ライフサイエンスコーパス: major metabolite

1 o the pharmacokinetics of gefitinib (and its major metabolites).

2 g to give the biologically active 15-ol as a major metabolite.

3 -dependent manner, with (-)-OddCDP being the major metabolite.

4 taneously NTBPI, deferoxamine (DFO), and its major metabolite.

5 ive prodrug, and the O-aryl glucuronide is a major metabolite.

6 Ang III, and Ang IV, with Ang 1-7 being the major metabolite.

7 ma was analyzed for cyclophosphamide and its major metabolites.

8 cted by the transition temperatures of their major metabolites.

9 n (M1) and hydroxylation (M2) of GLB are the major metabolites.

10 ofloxacin (CIP) and desethylene-ENR were the major metabolites.

11 owed isogomphrenin III and gomphrenin III as major metabolites.

12 tant for removal of DFO (1.8 hour-1) and its major metabolite (0.6 hour-1).

13 Several of the major metabolites (1, 2-9) were additionally confirmed b

14 er Delta9-tetrahydrocannabinol (THC) and its major metabolites, 11-hydroxy-Delta9-tetrahydrocannabino

15 662 residues+iron nonheme cofactor) and its major metabolite 12S-hydroxyeicosatetraenoic acid have b

16 The results suggest that the F(2)-IsoP major metabolite 15-F(2t)-IsoP-M may be a more sensitive

17 study examined the effects of 17-AAG and its major metabolite, 17-aminogeldanamycin (17-AG), on Chk1

18 s of an antidepressant, lamotrigine, and its major metabolite (2-N-glucuronide), in environmental wat

19 gonist 1, Ki = 2.7 nM, was studied and three major metabolites (2, 4, and 5) were found.

20 Of note, melatonin and its two major metabolites, 2-hydroxymelatonin and AFMK, were als

21 representative pyrethroid pesticide) and its major metabolite 3-PBA were simultaneously detected to p

22 e-enkephalin (MENK) to PN and identified the major metabolite, 3-nitrotyrosine-methionine-sulfoxide (

23 ylglycolaldehyde, but not epinephrine or its major metabolite 4-hydroxy-3-methoxyphenylglycol, is a n

24 ed to serve as alternative precursors to the major metabolite, 4, of the cancer chemopreventive oltip

25 nd tobacco smoke, and glucuronidation of its major metabolite, 4-(methylnitrosamino)-1-(3-pyridyl)-1-

26 (1) the content of serotonin (5-HT) and its major metabolite 5-hydroxyindolacetic acid (5-HIAA), and

27 Compound 7-(R) and its major metabolites 5-(R) and 6-(R) were evaluated in seve

28 DG, 6-[18F]fluoro-L-m-tyrosine (FmT), or its major metabolite, 6-[18F]fluoro-3-hydroxyphenylacetic ac

29 tion in vivo resulting in the formation of a major metabolite, 6-oxo-M1dG.

30 The major metabolites, 6(OH)M and AFMK, were produced in all

31 of the model compound, testosterone, to its major metabolite, 6beta-hydroxy testosterone was noted.

32 inflammatory drug methotrexate (MTX) and its major metabolite, 7-hydroxymethotrexate (7OH-MTX) in hum

33 tiomerization was, however, observed for the major metabolite, a phenoxybutanoic acid.

34 ltiple-exposure temporal mass balance, three major metabolites accounted for >60% of BT.

35 However, with elaidoyl-CoA as a substrate, a major metabolite accumulated in the mitochondrial matrix

36 chiral PCBs to generate meta-OH-PCBs as the major metabolites after 60 min incubations.

37 naphthalene-1,2-diols, DHD1 and DHD3, as the major metabolites after oral administration in humans an

38 Salicylic acid (SA) is the major metabolite and active ingredient of aspirin; both

39 detecting diaminochlorotriazine (DACT), the major metabolite and biomarker of atrazine exposure.

40 carbonyl-4-phenylpiperidine is formed as the major metabolite and is an agonist at the mu-opioid rece

41 led that mixed-onium thiazolidine 29 was the major metabolite and that plasma cholinesterases do not

42 pha-thujone neurotoxicity and identifies its major metabolites and their role in the poisoning proces

43 t, CBB5 metabolized caffeine to theobromine (major metabolite) and paraxanthine (minor metabolite).

44 e size of microbial metabolomes (hundreds of major metabolites) and allow the nature, organisation an

45 extraction (SFE) behavior of cocaine and its major metabolite benzoylecgonine (BZE) was investigated

46 onsistent with production of 17alpha-hydroxy major metabolites, but functional and structural evidenc

47 and samples were assayed for monoamines and major metabolites by high-pressure liquid chromatography

48 ed for levels of NE, DA and 5-HT, as well as major metabolites, by high-pressure liquid chromatograph

49 Numerous molecules representing each of the major metabolite classes have been found that have a var

50 quantification of tryptophan and four of its major metabolites concurrently.

51 The major metabolites contributing to the discrimination wer

52 ynthetic building blocks associated with the major metabolite cyclomarin A, signifying that this mari

53 we investigated the effects of AMIO and its major metabolite, desethylamiodarone, on hERG channels e

54 levels of maternal plasma sertraline and its major metabolite, desmethylsertraline, were 30.7 ng/ml a

55 Acteoside was the major metabolite detected from July to November while tr

56 iquid chromatography for doxorubicin and the major metabolite doxorubicinol.

57 ogenously provided DGLA was converted to one major metabolite during cell stimulation; this product m

58 15 key metabolites, with carboxylic acids as major metabolites during gastric and intestinal stages.

59 simultaneous quantitation of cocaine and its major metabolites (ecgonine methyl ester, benzoylecgonin

60 -reactivity to TCC-related compounds and its major metabolites except for the closely related antimic

61 d 6-thioguanosine triphosphate ((S)GTP) is a major metabolite for these drugs.

62 ) values differed between ivermectin and its major metabolites for An. dirus or An. minimus., Additio

63 ith an oxygen atom eliminated one of the two major metabolites for this lead molecule.

64 ly metabolized by mice (~97%), with DPHP the major metabolite formed (34%-58%).

65 6,6'-Hexachlorobiphenyl-5-ol (5-136) was the major metabolite formed by microsomes from all other spe

66 Doxorubicinol (dxol) is the major metabolite formed in the hearts of cancer patients

67 5-oxo-eicosatrienoic acid (5-oxoETE), is the major metabolite formed within the murine peritoneal mac

68 analysis showed the presence of propranolol major metabolites formed by hydroxylation, correlating w

69 The major metabolites formed by P450 2B1 from the furanocoum

70 The diphosphate derivatives were the major metabolites formed in cells on both these agents,

71 a mucolytic agent, and the S-oxides are the major metabolites found in urine.

72 The three major metabolites generated by CYP3A4 were 1,23R,25(OH)(

73 Plasma exposures of remdesivir, its 2 major metabolites (GS-704277 and GS-441524), and the fre

74 For 135 strains, OP-1118, a major metabolite, had an MIC for inhibition of 50% of or

75 s of DHEA such as pregnenolone or six of its major metabolites, had no significant effect on prolifer

76 While AR pharmacokinetics and two major metabolites have been reported, the metabolic path

77 T-2 and its major metabolite HT-2 toxin are naturally occurring cont

78 yl derivatives of ketamine and of ketamine's major metabolites hydroxynorketamine (HNK), norketamine

79 As a major metabolite in anaerobic bacterial growth, hydrogen

80 sponding carboxylic acid was identified as a major metabolite in blood.

81 L-containing feed, and arsenobetaine was the major metabolite in breasts from chicks fed the UL-conta

82 e discovery of epoxypironetin as pironetin's major metabolite in human liver microsomes.

83 may explain why 3beta-hydroxytibolone is the major metabolite in human target tissues and why 3alpha-

84 6,6'-Hexachlorobiphenyl-4-ol (4-136) was the major metabolite in incubations with HLMs and monkey and

85 Formate is a major metabolite in the anaerobic fermentation of glucos

86 chniques identified N-dealkylated FECNT as a major metabolite in the rat brain, and reverse-phase HPL

87 A major metabolite in these sensitive cell lines has been

88 ally reside in the aquatic environment and a major metabolite in this habitat is the chitinous exoske

89 We then quantitate catecholamines and their major metabolites in human brain, plasma, and urine.

90 ll glucuronidation rates of nicotine and its major metabolites in smokers.

91 e presence of elevated dopamine (DA) and its major metabolites in the cytosol of neurons has been ass

92 We used CEST-MRI to map the major metabolites in tomato fruit at tissue level throug

93 study to report variability of all PCBs and major metabolites in two generations of people and sugge

94 onsistent study to evaluate all 209 PCBs and major metabolites in two generations of people living in

95 on legal and illegal psychoactive drugs, and major metabolites, in breast milk.

96 Major metabolites influenced by cropping period were alp

97 ed OlmO catalyzed complete conversion of the major metabolite into oligomycin C.

98 -biological profiling of chemicals and their major metabolites is a sensible alternative for the toxi

99 is approach gave accurate predictions of the major metabolite levels throughout fruit development, as

100 to this discovery was the identification of major metabolite M1, resulting from N-demethylation of l

101 tructures of parent compound GLB and its two major metabolites M1 and M2 were identified in plasma us

102 The two major metabolites M7 and M9 were unambiguously verified

103 Our discovery that MDMA and a major metabolite, MDA, induce prolonged mitogenic respon

104 oids lutein and zeaxanthin, along with their major metabolites, meso-zeaxanthin, and 3'-oxolutein, ar

105 both cell lines, conversion of 4-HPR to its major metabolite, N-[4-methoxyphenyl]retinamide, as well

106 cation of the drug amiodarone (AMIO) and its major metabolite, N-desethylamiodarone (NDEA), in single

107 In contrast, its major metabolite, N-desmethylclozapine (NDMC), is though

108 ceptors, particularly M(1) and M(4), and its major metabolite, N-desmethylclozapine, is a full agonis

109 Its major metabolite nelfinavir hydroxy-tert-butylamide exer

110 ies, were used to quantify clozapine and its major metabolite norclozapine in isolated perfused rat l

111 This was confirmed by its major metabolite norfluoxetine whose load did not increa

112 mine's psychoactive effects, ketamine or its major metabolite norketamine could act intracellularly t

113 The major metabolite O-des-methylibogaine was 75-fold less a

114 omitant increase in the concentration of the major metabolite o-desmethylvenlafaxine during the same

115 sappeared from plasma and was converted to a major metabolite, O6-Benzyl-8-oxoguanine.

116 In this study, we reported that NNAL, a major metabolite of a tobacco-specific carcinogen NNK, i

117 Desethylamiodarone, a major metabolite of amiodarone, also exerts voltage-inde

118 ethacin-sensitive fashion, and (c) PGE2, the major metabolite of arachidonic acid, stimulated cAMP fo

119 e-diagnosis levels of plasma salicylurate, a major metabolite of aspirin, in 396 pancreatic cancer ca

120 A major metabolite of BHA, tert-butylhydroquinone (tBHQ),

121 Because hydroxybupropion, a major metabolite of bupropion, is believed to contribute

122 Prostaglandin E2 is a major metabolite of COX activation.

123 concentrations of thiocyanate (SCN(-) ), the major metabolite of cyanide, in the bodily fluids of kon

124 The major metabolite of dietary gammaT, 2,7,8-trimethyl-2-(b

125 4-Hydroxyequilenin (4-OHEN), a major metabolite of equilin and equilenin, promotes 4-OH

126 Acetaldehyde, a major metabolite of ethanol, reacts with dG residues in

127 ine F(2)-isoprostanes, and urine levels of a major metabolite of F(2)-isoprostanes were unchanged by

128 Alpha-methyldopamine (alpha-MeDA) is a major metabolite of MDA.

129 nd, could be observed for BE, cocaine, and a major metabolite of MDMA (i.e., 4-hydroxy-3-methoxymetha

130 yl-N2-formyl-5-methoxykynuramine (AMFK) is a major metabolite of melatonin in mammals.

131 n levels of 6-sulphatoxymelatonin (aMTS6), a major metabolite of melatonin.

132 The related compound cotinine, the major metabolite of nicotine in humans, also slows down

133 Cotinine is the major metabolite of nicotine, and measuring serum cotini

134 dy to apply the measurement of cotinine, the major metabolite of nicotine, as a quantitative method t

135 A major metabolite of norepinephrine (NE) in brain is 4-hy

136 reflects lipid peroxidation in vivo) and the major metabolite of PGE(2) (PGE-M).

137 hydroxyphenyl)-5-phenylhydantoin (HPPH), the major metabolite of phenytoin in man, and the prevalence

138 The major metabolite of progesterone, 3alpha-hydroxy-dihydro

139 assay using 3-phenoxybenzoic acid (3-PBA), a major metabolite of pyrethroid insecticides as a model s

140 This indicates monohydroxy-TBECH as the major metabolite of TBECH by in vitro HLM-based assay.

141 Terfenadine carboxylate, the major metabolite of terfenadine, does not block either H

142 ple who use tobacco products are cotinine, a major metabolite of the addictive constituent nicotine,

143 we introduce florfenicol amine (FF-NH(2)), a major metabolite of the antibiotic florfenicol, which ac

144 2,7-Diaminomitosene (2,7-DAM), the major metabolite of the antitumor antibiotic mitomycin C

145 An asymmetric synthesis of the major metabolite of the calcitonin gene-related peptide

146 r condors from exposure to DDE (p,p'-DDE), a major metabolite of the chlorinated pesticide DDT.

147 19-Norandrosterone (19-NA) is the major metabolite of the steroid nandrolone, one of the m

148 th decreased concentrations of kynurenine, a major metabolite of tryptophan that plays a role in neur

149 The major metabolites of 11C-choline were phosphocholine in

150 One of the major metabolites of 2 is its P1-(R)-diastereoisomer, 3

151 Among the major metabolites of 4-HPR, 4-oxo-N-(4-hydroxyphenyl)ret

152 Major metabolites of 5-MeC were its proximate carcinogen

153 Major metabolites of 6-MeC were 6-MeC-1,2-diol, bay regi

154 im of the current study is to synthesize the major metabolites of [6]-shogaol and evaluate their inhi

155 The major metabolites of AA made by PMN, leukotriene B(4) an

156 These data indicate that all the major metabolites of APAP and multiple low-abundance met

157 indomethacin depressed urinary excretion of major metabolites of both TxA2, 2,3-dinor TxB2 (Tx-M), a

158 he NADPH and time-dependent formation of two major metabolites of D3 (i.e., 20-hydroxyvitamin D3 and

159 with human liver microsomes resulted in two major metabolites of each drug, which had HPLC retention

160 Herein we demonstrate that the major metabolites of ethanol in neural tissues, fatty ac

161 te and the urinary excretion of oxalate, the major metabolites of ethylene glycol, uniformly fell aft

162 y was to examine the inhibition potential of major metabolites of EXE through inhibition assays using

163 r simulations of the population dynamics and major metabolites of microbial communities from the huma

164 ured cerebrospinal fluid (CSF) levels of the major metabolites of serotonin (5-hydroxyindoleacetic ac

165 Sulindac sulfide is one of the major metabolites of sulindac that is believed to mediat

166 The major metabolites of tamoxifen (tam) formed by animal an

167 providing low cross-reactivity (<5%) to the major metabolites of TCS and to brominated diphenyl ethe

168 the zebra finch song system holds that both major metabolites of testosterone, dihydrotestosterone (

169 l (THC), cannabidiol and cannabinol, and two major metabolites of THC, 11-nor-9-carboxy-THC and 11-hy

170 yl or diaryl phosphates (DAPs), the expected major metabolites of the most prominent PFRs, and qualit

171 Two major metabolites of the tobacco-specific lung carcinoge

172 By doing so, we demonstrate that several major metabolites of these SCs retain their activity at

173 By doing so, we demonstrate that several major metabolites of these SCs retain their activity at

174 y B-glucuronidase, prompting us to probe the major metabolites of these SPAs.

175 cts and associated mechanisms of iAs and its major metabolites on adipogenesis were determined in 3T3

176 The effect of FDX and its major metabolite, OP-1118, on C. difficile growth and sp

177 Fatty acids were the major metabolites perturbed across the liver, portal vei

178 These findings indicate that gammaT and its major metabolite possess anti-inflammatory activity and

179 Nucleosides are major metabolite precursors for nucleotide biosynthesis

180 this work, sclerotiorin was obtained as the major metabolite produced in liquid fermentation by P. s

181 ,3,3',6,6'-hexachlorobiphenyl-5-ol being the major metabolite recovered from feces.

182 e (SFN-GSH) had little or no effect, the two major metabolites SFN-cysteine and SFN-N-acetylcysteine

183 e access to the absolute concentration of 14 major metabolites, showing significant differences betwe

184 Aspirin and its major metabolite sodium salicylate induced apoptosis and

185 of substantial plasma concentrations of the major metabolite, SU0020, for the entire treatment perio

186 Major metabolites such as uremic toxins (2,3-dihydroxy-5

187 ere measured as well as protein, starch, and major metabolites, such as hexoses, sucrose, organic aci

188 onolide AF is 231 times more potent than the major metabolite taccalonolide A and differs only by the

189 n polymorphonuclear leukocytes (PMNs) to two major metabolites that comigrated with synthetic 12(S)-

190 Two major metabolites, TLM K-1 and TLM K-2, together with th

191 in vivo evaluation of compound 1a showed its major metabolite to be a mu-opioid agonist, 4-methoxycar

192 -radiolabel associated with tamoxifen or its major metabolites was detected.

193 wed that urine levels of F(2)-IsoPs or their major metabolite were not significantly different betwee

194 The major metabolites were 3'-methoxy-4'-hydroxycinnamic aci

195 The PK of the parent compound and major metabolites were apparently linear, with a half-li

196 otein and fatty acid, and accumulation of 17 major metabolites were evaluated through FTIR and GC-MS.

197 Mass Spectrometry (LC-MS/MS) analysis, forty major metabolites were identified which may be responsib

198 eatment systems, pharmaceuticals and several major metabolites were measured in porewater, sediment,

199 trations of oblimersen (parent drug) and its major metabolites were variable.

200 ing the procarcinogenic 3,4-dihydrodiol as a major metabolite, whereas CYP1B1-null EF showed no signi

201 brain and gut exposure of thimerosal and its major metabolite, which had dopamine D3 receptor dissoci

202 re conditions, spirohexenolide A (1) was the major metabolite with traces of spirohexenolide B (2) ar

203 een groups were detected in any of the other major metabolites within this region (P > 0.05 for all c

204 r simultaneous quantification of TRP and its major metabolites would be highly desirable, and may be