.

13 l changes in DNA upon interaction with other macromolecules.

14 le tool for structural studies of biological macromolecules.

15 gest that this domain can interact with host macromolecules.

16 nsport of proteins, nucleic acids, and other macromolecules.

17 r of the strong 2:2 recognition chemistry to macromolecules.

18 anostructure capable of detecting biological macromolecules.

19 such unidirectional outward perviousness to macromolecules.

20 simulations monitor time-resolved motions of macromolecules.

21 to conventional ligands targeting monomeric macromolecules.

22 action reveal 3D contacts within and between macromolecules.

23 proach to explore the spatial environment of macromolecules.

24 time-averaged measurements of the component macromolecules.

25 rely are these found in synthetic non-chiral macromolecules.

26 that are permeable to water and ions but not macromolecules.

27 and the metabolic energy used to build those macromolecules.

28 prompt mucosal exudation of nonsieved plasma macromolecules.

29 ordinary" transition in solutions of charged macromolecules.

30 omechanical state and global conformation of macromolecules.

31 e diversity of architectures offered by such macromolecules.

32 ar (or quaternary) structures of associating macromolecules.

33 n coefficient, formed from similarly charged macromolecules.

34 ques that give solution structures for large macromolecules.

35 hetic polycationic branched polyethylenimine macromolecules.

36 les are too small to bind effectively to the macromolecules.

37 approach to generate well-defined functional macromolecules.

38 erties when compared with linear or branched macromolecules.

39 the length of constituent lipopolysaccharide macromolecules.

40 ich regulates nucleocytoplasmic transport of macromolecules.

41 of the three-dimensional (3D) structures of macromolecules.

42 y function and biophysical behavior of these macromolecules.

43 is mainly provided by azido moiety in their macromolecules.

44 me biogenesis for the efficient recycling of macromolecules.

45 nd concentration influence the solubility of macromolecules.

46 effects of pH on liquid phase separation of macromolecules.

47 form covalent adducts with amine-containing macromolecules.

48 tight junction complexes block the uptake of macromolecules.

49 tamine (+17%) ratios and decreased levels of macromolecules (-11%); these changes were positively cor

50 Chen, Macromolecules 53, 1180-1190 (2020)].

51 cellular retention by forming intracellular macromolecule adducts.

52 ing high-resolution structures of biological macromolecules amassing less than 100 kilodaltons (kDa)

53 gagement of a target protein or other chiral macromolecule, an observation that supports a mechanism

54 Here, we utilize gas-phase electrophoretic macromolecule analysis to show that a HydF dimer forms a

55 t allows for the precise assembly of a giant macromolecule and the adaptability needed to interact wi

56 n for subtomogram averaging in both purified macromolecules and cells.

57 se-efficient imaging of unstained biological macromolecules and cells.

58 The uptake of macromolecules and cellular debris through macropinocyto

59 Vs) are involved in the transport of fluids, macromolecules and central nervous system (CNS) immune r

60 ful due to their ability to compartmentalize macromolecules and chemical processes.

61 r RNAs create a dense network of interacting macromolecules and drive the phase separation.

62 nocytosis coordinates non-specific uptake of macromolecules and fluid.

63 Reactive cellular metabolites can modify macromolecules and form adducts known as nonenzymatic co

64 ngeal lymphatics have been reported to drain macromolecules and immune cells from CSF into cervical l

65 the meningeal lymphatics for the drainage of macromolecules and immune cells from the cerebrospinal f

66 ied to explore the distribution variation of macromolecules and microelements in single algal cells i

67 c program is ideally suited for synthesis of macromolecules and mimics the manner by which cancer cel

68 estigating targets of trace metal binding to macromolecules and pigments at environmentally relevant

69 allow for efficient transfer of ions and/or macromolecules and provide a platform for organelle fiss

70 periods of autophagy, which degrades damaged macromolecules and recycles them as nutrients to enhance

71 pH relative to the isoelectric point of the macromolecules and study how phase diagrams depend on pH

72 nmentally relevant factors including organic macromolecules and sunlight exposure.

73 s widely underestimated for the mechanics of macromolecules and that a polymer chain has competing en

74 l mLVs are hotspots for the clearance of CSF macromolecules and that both mLV integrity and CSF drain

75 direction of the water exchanges between the macromolecules and the solvent and the number of water m

76 variations of the interactions between these macromolecules and the solvent, as well as the volume ch

77 y following their ability to bind to protein macromolecules and their anti-inflammatory activity.

78 Vs packaged with a select array of bioactive macromolecules and they have been shown to play importan

79 Lymphatic vessels provide a route of fluid, macromolecule, and immune cell clearance, and lymphangio

80 including neutral molecules, ionic species, macromolecules, and biomolecules, have been extensively

81 quence definition in extended supramolecular macromolecules, and design principles remain nascent.

82 signal-to-noise ratio (SNR), small sizes of macromolecules, and high complexity of the cellular envi

83 Autophagy degrades and recycles proteins, macromolecules, and organelles for cells to survive star

84 systems, EZ water interfaces with membranes, macromolecules, and organelles, and its buildup appears

85 tangle grows with the vortex length, as for macromolecules, and saturates above a characteristic len

86 ery of exogenous materials (small molecules, macromolecules, and siRNA) into different types of cells

87 omes, nanoparticles, extracellular vesicles, macromolecules, and small molecules).

88 agonist, imiquimod (IMD), and a hydrophilic macromolecule, anti-CD47 antibody (alphaCD47), for macro

89 here as steps: 1) the coefficients for major macromolecules are calculated, 2) coenzymes and inorgani

90 manner and thus structural studies of static macromolecules are often complemented by biophysical ana

91 ganelle lysosome is the place where unwanted macromolecules are removed through degradation by hydrol

92 The macromolecules are SH3(5) (S) and PRM(5) (P), two pentam

93 Acidic macromolecules are traditionally considered key to calci

94 atropselective binding of PCBs to biological macromolecules are, therefore, needed to predict the atr

95 chRCC cells depended on extracellular macromolecules as an amino acid source by activating end

96 it for representing the primary structure of macromolecules as combinations of residues, caps, crossl

97 ESM is different from ENM in that it treats macromolecules as elastic solids.

98 describing protonation and deprotonation of macromolecules, as well as self-ionization of water.

99 ool for computing the behavior of biological macromolecules at equilibrium because it establishes a d

100 e exists another large and growing family of macromolecules based on the chemistry of phosphorus.

101 arly challenging barrier for the delivery of macromolecules because many of the transfection agents t

102 oosing the appropriate core, these versatile macromolecules become an excellent fluorescent biomarker

103 rystallographic investigations on biological macromolecules belong to an important class of experimen

104 nsional differential in-gel electrophoresis, macromolecule biosynthesis assays and fluorescence spect

105 ic metabolite used for energy production and macromolecule biosynthesis.

106 context, and how the synergy of simple phage macromolecules brings about complex behaviors.

107 inically advantageous attributes relative to macromolecules but have generally been hampered by their

108 ies on the selective targeting of biological macromolecules by low-molecular weight compounds.

109 odology to synthesize monodisperse synthetic macromolecules by self-interrupted living polymerization

110 The sequestration of biologically relevant macromolecules can be programmed by the addition of suit

111 The macromolecules can be synthesized using catalyst-transfe

112 nce of two comonomers in sequence-controlled macromolecules can be used to store binary information w

113 In conclusion, nonsieved plasma macromolecules can operate on the intact airway mucosa a

114 ge this view and demonstrate that low-charge macromolecules can vastly outperform their acidic counte

115 anaerobic metabolism and autophagy-mediated macromolecule catabolism; and (iii) activation of catabo

116 els with defects in endothelial transport of macromolecules: caveolin-1 knockout (Cav1-/-) and FcRn k

117 y becoming susceptible to adhesion of matrix macromolecules, cells, and fat.

118 ate three-dimensional structures of cellular macromolecule complexes in their native environment.

119 st, we study phase diagrams as a function of macromolecule concentration and temperature at the isoel

120 Macromolecule condensates, phase separation, and membran

121 peptidoglycan (PG), a cross-linked mesh-like macromolecule consisting of glycan strands interlinked b

122 However, synthetic macromolecules contain mixtures of different chain lengt

123 the mechanisms by which extracellular matrix macromolecules control collagen mineralization.

124 Lipids are important macromolecules could be found with much higher concentra

125 entrations since they originate in cell wall macromolecules degradation.

126 ellular biomass components such as the major macromolecules (DNA, RNA, proteins), lipids, coenzymes,

127 cryo-EM maps at various scales, from entire macromolecules down to individual atoms.

128 for biologic medications is ideal; however, macromolecule drugs are not readily absorbed into the bl

129 tform to orally deliver therapeutic doses of macromolecule drugs.

130 e required to enlarge this covalently closed macromolecule during growth, but how these autolytic enz

131 lpha-lactalbumin and concentrations of other macromolecules (e.g., phospholipid).

132 s the potential to quantitate other types of macromolecules (e.g., such as polymers, surfactants, etc

133 d complexes undergo phase separation to form macromolecule-enriched liquid droplets.

134 ells are in fact highly organized, with many macromolecules exhibiting nonuniform localization patter

135 Herein, natural-origin macromolecules exhibiting specific chemical moieties, na

136 m plays important roles in providing energy, macromolecules for membrane synthesis, and lipid-mediate

137 ltivalent metal ion binding site into target macromolecules for structural and biophysical characteri

138 arginine) to drive the synthesis of critical macromolecules for uncontrolled growth.

139 rostructures of graphene oxide and polyamine macromolecules, forming a network of ionic channels that

140 proteins (TJPs) as well as translocation of macromolecules from blood to brain and vice versa.

141 ta to define high-confidence multi-component macromolecules from diverse biological specimens.

142 e reveal that drainage of these inflammatory macromolecules from the brain led to a strikingly robust

143 nderstand how networks of such non-canonical macromolecules generate behavior.

144 oteins catalyzing the degradation of various macromolecules had reduced levels in CLN3-defective cell

145 ibrated character of the trajectories of the macromolecule has allowed development of a powerful theo

146 self-associate or form complexes with other macromolecules has important nutritional implications bu

147 oppositely charged macromolecules or neutral macromolecules have a stronger tendency to phase separat

148 ality control and exchange information about macromolecules, help systems biologists assemble global

149 Biologically essential elements and macromolecules impact individuals to ecosystems and vary

150 n paid to the supervised deep learning-based macromolecule in situ structural classification (i.e. su

151 to investigate complex kinetic behaviors of macromolecules in a cellular setting, and could be exten

152 am averaging (three-dimensional alignment of macromolecules in a complex sample).

153 foundation for future exploration of various macromolecules in a controlled environment.

154 e potential for encapsulating, and releasing macromolecules in a size-selective manner.

155 serves as the sole bidirectional gateway of macromolecules in and out of the nucleus.

156 ructural biology is to understand biological macromolecules in as much detail as possible.

157 Dynamic assembly of macromolecules in biological systems is one of the funda

158 can be used for the identification of these macromolecules in cheese whey and the detection of adult

159 d qNMR experiment (DF-qNMR) for quantitating macromolecules in complex matrices and (2) an overall me

160 This pressure is generated by solutions of macromolecules in contact with pores that are permeable

161 his review article discusses the role of ECM macromolecules in heart failure, focusing on both struct

162 olution and binding of fluorescently labeled macromolecules in real time.

163 ccurately characterizing dynamics of charged macromolecules in salty solutions, which are ubiquitous

164 The hand-held system enabled delivery of macromolecules in short, 60-s treatment times ex vivo.

165 The concentration of macromolecules in solution is a crucial property in many

166 ystal structures and the natural dynamics of macromolecules in solution, thus advancing a more compre

167 the ribosome and are among the most abundant macromolecules in the cell.

168 ge, localize, and track individually labeled macromolecules in the cytoplasm of living cells, allowin

169 s the interrogation of structural aspects of macromolecules in the gas phase, under the premise of ha

170 To study the role of extracellular macromolecules in the TME affecting endothelial cells we

171 structural changes is highly suited to study macromolecules, in which photoswitchable units trigger c

172 tories, also have the capacity to synthesize macromolecules including phospholipids, particularly car

173 primary membrane to remove particulates and macromolecules including proteins, and (iv) a secondary

174 DXR increases paracellular transit of small macromolecules, including bacterial products, through th

175 environment is highly crowded by biological macromolecules, including chromatin and mobile proteins,

176 Large macromolecules, including proteins and their complexes,

177 DroMiCo to the analysis of phase diagrams of macromolecules, including synthetic polymers and protein

178 x vivo, delivery of dermatological drugs and macromolecules, including those that cannot be given top

179 via manifold avenues including weak protein-macromolecule interactions.

180 These intracellular macromolecules interfere with the interactions of enzyme

181 Biomolecular condensates concentrate macromolecules into foci without a surrounding membrane.

182 omolecules or can recruit or exclude certain macromolecules into or from condensates.

183 vid-19 lungs, supporting the notion that the macromolecule is involved in ARDS caused by SARS-CoV-2.

184 Clustering of macromolecules is a fundamental cellular device underlyi

185 Compartmentalization of macromolecules is a ubiquitous molecular mechanism that

186 e mechanisms used to breakdown these complex macromolecules is lacking.

187 Crowding of the subcellular environment by macromolecules is thought to promote protein aggregation

188 ical and biotechnological importance of this macromolecule, its tertiary structure was never determin

189 x = glutamate + glutamine) and GABA+ (GABA + macromolecules) levels in 34 healthy men (17 neurotypica

190 by this, we sought to build a rapamycin-like macromolecule library to target new cellular proteins by

191 tly accelerate the drug screening process of macromolecule-ligand complexes.

192 eering of two RAS degraders based on protein macromolecules (macrodrugs) fused to specific E3 ligases

193 ces was the proposal to obtain structures of macromolecules, macromolecular complexes, and virus part

194 Peptidoglycan is a single macromolecule made of glycan chains crosslinked by pepti

195 anism development and positive regulation of macromolecule metabolic process to be primarily involved

196 The balance between sugars, fats, and other macromolecules must therefore be carefully considered wh

197 Here we extend these analyses to macromolecules, namely, multiply charged proteins genera

198 lecules, proteins, supramolecular complexes, macromolecules, nanoparticles and their self-assembly.

199 to characterizing small molecules, proteins, macromolecules, nanoparticles, and their self-assembly.

200 Dietary nutrients provide macromolecules necessary for organism growth and develop

201 The metabolic costs of synthesising the macromolecules necessary to build tissue are well define

202 concentration of cations and natural organic macromolecules (NOM) can significantly affect the oil re

203 In the experiment, 400 macromolecules of 20 representative types were packed in

204 de it possible to reconstitute molecules and macromolecules of simple geometry.

205 cross-chiral interactions can occur between macromolecules of the opposite handedness, including a p

206 mensional (3D) structure data for biological macromolecules often prove critical to dissecting and un

207 gically planar monomers react to form planar macromolecules, often termed 2D covalent organic framewo

208 s been used to analyze the effect of natural macromolecules on 2D NM aggregation.

209 Although macromolecules on cell surfaces are predominantly target

210 ization, can be triggered by small-molecule, macromolecule or even nanoobject initiators to produce v

211 valent interactions between phase-separating macromolecules or can recruit or exclude certain macromo

212 trongly depend on whether oppositely charged macromolecules or neutral macromolecules have a stronger

213 The most intense modifications are macromolecule oxidation and a considerable decrease in t

214 ng a snap-shot 3D structure of an individual macromolecule particle by aligning the tilt series of el

215 ve higher-order RNA structure and binding of macromolecule partners.

216 ied by electrical cell impedance sensing and macromolecule passage assay.

217 lso inhibited the increase in tight junction macromolecule permeability that occurs following Alterna

218 tin inhibited the increase in tight junction macromolecule permeability that was previously observed

219 -property relationships in chiral molecules, macromolecules (polymers), and supramolecules (crystals,

220 Soluble macromolecules present in the tumour microenvironment (T

221 en molecules that can interact with cellular macromolecules (proteins, lipids, nucleic acids) to eith

222 ng mechanisms by which cations interact with macromolecules remain more elusive.

223 ent control of shape, size, and chemistry of macromolecules remains a synthetic challenge.

224 Understanding structural transitions within macromolecules remains an important challenge in biochem

225 rtant for loading, separating, and releasing macromolecules, remains a challenge.

226 This double helix macromolecule represents one of the most rigid simple mo

227 tion of host cells to provide the energy and macromolecules required for efficient viral replication.

228 m glucose to glutamine to provide energy and macromolecules required for MDV replication, and optimal

229 rce for the TCA cycle to generate energy and macromolecules required for virus replication.

230 resolution structural analyses of biological macromolecules, resulting in a flood of new molecular in

231 ic proportions fail to synthesize sufficient macromolecules, resulting in cytoplasm dilution and a lo

232 Demixing of DNA from other globular macromolecules results from the overall repulsion betwee

233 al structures and compositions of biological macromolecules sheds light on their functions and also c

234 te, sulfite, sulfide, bicarbonate, and other macromolecule-stabilizing (kosmotropic) substances.

235 We have previously shown that macromolecules such as antibodies can be efficiently det

236 for improving the measurement sensitivity of macromolecules such as ferritin.

237 ine) function as nitrogen donors to generate macromolecules such as nucleotides and are indispensable

238 Biological macromolecules such as proteins and nucleic acids are mo

239 ated scaffold assemblies are devoid of large macromolecules such as ribosomes or other filament types

240 t of drugs (including DNA and metformin) and macromolecules (such as antibodies and proteins), good r

241 s), and specialized injury-associated matrix macromolecules (such as fibronectin and matricellular pr

242 hat MbnH could post-translationally modify a macromolecule, such as internalized CuMbn or its unchara

243 Intracellular delivery of functional macromolecules, such as DNA and RNA, across the cell mem

244 the metabolic dynamics of newly synthesized macromolecules, such as DNA, protein, lipids and glycoge

245 ls as well as a set of precursors needed for macromolecule syntheses; and (2) enzymes in each subnetw

246 powerful means to quantitatively interrogate macromolecule synthesis in heterogenous tissues at the o

247 ee-dimensional volumetric imaging of nascent macromolecule synthesis was performed in axolotl salaman

248 Covalent macromolecules tend to fragment under mechanical stress

249 r source of information on the volume of the macromolecule that has been imaged.

250 Melanins are synthesized macromolecules that are found in all biological kingdoms

251 energy in the monomers used to construct the macromolecules that comprise tissue (proteins, nucleic a

252 el describes a mixture composed of water and macromolecules that exist in three different charge stat

253 eraction of amelogenin scaffolds with acidic macromolecules that facilitate the formation of an amorp

254 ar behaviour by the in cellulo generation of macromolecules that have the ability to alter cellular m

255 matrix encompasses a reservoir of bioactive macromolecules that modulates a cornucopia of biological

256 astly different elastic solid model (ESM) of macromolecules that shares the same simplicity and effic

257 d programmable synthetic methods to generate macromolecules that span a systematic and wide range of

258 t designed ankyrin repeat proteins (DARPins) macromolecules that specifically inhibit the KRAS isofor

259 ge, we traced isotope-labeled nutrients into macromolecules that turn over more slowly than metabolit

260 linear and network polymers gives a class of macromolecules that undergo a new mechanism of degradati

261 Proteins are intrinsically flexible macromolecules that undergo internal motions with time s

262 n be manifested in the biased segregation of macromolecules, the differential partitioning of cell or

263 ny other AAA+ proteins function by threading macromolecules through a central pore of a disc-shaped h

264 ear envelope, which controls the exchange of macromolecules through nuclear pores(2).

265 ndensates, which are spontaneously formed by macromolecules through phase separation, suggest new pos

266 Getting large macromolecules through the plasma membrane and endosomal

267 to completion, on a three-armed star-shaped macromolecule to maximize efficiency during the molecula

268 Mesoporous materials allow macromolecules to diffuse into the waveguide, maximizing

269 nes act as a continuous barrier for salt and macromolecules to ensure proper physiological functions

270 The ability of proteins and other macromolecules to interact with inorganic surfaces is es

271 It generates depletion forces that push macromolecules together in crowded solutions and thus pr

272 We also packed filaments, membranes and macromolecules together, to obtain a simulated cryo-elec

273 is obtained by using the recently developed MacroMolecule Transmission Format to reduce the computat

274 suited for studying mechanical responses of macromolecules under external force.

275 uantifying the self-degradation of cytosolic macromolecules under nutrient-limiting conditions, we di

276 But under physiological conditions, macromolecules undergo continuous conformational changes

277 an aid the design of methods for identifying macromolecules using nanopores.

278 ynamics in the hydrophobic interior of large macromolecules utilizing methyl-geoHARD.

279 e complex self-assembly of nucleic acids and macromolecules via a condensation reaction.

280 proteins, pathogens, damaged organelles and macromolecules via delivery to lysosomes.

281 titis virus G protein (VSV-G) with bioactive macromolecules via split GFP complementation.

282 A macromolecule was approximated using multiple balls with

283 results, a signal-amplified effect based on macromolecules was introduced for the first time.

284 d by an extracellular matrix rich in anionic macromolecules was up-regulated in the BMAC group.

285 ll cations were on average depleted from the macromolecule/water interface, more strongly hydrated ca

286 Here, using four macromolecules, we demonstrate a range of phase behavior

287 While the ballast protein macromolecules were quantitatively eluted from the nano/

288 an milk oligosaccharides (HMO) are favorable macromolecules which are, interestingly, indigestible by

289 ene family encompass synthetic biodegradable macromolecules, which attain in vivo activity via antige

290 ol the aggregation of organic and biological macromolecules, which typically poses significant challe

291 Most life science systems contain hydrated macromolecules whose solubility, function and stability

292 lecular detection of chemical and biological macromolecules with a high degree of specificity and ult

293 ver, increased permeability was observed for macromolecules with biophysical properties known to enga

294 Polymerization produced macromolecules with controlled molecular weights on a mu

295 o a dendritic scaffold, resulting in complex macromolecules with discrete molecular weights, is an al

296 is a powerful approach for the synthesis of macromolecules with diverse compositions and complex arc

297 paradigms for generating stimuli-responsive macromolecules with enhanced functionalities.

298 ns provide a valuable strategy for preparing macromolecules with excellent control but are inherently

299 e methodology to produce large, well-defined macromolecules with programmable shape, size, and chemis

300 Folding can bestow macromolecules with various properties, as evident from